|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A mouse model for HBV immunotolerance and immunotherapy显示文摘一个适当小动物模型的缺乏仍然是一个主要障碍因为学习 immunotolerance 和 immunopathogenesis 由肝炎 B 病毒(HBV ) 导致了感染。在这研究,我们与 recombinant 在感染以后与持续 HBV viremia 报导一个老鼠模型带一个可复制的 HBV 染色体(AAV/HBV ) 的联系 adeno 的病毒(AAV ) 。类似于临床的 HBV 搬运人,感染 AAV/HBV 的老鼠为对 HBV 表面抗原(HBsAg ) 的抗体是 sero 否定的。有面对铝助手疫苗的常规 HBV 的免疫没能在这些老鼠对 HBV 得到有免疫力的回答。为了识别一支疫苗,那能潜在地围绕这忍耐, TLR9 收缩筋 CpG 作为一个助手被加到 HBsAg。有 HBsAg/CpG 的老鼠的种痘导致了 viremia,而且强壮的抗体生产和 T 房间回答的不仅清理。而且, DNA 复制和 HBV 的蛋白质表示显著地在 AAV/HBV-infected 鼠标的肝被减少。因此, AAV/HBV-infected 老鼠可以作为一个柔韧的模型被使用调查 HBV immunotolerance 并且为开发新奇免疫疗法根除的内在的机制 HBV 感染。 | Dan Yang Longchao Liu Danming Zhu Hua Peng Lishan Su Yang-Xin Fu Liguo Zhang | 2014 | Cellular & Molecular Immunology2014，11，1： | 25 |
| 2 | Ultrasound enhanced heterogeneous activation of peroxydisulfate by bimetallic Fe-Co/GAC catalyst for the degradation of Acid Orange 7 in water显示文摘Bimetallic Fe-Co/GAC(granular activated carbon) was prepared and used as heterogeneous catalyst in the ultrasound enhanced heterogeneous activation of peroxydisulfate(PS, S2O2-8) process. The effect of initial pH, PS concentration, catalyst addition and stirring rate on the decolorization of Acid Orange 7(AO7) was investigated. The results showed that the decolorization efficiency increased with an increase in PS concentration from 0.3 to 0.5 g/L and an increase in catalyst amount from 0.5 to 0.8g/L. But further increase in PS concentration and catalyst addition would result in an unpronounced increase in decolorization efficiency. In the range of 300 to 900 r/min, stirring rate had little effect on AO7 decolorization. The catalyst stability was evaluated by measuring decolorization efficiency for four successive cycles. | Chun Cai Liguo Wang Hong Gao Liwei Hou Hui Zhang | 2014 | Journal of Environmental Sciences2014，26，6： | 16 |
| 3 | Tectonic Framework and Deep Structure of South China and Their Constraint to Oil-Gas Field Distribution显示文摘华南能在包围区域被划分成一稳定的 craton , Yangtze Craton ( YzC ),和几条 orogenic 带,那在北方是三叠纪的 Qinling-Dabie Orogenic 带( QDOB ),在西北的 Songpan-Garz ê Orogenic 带( SGOB ),在西方,在西南的 Youjiang Orogenic 带(出生年),在东南的中间的古生代的 Huanan Orogenic 带(壁炉内部的一锅架),和沿着海岸的中生代新生代海上的 Orogenic 带(乌合之众)的中生代新生代三河的 Orogenic 带( TOB )。地震 tomographic 图象表明莫霍深度比 40 km 深,岩石圈是在 YzC 下面厚的大约 210 km。SGOB 被厚外壳(>40 km ) 和薄岩石圈(<150 km ) 描绘。壁炉内部的一锅架,出生年和乌合之众有一个薄外壳(<40 km ) 和薄岩石圈(<150 km ) 。陆上的热流动调查分别地在 TOB 和乌合之众在东方 YzC 和西方的壁炉内部的一锅架和二个高热流动区域与一个低热流动区域揭示了一个分发模式。如此的“ high-low-high ”热流动分发模式能在 welling 上面源于新生代岩流圈。所有油气体地在 YzC 的中央部分被集中。残余油水池沿着 YzC 和它的邻近的 orogenic 带的南部的边缘被发现了。从地质、地球物理的结构,在有厚岩石圈和低热流动价值的华南的区域,以及弱变丑的一个观点,可能是为进一步的石油探索的理想的区域。 | WANG Qingchen LIU Jinsong DU Zhili CAI Liguo | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 16 |
| 4 | Poly(lactic-co-glycolic acid)-based composite bone-substitute materials显示文摘Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics.Recently,poly(lactic-co-glycolic acid)(PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility,degradability,mechanical properties,and capabilities to promote bone regeneration.In this article,we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances,elaborate on their applications for bone regeneration with or without bioactive factors,and prospect the challenges and opportunities in clinical bone regeneration. | Duoyi Zhao Tongtong Zhu Jie Li Liguo Cui Zhiyu Zhang Xiuli Zhuang Jianxun Ding | 2021 | Bioactive Materials2021，6，2： | 14 |
| 5 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 6 | Pyrolysis of oil at high temperatures:Gas potentials,chemical and carbon isotopic signatures显示文摘Although the gas cracked from oil has been believed to be one of the important sources in highly matured marine basins, there are still some debates on its resource potentials and chemical and isotopic compositions. In this study a Cambrian-sourced marine oil sample from the Silurian reservoir of well TZ62 in the central Tarim basin was pyrolyzed using sealed gold tubes with two different pyrolysis schemes: continuous pyrolysis in a closed system and stepwise semi-open pyrolysis. The results show