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| 1 | Migration of Some Elements and Radionuclides across aGranite-Granite Contact Zone: A Natural Analoguefor Safe Disposal of High-Level Radwastes显示文摘Elements and natural radionuclides in the contact zone of two granites with different ages would migrate from one to the other because of the difference in their chemical contents and later water-rock interactions. This migration could serve as an analogue for the near-field process of radwastes in a high-level radwaste deep geological disposal repository.In the contact between the Indosinian granite (whole-rock Rb-Sr isochron age at 214@3 Ma) and Hercynian granite (zircon U-Pb isochron age at 296@31 Ma) located in Ziyuan County, Guangxi, the O and Pb isotope characteristics and the activity ratios of 234U/238U, 230Th/238U, 230Th/234U and 226Ra/230Th show that, based on the whole-rock chemical contents, both of the two granites have maintained a relatively open chemical system in their evolution processes. However, as there is no obvious open fault, the migration of major elements, trace elements and natural U-series nu-clides takes place within only 1-2 m in the contact zone, and water-rock | LUO Xingzhang MIN Maozhong ZHANG Guanghui LI Xianguo YANG Zhe ZHAI Liying Zhu Deling | 1999 | Acta Geologica Sinica(English Edition)1999，73，4： | 4 |
| 2 | Organic carbon and nitrogen isotopes in surface sediments from the western Arctic Ocean and their implications for sedimentary environments显示文摘 | CHEN Zhihua SHI Xuefa CAI Deling HAN Yibing YANG Zuosheng | 2006 | Acta Oceanologica Sinica2006，25，5： | 4 |
| 3 | Burial fluxes and sources of organic carbon in sediments of the central Yellow Sea mud area over the past 200 years显示文摘Long-term changes of composition,sources and burial fluxes of TOC(total organic carbon) in sediments of the central Yellow Sea mud area and their possible affecting factors are discussed in this paper.Firstly,similarity analysis is employed to confirm that the carbon burial features resulted from two collected cores are typical in the central Yellow Sea mud area where YSWC(Yellow Sea Warm Current) is prevalent.On this basis,the burial flux of TOC here was considered to be 235.5–488.4 μmol/(cm2?a) since the first industrial revolution,accounting for about 70%–90% among burial fluxes of TC(total carbon) in the sediments.Compared TOC/TC ratio in the two cores with that in other marine sediments worldwide,we suggest that the growth of calcareous/non-calcareous organisms and dissolution of IC(inorganic carbon) are important factors controlling the TOC/TC ratio in sediment.Results of two-end mixed model based on δ13C data indicate that marine-derived organic carbon(OCa)is the main part among total burial organic carbon which accounts for a ratio over 85%.Due to the high TOC/TC ratio in the two cores,TC in the sediments also mainly exists as OCa,and the proportion of OCa is about 60%–80%.Away from the shore and relatively high primary production in upper waters are the main reasons that OCa is predominant among all burial OC in sediments of the central Yellow Sea mud area.Burial of OC in this mud area is probably mainly influenced by the human activities.Although the economic development during the late 19 th century caused by the first industrial revolution in China did not obviously increase the TOC burial fluxes in the sediments,the rise of industry and agriculture after the founding of new China has clearly increased the TOC burial flux since 1950 s.Otherwise,we also realize that among TC burial fluxes,TIC account for about 10%–30% in sediments of the central Yellow Sea mud area,so its burial could not be simply ignored here.Distinct from TOC burial,long-term TIC burial fluxes variations relate with climate changes more closely:the East Asian summer monsoon may influence the strength of the Huanghe River(Yellow River) flood,which could further affect the transport of terrestrial IC from land to the central Yellow Sea as well as the burial of these IC in the sediments. | YANG Shu YANG Qian LIU Sai CAI Deling QU Keming SUN Yao | 2015 | Acta Oceanologica Sinica2015，34，10： | 3 |
