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| 1 | Pentoxifylline versus prednisolone for severe alcoholic hepatitis:A randomized controlled trial显示文摘AIM:To compare the efficacy of pentoxifylline and prednisolone in the treatment of severe alcoholic hepatitis,and to evaluate the role of different liver function scores in predicting prognosis.METHODS:Sixty-eight patients with severe alcoholic hepatitis(Maddrey score≥32)received pentoxifylline(n=34,groupⅠ)or prednisolone(n=34,groupⅡ) for 28 d in a randomized double-blind controlled study,and subsequently in an open study(with a tapering dose of prednisolone)for a total of 3 mo,and were followed up over a period of 12 mo.RESULTS:Twelve patients in groupⅡdied at the end of 3 mo in contrast to five patients in groupⅠ.The probability of dying at the end of 3 mo was higher in groupⅡas compared to groupⅠ(35.29%vs 14.71%,P=0.04;log rank test).Six patients in groupⅡ developed hepatorenal syndrome as compared to none in groupⅠ.Pentoxifylline was associated with a significantly lower model for end-stage liver disease(MELD)score at the end of 28 d of therapy(15.53±3.63 vs 17.78±4.56,P=0.04).Higher baseline Maddrey score was associated with increased mortality.CONCLUSION:Reduced mortality,improved risk-benefit profile and renoprotective effects of pentoxifylline compared with prednisolone suggest that pentoxifylline is superior to prednisolone for treatment of severe alcoholic hepatitis. | Binay Krishna De Subhabrata Gangopadhyay Deep Dutta Sumanta Das Baksi Adyapad Pani Pramit Ghosh | 2009 | World Journal of Gastroenterology2009，15，13： | 26 |
| 2 | Review of the diagnosis,classification and management of autoimmune pancreatitis显示文摘Autoimmune pancreatitis(AIP)is a rare form of chronic pancreatitis,with as yet undetermined incidence and prevalence in the general population.Our understanding of it continues to evolve.In the last few years,2separate subtypes have been identified:type 1 AIP has been recognised as the pancreatic manifestation of a multiorgan disease,named immunoglobulin G4(IgG4)-related disease while type 2 AIP is a pancreas specific disorder not associated with IgG4.International criteria for the diagnosis of AIP have been defined:the HISORt criteria from the Mayo clinic,the Japan consensus criteria and,most recently,the international association of pancreatology'International Consensus Diagnostic Criteria'.Despite this,in clinical practice it can still be very difficult to confirm the diagnosis and differenti-ate AIP from a pancreatic cancer.There are no large studies into the long-term prognosis and management of relapses of AIP,and there is even less information at present regarding the Type 2 AIP subtype.Further studies are necessary to clarify the pathogenesis,treatment and long-term outcomes of this disease.Critically for clinicians,making the correct diagnosis and differentiating the disease from pancreatic cancer is of the utmost importance and the greatest challenge. | Derek A O'Reilly Deep J Malde Trish Duncan Madhu Rao Rafik Filobbos | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 14 |
| 3 | 单重和多重调谐质量惯容阻尼器控制连体超高层建筑风振响应比较研究显示文摘连体超高层建筑因存在强烈的气动干扰,在强风下可能会出现大幅相对振动,调谐质量惯容阻尼器(TMDI)是一种振动控制装置,其惯容器两端的相对加速度较大时,TMDI振动控制效果较好。结合两者各自的特点提出了多重调谐质量惯容阻尼器(MTMDI)控制连体超高层建筑的风振响应,两个TMDI分别控制两栋建筑各自的一阶自振频率。首先建立了MTMDI控制连体超高层建筑风致响应数学模型,然后开展了某连体超高层建筑的刚性模型同步测压风洞试验;最后,基于该数学模型和测压风洞试验结果分析了该连体建筑在分别安装两个和单个TMDI对风振加速度和位移响应的减振效果。研究结果表明:虽然两个TMDI的总质量和总惯容量比单个TMDI相应的参数小,但两者的减振效果基本相同,两者都能有效地减小两栋建筑在各个风向角下的加速度响应,如在270°风向角下,安装TMDI后两栋建筑顶层加速度响应分别减小了37.5%和50.0%;对于位移响应,两者都可以减小高栋建筑的响应,其对低栋建筑在少部分风向角下的减振效果并不理想。 | 王钦华 雷伟 祝志文 TIWARI Nayan Deep | 2021 | 建筑结构学报2021，42，4： | 10 |
