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| 1 | GRADE指南:Ⅰ.导论--GRADE证据概要表和结果总结表显示文摘本文是GRADE(Grading of Recommendations Assessment,Development,and Evaluation)系列文章的导论。该系列文章为使用GRADE系统提供指导,介绍如何将该系统用于系统评价、卫生技术评估(HTAs)及临床实践指南中备选方案的证据质量评价和推荐强度评级。GRADE方法始于提出一个明晰的问题,包括对所有重要结果的详细说明。证据被收集和汇总后,GRADE提供了明确的标准来评价其质量,包括研究设计、偏倚风险、不精确性、不一致性、间接性及效应量大小。根据支撑证据质量及备选方案带来的预期和非预期结果间的平衡情况,推荐强度以强/弱(或表述为'有条件的'/'任意的')作为特征。GRADE建议用简洁、透明、信息量丰富的结果总结表来汇总证据(以显示证据质量及每一重要结果的相对效应量和绝对效应量),和(或)以证据概要表形式额外提供证据质量评价理由的详细信息。本系列的后续文章涉及如何采用GRADE方法明确构建问题、评价证据质量及形成推荐意见。 | Gordon Guyatt Andrew D.Oxman Elie Akl Regina Kunz Gunn Vist Jan Brozek Susan Norris Yngve Falck-Ytter Paul Glasziou Hans deBeer Roman Jaeschke David Rind Joerg Meerpohl Philipp Dahm Holger J.Schünemann GRADE工作组 李幼平 杨晓妍 蒋兰慧 沈建通 | 2011 | 中国循证医学杂志2011，11，4： | 205 |
| 2 | The Critical Rainfall Characteristics for Torrents and Debris Flows in the Wenchuan Earthquake Stricken Area显示文摘Critical rainfall assessment is a very important tool for hazard management of torrents and debris flows in mountainous areas. The Wenchuan Earthquake 2008 caused huge casualties and property damages in the earthquake-stricken area,which also generated large quantities of loose solid materials and increased occurrence probabilities of debris flows. There is an urgent need to quantify the critical rainfall distribution in the area so that better hazard management could be planned and if real time rainfall forecast is available,torrent and debris flow early-warning could be issued in advance. This study is based on 49-year observations (1954-2003) of up to 678 torrent and debris flow events. Detailed contour maps of 1 hour and 24 hour critical rainfalls have been generated (Due to the data limitation,there was insufficient 10 minute critical rainfall to make its contour map). Generally,the contour maps from 1 hour and 24 hours have similar patterns. Three zones with low,medium and high critical rainfalls have been identified. The characteristics of the critical rainfall zones are linked with the local vegetation cover and land forms. Further studies and observations are needed to validate the finding and improve the contour maps. | CHEN Ningsheng YANG Chenglin ZHOU Wei HU Guisheng LI Huan David Han | 2009 | Journal of Mountain Science2009，6，4： | 35 |
| 3 | A new feathered maniraptoran dinosaur fossil that fills a morphological gap in avian origin显示文摘Recent fossil discoveries have substantially reduced the morphological gap between non-avian and avian dinosaurs, yet avians including Archaeopteryx differ from non-avian theropods in their limb proportions. In particular, avians have proportionally longer and more robust forelimbs that are capable of supporting a large aerodynamic surface. Here we report on a new maniraptoran dinosaur, Anchiornis huxleyi gen. et sp. nov., based on a specimen collected from lacustrine deposits of uncertain age in western Liaoning, China. With an estimated mass of 110 grams, Anchiornis is the smallest known non-avian theropod dinosaur. It exhibits some wrist features indicative of high mobility, presaging the wing-folding mechanisms seen in more derived birds and suggesting rapid evolution of the carpus. Otherwise, Anchiornis is intermediate in general morphology between non-avian and avian dinosaurs, particularly with regard to relative forelimb length and thickness, and represents a transitional step toward the avian condition. In contrast with some recent comprehensive phylogenetic analyses, our phylogenetic analysis incorporates subtle morphological variations and recovers a conventional result supporting the monophyly of Avialae. | XU Xing ZHAO Qi NORELL Mark SULLIVAN Corwin HONE David ERICKSON Gregory WANG XiaoLin HAN FengLu GUO Yu | 2009 | Chinese Science Bulletin2009，54，3： | 15 |