that the maximum weight yield of C1-5 gases occurs at EasyRo=2.3% and the residual gas poten-tial after this maturity is only 43.4 mL/g, about 12% of the yield of 361 mL/g at EasyRo=2.3%. Combined with the results of kinetic modeling, the main stage of gas generation from oil cracking is believed within the EasyRo=1.6%―2.3%. The increase in the volume yield of C1-5 gases at EasyRo>2.3% in a closed system is mainly related to the re-cracking of previously formed C2-5 wet gases, not the direct cracking of oil. The stepwise pyrolysis experiments show that the gas from the cracking of residual oil at EasyRo>2.3% is characterized by very high dryness index (higher than 92%) and heavy methane carbon isotopes ranging from ?28.7‰ to ?26.7‰, which is quite different from the gases from the con-tinuous pyrolysis in a closed system. The kinetic modeling of methane carbon isotope fractionation shows that the carbon isotopes of methane within the main stage of gas generation (EasyRo<2.3%) are far lighter than the carbon isotopes of the precursor oils under a geological heating rate of 2 ℃ /Ma. The above observations and results provide some new clues to the accurate recognition and objective resource evaluation of oil cracking gas in highly mature marine basins. | TIAN Hui XIAO XianMing YANG LiGuo XIAO ZhongYao GUO LiGuo SHEN JiaGui LU YuHong | 2009 | Chinese Science Bulletin2009，54，7： | 12 |
| 7 | The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection显示文摘(EV71 ) Entero 病毒 71 引起手,脚,和嘴疾病(HFMD ) 并且偶尔导致严重神经病学的复杂并发症甚至死亡。(SCARB2 ) Scavenger 受体班 B 成员 2 是为 EV71 的功能的受体,调停病毒的附件,成为主观,和 uncoating。然而, SCARB2 上的 EV71 的准确有约束力的地点是未知的。在这研究,我们产生了绑在人然而并非老鼠 SCARB2 的 monoclonal 抗体(mAb ) 。它被称为 JL2,并且它能有效地禁止目标房间的 EV71 感染。用人和老鼠 SCARB2 的一套怪物,我们鉴别包含人的 SCARB2 的残余 77-113 的区域显著地作出贡献到 JL2 绑定。SCARB2-JL2 建筑群的结构表明 JL2 绑在包含 -helices 的 SCARB2 的顶端的区域 2, 5,和 14。我们的结果在 SCARB2 和 EV71 入口的分子的机制上为 EV71 提供新卓见进潜在的有约束力的地点。 | Xuyuan Zhang Pan Yang Nan Wang Jialong Zhang Jingyun Li Hao Guo Xiangyun Yin Zihe Rao Xiangxi wang Liguo Zhang | 2017 | Protein & Cell2017，8，8： | 10 |
| 8 | Combination Mechanism and Enhanced Visible-Light Photocatalytic Activity and Stability of CdS/g-C3N4 Heterojunctions显示文摘In this study,CdS/g-C_3N_4(CSCN) heterojunctions were in situ fabricated with a large amount of Cd S nanoparticles anchored on g-C_3N_4 nanosheets.A wet chemical method was developed for the first time to determine the actual content of Cd S in CSCN composites.X-ray diffraction(XRD),Fourier transform infrared spectra(FTIR),high-resolution transmission electron microscopy(HRTEM) and UV-vis diffuse reflectance spectra(DRS) were employed to characterize the composition,structure and optical property of CSCN composites.Based on the isoelectric point(IEP) analysis of g-C_3N_4,a conclusion was obtained on the combination mechanism between Cd S nanoparticles and g-C_3N_4 nanosheets.The photocatalytic activity of CSCN composites was much better than those of individual Cd S and g-C_3N_4 for the degradation of azo dye Methyl Orange(MO) by 40 min adsorption in the dark followed by 15 min photocatalysis under visible light irradiation.After 5 cycles,CSCN composites still maintained high reactive activity with the MO degradation efficiency of 93.8%,exhibiting good photocatalytic stability.The Cd2+concentration dissolved in the supernatant detected by atomic absorption spectroscopy(AAS) of CSCN composites was lower than that of pure Cd S,implying that the photocorrosion of Cd S could be suppressed via the combination with g-C_3N_4.Photoluminescence emission spectra(PL) results clearly revealed that the recombination of photogenerated electron-hole pairs in CSCN composites was effectively inhibited due to the formation of heterojunctions.Based on the band alignments of g-C_3N_4 and Cd S,the possible photocatalytic mechnism was discussed. | Huanyan Xu Licheng Wu Liguo Jin Kejia Wu | 2017 | Journal of Materials Science & Technology2017，33，1： | 10 |
