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| 1 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 2 | The mechanisms of sorafenib resistance in hepatocellular carcinoma:theoretical basis and therapeutic aspects显示文摘Sorafenib is a multikinase inhibitor capable of facilitating apoptosis,mitigating angiogenesis and suppressing tumor cell proliferation.In late-stage hepatocellular carcinoma(HCC),sorafenib is currently an effective first-line therapy.Unfortunately,the development of drug resistance to sorafenib is becoming increasingly common.This study aims to identify factors contributing to resistance and ways to mitigate resistance.Recent studies have shown that epigenetics,transport processes,regulated cell death,and the tumor microenvironment are involved in the development of sorafenib resistance in HCC and subsequent HCC progression.This study summarizes discoveries achieved recently in terms of the principles of sorafenib resistance and outlines approaches suitable for improving therapeutic outcomes for HCC patients. | Weiwei Tang Ziyi Chen Wenling Zhang Ye Cheng Betty Zhang Fan Wu Qian Wang Shouju Wang Dawei Rong F.P.Reiter E.N.De Toni Xuehao Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 19 |
| 3 | Understanding environmental impacts on initial atmospheric corrosion based on corrosion monitoring sensors显示文摘Atmospheric corrosion monitoring(ACM)sensors were employed to study the initial atmospheric corrosion of carbon steels over a one-month period in six outdoor dynamic atmospheric environments in China.Based on the~250,000 corrosion data sets collected,the environmental impacts of relative humidity,temperature and rainfall on the initial corrosion behavior of carbon steels were investigated.The results showed that rainfall was the strongest environmental factor influencing the initial atmospheric corrosion rate.Relative humidity significantly influenced the corrosion of carbon steels in low-precipitation environments and non-rainfall period. | Zibo Pei Xuequn Cheng Xiaojia Yang Qing Li Chenhan Xia Dawei Zhang Xiaogang Li | 2021 | Journal of Materials Science & Technology2021，，5： | 12 |
| 4 | Major accident analysis and prevention of coal mines in China from the year of 1949 to 2009显示文摘From the year of 1949 to the present, the China national coal output has been increasing quickly and became first in the world in 2009. But at the same time, major coal mining accidents still exist nowadays. In order to review the overall situation and provide information on major accidents of coal mines in China, we investigated 26 major coal mining accidents in China between the years of 1949 and 2009 through statistical methods, each of which led to more than 100 fatalities. Statistical characteristics about accident-related factors such as time, death toll, accident reasons, characters and nature of enterprise were analyzed. And some special conclusions have been achieved. For example, although we have made great progress, the safety situation in China coal mining industry is still serious, and the reasons for the mining accidents are all human errors which are not inevitable. Such results may be helpful to prevent major accidents in coal mines. Moreso, based on both the knowledge of other countries which have good safety situation nowadays and the safety management situation of China, we made suggestion on safety management of China coal mining. In conclusion, countermeasures were proposed in accordance with the results of statistical studies and the analyses of problems existed in coal mines, including the perfec- tion of safety supervision organization, the establishment of cooperating agency among government, coal mines and workers, the perfection of safety rules and regulations, the improvement of safety investment, the enhancement of safety training, the development of safety technique, and the development of emer- gency rescue technique and equipment. | Wu Lirong Jiang Zhongan Cheng Weimin Zuo Xiuwei Lv Dawei Yao Yujing | 2011 | Mining Science and Technology2011，21，5： | 12 |
| 5 | MiRNA-429 suppresses the growth of gastric cancer cells in vitro显示文摘Micro-RNAs(miRNAs) have been found to be implicated in a very wide range of physiological processes.This study was aimed to investigate the regulation of miRNA-429(miR-429) in gastric cancer cells on cell proliferation and apoptosis.Quantitative PCR was employed to detect the expressions of miR-429 after eukaryotic expression plasmid of miR-429 and its inhibitor were transiently transfected into poorly differentiated human gastric can-cer cell line BGC823.The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) reduction as-says were used to examine proliferation ability.Apoptosis was analyzed by flow cytometry after transfection.The results showed that 48 h after transfection,overexpression of miR-429 reached maximum efficiency.Compared with mock transfection,miR-429 inhibited tumor cell proliferation significantly(P < 0.05) at 48 h and 72 h.of Overexpression of miR-429 promoted tumor cell apoptosis when compared with mock transfected cells(P < 0.05).On the contrary,miR-429 inhibitor promoted tumor cell proliferation and inhibited apoptosis when compared with controls(P < 0.05).Our results suggested that miRNA-429 may serve as a tumor suppressor during tumorigenesis of gastric cancer and may be a potential gastric cancer therapeutic target. | Di Liu Peng Xia Dongmei Diao Yao Cheng Hao Zhang Dawei Yuan Chen Huang Chengxue Dang | 2012 | The Journal of Biomedical Research2012，26，5： | 12 |
