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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 3 | Anti-inflamma- tory activity of Chinese medicinal vine plants 显示文摘 | Rachel WL G David L Stephen PM | 2003 | J Ethnopharmacol2003，85，1： | 1 |
| 4 | n-3PUFA and membrane microdomains: a new frontier in bioactive lipid research 显示文摘 | David WL Mia L Jeongrnin Seoa | 2004 | Journal of Nutritional Biochemistry2004，，15： | 1 |
| 5 | Result of a phase I trial of concurrent chemotherapy and escalating doses of radiation for unpresectable non-small-cell lung cancer显示文摘 | Schild SE McGinnis WL David Graham | 2006 | Int J Radiat Oncol Biol Phys2006，65，4： | 1 |
| 6 | Bacterial diversity within the human subgingival crevice 显示文摘 | Ian K Paul WL David AR | 1999 | Proe Natl Acad Sci USA1999，96，14： | 1 |
| 7 | Anti-inflammatory activity of Chinese medicinal vine plants 显示文摘 | Rachel WL David GL Stephen PM | 2003 | J Ethnopharmachol2003，85，1： | 1 |
| 8 | Conjugated linoleic acid in canadian dairy and beef products 显示文摘 | David WL Ma Antoni A Wierzbicki Catherine J Field | 1999 | J Agric Food Chem1999，49，： | 1 |
| 9 | Fabrica- tion mad biocombility of pol)pyrrole implants suitable Ibr neural prosthetics显示文摘 | Paul MG Alvin WL David AL | 2005 | Biomaterials2005，26，： | 1 |
| 10 | Anti-inflammatory activity of Chinesemedicinal vine plants显示文摘 | Rachel WL David GL Stephen PM | | 0，，01： | 1 |
| 11 | Anti-inflammatory activity of Chinese medicinal vine plants显示文摘 | Rachel WL G David L Stephen PM | 2003 | Journal of Ethnopharmacology2003，85，1： | 1 |
| 12 | Preparation of conjugated linolenic acid from safflower oil显示文摘 | David WL | 1999 | JAOCS1999，76，6： | 1 |
| 13 | Diabetic retinopathy:more than meets the eye显示文摘 | Thomas WG David A Alistair JB Kathryn FL Steven WL The penn state retina research group | 2002 | Surv Ophthalmol2002，47，2： | 1 |
| 14 | Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus显示文摘 | Susan PH David RR Rita WL | 1991 | N Engl J Med1991，325，3： | 1 |
| 15 | Percutaneous coronary intervention in the current era compared with 1985-1986: the national heart,lung, and blood institute registries 显示文摘 | David OW Holubkov R Yeh WL | 2000 | Circulation2000，102，： | 1 |
| 16 | Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus显示文摘 | Susan PH David RR Rita WL | 1991 | N Engl J Med1991，325，3： | 1 |
| 17 | Strategic alliances and the rate of new product development:an empirical study of entrepreneurial biotechnology firms显示文摘 | DAVID L DEEDS CHARLES WL HILL | 1996 | Journal of Business Venturing1996，11，1： | 1 |
| 18 | Muscle weak- ness in mechanically ventilated patients with severe asthma 显示文摘 | Leatherman JW Fiuegel WL David WS | 1996 | American Journal of Respiratory and Critical Care Medicine1996，153，5： | 1 |
| 19 | Development of a scaleable route for the production of cis-N-benzyl-3- methylamino-4-methylpiperidine 显示文摘 | David HBR Stefan A Cai WL | 2003 | Org Process Res Dev2003，7，1： | 1 |
| 20 | Primary aorto-duodenal fistula:A case report and review of the literature显示文摘 | David WL Joseph DR Carlton M | 2003 | J Vase Stag2003，37，3： | 1 |
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