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| 1 | Acute heart failure in elderly patients:a review of invasive and non-invasive management显示文摘Acute heart failure(AHF)is a major cause of unplanned hospitalisations in the elderly and is associated with high mortality.Its prevalence has grown in the last years due to population aging and longer life expectancy of chronic heart failure patients.Although international societies have provided guidelines for the management of AHF in the general population,scientific evidence for geriatric patients is often lacking,as these are underrepresented in clinical trials.Elderly have a different risk profile with more comorbidities,disability,and frailty,leading to increased morbidity,longer recovery time,higher readmission rates,and higher mortality.Furthermore,therapeutic options are often limited,due to unfeasibility of invasive strategies,mechanical circulatory support and cardiac transplantation.Thus,the in-hospital management of AHF should be tailored to each patient's clinical situation,cardiopulmonary condition and geriatric assessment.Palliative care should be considered in some cases,in order to avoid unnecessary diagnostics and/or treatments.After discharge,a strict follow-up through outpatient clinic or telemedicine is can improve quality of life and reduce rehospitalisation rates.The aim of this review is to offer an insight on current literature and provide a clinically oriented,patient-tailored approach regarding assessment,treatment and follow-up of elderly patients admitted for AHF. | Gregorio Tersalvi Alessio Gasperetti Marco Schiavone Jeroen Dauw Cecilia Gobbi Marialessia Denora Joel Daniel Krul Giacomo Maria Cioffi Gianfranco Mitacchione Giovanni B.Forleo | 2021 | Journal of Geriatric Cardiology2021，18，7： | 4 |
| 2 | Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures显示文摘二进制不对称的 nanocrystals (BNC ) ,加入的光敏的 TiO 2 nanorod 填写了 superparamagnetic -Fe2O3 球形的领域,在聚乙烯乙二醇被嵌入修改 phospholipid micelle 并且成功地 bioconjugated 到包含一个 RGD 主题的合适设计的肽。BNC 表示由于在一个粒子的二个不同领域的共存,相关多功能的 nanomaterial 由高 photoactivity 和磁性描绘了,那特别地在生物成像用作光线疗法和过高热代理人以及一根磁性的探针被适合。我们选择了 RGD 主题以便指向在激活的 endothelial 房间和癌症房间的几种类型上表示的 integrin。准备 RGD-peptide/BNC 结合,包括地由使用互补光、结构的技术监视了,在生物媒介表明了高稳定性和一致可分散性。RGD-peptide/BNC 的 cytotoxicity 结合在 vitro 被学习。RGD 肽的细胞的举起在房间结合,在房间 lysates 借助于二条不同途径,也就是共焦的显微镜学分析和排放光谱学决心估计了, RGD-peptide-BNC 的显示的选择为 v3 integrin 结合。这些 RGD-peptide-BNC 结合为癌症的 theranostic 治疗有一个高潜力。 | Gianpiero Valente Nicoletta Depalo Ivan de Paola Rosa Maria lacobazzi Nunzio Denora Valentino Laquintana Roberto Comparelli Emiliano Altamura Tiziana Latronico Michele Altomare Elisabetta Fanizza Marinella Striccoli Angela Agostiano Michele Saviano Annarita Del Gatto Laura Zaccaro Maria Lucia Curri | 2016 | Nano Research2016，9，3： | 2 |
| 3 | New strategies to deliver anticancer drugs to brain tumors 显示文摘 | Laquintana V Trapani A Denora N | 2009 | Expert Opin Drug Deliv2009，6，10： | 1 |
| 4 | Methotrexate-loaded chitosan- and glycolchitosan-based nanopartieles: a promising strategy for the administration of the anticaneer drug to brain tumors显示文摘 | Trapani A Denora N Iacobellis G | 2011 | AAPS PharmSeiTech2011，12，4： | 1 |
| 5 | Novel L Dopa and dopamine prodrugs containing a 2 phenyl imidazopyridinemoiety 显示文摘 | Denora N Laquintana V Lopedota A | 2007 | PharmRes2007，24，7： | 1 |
| 6 | Methotrexate- loaded chitosan and glycolchitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors显示文摘 | Trapani A Denora N IacobeUis G | 2011 | AAPS Pharm Sci Tech2011，12，4： | 1 |