| 6 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 7 | Ultrathin MXene-aramid nanofiber electromagnetic interference shielding films with tactile sensing ability withstanding harsh temperatures显示文摘Ultrathin and flexible electromagnetic shielding materials hold great potential in civil and military applications.Despite tremendous research efforts,the development of advanced shielding materials is still needed to provide additional functionalities for various artificial-intelligence-driven systems,such as tactile sensing ability.Herein,a layering design strategy is proposed to fabricate ultrathin Ti_(3)C_(2)T_(x)MXene-aramid nanofiber(MA)films by a layer-by-layer assembling process.Compared to that of randomly mixed films,the designed MA films exhibited a higher EMI shielding efficiency at an ultrathin thickness of 9 pm,which increased from 26.4 to 40.7 dB,owing to the additional multiple-interface scattering mechanism.Importantly,the novel MA films displayed strong EMI shielding ability even after heating/cooling treatments within a wide temperature range of-196 to 300℃.Moreover,the same material displayed a tensile strength of 124.1±2.7 MPa and a toughness of 6.3±1.1 MJ·m^(-3),which are approximately 9.1 times and 45 times higher than those of pure MXene films,respectively.The MA film is also capable of detecting tactile signals via the triboelectric effect.A 2×4 tactile sensor array was developed to achieve an accurate signal catching capability.Therefore,in addition to the shielding performance,the manifestation of tactile perception by the MA films offers exciting opportunities in the fields of soft robotics and human-machine interactions. | Dawei Hu Siqi Wang Cheng Zhang Pengshu Yi Pingkai Jiang Xingyi Huang | 2021 | Nano Research2021，14，8： | 4 |
| 8 | Halide Homogenization for High-Performance Blue Perovskite Electroluminescence显示文摘Metal halide perovskite light-emitting diodes(LEDs)have achieved great progress in recent years.However,bright and spectrally stable blue perovskite LED remains a significant challenge.Three-dimensional mixed-halide perovskites have potential to achieve high brightness electroluminescence,but their emission spectra are unstable as a result of halide phase separation.Here,we reveal that there is already heterogeneous distribution of halides in the as-deposited perovskite films,which can trace back to the nonuniform mixture of halides in the precursors.By simply introducing cationic surfactants to improve the homogeneity of the halides in the precursor solution,we can overcome the phase segregation issue and obtain spectrally stable single-phase blueemitting perovskites.We demonstrate efficient blue perovskite LEDs with high brightness,e.g.,luminous efficacy of 4.7,2.9,and 0.4 lmW^(-1) and luminance of over 37,000,9,300,and 1,300 cdm^(-2) for sky blue,blue,and deep blue with Commission Internationale de l’Eclairage(CIE)coordinates of(0.068,0.268),(0.091,0.165),and(0.129,0.061),respectively,suggesting real promise of perovskites for LED applications. | Lu Cheng Chang Yi Yunfang Tong Lin Zhu Gunnar Kusch Xiaoyu Wang Xinjiang Wang Tao Jiang Hao Zhang Ju Zhang Chen Xue Hong Chen Wenjie Xu Dawei Liu Rachel AOliver Richard HFriend Lijun Zhang Nana Wang Wei Huang Jianpu Wang | 2020 | Research2020，，1： | 4 |
| 9 | Optimal trajectory and downlink power control for multi-type UAV aerial base stations显示文摘Unmanned Aerial Vehicles(UAVs)enabled Aerial Base Stations(UABSs)have been studied widely in future communications.However,there are a series of challenges such as interference management,trajectory design and resource allocation in the scenarios of multi-UAV networks.Besides,different performances among UABSs increase complexity and bring many challenges.In this paper,the joint downlink transmission power control and trajectory design problem in multi-type UABSs communication network is investigated.In order to satisfy the signal to interference plus noise power ratio of users,each UABS needs to adjust its position and transmission power.Based on the interactions among multiple communication links,a non-cooperative Mean-Field-Type Game(MFTG)is proposed to model the joint optimization problem.Then,a Nash equilibrium solution is solved by two steps:first,the users in the given area are clustered to get the initial deployment of the UABSs;second,the Mean-Field Q(MFQ)-learning algorithm is proposed to solve the discrete MFTG problem.Finally,the effectiveness of the approach is verified through the simulations,which simplifies the solution process and effectively reduces the energy consumption of each UABS. | Lixin LI Yan SUN Qianqian CHENG Dawei WANG Wensheng LIN Wei CHEN | 2021 | Chinese Journal of Aeronautics2021，34，9： | 4 |