| 4 | An international program on Silk Road Disaster Risk Reduction--a Belt and Road initiative (2016-2020)显示文摘Belt and Road Initiative(BRI) is a Chinese national strategy which calls for cooperative economic, political and cultural exchange at the global level along the ancient Silk Road. The overwhelming natural hazards located along the belt and road bring great challenges to the success of BRI. In this framework, a 5-year international program was launched to address issues related to hazards assessment and disaster risk reduction(DRR). The first workshop of this program was held in Beijing with international experts from over 15 countries. Risk conditions on Belt and Road Countries(BRCs) have been shared and science and technology advancements on DRR have been disseminated during the workshop. Under this program, six task forces have been setup to carry out collaborative research works and three prioritized study areas have been established. This workshop announced the launching of this program which involved partners from different countries including Pakistan, Nepal, Russia, Italy, United Kingdom, Sri Lanka and Tajikistan. The program adopted the objectives of Sendai Framework for Disaster Risk Reduction 2015-2030 and United Nation Sustainable Development Goals 2030 and was implemented to assess disaster risk in BRCs and to propose suitable measures for disaster control which can be appropriate both for an individual country and for specific sites. This paper deals with the outcomes of the workshop and points out opportunities for the near future international cooperation on this matter. | LEI Yu CUI Peng Amar Deep REGMI Virginia MURRAY Alessandro PASUTO Giacomo TITTI Muhammad SHAFIQUE Tilak PRIYADARSHANA D.G. | 2018 | Journal of Mountain Science2018，15，7： | 8 |
| 5 | Landslide susceptibility assessment of the region affected by the 25 April 2015 Gorkha earthquake of Nepal显示文摘Nepal was hit by a 7.8 magnitude earthquake on 25^(th) April,2015.The main shock and many large aftershocks generated a large number of coseismic landslips in central Nepal.We have developed a landslide susceptibility map of the affected region based on the coseismic landslides collected from remotely sensed data and fieldwork,using bivariate statistical model with different landslide causative factors.From the investigation,it is observed that most of the coseismic landslides are independent of previous landslides.Out of 3,716 mapped landslides,we used 80% of them to develop a susceptibility map and the remaining 20% were taken for validating the model.A total of 11 different landslide-influencing parameters were considered.These include slope gradient,slope aspect,plan curvature,elevation,relative relief,Peak Ground Acceleration(PGA),distance from epicenters of the mainshock and major aftershocks,lithology,distance of the landslide from the fault,fold,and drainage line.The success rate of 87.66% and the prediction rate of86.87% indicate that the model is in good agreement between the developed susceptibility map and theexisting landslides data.PGA,lithology,slope angle and elevation have played a major role in triggering the coseismic mass movements.This susceptibility map can be used for relocating the people in the affected regions as well as for future land development. | Amar Deep Regmi Megh Raj Dhital ZHANG Jian-qiang SU Li-jun CHEN Xiao-qing | 2016 | Journal of Mountain Science2016，13，11： | 7 |
| 6 | Landslide Susceptibility Mapping along Bhalubang–Shiwapur Area of Mid-Western Nepal Using Frequency Ratio and Conditional Probability Models显示文摘Roads constructed in fragile Siwaliks are prone to large number of instabilities. Bhalubang–Shiwapur section of Mahendra Highway lying in Western Nepal is one of them. To understand the landslide causative factor and to predict future occurrence of the landslides, landslide susceptibility mapping(LSM) of this region was carried out using frequency ratio(FR) and weights-of-evidence(W of E) models. These models are easy to apply and give good results. For this, landslide inventory map of the area was prepared based on the aerial photo interpretation, from previously published/unpublished reposts, and detailed field survey using GPS. About 332 landslides were identified and mapped, among which 226(70%) were randomly selected for model training and the remaining 106(30%) were used for validation purpose. A spatial database was constructed from topographic, geological, and land cover maps. The reclassified maps based on the weight values of frequency ratio and weights-of-evidence were applied to get final susceptibility maps. The resultant landslide susceptibility maps were verified andcompared with the training data, as well as with the validation data. From the analysis, it is seen that both the models were equally capable of