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| 1 | Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies显示文摘Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes.Methods:An umbrella review of systematic reviews with meta-analyses of observational studies was conducted.We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess significance.We graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 outcomes.Overall,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing evidence.Three associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as disability.To further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes. | Pinar Soysal Christopher Hurst Jacopo Demurtas Joseph Firth Reuben Howden Lin Yang Mark A.Tully Ai Koyanagi Petre Cristian Ilie Guillermo F.Lopez-Sanchez Lukas Schwingshackl Nicola Veronese Lee Smith | 2021 | Journal of Sport and Health Science2021，10，3： | 5 |
| 2 | Expression of sur- vivin protein in pterygium and relationship with oxidative DNAdamage 显示文摘 | Maxia C Perra MT Demurtas P | 2008 | J Cell Mol Med2008，12，6： | 1 |
| 3 | Utility of flow cytometry immunophenotyping in fine-needle aspirate cyto- logic diagnosis of non-Hodgkin lymphoma: A series of 252 cases and review of the literature显示文摘 | Demurtas A Accinelli G Pacchioni D | 2010 | Appl Immunohistochem Mol Morphol2010，18，4： | 1 |
| 4 | Utility of flow cytometry immunophenotyping in fine-needle aspirate cytologic diagnosis of non-Hodgkin lymphoma: A series of 252 cases and review of the literature 显示文摘 | Demurtas A Accinelli G Pacchioni D | 2010 | Appl Immunohistochem Mol Morphol2010，18，4： | 1 |
| 5 | Flow cytometry in the bone marrow staging of mature B-cell neoplasms 显示文摘 | Stacchini A Demurtas A Godio L | 2003 | Cytometry2003，54，1： | 1 |
| 6 | Insertion of nanoparticle clusters into vesicle bilayers显示文摘 | BONNAUD C MONNIRT C A DEMURTAS D | 2014 | Acs Nano2014，8，4： | 1 |
| 7 | Structure and secretory activity of cultured chondrocytes from patients with osteoarthritis 显示文摘 | Montrull HL Brizuela NY Demurtas SL | 2005 | Biocell2005，2，： | 1 |
| 8 | Utility of flow cytometry immunophenotyping in fine-needle aspirate cytologic diagnosis of non-Hodgkin lymphoma:A series of 252 cases and review of the literature显示文摘 | Demurtas A Accinelli G Pacchioni D | | 0，，04： | 1 |
| 9 | Collagenase production increases in rheumatoid arthritis and osteoarthritis synoviocytes incubated 显示文摘 | Montrull HL Brizuela NY Demurtas SL | 2000 | Rev Fac Cien Med Univ Nac Cordoba2000，57，1： | 1 |
| 10 | Utility of flow cytometry immunophenotyping in fine - needle aspirate cyto- logic diagnosis of non- Hodgkin lymphoma显示文摘 | DEMURTAS A ACCINELLI G PACCHIONI D | 2010 | Appl Immunohis- tochem Mol Morphol2010，18，4： | 1 |
| 11 | Flow cytometry in the bone marrow staging of mature B-cell neoplasms 显示文摘 | Staechini A Demurtas A Godio L | 2003 | Cytometry2003，54，1： | 1 |
| 12 | Relationship between the expression of cyclooxygenase-2 and surviving in primary pterygium显示文摘 | MAXIA C PERRA M T DEMURTAS P | 2009 | Mol Vis2009，15，： | 1 |
| 13 | Usefulness of multiparametric flow cytometry in detecting composite lymphoma:study of 17 cases in a 12-year period显示文摘 | Demurtas A Aliberti S Bonello L | 2011 | Am J Clin Pathol2011，135，4： | 1 |
| 14 | Expression of survivin protein in pterygium and relationship with oxidative DNA damage显示文摘 | Maxia C Perra MT Demurtas P | | 0，，6： | 1 |
| 15 | Flow cytometry in the bone marrow staging of mature B-cell neoplasms显示文摘 | Stacchini A Demurtas A Godio L | 2003 | Cytometry B Clin Cytom2003，54，： | 1 |
| 16 | Flow cytometry in the bone marrow staging of mature B-cell neoplasms显示文摘 | Stacchini A Demurtas A Godio L | 2003 | Cytometry B Clin Cytom2003，54，1： | 1 |
| 17 | Relationship between the ex-pression of eyclooxygenase-2 and survivin in primary pterygium显示文摘 | Maxia C Perra MT Demurtas P | 2009 | Mol Vis2009，15，2： | 1 |
| 18 | A chlamydomonasderived human papillomavirus 16 e7 vaccine induces specific tumor protection显示文摘 | Demurtas OC Massa S Ferrante P | | 0，，4： | 1 |
| 19 | Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium 显示文摘 | Maxia C Perra MT Demurtas P Minerba L Murtas D Piras F | 2009 | Mol Vis2009，15，5： | 1 |
| 20 | Oxidative stress in pterygium : relationship between p53 and 8-hydroxydeoxyguanosine 显示文摘 | Perra MT Maxia C Corbu A Minerba L Demurtas P Colombari R | 2006 | Mol Vis2006，12，13： | 1 |
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