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| 1 | Clinical significance of main pancreatic duct dilation on computed tomography: Single and double duct dilation显示文摘AIM: To study the patients with main pancreatic duct dilation on computed tomography (CT) and thereby to provide the predictive criteria to identify patients at high risk of significant diseases, such as pancreatic cancer, and to avoid unnecessary work up for patients at low risk of such diseases. METHODS: Patients with dilation of the main pancreatic duct on CT at Emory University Hospital in 2002 were identified by computer search. Clinical course and ultimate diagnosis were obtained in all the identified patients by abstraction of their computer database records. RESULTS: Seventy-seven patients were identified in this study. Chronic pancreatitis and pancreatic cancer were the most common causes of the main pancreatic duct dilation on CT. Although the majority of patients with isolated dilation of the main pancreatic duct (single duct dilation) had chronic pancreatitis, one-third of patients with single duct dilation but without chronic pancreatitis had pancreatic malignancies, whereas most of patients with concomitant biliary duct dilation (double duct dilation) had pancreatic cancer. CONCLUSION: Patients with pancreatic double duct dilation need extensive work up and careful followup since a majority of these patients are ultimately diagnosed with pancreatic cancer. Patients with single duct dilation, especially such patients without any evidence of chronic pancreatitis, also need careful follow-up since the possibility of pancreatic malignancy, including adenocarcinoma and intraductal papillary mucinous tumors, is still high. | Mark D Edge Maarouf Hoteit Amil P Patel Xiaoping Wang Deborah A Baumgarten Qiang Cai | 2007 | World Journal of Gastroenterology2007，13，11： | 9 |
| 2 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 3 | Imaging of intrauterine contraceptive, devices 显示文摘 | Nagamani P Dsvid G Deborah L | 2007 | J Ultrasound Med2007，，7： | 1 |
| 4 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 5 | Radiation-induced epigenetic DNA methylation modification of radiation-response pathways显示文摘 | Deborah A Antwih Kristina M Gabbara Wayne D Lancaster Douglas M Ruden Steven P Zielske | 2013 | Epigenetics2013，，8： | 1 |
| 6 | Natriuretic Peptides,Their Receptors and cGMP-dependent Signa-ling Functions显示文摘 | Lincoln R P Sarah A H Deborah M D | 2005 | Endocrine Reviews2005，16，： | 1 |
| 7 | Illegitimate Cre dependent chromosome rearrangements in transgenic mouse spermatics显示文摘 | EDWARD E S DEBORAH S T JUSTIN R P | 2000 | PNAS2000，97，13： | 1 |
| 8 | The Prevalence of Depression in a Cohort of the very Dlderly显示文摘 | Deborah M G Claire B Eugene S P | 1995 | Journal of Affective Disorders1995，34，： | 1 |
| 9 | 显示文摘 | David M P Lawrence F D Deborah G C | 2004 | J Am Chem Soc2004，126，14： | 1 |
| 10 | Long-term influences of livestock management and a non-native grass on grass dynamics in the Desert Grassland显示文摘 | Deborah L A Mitchel P M | 2001 | Journal of Arid Environments2001，49，： | 1 |
| 11 | The impact of complications on outcomes after resection for esophageal and gastroesophageal junction carcinoma显示文摘 | Nabil P Rizk Peter B Bach Deborah Schrag Manjit S Bains Alan D Turnbull Martin Karpeh Murray F Brennan Valerie W Rusch | 2004 | Journal of the American College of Surgeons2004，，1： | 1 |
| 12 | Zinc phytoextraction in the spicaertdescens显示文摘 | MITCH M L NICOLE S P DEBORAH L D | 2001 | International Journal of Phytoremediation2001，3，： | 1 |
| 13 | Two-dimensional gel electrophoresis and mass spectrometry for biomarker discovery显示文摘 | DEBORAH P | 2009 | Proteomics ClinAppl2009，3，2： | 1 |
| 14 | Illegitimate Cre dependent chromosome rearrangements in transgenic mouse spermaties显示文摘 | Edward E S Deborah S T Justin R P | 2000 | PNAS2000，97，13： | 1 |
| 15 | The quality and frequency of mothertoddler conflict : Links with attachment and temperament 显示文摘 | Deborah L Tia P Drika M | 2008 | Child Development2008，79，2： | 1 |
| 16 | Framework for COPD forecas- ting in the UK using weather and climate change predictions 显示文摘 | Deborah H Colma A James P | 2009 | Earth Environ Sei2009，6，14： | 1 |
| 17 | Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?显示文摘 | David Moher Ba’ Pham Alison Jones Deborah J Cook Alejandro R Jadad Michael Moher Peter Tugwell Terry P Klassen | 1998 | The Lancet . 1998 (9128)1998，，9128： | 1 |
| 18 | Spill hazard evaluation for chemicals shipped in bulk using modeling 显示文摘 | Deborah P F MeCay Nicole W Matthew W | 2006 | Environmental Modelling & Software2006，21，： | 1 |
| 19 | Expression of acrB, acrF, acrD, marA, and soxS in Salmonella enterica serovar Typhimuri- urn: role in multiple antibiotic resistance 显示文摘 | Deborah J E Laura J V P Vito R | 2004 | Antimicrob Agents Chemother2004，48，4： | 1 |
| 20 | Connecting the physical world with pervasive networks 显示文摘 | DEBORAH E DAVID C KRIS P | 2002 | IEEE Pervasive Computing2002，12，1： | 1 |
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