predicting landslide susceptibility of the region(W of E model(success rate = 83.39%, prediction rate = 79.59%); FR model(success rate = 83.31%, prediction rate = 78.58%)). In addition, it was observed that the distance from highway and lithology, followed by distance from drainage, slope curvature, and slope gradient played major role in the formation of landsides. The landslide susceptibility maps thus produced can serve as basic tools for planners and engineers to carry out further development works in this landslide prone area. | Amar Deep REGMI Kohki YOSHIDA Hamid Reza POURGHASEMI Megh Raj DHITAL Biswajeet PRADHAN | 2014 | Journal of Mountain Science2014，11，5： | 5 |
| 7 | Chinese expert consensus on programming deep brain stimulation for patients with Parkinson’s disease显示文摘Background:Deep Brain Stimulation(DBS)therapy for the treatment of Parkinson’s Disease(PD)is now a well-established option for some patients.Postoperative standardized programming processes can improve the level of postoperative management and programming,relieve symptoms and improve quality of life.Main body:In order to improve the quality of the programming,the experts on DBS and PD in neurology and neurosurgery in China reviewed the relevant literatures and combined their own experiences and developed this expert consensus on the programming of deep brain stimulation in patients with PD in China.Conclusion:This Chinese expert consensus on postoperative programming can standardize and improve postoperative management and programming of DBS for PD. | Shengdi Chen Guodong Gao Tao Feng Jianguo Zhang The Chinese Medical Association neurosurgery branch of functional neurosurgery group The Chinese Medical Association neurology branch of Parkinson’s disease,Movement disorders group The Chinese Physician Association neurosurgeon branch of functional neurosurgery expert committee The Chinese Physician Association neurologist branch of Parkinson’s disease and Movement disorders professional committee Chinese expert committee on Deep Brain Stimulation for Parkinson’s Disease | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 8 | Transarterial chemoembolization for liver metastases from solid pseudopapillary epithelial neoplasm of pancreas: A case report显示文摘Solid pseudo-papillary epithelial neoplasm(SPEN) is a rare epithelial tumor of pancreas with a low malignant potential occurs most commonly in young females. We report a case of 40 years old woman presented withextensive liver metastasis from SPEN of pancreatic body for which she was operated four years ago. Due to the extensive nature of metastatic disease she was offered Transarterial chemoembolisation(TACE) using gemcitabine as chemotherapeutic agent. Short term follow up after a month of TACE with multiphase computed tomography showed > 90% resolution in the viable tumor with significant clinical improvement. TACE ensures targeted delivery of chemotherapeutic drugs in higher doses with least systemic toxicity and is more effective and safe than systemic chemotherapy. TACE with gemcitabine was found to be very effective in our patient with numerous liver metastasis. | TV Prasad KS Madhusudhan Deep N Srivastava Nihar R Dash Arun K Gupta | 2015 | World Journal of Radiology2015，7，3： | 5 |
| 9 | A coupled elasto-plastic-damage mechanical model for marble显示文摘A profound understanding of the mechanical behaviors of marble is very important for the design and construction of deep diversion tunnels in Jinping II hydropower station.In this paper,a coupled elasto-plastic-damage mechanical model is presented for Jinping marble.Firstly,the experimental investigations on Jinping marble are summarized.Then,based on the framework of continuum damage and plastic theories,a general mechanical model is proposed to predict the mechanical responses of Jinping marble.The proposed model is used to simulate the triaxial compressive tests,and there is a general good agreement between experimental data and numerical predictions in a qualitative manner.The proposed model is able to capture the main features of Jinping marble observed in experiments,such as progressive yielding process,damage induced by plastic distortion,dilation,elastic degradation and stress sensitivity. | ZHOU Hui 1,ZHANG Kai 2 & FENG XiaTing 1 1 State Key Laboratory of Geomechanics and Geotechnical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences,Wuhan 430071,China 2 State Key Laboratory for Geomechanics and Deep Underground Engineering,China University of Mining&Technology,Xuzhou 221008,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 4 |