| 9 | Refill friction stir spot welding of 5083-O aluminum alloy显示文摘In this work,refill friction stir spot welding(RFSSW) was used to weld 2 mm-thick 5083-O alloy.The Box–Behnken experimental design was used to investigate the effect of welding parameters on the joint lap shear property.Results showed that a surface indentation of 0.3 mm effectively eliminated the welding defects.Microhardness of the stir zone(SZ) was higher than that of the base material(BM) and the hardness decreased with increasing the heat input during welding.The optimum failure load of 7.72 k N was obtained when using rotating speed of 2300 rpm,plunge depth of 2.4 mm and refilling time of 3.5 s.Three fracture modes were obtained during the lap shear test and all were affected by the hook defect. | Zhiwu Xu Zhengwei Li Shude Ji Liguo Zhang | 2018 | Journal of Materials Science & Technology2018，34，5： | 10 |
| 10 | Microstructure, mechanical properties and deformation mechanisms of an as-cast Mg–Zn–Y–Nd–Zr alloy for stent applications显示文摘A new Mg-2Zn-0.2Y -0.5N d-0.4Zr (wt%) alloy designed specially for stent applications has been developed. The as-cast alloy is featured with equiaxed grains with a mean size of about 40 μm and a small am ount of second phase (T phase) distributed discontinuously either at the grain boundaries or inside the grains. This alloy exhibits a tensile elongation of up to 35%, which is much larger than that of most reported other as-cast Mg alloys. The tensile deform ation mechanisms have also been investigated. The results show that, besides basal slip,{10-12} extension twining and non-basal pyramidal slips can also be observed at initial stage and later stage during tensile deform ation, respectively, which are responsible for the good room -tem perature ductility. | Jianfeng Wang Hongbo Zhou Liguo Wang Shijie Zhu Shaokang Guan | 2019 | Journal of Materials Science & Technology2019，35，7： | 9 |
| 11 | Proanthocyanidins Inhibit Seed Germination by Maintaining a High Level of Abscisic Acid in Arabidopsis thaliana显示文摘Proanthocyanidins (PAs) are the main products of the flavonoid biosynthetic pathway in seeds, but their biological function during seed germination is still unclear. We observed that seed germination is delayed with the increase of exogenous PA concentration in Arabidopsis. A similar inhibitory effect occurred in peeled Brassica napus seeds, which was observed by measuring radicle elongation. Using abscisic acid (ABA), a biosynthetic and metabolic inhibitor, and gene expression analysis by real-time polymerase chain reaction, we found that the inhibitory effect of PAs on seed germination is due to their promotion of ABA via de novo biogenesis, rather than by any inhibition of its degradation. Consistent with the relationship between PA content and ABA accumulation in seeds, PA-deficient mutants maintain a lower level of ABA compared with wild-types during germination. Our data suggest that PA distribution in the seed coat can act as a doorkeeper to seed germination. PA regulation of seed germination is mediated by the ABA signaling pathway. | Liguo Jia Qiuyu Wu Nenghui Ye Rui Liu Lu Shi Weifeng Xu Hui Zhi A. N. M. Rubaiyath Bin Rahman Yiji Xia Jianhua Zhang | 2012 | Journal of Integrative Plant Biology2012，54，9： | 9 |
| 12 | Effect of spinal manipulation on degenerative scoliosis显示文摘OBJECTIVE:To investigate the effect of spinal manipulation(SM)on degenerative scoliosis by evaluating patients’visual analog scale(VAS)scores,Cobb angles,sagittal vertical axis(SVA),and apical vertebral rotation(AVR)and to explore factors that influence treatment effect.METHODS:A total of 55 patients with degenerative scoliosis received 4 weeks of SM.After treatment,patients were divided into two groups:the remission group(VAS score<40 mm)and the non-remission group(VAS score≥40 mm).Pre-versus post-treatment VAS scores,Cobb angles,SVA,and AVR were compared in each group and in the total population.Baseline data(sex,age,symptom characteristics,duration of symptoms,VAS score,Cobb angle,SVA,and AVR)were compared between groups.Factors influencing the post-treatment VAS score were explored with multiple linear regression analysis.RESULTS:No changes were found in the Cobb angle(P=0.722)or AVR(P=0.424)after