| 10 | Monitoring of 1997 EI Nio from TOPEX/Poseidon显示文摘In early 1997, one EI Nio event occurred. The change of the sea surface height during the event was monitored with TOPEX altimetric data, and this is helpful to the study on the formation and development mechanism of an El Nio event and its impact on the global climatic change. | DONG Xiaojun, HUANG Cheng, ZHENG Dawei and WU HongqiuCenter for Astrogeodynamic Research , Shanghai Observatory, Chinese Academy of Sciences , Shanghai 200030, China | 1999 | Chinese Science Bulletin1999，44，4： | 3 |
| 11 | Thermal-structural response and low-cycle fatigue damage of channel wall nozzle显示文摘To investigate the thermo-mechanical response of channel wall nozzle under cyclic working loads,the fnite volume fluid-thermal coupling calculation method and the fnite element thermal-structural coupling analysis technique are applied.In combination with the material lowcycle fatigue behavior,the modifed continuous damage model on the basics of local strain approach is adopted to analyze the fatigue damage distribution and accumulation with increasing nozzle work cycles.Simulation results have shown that the variation of the non-uniform temperature distribution of channel wall nozzle during cyclic work plays a signifcant role in the thermal-structural response by altering the material properties;the thermal–mechanical loads interaction results in serious deformation mainly in the front region of slotted liner.In particular,the maximal cyclic strains appear in the intersecting regions of liner gas side wall and symmetric planes of channel and rib,where the fatigue failure takes place initially;with the increase in nozzle work cycles,the residual plastic strain accumulates linearly,and the strain amplitude and increment in each work cycle are separately equal,but the fatigue damage grows up nonlinearly.As a result,a simplifed nonlinear damage accumulation approach has been suggested to estimate the fatigue service life of channel wall nozzle.The predicted node life is obviously conservative to the Miner’s life.In addition,several workable methods have also been proposed to improve the channel wall nozzle durability. | Cheng Cheng Wang Yibai Liu Yu Liu Dawei Lu Xingyu | 2013 | Chinese Journal of Aeronautics2013，26，6： | 2 |
| 12 | An attack-immune trusted architecture for supervisory aircraft hardware显示文摘With the wide application of electronic hardware in aircraft such as air-to-ground communication,satellite communication,positioning system and so on,aircraft hardware is facing great secure pressure.Focusing on the secure problem of aircraft hardware,this paper proposes a supervisory control architecture based on secure System-on-a-Chip(So C)system.The proposed architecture is attack-immune and trustworthy,which can support trusted escrow application and Dynamic Integrity Measurement(DIM)without interference.This architecture is characterized by a Trusted Monitoring System(TMS)hardware isolated from the Main Processor System(MPS),a secure access channel from TMS to the running memory of the MPS,and the channel is unidirectional.Based on this architecture,the DIM program running on TMS is used to measure and call the Lightweight Measurement Agent(LMA)program running on MPS.By this method,the Operating System(OS)kernel,key software and data of the MPS can be dynamically measured without disturbance,which makes it difficult for adversaries to attack through software.Besides,this architecture has been fully verified on FPGA prototype system.Compared with the existing systems,our architecture achieves higher security and is more efficient on DIM,which can fully supervise the running of application and aircraft hardware OS. | Dongxu CHENG Chi ZHANG Jianwei LIU Dawei LI Zhenyu GUAN Wei ZHAO Mai XU | 2021 | Chinese Journal of Aeronautics2021，34，11： | 2 |
| 13 | Thermodynamic Performances of[mmim]DMP/Methanol Absorption Refrigeration显示文摘In order to study the theoretical cycle characteristic of [mmim]DMP(1-methyl-3-methylimidazolium dimethylphosphate)/methanol absorption refrigeration,the modified UNIFAC group contribution model and the Wilson model are established through correlating the experimental vapor pressure data of [mmim]DMP/methanol at T=280~370K and methanol mole fraction x=0.529~0.965.Thermodynamic performances of absorption refrigeration utilizing [mmim]DMP/methanol,LiBr/H2O and H2O/NH3 are investigated and compared with each other under the same operating conditions.From the results,some conclusions are obtained as follows:1)the circulation ratio of the [mmim]DMP /methanol absorption refrigeration is higher than that of the LiBr/H2O absorption refrigeration,but still can be acceptable and tolerable.2)The COP of the [mmim]DMP/methanol absorption refrigeration is smaller than that of the LiBr/H2O absorption refrigeration,while it is higher than that of the H2O/NH3 absorption refrigeration under most operating conditions.3)The[mmim]DMP/methanol absorption refrigeration are still available with high COP when the heat source temperature is too high to drive LiBr/H2O absorption refrigeration. | Wei Chen Shiqiang Liang Yongxian Guo Keyong Cheng Xiaohong Gui Dawei Tang | 2012 | Journal of Thermal Science2012，21，6： | 2 |