| 4 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 5 | The “1-3-7” Approach to Malaria Surveillance and Response--Henan Province, China, 2012−2018显示文摘What is already known about this topic?The“1-3-7”approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization(WHO)as an international guideline for malaria surveillance and response in 2018.What is added by this report?The“1-3-7”approach was well implemented in Henan Province from 2012−2018.Over this study period,a total of 1,294 malaria cases were detected and reported,and all cases were diagnosed and reported within 1 day with 99.23%(1,284/1,294)of cases were investigated within 3 days.In addition,93.7%(1,212/1,294)of foci were investigated and vector control was implemented within 7 days at all residual non-active foci to prevent further spread.What are the implications for public health practice?The“1-3-7”controlling pattern would be an effective and approachable method for implementation especially in malaria-eliminating countries and regions,but the interval from symptom onset to diagnosis cannot be ignored.Thus,the roles and responsibilities that all actors involved in the health sector must be specified too. | Qunqun Zhang Ying Liu Yabo Hu Yuling Zhao Chengyun Yang Dan Qian Ruimin Zhou Suhua Li Zhou Guan Deling Lu Hongwei Zhang Wanshen Guo | 2020 | China CDC weekly2020，2，17： | 3 |
| 6 | Non-viral gene carrier mediated short hairpin RNA interference for inhibition of tumor cells growth显示文摘A tumor-targeting gene vector G250mAb-PEI-PEG has been prepared by modification of polyethylenimine (PEI) with polyethyleneglycol (PEG) and G250, a monoclonal antibody against the G250 antigen on tumor cell surface. The transfection efficiency was as high as 70% in G250 positive HeLa cells, whereas the transfection efficiency was relatively low (30%) in normal NIH3T3 cells. A plasmid encoding the short hairpin RNA (shRNA) specific for nucleostemin gene (NS) was efficiently transfected into the HeLa cells with this nonviral gene vector. RNA interference down-regulated the expression of NS gene in HeLa cells, inhibited cells proliferation and induced apoptosis. However, the growth and activity of the NIH3T3 cells were not affected under the same treatment. These results indicate that the reported nonviral gene vector, G250mAb-PEI-PEG, can target and efficiently deliver genes into HeLa cells, and has the potential for the cervical cancer treatment. | DUAN YaJun YANG CuiHong ZHANG ZhenFang LIU JianFeng ZHENG JunNian XU Yong KONG DeLing YU YaoTing | 2009 | Chinese Science Bulletin2009，54，17： | 2 |
| 7 | Free chlorine loss during spraying of membraneless acidic electrolyzed water and its antimierobial effect on airborne bacteria from poultry house显示文摘 | Yang Zhao Hongwei Xin Deling Zhao | 2014 | Annals of Agricultural and Envimnmental Medicine2014，21，2： | 1 |
| 8 | Supramolecular co-assembly of self-adjuvanting nanofibrious peptide hydrogel enhances cancer vaccination by activating MyD88-dependent NF-κB signaling pathway without inflammation显示文摘Peptide vaccine targeting tumor-specific antigens is a promising cancer treatment regimen.However,peptide vaccines are commonly low-immunogenic,leading to suboptimal antitumor T-cell responses.Current peptide vaccination approaches are challenged by the variability of peptide physicochemical characters and vaccine formulations,flexibility,and the broad feasibility.Here,the supramolecular co-assembly of antigen epitope-conjugated peptides(ECPs)targeting CD8 or CD4 T-cell receptors was used to engineer a nanofibrious hydrogel vaccine platform.This approach provided precise and tunable loading of peptide antigens in nanofibers,which notably increased the antigen uptake,cross-presentation,and activation of dendritic cells(DCs).Immunization in mice indicated that the co-assembled peptide hydrogel did not induce local inflammation responses and elicited significantly promoted T-cell immunity by activating the MyD88-dependent NF-κB signaling pathway in DCs.Vaccination of mice using co-assembled peptide vaccine stimulated both enhanced CD8 and CD4 T cells against EG.7-OVA tumors without additional immunoadjuvants or delivery systems,and resulted in a more remarkable cancer immunotherapy efficacy,compared with free peptide vaccine or aluminum-adjuvanted peptide formulation.Altogether,peptide co-assembly demonstrated by three independent pairs of ECPs is a facile,customizable,and chemically defined approach for co-delivering peptide antigens in self-adjuvanting hydrogel vaccines that could induce stronger anticancer T-cell responses. | Qi Su Huijuan Song Pingsheng Huang Chuangnian Zhang Jing Yang Deling Kong Weiwei Wang | 2021 | Bioactive Materials2021，6，11： | 1 |
| 9 | A Measuring System for Time of Flight Spectrum of Neutron Based on Pulse Time Sequences Detection显示文摘 | Yong Reni Peng Feng Fan Yang Jiansheng Li Deling Mi | 2013 | 应用物理前沿(中英文版)2013，1，3： | 0 |