| 4 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 5 | 高铌X80管道不同强度匹配环焊接头性能及应变演化显示文摘为探究管道环焊缝断裂失效机理,测试了两种不同强度匹配的高铌X80环焊缝接头的组织和性能,并借助数字图像相关法(digital image correlation, DIC)观测了焊接接头在拉伸载荷下的应变行为.结果表明,低强匹配和高强匹配的高铌X80管道环焊接头均具有较好的冲击韧性,二者的夏比冲击吸收能量平均值相当,热影响区韧性离散主要是粗晶区组织不均匀性所致;高铌X80管线钢碳当量CEIIW较低,环焊缝接头热影响区存在一定程度软化.在轴向拉伸载荷下,无论是低强匹配还是高强匹配,应变集中最先出现在环焊缝的根焊和热影响区部位.随着拉伸载荷的增加,高强匹配环焊缝接头的应变集中逐渐从根焊和热影响区转移到母材,管道承受轴向载荷和变形的能力大于低强匹配环焊接头;而对于低强匹配,因在焊缝和热影响区产生塑性应变累积,即使具有较好的韧性,环焊接头也会发生断裂. | 何小东 高雄雄 David Han 池强 霍春勇 JoséB Bacalhau | 2022 | 焊接学报2022，43，2： | 11 |
| 6 | Convergence of ADMM for multi-block nonconvex separable optimization models显示文摘为解决没有联合变量和抑制函数,其客观功能是二个函数的和的最小化问题是线性的, multipliers (ADMM ) 的轮流出现的方向方法展出了它的效率和它的集中很好被理解。可分离的功能的深奥数字什么时候也是超过二,或有 nonconvex 功能, ADMM 或它的直接扩大的版本不能收敛。在这份报纸,我们与深奥部件功能的凸状的线性限制和缺席认为多块是可分离的优化问题。在联系功能满足的假设下面 Kurdyka- Lojasiewicz 不平等,我们证明 ADMM 产生的反复的顺序的任何簇点是一个批评的点,在惩罚参数足够地大的温和条件下面。我们也介绍保证 sublinear 和算法的集中的线性率的一些足够的条件。 | Ke GUO Deren HAN David Z. W. WANG Tingting WU | 2017 | Frontiers of Mathematics in China2017，12，5： | 10 |
| 7 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 8 | 不同强度匹配的X80钢环焊接头力学性能及变形能力显示文摘环焊接头的强度匹配与韧性对管道服役安全至关重要。为了更深入掌握环焊缝的失效机理,采用力学性能测试、微观分析等方法,测试了两种不同强度匹配的高铌X80钢环焊接头的组织和性能,并借助数字图像相关法(Digital Image Correlation,DIC)研究了焊接接头在拉伸载荷下的应变行为。结果表明:低强匹配与高强匹配的环焊接头均具有较好的冲击韧性,二者的夏比冲击吸收能量平均值相当。在拉伸载荷下,应变集中最先出现在环焊缝的根焊及热影响区部位。随着拉伸载荷的增加,高强匹配环焊接头的应变集中逐渐转移至母材,管道承受轴向载荷及变形的能力大于低强匹配环焊接头;低强匹配环焊接头虽具有较好的韧性,但因其在焊缝及热影响区存在塑性应变累积效应,易发生断裂。(图9,表4,参22) | 何小东 高雄雄 David Han 池强 霍春勇 José B.Bacalhau | 2022 | 油气储运2022，41，1： | 9 |
| 9 | Electro-Pulse-Boring(EPB): Novel Super-Deep Drilling Technology for Low Cost Electricity显示文摘The inexhaustible heat deposit in great depths(5–10km) is a scientific fact. Such deposit occurs around the globe. Thereby,everybody is enabled to generate autonomously clean and renewable energy,ample electricity and heat. The economical exploration and exploitation of this superdeep geothermal heat deposit requires a novel drilling technique,because the currently only deep drilling method(Rotary) is limited to about 5km,due to the rising costs,depending exponentially on depth. Electro-pulse-boring(EPB) is a valuable option to Rotary drilling. EPB,originally investigated in Russia,is ready to be developed for industrialization. The feasibility of EPB is proven by many boreholes drilled up to 200 m in granite(crystalline). Estimates show outstanding low costs for drilling by EPB: 100 €/m for a borehole with a large diameter such as 20'(50 cm),independent on depth and applicable likewise for sediments and crystalline rocks,such as granite. The current rate of penetration(ROP) of 3 m per hour is planned to be augmented up to 35m per hour,and again,irrespective whether in sedimentary or crystalline formations. Consequently,a 10km deep borehole with 50 cm will ultimately be drilled within 12 days. EPB will create new markets,such as:(i) EPB shallow drilling for geotechnics,energy piles,measures in order to mitigate natural hazards,etc.,(ii) EPB deep drilling(3–5km) for hydro-geothermics,exploration campaigns etc. and(iii) EPB super-deep drilling(5–10km) for petro-geothermics,enabling the economic generation of electricity. The autonomous and unlimited supply with cost efficient electricity,besides ample heat,ensures reliably clean and renewable energy,thus,high supply security. Such development will provide a substantial relief to cope with the global challenge to limit the climate change below 2 oC. The diminution of fossil fuels,due to the energy transition in order to mitigate the climate change,implies likewise the decrease of air pollution. | Hans O.Schiegg Arild Rdland Guizhi Zhu David A.Yuen | 2015 | Journal of Earth Science2015，26，1： | 8 |
