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| 1 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 2 | Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo显示文摘BACKGROUND:12-lipoxygenase(12-LOX) has been reported to be an important gene in cancer cell proliferation and survival,and tumor metastasis.However,its role in hepatocellular carcinoma(HCC) cells remains unknown.METHODS:Expression of 12-LOX was assessed in a diethylnitrosamine-induced rat HCC model,and in SMMC-7721,HepG2 and L-02 cells using immunohistochemical staining and reverse transcriptase-polymerase chain reaction(RT-PCR).GST-π and Ki-67 were determined in vivo by immunohistochemical staining.Apoptosis was evaluated by TUNEL assay.Cell viability and apoptosis were determined by MTT assay and flow cytometry,respectively.Apoptosis-related proteins in SMMC-7721 and HepG2 cells were detected by Western blotting.RESULTS:Immunohistochemical staining and RT-PCR showed that 12-LOX was over-expressed in rat HCC and two HCC cell lines,while the expression was inhibited by baicalein,a specific inhibitor of 12-LOX.Baicalein inhibited cell proliferation and induced apoptosis in rat HCC and both cell lines in a dose-and time-dependent manner.Our in vivo study demonstrated that baicalein also reduced neoplastic nodules.Mechanistically,baicalein reduced Bcl-2 protein expression coupled with a slight increase of the expression of Bax and activation of caspase-3.Furthermore,baicalein inhibited the activation of ERK-1/2(phosphorylated).Interestingly,the effects of baicalein were reversed by 12(S)-HETE,a metabolite of 12-LOX.CONCLUSIONS:Inhibition of 12-LOX leads to reduced numbers of HCC cells,partially caused by increased apoptosis.12-LOX may be a potential molecular target for HCC prevention and treatment. | Xi-Ming Xu,Guang-Jin Yuan,Jun-Jian Deng,Hong-Ting Guo,Miao Xiang,Fang Yang,Wei Ge and Shi-You Chen Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China Cancer Center, the 82nd Hospital of the Chinese PLA, Huai’an 223001, China Department of Physiology, Medical College of Wuhan University, Wuhan 430071, China Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 20 |
| 3 | Sperm DNA damage has a negative effect on early embryonic development following in vitro fertilization显示文摘精子 DNA 损坏作为男不孕的重要 biomarker 被认出。调查这,精子 DNA 损坏被精液的测试和能动精子由联合密度坡度 centrifugation (DGC ) 收获了的精子染色质分散(SCD ) 估计,在 161 的游泳起来联合在 vitro 授精(IVF ) 经历。精液分析和精子 DNA 损坏结果在确实完成了怀孕的夫妇之间被比较。精子 DNA 损坏水平在二个组之间是显著地不同的(P < 0.05 ) 并且否定地与 IVF 结果被相关。逻辑回归分析证实它是为完成临床的怀孕的一个独立预言者。IVF 结果上的精子 DNA 损坏的不同层次的效果也被比较。在白天 3 胚胎质量,胚囊形成率,和培植和怀孕率有重要差别(P < 0.05 ) ,然而并非处于在二个组之间的基本授精率。因此,由 SCD 测量了的精子 DNA 损坏为预言临床的怀孕率追随者 IVF 显得有用。 | Wei-Wei Zheng Ge Song Qi-Ling Wang Shan-Wen Liu Xiao-Li Zhu Shun-Mei Deng An Zhong Yu-Mei Tan Ying Tan | 2018 | Asian Journal of Andrology2018，20，1： | 19 |
| 4 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 5 | Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury显示文摘Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects and has been used to treat cardiovascular and cerebrovascular diseases in China. However, the mechanisms by which scutellarin mediates neuroprotection in cerebral ischemia remain unclear. The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity. Cultures of primary astrocytes isolated from the cerebral cortex of neonatal Sprague-Dawley rats were pretreated with 2, 10 or 50 μM scutellarin for 30 minutes. The astrocytes were then subjected to oxygen/glucose deprivation by incubation for 2 hours in glucose-free Dulbecco's modified Eagle's medium in a 95% N2/5% CO_2 incubator, followed by simulated reperfusion for 22 hours. Cell viability was assessed by cell counting kit-8 assay. Expression levels of NOX2, connexin 43 and caspase-3 were assessed by western blot assay. Reactive oxygen species were measured spectrophotometrically. Pretreatment with 10 or 50 μM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion. We also assessed the effects of scutellarin in vivo in the rat transient middle cerebral artery occlusion model