| 10 | Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration显示文摘Tissue regeneration requires exogenous and endogenous signals,and there is increasing evidence that the exogenous microenvironment may play an even more dominant role in the complex process of coordinated multiple cells.The short-distance peripheral nerve showed a spontaneous regenerative phenomenon,which was initiated by the guiding role of macrophages.However,it cannot sufficiently restore long-distance nerve injury by itself.Based on this principle,we firstly constructed a proinflammatory model to prove that abnormal M2 expression reduce the guidance and repair effect of long-distance nerves.Furthermore,a bionic peptide hydrogel scaffold based on self-assembly was developed to envelop M2-derived regenerative cytokines and extracellular vesicles(EVs).The cytokines and EVs were quantified to mimic the guidance and regenerative microenvironment in a direct and mild manner.The bionic scaffold promoted M2 transformation in situ and led to proliferation and migration of Schwann cells,neuron growth and motor function recovery.Meanwhile,the peptide scaffold combined with CX3CL1 recruited more blood-derived M2 macrophages to promote long-distance nerve reconstruction.Overall,we systematically confirmed the important role of M2 in regulating and restoring the injury peripheral nerve.This bionic peptide hydrogel scaffold mimicked and remodeled the local environment for M2 transformation and recruitment,favoring long-distance peripheral nerve regeneration.It can help to explicate regulative effect of M2 may be a cause not just a consequence in nerve repair and tissue integration,which facilitating the development of pro-regenerative biomaterials. | Pengxiang Yang Yong Peng Xiu Dai Jing Jie Deling Kong Xiaosong Gu Yumin Yang | 2023 | Bioactive Materials2023，，12： | 0 |
| 11 | Micro-nanofiber composite biomimetic conduits promote long-gap peripheral nerve regeneration in canine models显示文摘Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to repair.Autografting is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominent donor-site complications.Instead,imitating the native neural microarchitecture using synthetic conduits is expected to offer an alternative strategy for improving nerve regeneration.Here,we designed nerve conduits composed of high-resolution anisotropic microfiber grid-cordes with randomly organized nanofiber sheaths to interrogate the positive effects of these biomimetic structures on peripheral nerve regeneration.Anisotropic microfiber-grids demonstrated the capacity to directionally guide Schwann cells and neurites.Nanofiber sheaths conveyed adequate elasticity and permeability,whilst exhibiting a barrier function against the infiltration of fibroblasts.We then used the composite nerve conduits bridge 30-mm long sciatic nerve defects in canine models.At 12 months post-implant,the morphometric and histological recovery,gait recovery,electrophysiological function,and degree of muscle atrophy were assessed.The newly regenerated nerve tissue that formed within the composite nerve conduits showed restored neurological functions that were superior compared to sheaths-only scaffolds and Neurolac nerve conduit controls.Our findings demonstrate the feasibility of using synthetic biophysical cues to effectively bridge long-gap peripheral nerve injuries and indicates the promising clinical application prospects of biomimetic composite nerve conduits. | Xianhao Dong Yueyue Yang Zheheng Bao Adam C.Midgley Feiyi Li Shuxin Dai Zhuangzhuang Yang Jin Wang Lihua Liu Wenlei Li Yayuan Zheng Siyang Liu Yang Liu Weijian Yu Jun Liu Meng Fan Meifeng Zhu Zhongyang Shen Gu Xiaosong Deling Kong | 2023 | Bioactive Materials2023，，12： | 0 |
| 12 | Extraction of phenol from water by primary amine primene JMT显示文摘In this work,liquid-liquid extraction of phenol from aqueous solutions using primary amine Primene JMT(Primene®JM-T)was investigated.The extraction capability of Primene®JM-T with different diluents,including 3-heptanone,sulfonated kerosene,methyl isobutyl ketone,n-octanol,toluene and petroleum ether was studied.The experimental results indicated that the distribution coefficient of phenol extracted using Primene®JM-T that was diluted in 3-heptanone could reach 101.74 under the pH of 9.2.Moreover,the extraction reaction was exothermic(enthalpy change for the extraction reaction(DrHm)was21.03 kJ/mol).High temperature showed a negative effect on the extraction of phenol.The results also showed that adding mineral salt was conducive to the extraction process,and the extraction effi-ciency fell in the descending order of:(NH_(4))_(2)SO_(4)>NaCl>NH_(4)Cl.Two empirical correlations were put forward to quantitatively describe the salting effect.Furthermore,the equilibrium constants of phenol extraction using Primene®JM-T were calculated to be 78.2 L/mol.The phenol was extracted using Primene®JM-T with the possible stoichiometric formula of:[RNH_(3)^(+),PhOH]_(org),where R represents the alkyl group of the amine. | Qingjie Wang Yanchun Shi Deling Yang Pengge Ning | 2022 | Emerging Contaminants2022，8，1： | 0 |
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