intervention in the overall population.However,the SVA(P<0.001)and VAS score(P=0.000)changed significantly after treatment.Similar changes were observed in the remission group(n=29).Multiple linear regression revealed that the only factors influencing treatment effect were symptom characteristics,SVA,and VAS score.CONCLUSION:SM relieved pain and improved sagittal imbalance in patients with degenerative scoliosis.It did not lessen the severity of coronal curvature or vertebral rotation.Factors influencing the effect of SM included symptom characteristics,VAS score,and SVA.A larger randomized trial is needed to further confirm our results. | Sun Wu Gao Jinghua Zhu Liguo Wang Baojian Xiao Wei Wang Zhenzhong Yang Kexin | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 8 |
| 13 | Design of Reflective Concentrator Model with Application for Concentrator Photovoltaic System显示文摘The nonuniform irradiation in the standard photovoltaic(PV) cells causes their relatively high series resistance,which results in a considerably lowered efficiency of PV cells.Currently the concentrator of uniform irradiation designed for concentrator photovoltaic is rare in China and lack sufficient theoretical research.In this paper,a systematic research on the solar reflective concentrator is conducted.A novel structure for a solar reflective concentrator is designed with the application of a flat mirror matrix to concentrate the sunlight for concentrator photovoltaic(CPV) systems.Sunlight beams are focused through the reflection of the mirror array on the solar cell to generate electricity.The concentrator is capable of producing much more uniform sunlight with a certain concentration ratio.The design scheme includes laying out the flat mirrors,optimizing the optical pathway and the parameters of each mirror.The prototype of the CPV system was installed at Nanjing,China.In the configuration of the prototype,it is composed of 24 pieces parallelogram flat mirrors,which are arranged into a total reflective array of 5 rows and 5 columns.In comparison with the parabolic trough concentrator,the experimental measurements verify such design has high efficiency.The concentrator model of a flat mirror matrix and the proposed new design method will lay a solid foundation for designing the concentrator of uniform irradiation. | SU Zhongyuan ZHANG Yaoming JIA Minping SUN Liguo XU Feiyun WANG Jun | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 8 |
| 14 | Advances of drag-reducing surface technologies in turbulence based on boundary layer control显示文摘Our living environment is surrounded by turbulence, which is also a concern of the global energy consumption and the greenhouse gas emission, and the viscous force on the solid-liquid/solid-gas interface is an important part of the turbulence. Reducing friction force in turbulence to the greatest extent is becoming an urgent issue to be resolved at present. In this paper, the various state-of-the-art approaches of drag-reducing and energy-saving technologies based on the boundary layer control are reviewed, focusing on the polymer drag reduction additives, the micro-morphology, the super-hydrophobic surface, the micro air bubbles, the heating wall, the vibrant flexible wall and the composite drag reduction methods. In addition, the mechanisms of different drag reductions based on the boundary layer control and the potential applications in fluid engineering are discussed. This paper aims not only to contribute to a better understanding of drag reduction mechanisms, but also to offer new perspectives to improve the current drag-reducing and energy saving technologies. | LUO Yuehao WANG Liguo GREEN Lork SONG Kenan WANG Liang SMITH Robert | 2015 | Journal of Hydrodynamics2015，27，4： | 8 |
| 15 | A New Kernel Function Yielding the Best Known Iteration Bounds for Primal-Dual Interior-Point Algorithms显示文摘内核函数在为解决线性优化问题为最初双的内部点的算法定义新搜索方向起一个重要作用。在这篇论文我们在场与最好已知的复杂性产出一个算法的新核功能为大更改、小更改的方法跳了。 | Yan Qin BAI Jin LiGUO Cornelis ROOS | 2009 | Acta Mathematica Sinica,English Series2009，25，12： | 7 |