of cerebral ischemia-reperfusion injury. Rats were given intraperitoneal injection of 100 mg/kg scutellarin 2 hours before surgery. The Bederson scale was used to assess neurological deficit, and 2,3,5-triphenyltetrazolium chloride staining was used to measure infarct size. Western blot assay was used to assess expression of NOX2 and connexin 43 in brain tissue. Enzyme-linked immunosorbent assay was used to detect 8-hydroxydeoxyguanosine(8-OHd G), 4-hydroxy-2-nonenal(4-HNE) and 3-nitrotyrosin(3-NT) in brain tissue. Immunofluorescence double staining was used to determine the co-expression of caspase-3 and Neu N. Pretreatment with scutellarin improved the neurological function of rats with focal cerebral ischemia, reduced infarct size, diminished the expression of NOX2, reduced levels of 8-OHd G, 4-HNE and 3-NT, and reduced the number of cells co-expressing caspase-3 and Neu N in the injured brain tissue. Furthermore, we examined the effect of the NOX2 inhibitor apocynin. Apocynin substantially increased connexin 43 expression in vivo and in vitro. Collectively, our findings suggest that scutellarin protects against ischemic injury in vitro and in vivo by downregulating NOX2, upregulating connexin 43, decreasing oxidative damage, and reducing apoptotic cell death. | Jing-Bo Sun Yan Li Ye-Feng Cai Yan Huang Shu Liu Patrick KK Yeung Min-Zhen Deng Guang-Shun Sun Prince LM Zilundu Qian-Sheng Hu Rui-Xin An Li-Hua Zhou Li-Xin Wang Xiao Cheng | 2018 | Neural Regeneration Research2018，13，8： | 16 |
| 6 | Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction显示文摘 | Mei Hua Jiang Bing Cai Ying Tuo Jiancheng Wang Zhi Jun Zang Xiang'an Tu Yong Gao Zhijian Su Weiqiang Li Guilan Li Min Zhang Jianwei Jiao Zi Wan Chunhua Deng Bruce T Lahn Andy Peng Xiang | 2014 | Cell Research2014，24，12： | 14 |
| 7 | Effects of water content, water type and temperature on the rheological behaviour of slag-cement and fly ash-cement paste backfill显示文摘The pumping ability and placement performance of fresh cemented paste backfill(CPB) in underground mined cavities depend on its rheological properties. Hence, it is crucial to understand the rheology of fresh CPB slurry, which is related to CPB mixture design and the temperature underground. This paper presented an experimental study investigating the effects of binder type, content, water chemical properties and content, and temperature, on the rheological properties of CPB material prepared using the tailings of a copper mine in South Australia. Portland cement(PC), a newly released commercially manufactured cement called Minecem(MC) and fly ash(FA) were used as the binders added to the mine tailing materials. Various amounts of two different water types were added to the mixtures in the preparation of backfill material slurry. Six different temperatures ranging from 5 to 60 °C were to investigate the effect of temperature on CPB rheology. Overall, the increasing water content and decreasing temperature lead to lower yield stress. Based on the results obtained from the rheological properties of CPB slurry, it was found that at room temperature(25 °C), with regards to the unconfined compressive strength(UCS) performance, the replacement of 4% PC mixed CPB(28 days UCS 425 k Pa) to 3% MC mixed CPB(28 days UCS 519 k Pa), reduced the slurry yield stress from 210.7 to 178.5 Pa. The results also showed that the chemical composition of water affects the yield stress of CPB slurry and that MC mitigates the negative effect of mine-processed water(MW) and thus lead to improve the rheological properties of the slurry. However, the results suggested that the rheological properties of a mixture using MC is very sensitive to the water volume and temperature change. Therefore, using MC in backfill requires better quality control in slump mixing. | Yue Zhao Abbas Taheri Murat Karakus Zhongwei Chen An Deng | 2020 | International Journal of Mining Science and Technology2020，30，3： | 13 |