| 10 | Quantitative assessment of the complexity of geological structures in terms of seismic propagators显示文摘How a wave interacts with heterogeneous media has been pursued by many geophysicists.The complexity of subsurface heterogeneities is seismologically a relative concept to wavelengths of seismic waves.A growing perception is that velocity variations,propagation angles,and computational accuracies are closely related at a variety of scales.A tentative strategy to quantitatively evaluate the complexity of subsurface heterogeneous media is presented in this article to see what scales of geological heterogeneities to be captured by waves.We express complex subsurface structures as the slowness-and angularheterogeneity spectra to quantify velocity contrasts and dipping-angle distributions of complex geological structures.On the other hand,the scaling characteristics of a propagator are measured through dispersion analysis by its angular spectra plotted against refractive indexes and propagation angles,respectively.A parameter termed as imaging efficiency is introduced by associating the geological heterogeneity spectra with the propagator's angular spectra to understand the coherent interference between the medium's heterogeneity and the propagator's scaling characteristics.Furthermore,a complexity coefficient can be defined to evaluate geological complexities in terms of propagators.The application of this strategy is demonstrated to the SEG/EAEG salt model. | FU LiYun Key Laboratory of the Earth’s Deep Interior,Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing 100029,China | 2010 | Science China Earth Sciences2010，53，1： | 4 |
| 11 | Cancer stem cells and HER2 positive breast cancer:The story so far显示文摘Human Epidermal Growth Factor Receptor type 2(HER2)gene amplification and/or protein overexpression is observed in patients suffering from HER2t breast cancer.This subtype of breast cancer has improved prognosis due to availability of anti-HER2 therapy.However,drug resistance and tumor recurrence still remains a major concern.Cancer Stem Cells(CSCs)are believed to constitute the subset of cell population that is resistant to drug treatment and possesses characteristics of stem cells.CSCs enable the tumors to thrive despite major insults.This review provides a comprehensive idea about the concept of CSCs in context of HER2t breast cancer by providing the description of the markers that are used for the identification of CSCs and by elucidating the signaling pathways that are associated with HER2t breast CSCs.Furthermore,the review also describes the interaction of HER2 with those signaling pathways and the future of targeting CSCs in HER2t breast cancer. | Deep Shah Clodia Osipo | 2016 | Genes & Diseases2016，3，2： | 3 |
| 12 | 深部重大工程灾害的孕育演化机制与动态调控理论研究进展显示文摘深部重大工程灾害的孕育演化机制、预测预报和防治理论的研究是我国水利水电、交通、国防、深部基础物理实验等工程安全建设与运行以及金属矿山安全高效开采中的重大课题。本文介绍了973计划项目'深部重大工程灾害的孕育演化机制与动态调控理论'近5年的重要研究成果,包括:深部岩体结构与地应力特征、深部岩体变形破坏过程的分析方法、岩爆灾害的孕育演化机制、预测预警与调控技术、以及能量调控诱导破岩方法等方面,研究成果已成功应用于我国多个典型深部工程,推动了深部工程开挖开采过程中灾害的预测预报、防控理论和技术的进步。 | The project office for 973 project 'Theories on evolution mechanism and dynamical control of great disasters in deep engineering' Institute of Rock and Soil Mechanics,Chinese Academy of Sciences | 2014 | 中国基础科学2014，16，4： | 3 |