| 16 | Mathematical model of heat transfer for bloom continuous casting显示文摘A mathematical model for heat transfer during solidification in continuous casting of automobile steel,was established on researching under the influence of the solidifying process of bloom quality of CCM in the EAF steelmaking shop,at Shijiazhuang Iron and Steel Co.Ltd.Several steel grades were chosen to research,such as,40Cr and 42CrMo.According to the results of the high temperature mechanical property tests of blooms,the respective temperature curves for controlling the solidification of different steels were acquired,and a simulating software was developed.The model was verified using two methods,which were bloom pin- shooting and surface strand temperature measuring experiments.The model provided references for research on the solidifying proc- ess and optimization of a secondary cooling system for automobile steel.Moreover,it was already applied to real production.The calculated temperature distribution and solidification trend of blooms had offered a reliable theory for optimizing the solidifying process of blooms,increasing withdrawal speed,and improving bloom quality.Meanwhile,a new secondary cooling system was designed to optimize a secondary cooling water distribution,including choice and arrangements of nozzles,calculation of cooling water quantity,and so on. | Qing Liu Liangzhou Wang Liqiang Zhang Liguo Cao Xiuzhong Ding Mei Liang Yongge Qi | 2008 | Journal of University of Science and Technology Beijing2008，15，1： | 7 |
| 17 | Fabrication and characterization of biodegradable Mg-Zn-Y-Nd-Ag alloy:Microstructure,mechanical properties,corrosion behavior and antibacterial activities显示文摘Magnesium(Mg),a potential biodegradable material,has drawn wide attention in the bone reconstruction field.However,Mg alloys,served as the bone graft substitution,remain a clinical challenge,the antibacterial activity of which is required to be enhanced.Here,we prepared biodegradable magnesium Mg-Zn-Y-Nd-Ag and then had it been further densified by extruding.The microstructure evolution of the as-cast and as-extruded Mg-Zn-Y-Nd-Ag was characterized using optical microscope and X-ray diffraction analyses(XRD).The results showed that the microstructure of the as-cast alloys was mainly dendrites,between which,the second phase was mainly distributed;with the increase of Ag additions,grain structure was further refined as well as the increase of amount of the second phase.After the extrusion,the grains were further refined.Microhardness tests indicated that both of the increase of Ag content and the extrusion process improved the microhardness of the alloys,specially the later.A systematic investigation of the in vivo antibacterial capability of Staphylococcus aurous and Escherichia coli was performed,and the results of which indicated that all Mg-Zn-Y-N-xAg(x?0.2,0.4,0.6,0.8)alloys exhibited certain antibacterial property,which would increased with the increase of Ag content.Taken all together,the antimicrobial property of the as-extruded alloy containing 0.4 wt%Ag exhibited the relatively better antimicrobial properties and mechanical property with the relatively small loss in corrosion resistance,which suggested the potential utility of as-extruded Mg-Zn-Y-N-0.4Ag in treating orthopedic infections. | Yashan Feng Shijie Zhu Liguo Wang Lei Chang Yachen Hou Shaokang Guan | 2018 | Bioactive Materials2018，3，3： | 7 |
| 18 | Transcriptome analysis of blood stasis syndrome in subjects with hypertension显示文摘OBJECTIVE:To screen for m RNAs associated with blood stasis syndrome and to explore the genetic mechanisms of blood stasis syndrome in hypertension.METHODS:This study involved groups of patients with hypertension and blood stasis,including those with Qi deficiency,Qi stagnation,cold retention and heat retention;as well as hypertensive patients without blood stasis and healthy individuals.Human umbilical vein endothelial cells were co-cultured with the sera of these healthy individuals and patients with blood stasis syndrome.Total RNA was extracted from these cells and assessed by a high-throughput sequencing method(Solexa)and