| 14 | 3D aperiod- ic hierarchical porous graphitic carbon material for high rate electrochemical capacitive energy storage显示文摘 | Wang Dawei LI Feng Cheng Huiming | 2008 | Angew Chem Int Ed2008，47，： | 1 |
| 15 | Muhiobjectice optimization using genetic algorithm显示文摘 | Zhang Dawei Gen Mitsuo Cheng Runwei | 1999 | Engineering Valuation and Cost Analysis1999，2，： | 1 |
| 16 | On the charged aerosols generated by atmospheric pressure non‐equilibrium plasma显示文摘Recently,charged aerosols are used widely in many applications,such as fog elimination,inactivation of airborne viruses and so on.Atmospheric pressure non‐equilibrium plasma(APNP)have become an efficient way to generate charged aerosols.Except the traditional pin‐plate or wire‐plate APNP sources,the new APNP sources such as large scale corona discharge system and air plasma jet array are introduced.These sources can increase the ion density in open air and generate adjustable large plasma plume,which are helpful in increasing the charging efficiency on aerosols.Although the interactions between plasma and aerosols is quite complicated,the preliminary study suggests that the diffusion charging dominates aerosols below 0.1μm,field charging dominates aerosols larger than 1μm,and the photo charging also contributes to aerosols charging.These reactive charged aerosols have shown their potential in the artificial rain enhancement,biomedicine,and ma-terial processing.Finally,challenges and opportunities for theoretical,experimental,and application research in related cross‐disciplinary areas are presented to stimulate critical discussions and collaborations in the future. | Yanzhe Zhang He Cheng Haotian Gao Dawei Liu Xinpei Lu | 2021 | High Voltage2021，6，3： | 1 |
| 17 | A Scalable Bacterial Cellulose Ionogel for Multisensory Electronic Skin显示文摘Electronic skin(e-skin),a new generation of flexible electronics,has drawn interest in soft robotics,artificial intelligence,and biomedical devices.However,most existing e-skins involve complex preparation procedures and are characterized by singlesensing capability and insufficient scalability.Here,we report on a one-step strategy in which a thermionic source is used for the in situ molecularization of bacterial cellulose polymeric fibers into molecular chains,controllably constructing an ionogel with a scalable mode for e-skin.The synergistic effect of a molecular-scale hydrogen bond interweaving network and a nanoscale fiber skeleton confers a robust tensile strength(up to 7.8 MPa)and high ionic conductivity(up to 62.58 mS/cm)on the as-developed ionogel.Inspired by the tongue to engineer the perceptual patterns in this ionogel,we present a smart e-skin with the perfect combination of excellent ion transport and discriminability,showing six stimulating responses to pressure,touch,temperature,humidity,magnetic force,and even astringency.This study proposes a simple,efficient,controllable,and sustainable approach toward a low-carbon,versatile,and scalable e-skin design and structure-performance development. | Geyuan Jiang Gang Wang Ying Zhu Wanke Cheng Kaiyue Cao Guangwen Xu Dawei Zhao Haipeng Yu | 2022 | Research2022，，4： | 1 |
| 18 | Paleo-Environment Reconstruction of the Middle Permian Lucaogou Formation,Southeastern Junggar Basin,NW China:Implications for the Mechanism of Organic Matter Enrichment in Ancient Lake显示文摘The Middle Permian Lucaogou Formation is the source rock and the main oil shale producing formation in the southeastern Junggar Basin.This study focused on the Lucaogou Formation exposed in two outcrop sections on the northern flank of the Bogda Mountain,namely the Jingjingzigou and Dalongkou sections.Here,we present integrated analysis of the sedimentology,major and trace elements,mineral components and total organic carbon contents.The paleo-environment was reconstructed including provenance,redox conditions,paleo-salinity,chemical weathering intensity and primary organic matter productivity.The results showed that the upper and lower units were deposited in distinct depositional environments with different organic matter accumulation mechanisms.The lower unit was characterized by low lake level,dry climate,fresh-brackish and well-oxygenated water.While during the deposition of the upper unit the lake level rose,climate turned wetter and the bottom water became less oxidized and much saltier.The mechanism of the organic matter accumulation is different for these two units.The preserved organic matters were mainly controlled by the primary productivity in the lower unit and by the redox conditions in the upper unit. | Dawei Cheng Chuanmin Zhou Zhijie Zhang Xuanjun Yuan Yinhe Liu Xingyu Chen | 2022 | Journal of Earth Science2022，33，4： | 1 |
| 19 | Filtering method for SAR interferograms with strong noise显示文摘 | Li Zhiwei Ding Xiaoli Huang Cheng Zheng Dawei W.B.ZOU Y.K.SHEA | | 0，，01： | 1 |
| 20 | Least Squares-Based Filter for Remote Sensing Image Noise Reduction显示文摘 | Li Zhiwei Ding Xiaoli Zheng Dawei Huang Cheng | | 0，，07： | 1 |
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