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| 1 | Mini-Cog测试结果与老年骨折患者并发症及谵妄高风险有关显示文摘既位对于围手术期危险因素的分析,通常采用美国麻醉医师协会(American Society of Anesthesiologists,ASA)评分等全身状态分类方法。Mini-Cog测试是一种快速、易行、有效且观察者间变异较小的认知评估工具,可测量急性应激状态下患者在执行功能障碍和回忆方面的认知储备。 | Heng M Eagen CE Javedan H 胡玮 杨进城 | 2016 | 中国骨科临床与基础研究杂志2016，8，4： | 3 |
| 2 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 3 | 老龄小鼠模型内皮细胞衰老导致射血分数保留的心力衰竭显示文摘由于全球老龄化,射血分数保留的心力衰竭(heart failure with preserved ejection fraction,HFpEF)发生率持续上升。虽然HFpEF的病理生理机制仍然不完全清楚,但通常认为内皮炎症发挥了核心作用。细胞衰老是一种与老化和炎症有关的细胞生长停滞过程。Gevaert等使用加速老化的小鼠(senescence-accelerated mice,SAM)模型探究细胞衰老在HFpEF发生发展中的作用。 | 刘莉 叶鹏 Gevaert AB Shakeri H Leloup AJ Van Hove CE De Meyer GRY Vrints CJ Lemmens K Van Craenenbroeck EM | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 5 | Meconium aspiration produces airway hyperresponsiveness and eosinophilic inflammation in a mufine model显示文摘 | Khan AM Elidemir O Epstein CE Lally KP Xue H Blackbum M | 2002 | Am J Physiol Lung Cell Moll Physiol2002，283，4： | 1 |
| 6 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 7 | Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B显示文摘 | Westland CE Yang H Delaney WEt | 2003 | Hepatology2003，38，： | 1 |
| 8 | Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts 显示文摘 | Murry CE Soonpaa MH Reinecke H | 2004 | Nature2004，428，： | 1 |
| 9 | Haematopoietic stem ceils do not Transdifferentiate into cardiac myocytes in myocardial infarcts 显示文摘 | Murry CE Soopnaa MH Reineeke H | 2004 | Nature2004，428，6983： | 1 |
| 10 | Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage:a systematic review of published and unpublished studies显示文摘 | Loveloek CE Cordonnier C Naka H | 2010 | Stroke2010，41，： | 1 |
| 11 | CD28 and CTLA--4 co- receptor expression and signal transduction显示文摘 | Rudd CE Taylor A Schneider H | 2009 | Immunol Rev2009，229，1： | 1 |
| 12 | VATS lobectomy has better perioperative outcomes than open lobectomy: CALGB 31001, an ancillary analysis of CALGB 140202 (Alliance)显示文摘 | Nwogu CE D' CunhaJ Pang H | 2015 | Ann Thorac Surg2015，99，39： | 1 |
| 13 | Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts显示文摘 | Murry CE Soonpaa MH Reinecke H | 2004 | Nature2004，428，6983： | 1 |
| 14 | Preoperat ive indica-tions for percutaneous nephrolithotripsy in 2009显示文摘 | Probst CE Denst edt JD Razvi H | 2009 | Endourol2009，23，10： | 1 |
| 15 | IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation显示文摘 | Sandig H Jobbings CE Roldan NG | | 0，，04： | 1 |
| 16 | CD28 and CTLA-4coreceptor expression and signal transduction 显示文摘 | RUDD CE TAYLOR A SCHNEIDER H | 2009 | ImmunolRev2009，229，1： | 1 |
| 17 | Analysis of matrix met- allo- proteases and the plasminogen system in mild cognitive impair- ment and Alzheimer's disease cerebrospinal fluid 显示文摘 | Hanzel CE Iulita MF Eyjolfsdottir H | 2014 | J Alzheimers Dis2014，40，： | 1 |
| 18 | Surgery versus physical therapy for a meniscal tear and osteoarthritis显示文摘 | Katz J N Brophy R H Chaisson CE | 2013 | N Engl J Med2013，368，18： | 1 |
| 19 | Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine显示文摘 | Tomsig JL Sohma H Creutz CE | 2004 | Biochem J2004，378，15： | 1 |
| 20 | APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons 显示文摘 | Chen H Lilley CE Yu Q | 2006 | Curt Biol2006，16，5： | 1 |
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