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| 1 | Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation显示文摘AIM: Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS: A reporter gene system in HT-29 cells was used to measure levels of NF-KB activation after challenge with bifidobacteria or after bacterial pre-treatment following LPS challenge. IL-8 protein and pro-inflammatory gene expression was investigated using normal HT-29 cells. RESULTS: None of the bifidobacteria tested induced activation of nuclear factor KB (NF-KB) indicating that bifidobacteria themselves do not induce inflammatory events in IECs. However, six out of eight bifidobacteria tested inhibited lipopolysaccharide- (LPS-) induced NFKB activation in a dose- and strain-dependent manner. In contrast, NF-KB activation in response to challenge with tumor necrosis factor-α(TNF-α) was affected by none of the tested bifidobacteria, indicating that the inhibitory effect of bifidobacteria is specific for LPS-induced inflammation in IECs. As shown with two of the six inhibitionpositive bifidobacteria, LPS-induced inhibition of NFKB activation was accompanied by a dose-dependent decrease of interleukin 8 (IL-8) secretion and by lower mRNA levels for IL-8, TNF-a, cyclooxygenase 2 (Cox-2), and intercellular adhesion molecule 1 (ICAM-1). CONCLUSION: Some strains of bifidobacteria are effective in inhibiting LPS-induced inflammation and thus might be appropriate candidates for probiotic intervention in chronic intestinal inflammation. | Christian U Riedel Francis Foata David Philippe Oskar Adolfsson Bernhard J Eikmanns Stephanie Blum | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 2 | Short mucin 1 alleles are associated with low virulent H pylori strains infection显示文摘TO THE EDITOR We read with interest the article published by Nguyen et al[1] in the World Journal of Gastroenterology, | Bárbara Peleteiro Nuno Lunet Filipe Santos-Silva Leonor David Céu Figueiredo Henrique Barros | 2007 | World Journal of Gastroenterology2007，13，12： | 3 |
| 3 | The Importance of Medial Support in Locked Plating of Proximal Humerus Fractures显示文摘 | Michael J Gardner Yoram Weil Joseph U Barker Bryan T Kelly David L Helfet Dean G Lorich | 2007 | Journal of Orthopaedic Trauma2007，，3： | 2 |
| 4 | Large cystic lesions of the liver in adults: a 15-year experience in a tertiary center 1 1 No competing interests declared.显示文摘 | Arie Regev K.Rajender Reddy Mariana Berho Dan Sleeman Joe U Levi Alan S Livingstone David Levi Unzila Ali Enrique G Molina Eugene R Schiff | 2001 | Journal of the American College of Surgeons2001，，1： | 2 |
| 5 | Simultaneous measurement of phytoplanktonic primary production,nutrient and light availability along a turbid,eutrophic UK east coast estuary(the Colne Estuary)显示文摘 | ESRA K GRAHAM J C U DAVID B N | 2002 | Marine Ecology Progress Series2002，231，： | 1 |
| 6 | New frontiers in food enzymology: recombinant lipoxygenases显示文摘 | Casey R West S I Hardy D David S Robinson Zecai W u Richard K Hughes | 1999 | Trends in Food Science & Technology1999，10，： | 1 |
| 7 | One-stage revision of infected toted hip arthoplasty with bone graft显示文摘 | Sergio R David U Emerson H | 2008 | The Journal of Arthroplasty2008，8，： | 1 |
| 8 | Scanning probe microscopy显示文摘 | Colton Richard J Baselt David R Dufrêne Yves F Green John-Bruce D Lee Gil U | 1997 | Chemical Biology1997，1，3： | 1 |
| 9 | Contemporary issues in heritage and environmental interpretation显示文摘 | David U Roy B | 2000 | Annals of Tourism Research2000，27，4： | 1 |
| 10 | Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4显示文摘 | Hai U Wang Zhou-Feng Chen David J Anderson | 1998 | Cell1998，，5： | 1 |
| 11 | Effectiveness of various cover scenarios on the rate of sulfide oxidation of mine tailings 显示文摘 | Connie G R Mayer K U David R J | 2003 | Journal of Hydrology2003，271，14： | 1 |
| 12 | Costing for long-term care:The development of Scottish health service resource utilization groups as a case-mix instrument 显示文摘 | James U David CK Peter SM | 1999 | Age and Ageing1999，28，2： | 1 |
| 13 | Model parameter estimation from data assimilation modelling:temporal and spatial variability of bottom drag coefficient显示文摘 | DAVID S U ROBERT E W | 1998 | Journal of Geophysical Research1998，103，： | 1 |
| 14 | A Control Engineer's Guide to Sliding Mode Control 显示文摘 | K David Young Vadim I Utkin U' mit O' zgu'ner | 1999 | IEEE Transactions on Control Systems Technology (S1063-6536)1999，7，3： | 1 |
| 15 | Electro-optic probing of RF signals in submicrometre MMIC devices 显示文摘 | Bussek P Auer U | 1995 | Electro Lett1995，31，25： | 1 |
| 16 | Modeling of magnetic properties of polymer bonded Nd-Fe-B magnets with surface modifications 显示文摘 | Joshua U O David C J | 2000 | Journal of Magnetism and Magnetic Materials2000，218，： | 1 |
| 17 | Low pH,caprylate incubation as a second viral inactivation step in the manufacture of albumin:Parametric and validation studies显示文摘 | Anna J Eric U David J John W | | 0，，03： | 1 |
| 18 | Life cycle assessment as a tool to enhance the environmental performance of carbon nanotube products: A review 显示文摘 | VENKATA K U DAVID E M CURRANrran M A | 2012 | J Cleaner Prod2012，26，5： | 1 |
| 19 | Structural and stratigraphicevolution of the Connemara discovery,northern Por-cupine Basin:Significance for basin development andpetroleum prospectivity along the Irish Atlantic Margin显示文摘 | David W J John R U | 2011 | Petroleum Geoscience2011，17，4： | 1 |
| 20 | Present state of non-heartbeating lung donation显示文摘 | Gomez A David Varela U | 2008 | Current Opinion in Organ Transplantation2008，13，6： | 1 |
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