| 8 | Factor Analysis on the Factors that Influencing Rural Environmental Pollution in the Hilly Area of Sichuan Province,China显示文摘By using factor analysis method and establishing analysis indicator system from four aspects including crop production,poultry farming,rural life and township enterprises,the difference,features,and types of factors influencing the rural environmental pollution in the hilly area in Sichuan Province,China.Results prove that the major factor influencing rural environmental pollution in the study area is livestock and poultry breeding,flowed by crop planting,rural life,and township enterprises.Hence future pollution prevention and control should set about from livestock and poultry breeding.Meanwhile,attention should be paid to the prevention and control of rural environmental pollution caused by rural life and township enterprise production. | LING Jing1,2,DENG Liang-ji1,2 1.School of Resource and Environment,Sichuan Agricultural University,Ya’an 625014,China 2.Key Laboratory of Land Information in Sichuan Province,Ya’an 625014,China | 2011 | Asian Agricultural Research2011，3，2： | 13 |
| 9 | Isolation and characterization of Zika virus imported to China using C6/36 mosquito cells显示文摘Dear Editor,Zika virus(ZIKV)is a mosquito-borne flavivirus that usually causes asymptomatic infections or mild illness in humans.However,the unprecedented epidemics of ZIKV in Latin America since early 2015 have made this flavivirus an international health risk(Liu and Zhang,2016).In particular,the potential association of ZIKV infection with the remarkable increase in the number | Chenglin Deng Siqing Liu Qiuyan Zhang Mingyue Xu Honglei Zhang Dayong Gu Lei Shi Jian'an He Gengfu Xiao Bo Zhang | 2016 | Virologica Sinica2016，31，2： | 12 |
| 10 | X-ray-charged bright persistent luminescence in NaYF_(4):Ln^(3+)@NaYF_(4) nanoparticles for multidimensional optical information storage显示文摘NaYF_(4):Ln^(3+),due to its outstanding upconversion characteristics,has become one of the most important luminescent nanomaterials in biological imaging,optical information storage,and anticounterfeiting applications.However,the large specific surface area of NaYF_(4):Ln^(3+)nanoparticles generally leads to serious nonradiative transitions,which may greatly hinder the discovery of new optical functionality with promising applications.In this paper,we report that monodispersed nanoscale NaYF_(4):Ln^(3+),unexpectedly,can also be an excellent persistent luminescent(PersL)material.The NaYF_(4):Ln^(3+)nanoparticles with surface-passivated core–shell structures exhibit intense X-ray-charged PersL and narrow-band emissions tunable from 480 to 1060 nm.A mechanism for PersL in NaYF_(4):Ln^(3+)is proposed by means of thermoluminescence measurements and host-referred binding energy(HRBE)scheme,which suggests that some lanthanide ions(such as Tb)may also act as effective electron traps to achieve intense PersL.The uniform and spherical NaYF_(4):Ln^(3+)nanoparticles are dispersible in solvents,thus enabling many applications that are not accessible for traditional PersL phosphors.A new 3-dimensional(2 dimensions of planar space and 1 dimension of wavelength)optical information-storage application is demonstrated by inkjet-printing multicolor PersL nanoparticles.The multicolor persistent luminescence,as an emerging and promising emissive mode in NaYF_(4):Ln^(3+),will provide great opportunities for nanomaterials to be applied to a wider range of fields. | Yixi Zhuang Dunrong Chen Wenjing Chen Wenxing Zhang Xin Su Renren Deng Zhongfu An Hongmin Chen Rong-Jun Xie | 2021 | Light(Science & Applications)2021，10，7： | 12 |
