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| 1 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma显示文摘Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. | Esther Llop Pedro E Guerrero AdriàDuran Sílvia Barrabés Anna Massaguer María JoséFerri Maite Albiol-Quer Rafael de Llorens Rosa Peracaula | 2018 | World Journal of Gastroenterology2018，24，24： | 4 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation显示文摘 | Jose A. Rodríguez-Navarro Laura Rodríguez María J. Casarejos Rosa M. Solano Ana Gómez Juan Perucho Ana María Cuervo Justo García de Yébenes María A. Mena | 2010 | Neurobiology of Disease2010，，3： | 2 |
| 5 | Neurophysiological evidence of corticospinal tract abnormality in patients with Parkin mutations 显示文摘 | De Rosa A Volpe G Marcantonio L | 2006 | Neurol2006，253，3： | 1 |
| 6 | Striatal and forebrain nuclei volumes:contribution to motor function and working memory deficits in alcoholism显示文摘 | Sullivan EV Deshmukh A De Rosa E | 2005 | Biol Psychiatry2005，57，7： | 1 |
| 7 | 查看详情显示文摘 | De Rosa C Auriemma F Di Capua A Resconi L. Guidotti S. Camurati I. Nifant'ev I.E.and Laishevtsev I.P | | 0，，： | 1 |
| 8 | Glutathione deficiency is associated with impaired survival in HIV disease 显示文摘 | HERZENBERG L A DE ROSA S C DUBS J G | 1997 | Proc Nat Acad Sci1997，94，5： | 1 |
| 9 | Macroscopic and histological effects of magnetic field exposi- tion in the process of tissue reparation in Wistar rats显示文摘 | Bertolino G De Freitas Braga A De Oliveira Limado Couto Rosa K | 2006 | Arch Der- matol Res2006，298，： | 1 |
| 10 | On the inter-harmonics components generated by adjustable speed drives显示文摘 | De Rosa F Langella R Sollazzo A | 2005 | IEEE Trans on Power Delivery2005，20，4： | 1 |
| 11 | Subacute combined de-generation of the spinal cord in a vegan显示文摘 | De Rosa A Rossi F Lieto M | | 0，，7： | 1 |
| 12 | Subacute combined degeneration of the spinal cord in a ve- gan显示文摘 | De Rosa A Rossi F Lieto M | 2012 | Clinical Neurol Neurosurg2012，114，： | 1 |
| 13 | Enantioselective aldol condensation of O-silyl dienolates to aldehydes mediated by chiral BINOL-titanium complexes 显示文摘 | De Rosa M Soriente A Scettri A | 2000 | Tetrahedron: Asymmetry2000，11，： | 1 |
| 14 | Gel and solid matrix systems for the controlled delivery of drug carrier -associated nucleic acids显示文摘 | E Fattal G De Rosa A Bochot | 2004 | International Journal of Pharmaceutics2004，277，： | 1 |
| 15 | Recovery of ammonia in diges- tales of calf manure through a struvite precipitation plxcess using unconventional reagents 显示文摘 | Siciliano A De Rosa S | 2014 | Environ Technol2014，35，58： | 1 |
| 16 | Probabilistic approach for determining Salmonella spp. and L. monocytogenes concentration in pork meat from presence/absence microbiological data显示文摘 | Antonio Valero Marta Hernandez Alessandra De Cesare Gerardo Manfreda Rosa Maria García-Gimeno Patricia González-García David Rodríguez Lázaro | 2014 | International Journal of Food Microbiology2014，，： | 1 |
| 17 | Thymosin cd continues to show promise as an enhancer for vaccine response 显示文摘 | Tuthill C Rios I De Rosa A | 2012 | Ann N Y Acad Sci2012，1270，1： | 1 |
| 18 | Identification,isolation,characterization,and banking of human dental pulp stem cells显示文摘 | Tirino V Paino F De Rosa A | | 0，，： | 1 |
| 19 | Degradation of dental plaque glucans and prevention of glucan formation using commercial enzymes显示文摘 | Marotta M Martino A De Rosa A | 2002 | Process Biochemistry2002，38，1： | 1 |
| 20 | Statistical evaluation of E1S and ENM data collected for monitoring corrosion barrier prop- erties of organic coatings on AI - 2024 - T3 显示文摘 | De Rosa R L Earl D A Bierwagen G P | 2002 | Corrosion Sci- ence2002，44，： | 1 |
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