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| 1 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 2 | Relationship between myocardial injury and soluble P-selectin in non-ST elevation acute coronary syndromes显示文摘 | Yazici M Demircan S Duma K | 2005 | Circ J2005，69，5： | 1 |
| 3 | Left ventricular diverticulum in two adult patients 显示文摘 | Yazici M Demircan S Duma K | 2005 | Int Heart J2005，46，1： | 1 |
| 4 | Relationship between myocardial injury and soluble P-selection in non-ST elevation acute coronary syndromes显示文摘 | Yazici M Demircan S Durna K | 2005 | Circ J2005，69，53： | 1 |
| 5 | Relationship between myocardial injury and P-selectin in non-ST-elevation acute coronary syndromes 显示文摘 | Yazici M Demircan S Duma K | 2005 | Circ J2005，69，5： | 1 |
| 6 | The role of adrenergic activity in slow coronary flow and its relationship to TIMI frame count显示文摘 | Yazici M Demircan S Durna K | 2007 | Angiology2007，58，4： | 1 |
| 7 | Curcumin improves early functional results after experimental spinal cord injury显示文摘 | Cemil B Topuz K Demircan MN | | 0，，： | 1 |
| 8 | Relationship between myocardial injury and soluble P-selectin in non-ST elevation acute coronary syndromes显示文摘 | Yazici M Demircan S Duma K | | 0，，： | 1 |
| 9 | The role of adrenergic activity in slow coronary flow and its relationship to TIMI frame count 显示文摘 | Yazici M Demircan S Duma K | 2007 | Angiology2007，58，4： | 1 |
| 10 | Frequent deletion and down-regulation of ING4,a candidate tumor suppressor gene at12p13,in head and neck squamous cell carcinomas显示文摘 | Gunduz M Nagatsuka H Demircan K | | 0，，： | 1 |
| 11 | Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas显示文摘 | Gunduz M Nagatsuka H Demircan K | 2005 | Gene2005，356，1： | 1 |
| 12 | Lipoprotein(a) levels in patients with unstable angina and their relationship with atherothrombosis and myocardial damage显示文摘 | YAZIC1 M DEMIRCAN S DURNA K | 2005 | Int J Clin Pract2005，59，2： | 1 |
| 13 | Frequent deletion and down - regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas显示文摘 | Gunduz M Nagatsuka H Demircan K | 2005 | Gene2005，356，1： | 1 |
| 14 | Relationship between myocardial injury and soluble P2 selectin in non-ST elevation acute coronary syndromes 显示文摘 | Yazici M Demircan S Duma K | 2005 | Circ J2005，69，5： | 1 |
| 15 | Frequent deletion and downregulation of INC,4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas显示文摘 | Gunduz M Nagatsuka H Demircan K | 2005 | Gene2005，356，： | 1 |
| 16 | The role of adrenergic activity in slow coronary flow and its relationship to TIMI frame count显示文摘 | YAZICI M DEMIRCAN S DURNA K | 2007 | Angiology2007，58，4： | 1 |
| 17 | Lipoprotein(a)levels in patients with unstable angina and their relationship with atherothrombosis and myocardial damage显示文摘 | Yazici M Demircan S Durna K Sahin M | 2005 | Int J Clin Pract2005，59，2： | 1 |
| 18 | Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13,in head and neck squamous cell carcinomas显示文摘 | Gunduz M Nagatsuka H Demircan K | 2005 | Gene2005，356，： | 1 |
| 19 | Increased mR- NA expression of ADAMTS metalloproteinases in metastat- ic loci of head and neck cancer 显示文摘 | Demircan K Gunduz E Gunduz M | 2009 | Head Neck2009，31，6： | 1 |
| 20 | Left ventrieular diverticulum in two adult patients显示文摘 | Yazici M Demircan S Durna K | 2005 | Int Heart J2005，46，： | 1 |
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