| 11 | Thermoelastic properties of sandwich materials with pin-reinforced foam cores显示文摘Pin-reinforced foam is a novel type of sandwich core materials formed by inserting pins(trusses) into a foam matrix to create a truss-like network reinforced foam core.Upon loading,the pins deform predominantly by local stretching whilst the deformation of foam is governed by local bending.This paper presents a theoretical study on the thermoelasticity of pin-reinforced foam sandwich cores.To calculate the effective thermoelastic properties of pin-reinforced foam cores,the energy-based homogenization approach is employed to develop a micromechanics-based model,calibrated by the existing experimental data.It is found that the stiffness of the sandwich core is mainly governed by pin reinforcements:the foam matrix contributes little to sandwich stiffness.Compared with traditional foam cores without pin reinforcements,the changes in inplane thermal expansion coefficients are not vigorous as a result of pin reinforcements,while the through-thickness thermal expansion coefficient changes significantly.It is also demonstrated that it is possible to design materials with zero or negative thermal expansion coefficients under such a context. | LU TianJian1,LIU Tao2,3 & DENG ZiChen2,4 1 MOE Key Laboratory of Strength and Vibration,School of Aerospace,Xi’an Jiaotong University,Xi’an 710049,China 2 Department of Engineering Mechanics,Northwestern Polytechnical University,Xi’an 710072,China 3 Department of Engineering,University of Cambridge,Cambridge CB2 1PZ,UK 4 State Key Laboratory of Structural Analysis of Industrial Equipment,Dalian University of Technology,Dalian 116024,China | 2008 | Science China(Technological Sciences)2008，51，12： | 10 |
| 12 | Colorectal cancer screening behavior and willingness:An outpatient survey in China显示文摘AIM:To identity the factors influencing colorectal cancer(CRC) screening behavior and willingness among Chinese outpatients.METHODS:An outpatient-based face-to-face survey was conducted from August 18 to September 7,2010 in Changhai Hospital.A total of 1200 consecutive patients aged ≥ 18 years were recruited for interview.The patient's knowledge about CRC and screening was pre-measured as a predictor variable,and other predictors included age,gender,educational level,monthly household income and health insurance status.The relationship between these predictors and screening behavior,screening willingness and screening approach were examined using Pearson's χ2 test and logistic regression analyses.RESULTS:Of these outpatients,22.5% had undergone CRC screening prior to this study.Patients who had participated in the screening were more likely to have good knowledge about CRC and screening(OR:5.299,95% CI:3.415-8.223),have health insurance(OR:1.996,95% CI:1.426-2.794) and older in age.Higher income,however,was found to be a barrier to the screening(OR:0.633,95% CI:0.467-0.858).An analysis of screening willingness showed that 37.5% of the patients would voluntarily participated in a screen at the recommended age,but 41.3% would do so under doctor's advice.Screening willingness was positively correlated with the patient's knowledge status.Patients with higher knowledge levels would like to participate in the screening(OR:4.352,95% CI:3.008-6.298),and they would select colonoscopy as a screening approach(OR:3.513,95% CI:2.290-5.389).However,higher income level was,again,a barrier to colonoscopic screening(OR:0.667,95% CI:0.505-0.908).CONCLUSION:Patient's level of knowledge and income should be taken into consideration when conducting a feasible CRC screening. | Shang-Xin Deng Jie Gao Wei An Jie Yin Quan-Cai Cai Hua Yang Zhao-Shen Li | 2011 | World Journal of Gastroenterology2011，17，26： | 10 |
| 13 | Distribution and deposition of polycyclic aromatic hydrocarbons in precipitation in Guangzhou, South China显示文摘Polycyclic aromatic hydrocarbons (PAHs) were measured in precipitation from March to August 2005 in Guangzhou, South China. Fourteen PAHs were studied, and their total concentrations varied from 616.6 to 3486.7 ng/L in dissolved phase and from 403.8 to 3125.5 ng/L in particulate phase. The estimated deposition loading of PAHs was 3568 μg/m2 during the monitoring period. The deposition of PAHs was a potential source for Pearl River comparing with the contents of surface water. In addition, the high concentration in precipitation here implied that PAHs pollution was a potential environmental problem in Guangzhou. Most precipitation concentrations of PAHs in March (the last month in winter in Guangzhou) were higher than in the other months (in rainy season). PAHs inclined to be adsorbed to particulate phase with the increase of molecular weight in rainwater. Combustion of fossil fuel and biomass might be the major source of PAHs, while the direct leakage or volatilization from petroleum products might be insignificant. | HUANG Deyin PENG Ping'an XU Yigang DENG Yunyun DENG Hongmei | 2009 | Journal of Environmental Sciences2009，21，5： | 9 |