| 13 | Hemodynamic effects of propranolol with spironolactone in patients with variceal bleeds: A randomized controlled trial显示文摘AIM: To study the hemodynamic effects of spironolactone with propranolol vs propranolol alone in the secondary prophylaxis of variceal bleeding. METHODS: Thirty-five cirrhotics with variceal bleeding randomly received propranolol (n = 17: Group A) or spironolactone plus propranolol (n = 18: Group B). Hemodynamic assessment was performed at baseline and on the eighth day. RESULTS: Spironolactone with propranolol caused a greater reduction in the hepatic venous pressure gradient than propranolol alone (26.94% vs 10.2%; P < 0.01). Fourteen out of eighteen patients on the combination treatment had a reduction in hepatic venous pressure gradient to ≤ 12 mmHg or a 20% reduction from baseline in contrast to only six out of seventeen (6/17) on propranolol alone (P < 0.05). CONCLUSION: Spironolactone with propranolol results in a better response with a greater reduction in hepatic venous pressure gradient in the secondary prophylaxis of variceal bleeding. A greater number of patients may be protected by this combination therapy than by propranolol alone. Hence, this combination may be recommended for secondary prophylaxis in patients with variceal bleeding. | Binay K De Deep Dutta Rimi Som Pranab K Biswas Subrata K Pal Anirban Biswas | 2008 | World Journal of Gastroenterology2008，14，12： | 3 |
| 14 | Nanomaterials for sensing of formaldehyde in air: Principles, applications, and performance evaluation显示文摘Despite the improvement in sensing technologies, detection of small and highly reactive molecules like formaldehyde remains a highly challenging area of research. Applications of nanomaterials/nanostructures and their composites have increased as effective sensing platforms (e.g., reaction time, sensitivity, and selectivity) for the detection of aqueous or gaseous formaldehyde based on diverse sensing principles. In this review, the basic aspects of important nanomaterial-based sensing systems (e.g., electrochemical, electrical, biological, and mass variation sensors) were evaluated in relation to performance, cost, and practicality of sensing gas phase formaldehyde. Accordingly, existing knowledge gaps in such applications were assessed in various respects along with suitable recommendations for building a new roadmap for the expansion of chemical sensing technology of gas phase formaldehyde. | Deepak Kukkar Kowsalya Vellingiri Rajnish Kaur Sanjeev Kumar Bhardwaj Akash Deep Ki-Hyun Kim | 2019 | Nano Research2019，12，2： | 3 |
| 15 | Bipolar radiofrequency ablation of tibialchondroblastomas: A report of three cases显示文摘Chondroblastoma is a rare benign cartilaginous neoplasm of bone. The recurrence rate is high and complications are frequent following open curettage with bone grafting which is the standard treatment forchondroblastomas. We performed radiofrequency ablation in three cases of tibialchondroblastoma using the bipolar system. One patient experienced residual pain for which repeat ablation was performed. No other complications were observed during follow-up. Radiofrequency ablation may offer an effective alternative for the treatment of selected cases of chondroblastoma. The lesion characteristics which are likely to influence treatment outcome and the advantages offered by the bipolar system are discussed. | Prathiba Rajalakshmi Deep N Srivastava Shivanand Gamanagatti Pramod Kumar Julka Sushma Bhatnagar Shishir Rastogi | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 16 | Radiological interventions in malignant biliary obstruction显示文摘Malignant biliary obstruction is commonly caused by gall bladder carcinoma, cholangiocarcinoma and metastatic nodes. Percutaneous interventions play an important role in managing these patients. Biliary drainage, which forms the major bulk of radiological interventions, can be pal iative in inoperable patients or pre-operative to improve liver function prior to surgery. Other interventions include cholecystostomy and radiofrequency ablation. We present here the indications, contraindications, technique and complications of the radiological interventions performed in patients with malignant biliary obstruction. | Kumble Seetharama Madhusudhan Shivanand Gamanagatti Deep Narayan Srivastava Arun Kumar Gupta | 2016 | World Journal of Radiology2016，8，5： | 2 |
| 17 | Evaluation of the role of preoperative Double-J ureteral stenting in retroperitoneal laparoscopic pyelolithotomy显示文摘 | Jagdish Chander Anuj Deep Dangi Nikhil Gupta Anubhav Vindal Pawanindra Lal V. K. Ramteke | 2010 | Surgical Endoscopy2010，，7： | 2 |