| 7 | Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands显示文摘 | Trapani G Laquintana V Denora N | | 0，，： | 1 |
| 8 | Recent advances in medicinal chemistry and pharmaceutical technology-strategies for drug delivery to the brain显示文摘 | Denora N Trapani A Laquintana V | | 0，，02： | 1 |
| 9 | 2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors:Synthesis,binding affinity and electrophysiological studies显示文摘 | Denora N Laquintana V Pisu M G | | 0，，： | 1 |
| 10 | New strategies to deliver anticancer drugs to brain tumors显示文摘 | Laquintana V Trapani A Denora N | | 0，，10： | 1 |
| 11 | Translocator protein(TSPO)Ligand-Ara-C(cytarabine)conjugates as a strategy to deliver antineoplastic drugs and to enhance drug clinical potential显示文摘 | Denora N Laquintana V Trapani A | | 0，，06： | 1 |
| 12 | Eudragit RS 100 microparti- cles containing 2-hydroxypropyl-13-cyclodextrin and glutathione: Physi- cochemical characterization, drug release and transport studies 显示文摘 | Trapani A Laquintana V Denora N | 2007 | European journal of pharmaceutical sciences2007，30，1： | 1 |
| 13 | New strategies to deliver anticancer drugs to brain tumors显示文摘 | Laquintana V Trapani A Denora N | 2009 | Expert Opin Drag Deliv2009，6，10： | 1 |
| 14 | Eudragit RS 100 microparticles containing 2-hydroxypropyl-adriana trapani, valentino laquintana, nunzio denora-显示文摘 | Trapani A Laquintana V Denora N | 2007 | Eur J Pharm Sci2007，30，1： | 1 |
| 15 | Recent advances in medicinal chemistry and pharmaceutical technology-strategies for drug delivery to the brain显示文摘 | Denora N Trapani A Laquintana V | 2009 | Curr Top Med Chem2009，9，2： | 1 |
| 16 | Novel L-Dopa and dopamine prodrugs containing a 2-phenyl-imidazopyridine moiety显示文摘 | Denora N Laquintana V Lopedota A | 2007 | Pharm Res2007，24，7： | 1 |
| 17 | Sorafenib delivery nanoplatform based on superpara- magnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma显示文摘当前, sorafenib 是能够增加 hepatocellular 癌病人的全面幸存的唯一的全身的治疗。不幸地,它的副作用,特别地它的全面毒性,限制能被完成的治疗学的反应。因为他们能通过一个磁场的申请在身体被指向到特定的地点, Superparamagnetic 氧化铁 nanoparticles (SPION ) 为药交货是很吸引人的,因此改进 intratumoral 累积并且减少不利效果。这里, nanoformulations 由互补技术基于聚乙烯乙二醇修改了 phospholipid 微粒,与 SPION 和 sorafenib 装载了,成功地被准备并且彻底地调查了。这个 nanovector 系统提供了有效的药交货,有大约 125 nm 的一条平均水动力学直径,在水的媒介有好稳定性,并且允许控制的药装载。磁性的分析允许在每 micelle 嵌入的 SPION 的数量的精确决心。一在里面 vitro 系统被设计测试 SPION 微粒是否能高效地在在人的肝发现的典型流动条件下面用一个磁场被保持。人的 hepatocellular 癌(HepG2 ) 房间是被选择一在里面评估指向 superparamagnetic 微粒的功效的肿瘤房间的 vitro 系统与 sorafenib 装载了。这些实验证明这个交货平台能由磁性的指向提高 sorafenibs antitumor 有效性。磁性的 nanovectors 这里描述了为指向特定的肝的肿瘤地点代表有希望的候选人,在 sorafenib 的选择版本能改进它的功效和安全侧面的地方。 | Nicoletta Depalo Rosa Maria lacobazzi Gianpiero Valente Ilaria Arduino Silvia Villa Fabio Canepa Valentino Laquintana Elisabetta Fanizza Marinella Striccoli Annalisa Cutrignelli Angela Lopedota Letizia Porcelli Amalia Azzariti Massimo Franco Maria Lucia Curri Nunzio Denora | 2017 | Nano Research2017，10，7： | 1 |
| 18 | Properties of a Colloidal Alumina Bonded TiB2 Coating on Cathode Carbon Materials 显示文摘 | ФYE H A DENORA V DURUZ J J | 1997 | Essential Readings in Light Metals : Electrode Technology for Aluminum Production1997，4，： | 1 |
| 19 | A new complex of eureumin with sulfobutylether-β-cyclodextrin: characteriza- tion studies and in vitro evaluation of eytotoxie and antioxidant activity on HepG-2 cells显示文摘 | Cutrignelli A Lopedota A Denora N | 2014 | J Pharm Sci2014，103，12： | 1 |
| 20 | Recent advances in ligand targeted therapy显示文摘 | Trapani G Denora N Trapani A | 2012 | J Drug Target2012，20，： | 1 |
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