| 14 | Shear behavior of coarse aggregates for dam construction under varied stress paths显示文摘Coarse aggregates are the major infrastructure materials of concrete-faced rock-fill dams and are consolidated to bear upper and lateral loads. With the increase of dam height, high confining pressure and complex stress states complicate the shear behavior of coarse aggregates, and thus impede the high dam's proper construction, operation and maintenance. An experimental program was conducted to study the shear behavior of dam coarse aggregates using a large-scale triaxial shear apparatus. Through triaxial shear tests, the strain-stress behaviors of aggregates were observed under constant confining pressures: 300 kPa, 600 kPa, 900 kPa and 1200 kPa. Shear strengths and aggregate breakage characteristics associated with high pressure shear processes are discussed. Stress path tests were conducted to observe and analyze coarse aggregate response under complex stress states. In triaxial shear tests, it was found that peak deviator stresses increase along with confining pressures, whereas the peak principal stress ratios decrease as confining pressures increase. With increasing confining pressures, the dilation decreases and the contraction eventually prevails. Initial strength parameters (Poisson’s ratio and tangent modulus) show a nonlinear relationship with confining pressures when the pressures are relatively low. Shear strength parameters decrease with increasing confining pressures. The failure envelope lines are convex curves, with clear curvature under low confining pressures. Under moderate confining pressures, dilation is offset by particle breakage. Under high confining pressures, dilation disappears. | Liu Hanlong Deng An Shen Yang | 2008 | Water Science and Engineering2008，1，1： | 9 |
| 15 | Rapid drift of the Tethyan Himalaya terrane before two-stage India-Asia collision显示文摘The India-Asia collision is an outstanding smoking gun in the study of continental collision dynamics.How and when the continental collision occurred remains a long-standing controversy.Here we present two new paleomagnetic data sets from rocks deposited on the distal part of the Indian passive margin,which indicate that the Tethyan Himalaya terrane was situated at a paleolatitude of∼19.4°S at∼75 Ma and moved rapidly northward to reach a paleolatitude of∼13.7°N at∼61 Ma.This implies that the Tethyan Himalaya terrane rifted from India after∼75 Ma,generating the North India Sea.We document a new two-stage continental collision,first at∼61 Ma between the Lhasa and Tethyan Himalaya terranes,and subsequently at∼53−48 Ma between the Tethyan Himalaya terrane and India,diachronously closing the North India Sea from west to east.Our scenario matches the history of India-Asia convergence rates and reconciles multiple lines of geologic evidence for the collision. | Jie Yuan Zhenyu Yang Chenglong Deng Wout Krijgsman Xiumian Hu Shihu Li Zhongshan Shen Huafeng Qin Wei An Huaiyu He Lin Ding Zhengtang Guo Rixiang Zhu | 2021 | National Science Review2021，8，7： | 7 |
| 16 | Effects of wind waves of the Pacific westerly on the eastern Pacific wave transport显示文摘There exists a tongue-shaped swell-dominance pool known as Swell Pool(SP) in the Eastern Pacific region.The monthly-mean wave transports(WT) for each month of 2000 is computed using the wave products of ECMWF reanalysis data.By comparing the 2000 monthly-mean WT and monthly-mean wind field from QUICKSCAT,large differences are found between the wave transport direction and the wind direction over the Eastern Pacific.This may serve as an evidence for the existence of the SP in this region.The work done in this study indicates that the sources of swell in the Tropical Eastern Pacific(TEP) are in the westerly regions of the Southern and Northern Pacific. | DENG Zeng' an WU Kejian ZHAO Dongliang YU Ting | 2009 | Acta Oceanologica Sinica2009，28，1： | 6 |