| 18 | Is CT scan a predictor of instability in recurrent dislocation shoulder?显示文摘Purpose: Glenoid bone defect and the defect on the posterior-superior surface of the humerus “Hill- Sachs lesion” are the commonly seen bony lesions in patients with recurrent dislocation shoulder. Computed tomography (CT) scan is considered as the best option in assessing the bony defects in the recurrent dislocation shoulder. The aim of this study was to assess the clinical and radiological corelation in the patients with recurrent dislocation shoulder. Methods: Forty-four patients of recurrent dislocation shoulder who were evaluated between January 2015 and December 2017 at a tertiary care center, clinically and radiologically using CT scan and meeting the inclusion criteria, were included. The correlation between the clinical history of the number of dislocations and the bone loss using CT scan was evaluated. Two sided statistical tests were performed at a significance level of α=0.05. The analysis was conducted using IBM SPSS STATISTICS (version 22.0). Results: All the patients were male with mean age of 25.95 (SD ± 4.2) years were evaluated. Twenty-four patients sustained injury in sporting activities while 20 patients sustained injury in training. There were an average of 4.68 (SD ± 3.1, range 2e15, median 3) episodes of dislocation. Forty-one patients had the glenoid bone loss while 40 had the Hill-Sachs lesions. The mean glenoid width defect was 10.80%(range 0e27%) while the mean Hill-Sachs defect was 14.27 mm (range 0e26.6 mm). The mean area of bone loss of the glenoid surface was 10.81%(range 0e22.4%). The lesions were on track in 34 patients and off track in 10 patients. Conclusions: CT scan of the shoulder joint is an effective method for assessing the amount of bone loss. The number of dislocations are correlated significantly with off-track lesions and the amount of bone loss on the glenoid and Hill-Sachs lesion. The glenoid width bone loss of more than 9.80% or Hill-Sachs defect of more than 14.80 mm are the critical defects after which the frequency of dislocations increases. | K.P.Shijith Munish Sood Ajay Deep Sud Amresh Ghai | 2019 | Chinese Journal of Traumatology2019，22，3： | 2 |
| 19 | Cosmogenic ^(21)Ne concentrations and exposure ages of summit bedrocks in the Grove Mountains,Antarctica显示文摘Various sources of 21Ne and 22Ne exist in surface rocks:cosmogenic,in situ nucleogenic from internal U and Th,trapped crustal nucleogenic and trapped atmospheric.This paper reports the first measurement,in China,of cosmogenic 21Ne and 22Ne in surface bedrocks.We developed a unique sample pre-treatment procedure that effectively removed inclusions inside quartz grains,and thus maximally reduced nucleogenic contributions of 21Ne and 22Ne.Step-heating experiments show that concen-trations of cosmogenic 21Ne and 22Ne in summit bedrock samples R9202 and R9203 from Grove Mountains,Antarctica,are(3.83±0.87)×108 and(5.22±0.51)×108 atoms/g,respectively.The corresponding minimum exposure ages are 2.2±0.5 and 3.0±0.3 Ma.This indicates that the ice sheet in East Antarctica was uncovered the crest of Mount Harding,a typical nunatak in Grove Mountains,since at least mid-Pliocene. | KONG Ping1,2,DING Lin2,LAI QingZhou2 & HUANG FeiXin3 1 Key Laboratory of the Earth’s Deep Interior,Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing 100029,China 2 Key Laboratory of Continental Collision and Plateau Uplift,Institute of Tibetan Plateau Research,Chinese Academy of Sciences,Beijing 100085,China 3 Institute of Mineral Resources Research,China Metallurgical Geology Bureau,Beijing 100025,China | 2010 | Science China Earth Sciences2010，53，4： | 2 |
| 20 | Application of artificial neural networks in detection and diagnosis of gastrointestinal and liver tumors显示文摘As a form of artificial intelligence,artificial neural networks(ANNs)have the advantages of adaptability,parallel processing capabilities,and non-linear processing.They have been widely used in the early detection and diagnosis of tumors.In this article,we introduce the development,working principle,and characteristics of ANNs and review the research progress on the application of ANNs in the detection and diagnosis of gastrointestinal and liver tumors. | Wei-Bo Mao Jia-Yu Lyu Deep K Vaishnani Yu-Man Lyu Wei Gong Xi-Ling Xue Yang-Ping Shentu Jun Ma | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
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