| 10 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 11 | Adenoviral-mediated Hath1-EGFP gene transfer into guinea pig cochlea through intact round window membrane显示文摘Objective To study expression of adenoviral-mediated Hath1-EGFP gene in the guinea pig cochlea after transfer through intact round window membrane(RWM), and to assess its effects on hearing. Methods Twenty adult guinea pigs were used, of which: 12 were surgically inoculated with Ad-Hath1-EGFP in the bony groove of round window niche, and 8 with artificial perilymph. Auditory brainstem response(ABR) thresholds were determined in all animals before and 5 days after surgery. On post-surgery day 5 and day 14, animals were sacrificed and whole mounts of cochlea and frozen sections were examined. Results ABR tests showed no significant change of hearing after the surgery. Strong fluorescence staining in the cochleae was seen in Ad-Hath1-EGFP groups. The highest levels of gene expression were seen in the post-surgery day 5 group with little decrease on post-surgery day 14.The contralateral cochlea and those in the control groups were free of fluorescence staining. Conclusion The transgenic Hath1-EGFP can be effectively delivered into the inner ear through intact RWM, in an atraumatic manner. | CHEN Wei1☆, HU Yin-yan1☆, YANG Shi-ming1*, GUO Wei1, SUN Jian-he1, HAN Dong-yi1, ZHAI Suo-qiang1, YANG Wei-yan1, David Z.Z.He2 1. Neurologic Biological centre, Institute of Otolaryngology, Department of Otorhinolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing 100853, China 2. Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68175, USA | 2008 | Journal of Otology2008，3，1： | 7 |
| 12 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 13 | 几种典型X80管线钢管及其环焊缝性能研究显示文摘环焊缝质量是影响高钢级长输管道安全的重要因素之一。国际焊接研究中心(IWTC)针对几种典型X80管线钢的焊接开展了大量研究,测试了钢管管体和环焊缝的组织及关键力学性能,分析了X80管线钢管环焊工艺及环焊缝性能影响因素,给出了推荐工艺参数、控制措施等。采用焊接热模拟试验研究了2种不同Nb含量的X80钢管的焊接性,分析了Nb含量对焊缝区域微观组织的影响机制。结果表明,国内典型的X80管线钢管均具有良好的性能,其管体性能及焊接性满足工程需要;应采用合理的环焊工艺和质量控制措施以保证焊缝的性能;铌含量较高的X80管线钢具有更优越的焊接性,但必须严格遵从焊接工艺规范。 | David Han 齐丽华 霍春勇 José B.Bacalhau Marcos A.Stuart Nogueira Frank J.Barbaro 张永青 | 2021 | 石油管材与仪器2021，7，2： | 5 |
| 14 | 人为因素造成的大气中氮沉降、海洋富营养化以及有害藻类的暴发:是否存在相关性显示文摘在北大西洋流域,大气氮沉降(AD-N)源自北美和西欧的污染源,这些污染源从工业革命开始急剧增长(5~10倍)并且在地理上和沉降量上持续增长。依据本次研究的估计,AD-N的流量(11.2Tg N/a)占NAO中总的'新'氮或人为产生的氮流量的46%~57%。氮流动的生态学影响与富营养化有关,这可以通过有害(毒性,引发缺氧,食物网的改变)藻类暴发(HABs)来证明。在此,我们研究了有记载的北大西洋中来源于AD-N的'新'氮的沉降负荷导致HAB频率明显增加与其他AD-N对海洋生态系统影响间在概念上的潜在相关性。 | Hans W. Paerl David R. Whitall 王宏 | 1999 | AMBIO-人类环境杂志1999，28，4： | 5 |
| 15 | Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations显示文摘Tyrosine aminotransferase(TAT)catalyzes the transamination of tyrosine and other aromatic amino acids.The enzyme is thought to play a role in tyrosinemia type II,hepatitis and hepatic carcinoma recovery.The objective of this study is to investigate its biochemical and structural characteristics and substrate specificity in order to provide insight regarding its involvement in these diseases.Mouse TAT(mTAT)was cloned from a mouse cDNA library,and its recombinant protein was produced using Escherichia coli cells and purified using various chromatographic techniques.The recombinant mTAT is able to catalyze the transamination of tyrosine usingα-ketoglutaric acid as an amino group acceptor at neutral pH.The enzyme also can use glutamate and phenylalanine as amino group donors and p-hydroxyphenylpyruvate,phenylpyruvate and alpha-ketocaproic acid as amino group acceptors.Through macromolecular crystallography we have determined the mTAT crystal structure at 2.9Åresolution.The crystal structure revealed the interaction between the pyridoxal-5′-phosphate cofactor and the enzyme,as well as the formation of a disulphide bond.The detection of disulphide bond provides some rational explanation regarding previously observed TAT inactivation under oxidative conditions and reactivation of the inactive TAT in the presence of a reducing agent.Molecular dynamics simulations using the crystal structures of Trypanosoma cruzi TAT and human TAT provided further insight regarding the substrate-enzyme interactions and substrate specificity.The biochemical and structural properties of TAT and the binding of its cofactor and the substrate may help in elucidation of the mechanism of TAT inhibition and activation. | Prajwalini Mehere Qian Han Justin A.Lemkul Christopher J.Vavricka Howard Robinson David R.Bevan Jianyong Li | 2010 | Protein & Cell2010，1，11： | 4 |