| 17 | Mineralization,Geochemistry and Zircon U-Pb Ages of the Paodaoling Porphyry Gold Deposit in the Guichi Region,Lower Yangtze Metallogenic Belt,Eastern China显示文摘The newly discovered Paodaoling porphyry Au deposit from the Guichi region, Lower Yangtze River Metallogenic Belt(LYRB), contains >35 tons of Au at an average grade of ~1.7 g/t. It is a porphyry ‘Au-only' deposit, as revealed by current exploration in the depths, mostly above-400 m, which is quite uncommon among coeval porphyry mineralization along the LYRB. Additionally, there are also Cu-Au bearing porphyries and barren alkaline granitoids in the Paodaoling district. Zircon LA-ICP-MS U-Pb dating of the Cu-Au-bearing porphyries yield an age of 141–140 Ma, falling within the main magmatic stage of the LYRB, whereas the barren granites give an age of 125–120 Ma, coeval with the regional Atype granites. The Cu-Au-bearing porphyries are LILE-, LREE-enriched and HFSE-depleted, typical of arc magmatic affinities. The barren granites are HFSE-enriched, with lower LREE/HREE ratios and pronounced negative Eu anomalies. The Cu-Au-bearing porphyries in the Paodaoling district have high oxygen fugacities and high water content. Pyrite sulfur isotopes of the Paodaoling gold deposit indicate a magmatic-sedimentary mixed source for the ore-forming fluids. Based on the alteration and poly-metal zonation of the deepest exploration drill hole from the Paodaoling Au deposit, we propose that Cu ore bodies could lie at depth beneath the current Au ore bodies. The magmatism and associated Cu-Au mineralization of the Paodaoling district are likely to have formed in a subduction setting, during slab rollback of the paleo-Pacific plate. | DUAN Liu'an YANG Xiaoyong DENG Jianghong WANG Fangyue LEE Insung | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 6 |
| 18 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 19 | Chromatography studies on bio-affinity of nine ligands of a1-adrenoceptor to a1D subtypes overexpressed in cell membrane显示文摘To improve selectivity and specificity of cell membrane chromatography (CMC), the chromatography affinities of nine ligands of a1-adrenergic receptor(AR)to a1D-AR subtype were investigated. The human embryonic kidney (HEK) 293 cells expressed by cDNA of a1D-AR subtypes were cultured and cell membrane stationary phase (CMSP) was prepared. Then the interactions between ligands and a1D-AR in CMSP were investigated using CMC. The affinity rank order to a1D-AR subtype obtained from CMC for the nine a1-adrenoceceptor ligands is: prazosin, BMY7378, phentolamine, oxymetazoline, 5-methylurapidil, norepinephrine, phenyle- phrine, methoxamine, RS-17053. The affinity rank order is similar and correlates well with that obtained from others radioligand binding assays (RBA). CMSP prepared by transfected HEK293 cells with 1D-adrenoceptor cDNA and CMC method could be used to evaluate affinities of drug-receptor and drug-receptor subtypes and to screen drugs selective to a1D-AR. | ZHANG Dian1, YUAN Bingxiang1, DENG Xiuling1, YANG Guangde2, HE Langchong2, ZHANG Youyi3 & HAN Qide3 1. School of Medicine, Xi’an Jiaotong University, Xi’an 710061, China 2. College of pharmacy, Xi’an Jiaotong University, Xi’an 710061, China 3. Third Hospital, Beijing University, Beijing 100083, China | 2004 | Science China(Life Sciences)2004，47，4： | 6 |
| 20 | Determination of hydroxyl radical in Fenton system显示文摘在可见轻照明下面, 2,3-diaminophenazine (DAPN ) 在 Fe 3+/H2 O 2 答案。氢氧根基(哦) 在这个系统生产了被直接测量 DAPN 的集中决定。与传统的方法比较,决心更精确、简单。 | Yan Fen Fang An Ping Deng Ying Ping Huang | 2009 | Chinese Chemical Letters2009，20，10： | 6 |
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