digital gene expression.Differentially expressed genes among these six groups were compared using whole genome sequences,and m RNAs associated with blood stasis syndrome identified.Differences in gene use and gene ontology function were an-alyzed.Genes enriched significantly and their pathways were determined,as were network interactions,and encoded proteins.Gene identities were confirmed by real-time polymerase chain reactions.RESULTS:Compared with cells cultured in sera of the blood stasis groups,those culture in sera of healthy individuals and of the non-blood stasis group showed 11 and 301 differences,respectively in stasis-related genes.Genes identified as differing between the blood stasis and healthy groups included activating transcription factor 4,activating transcription factor 3,DNA-damage inducible transcription factor 3,Tribbles homolog 3,CCAAT/enhancer binding protein-β,and Jun proto-oncogene(JUN).Pathway and protein interaction network analyses showed that these genes were associated with endoplasmic reticulum stress.Cells cultured in sera of patients with blood stasis and Qi deficiency,Qi stagnation,heat retention,and cold retention were compared with cells cultured in sera of patients with the other types blood stasis syndrome.The comparison showed differences in expression of 28,28,34,and 32 specific genes,respectively.CONCLUSION:The pathogenesis of blood stasis syndrome in hypertension is related to endoplasmic reticulum stress and involves the differential expression of the activating transcription factor 4,activating transcription factor 3,DNA-damage inducible transcription factor 3,Tribbles homolog 3,CCAAT/enhancer binding protein-β,and JUN genes. | He Ling Fang Meixia Chen Liguo Zhou Jianhua Yuan Jing Xu Jing Shan Yan Xu Qingyun Xiong Tingting | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 7 |
| 19 | Surgical Management of Retinal Detachment Resulting from Macular Hole in a Setting of High Myopia显示文摘Purpose:To evaluate the anatomical and visual outcomes of pars plana vitrectomy (PPV) with internal limiting membrane (ILM).peeling and use of retinal tamponade for retinal detachments resulting from macular hole (MHRD) in highly myopic eyes. Methods:.Twenty-nine highly myopic patients.(29 eyes) underwent PPV with ILM peeling and retinal tamponade for MHRD were enrolled. Demographics and best-corrected visual acuity.(BCVA).were measured preoperatively and at final follow-up. Anatomical success and macular hole closure were analyzed. Results:.Patients' mean age of patients was 58.7±10.6 years, mean follow-up was 11.7±7.4 months. Twenty three eyes (23/26,88.5%)undergoing primary PPV combined with ILM peeling had successful initial retinal reattachment, including 19 eyes (19/19, 100%) with silicone oil tamponade and in 4 eyes (4/7,57.1%).with sulfur hexafluoride.(C3F8).tamponade. Overall anatomical success was achieved in 27 eyes (27/29, 93.1%)..The macular hole closure was observed in 17 eyes (17/26, 65.4%) with final anatomical success. Compared to preoperative BCVA,.the mean postoperative BCVA in the eyes with anatomical success was significantly improved (P = 0.007, Wilcoxon signed rank test). Conclusion:.As a primary or secondary procedure,.PPV combined with ILM peeling and usage of retinal tamponade serves as an effective method for MHRD in highly myopic eyes. | Liguo Feng Xiaohong Jin Jiuke Li Jing Zhai Wei Fang Jianfeng Mo Qirong Feng Yumin Li | 2012 | Eye Science2012，27，2： | 7 |
| 20 | Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence显示文摘Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant radiotherapy.Methods:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control group.Patients'outcome,adverse events,long-term recurrence and survival rates were investigated.Results:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin hepatectomy.Long-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC. | Weiqi Rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen Chengli Miao Liguo Liu Songlin An Changcheng Tao Weihu Wang Jianxiong Wu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员