| 16 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 17 | An optimized short-term wind power interval prediction method considering NWP accuracy显示文摘In recent years, the accuracy of the wind power prediction has been urgently studied and improved to satisfy the requirements of power system operation. In this paper, the relevance vector machine(RVM)-based models are established to predict the wind power and its interval for a given confidence level. An NWP improvement module is presented considering the characteristic of NWP error. Moreover, two parameter optimization algorithms are applied to further improve the prediction model and to compare each performance. To take three wind farms in China as examples, the performance of two RVM-based models optimized, respectively, by genetic algorithm(GA)and particle swarm optimization(PSO) are compared with predictions based on a genetic algorithm–artificial neural network(GA–ANN) and support vector machine. Results show that the proposed models have better prediction accuracy with GA–RVM model and more efficient calculation with PSO–RVM. | Yongqian Liu Jie Yan Shuang Han Infield David De Tian Linyue Gao | 2014 | Chinese Science Bulletin2014，59，11： | 4 |
| 18 | Polluted lake restoration to promote sustainability in the Yangtze River Basin,China显示文摘China has sought to address water pollution in the last decade by introducing a wide range of laws and regulations(Table S1), which led to nationwide water quality improvement ^([1]). However, recent quantitative assessment of progress toward Sustainable Development Goals (SDGs) in China suggests that some SDGs underpinning goals for water pollution and biodiversity have not been met ^([2]). | Boqiang Qin Yunlin Zhang Jianming Deng Guangwei Zhu Jianguo Liu David P.Hamilton Hans W.Paerl Justin D.Brookes Tingfeng Wu Kai Peng Yizhou Yao Kan Ding Xiaoyan Ji | 2022 | National Science Review2022，9，1： | 4 |
| 19 | Characterisation of pH decline and meat color development of beef carcasses during the early postmortem period in a Chinese beef cattle abattoir显示文摘This study investigated the pH/temperature decline of beef carcasses in a typical Chinese abattoir and color development as pH declined during rigor onset. A natural cubic spline model was used to model the pH/temperature decline for those carcasses which passed through pH 6.0. Six of the 97 carcasses that exhibited a high(≥6.10) ultimate pH(pHu)(darkcutting) in the M. longissimus lumborum(LL) were sampled, along with the same numbers of normal pHu and intermediate pHu carcasses(5.40–5.79; 5.80–6.10, respectively), to examine color development within 24h postmortem. It was shown that 66.7% of the modeled carcasses were outside the ideal pH/temperature window with a temperature@pH6.0 lower than ideal, suggesting the need for acceleration of the pH decline. The stable and low a~*, b~* and chroma values of high pHu beef within the first 12h indicated dark-cutting beef might be detected earlier than expected. | ZHANG Yi-min David L.Hopkins ZHAO Xiao-xiao Remy van de Ven MAO Yan-wei ZHU Li-xian HAN Guang-xing LUO Xin | 2018 | Journal of Integrative Agriculture2018，17，7： | 4 |
| 20 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
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