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| 1 | Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel,flavopiridol,and 5-fluorouracil显示文摘瞄准:有 docetaxel, flavopiridol,或 5 氟尿嘧啶(5-FU ) 的稳固的肿瘤的临床的治疗经常遇到不受欢迎的副作用和药抵抗。在 modulating chemosensitivity 并且更好与 docetaxel, flavopiridol,或 5-FU 评估联合治疗的潜在的角色的目的理解他们怎么可能临床上被使用的这研究。方法:HCT116 结肠癌房间在几不同行政时间表在试管内与 docetaxel, flavopiridol,和 5-FU 被对待,顺序或同时。房间幸存被 MTT 试金测量。caspase-3 的活动被 caspase-3 试金决定,软琼脂殖民地试金被用来在软琼脂测试 HCT116 房间的菌落形成。我们也建立了异种皮移植模型扩大在试管内观察到一个在活体内系统。结果:当人的结肠癌 HCT116 房间为 flavopiridol 为另一 24 h 为 24 h 和 5-FU 跟随的 1 h 与 docetaxel 被对待时,最大的细胞毒性被发现。这顺序的联合治疗不仅与另外的联合治疗相比更强烈禁止肿瘤细胞生长而且显著地在软琼脂减少菌落形成并且扩充 HCT116 细胞的 apoptosis。docetaxel 定序以后由 flavopiridol 跟随了 1 h,以后在异种皮移植模型由 5-FU 跟随了 24 h,也导致了推迟的肿瘤生长和更高的幸存率。结论:当把 docetaxel 与 flavopiridol 和 5-FU 相结合时,这些结果强调一张行政时间表的重要性,提供对它在临床的试用的发展的基本原理解释。 | Jun GUO An-wu ZHOU Yu-cai FW Udit N VERMA Debu TRIPATHY Eugene P FRENKEL Carlos R BECERRA | 2006 | Acta Pharmacologica Sinica2006，27，10： | 4 |
| 2 | Neoadjuvant chemotherapy with FOLFOX: Improved outcomes in Chinese patients with locally advanced gastric cancer显示文摘 | Zi‐YuLi Cherry E.Koh Zhao‐DeBu Ai‐WenWu Lian‐HaiZhang Xiao‐JiangWu QiWu Xiang‐LongZong HuiRen LeiTang Xiao‐PengZhang Ji‐YouLi YingHu LinShen Jia‐FuJi | 2012 | J Surg Oncol2012，，8： | 2 |
| 3 | Pancreatic cancer–Neoadjuvant therapy显示文摘In spite of the high mortality in pancreatic cancer, significant progress is being made. This review discusses multimodality therapy for patients with pancreatic cancer. Surgical therapy currently offers the only potential monomodal cure for pancreatic adenocarcinoma. However only 10%–20% of patients present with tumors that are amenable to resection, and even after resection of localized cancers, long term survival is rare. The addition of chemoradiation therapy significantly increases median survival. To achieve long-term success in treating this disease it is therefore increasingly important to identify effective neoadjuvant/adjuvant multimodality therapies. Preoperative chemoradiation for potentially resectable pancreatic cancer has the following advantages: (1) neoadjuvant treatment would eliminate the delay of adjuvant treatment due to postoperative complications; (2) neoadjuvant treatment could avoid unnecessary surgery for patients with metastatic disease evident on restaging after neoadjuvant therapy; (3) downstaging after neoadjuvant therapy may increase the likelihood for negative surgical margins; and (4) neoadjuvant treatment could prevent peritoneal tumor cell implantation and dissemination caused during surgery. This review systematically summarizes the current status, controversies, and prospects of neoadjuvant treatment of pancreatic cancer. | R. Krempien M. W. Munter W. Harms J. Debus | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，2： | 2 |
| 4 | Comparison of PET imaging with a 68 Ga-labelled PSMA ligand and 18 F-choline-based PET/CT for the diagnosis of recurrent prostate cancer显示文摘 | Ali Afshar-Oromieh Christian M. Zechmann Anna Malcher Matthias Eder Michael Eisenhut Heinz G. Linhart Tim Holland-Letz Boris A. Hadaschik Frederik L. Giesel Jürgen Debus Uwe Haberkorn | 2014 | European Journal of Nuclear Medicine and Molecular Imaging2014，，1： | 2 |
| 5 | Extracranial stereotactic radiation therapy:set-up accuracy of patients treated for liver metastases显示文摘 | Herfarth K K Debus J Lohr F | 2000 | Int J Radiat Oncol Biol Phys2000，46，2： | 1 |
| 6 | Colorectal cancer显示文摘 | WEITZ J KOCH M DEBUS J | 2005 | Lancet2005，365，9454： | 1 |
| 7 | Colorectal cancer显示文摘 | Weitz J Koch M Debus J | 2005 | Lancet2005，365，9454： | 1 |
| 8 | Colour flow Doppler ultrasound of the carotidbifurcation:can it replace routine angiography before carotid endarterectomy显示文摘 | Dinkel HP Moll R Debus S | 2011 | British Radiol2011，74，8： | 1 |
| 9 | LEOPARD-II:A randomized phase II study of radiochemotherapy RCT with 5FU and cisplatin plusminus cetuximab Cet in unresectable locally advanced esophageal cancer LAEC显示文摘 | Rades D Moehler MH Debus J | 2014 | J Clin Oncol2014，，： | 1 |
| 10 | Colorectal cancer显示文摘 | Weitz J Koch M Debus J | 2005 | Lancet2005，365，9454： | 1 |
| 11 | Cardiac arrhythmias and sudden death in infancy: implication for the medicalegal investigation显示文摘 | Wedekind H Schulze-Bahr E Debus V | 2007 | Int J Legal Med2007，121，4： | 1 |
| 12 | The role of growth factors in wound healing显示文摘 | Debus ES Schmidt K Ziegler UE | 2010 | Zentralbl Chir2010，125，1： | 1 |
| 13 | Outcome and late complications of radiotherapy in patients with unicentric Castleman disease显示文摘 | NEUHOF D DEBUS J | 2006 | Acta Oncol2006，45，8： | 1 |
| 14 | Assessment of the ecotoxic potential of soil contaminants by using a soil-algae test 显示文摘 | Hammel W Steubing L Debus R | 1998 | Ecotoxicol Environ Saf1998，40，： | 1 |
| 15 | Particle beams for cancer therapy 显示文摘 | Weyrather WK Debus J | 2003 | Clin Oncol (R Coll Radiol)2003，15，1： | 1 |
| 16 | A finite element model for the dynamics of flexible manipulators 显示文摘 | Bricout J N Debus J C Micheau P | 1990 | Mechanism and Machine Theory1990，25，1： | 1 |
| 17 | Aortomesenteric artery compression syndrome显示文摘 | Dietz UA Debus ES Heuko-Valiati L | 2000 | Chirurg2000，71，11： | 1 |
| 18 | Pharmacokinetics of liposomal amphotericin B (AmBisome) versus other lipid-based formulation显示文摘 | HEINEMANN V KAHNY B DEBUS A ed al | 1994 | Bone Marrow transplant1994，14，： | 1 |
| 19 | stereotactic singel2dose radiationtherapy of liver tumor:results of a phase Ⅰ / Ⅱ trial显示文摘 | Herfarth KK Debus J Lohr F | | 0，，01： | 1 |
| 20 | Degradation of xylene by a biofilm growing on a gas- permeable Membrane显示文摘 | Oliver Debus | 1992 | Wat Sci Tech1992，26，34： | 1 |
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