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| 1 | Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats显示文摘AIM:To determine the temporal expression and pattern of Rel/nuclear factor(NF)-κB proteins in renal tissue in polycystic kidney disease(PKD). METHODS: The renal expression of Rel/NF-κB proteins was determined by immunohistochemistry, immunofluorescence and immunoblot analysis in Lewis polycystic kidney rats(LPK, a genetic ortholog of human nephronopthsis-9) from postnatal weeks 3 to 20. At each timepoint, renal disease progression and the mR NA expression of NF-κB-dependent genes(TNFa and CCL2) were determined. NF-κB was also histologicaly assessed in human PKD tissue.RESULTS: Progressive kidney enlargement in LPK rats was accompanied by increased renal cell proliferation and interstitial monocyte accumulation(peaking at weeks 3 and 10 respectively), and progressive interstitial fibrosis(with a smooth muscle actin and Sirius Red deposition significantly increased compared to Lewis kidneys from weeks 3 to 6 onwards). Rel/NF-κB proteins(phosphorylated-p105, p65, p50, c-Rel and RelB) were expressed in cystic epithelial cells(CECs) of LPK kidneys as early as postnatal week 3 and sustained until latestage disease at week 20. From weeks 10 to 20, nuclear p65, p50, Rel B and cytoplasmic IκBa protein levels, and TNFa and CCL2 expression, were upregulated in LPK compared to Lewis kidneys. NF-κB proteins were consistently expressed in CECs of human PKD. The DNA damage marker γ-H2AX was also identified in the CECs of LPK and human polycystic kidneys. CONCLUSION: Several NF-κB proteins are consistently expressed in CECs in human and experimental PKD. These data suggest that the upregulation of both the canonical and non-canonical pathways of NF-κB signaling may be a constitutive and early pathological feature of cystic renal diseases. | Michelle HT Ta Kristina G Schwensen David Liuwantara David L Huso Terry Watnick Gopala K Rangan | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 2 | Is high serum uric acid a risk marker or a target for treatment Examination of its independent effect in a large cohort with low cardiovascular risk显示文摘 | Wen CP David Cheng TY Chan HT | 2010 | Am J Kidney Dis2010，56，2： | 1 |
| 3 | Haemodynamic consequences of mild therapeutic hypothermia after cardiac arrest显示文摘 | Remco Bergman Annemarije Braber Marlies A Adriaanse Roel van Vugt David HT Tjan Arthur RH van Zanten | 2010 | European Journal of Anaesthesiology2010，，4： | 1 |
| 4 | Nonendodontic coronalresection of fused and geminated vital teeth : a new technique显示文摘 | David HT Krakowiak PA Pirani AB | 1997 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod1997，83，4： | 1 |
| 5 | Effects of phosphorus limitation on respiratory metabolism in the green Alga Selenastrum minutum显示文摘 | MariaET IvorRE David HT etal | 1991 | Plant Physi- ology1991，95，10： | 1 |
| 6 | Is high serum uric acid a risk marker or a target for treatment Examination of its independent effect in a large cohort with low cardiovas- cular risk 显示文摘 | Wen CP David Cheng TY Chan HT | 2010 | Am J Kidney Dis2010，56，2： | 1 |
| 7 | Is high serum uric acid a risk marker or a target for treatment? Examination of its independent effect in a large cohort with low cardiovascular risk 显示文摘 | Wen CP David Cheng TY Chan HT | 2010 | Am J Kidney Dis2010，56，2： | 1 |
| 8 | Improvement of growth of Chlamydia pneumoniae on Hep-2 cells by pretreatment with polyethyleneglycol in combination with additional entrifugation and extension of culture time显示文摘 | Tjhie J HT Robert R David M | 1997 | J Clinic Microbiol1997，35，7： | 1 |
| 9 | Measuring patientstrust inPhysicians when assessing quality of care 显示文摘 | David HT Mark AH Gregory PL | 2004 | Health Affairs (Millwood)2004，，4： | 1 |
| 10 | Characterization of NADP-dependent malic enzyme from developing castor oil seed endosperm显示文摘 | David HT David TD | 2004 | Arch Biochem Biophys2004，429，： | 1 |
| 11 | Is high serum uric acid a risk marker or a target for treatment? Examination of its independent effect in a large cohort with low cardiovascular risk显示文摘 | Wen CP David Cheng TY Chan HT | 2010 | Am J Kidney Dis2010，56，2： | 1 |
| 12 | Temporal entrainment of cognitive functions Musical memonics induce brain plasticity and oscillatory synchrony in neural networks underlying memory 显示文摘 | Michael HT David A | 2005 | Ann N Y Acad SCI2005，1060，1： | 1 |
| 13 | Sex education:The case for primary prevention and peer education 显示文摘 | David LE John HT | 2006 | Current Paediatries2006，16，： | 1 |
| 14 | Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coil Topoisomerase Ⅳ 显示文摘 | John HT George A J David CH | 2005 | Antimicrob Agents Chemother2005，49，7： | 1 |
| 15 | Association of prior infection with chlamydia pneumoniae and angiographically demonstrated coronary artery disease显示文摘 | Grayston JT | 1992 | JAMA1992，268，： | 1 |
| 16 | Is high serum uric acid arisk marker or a target for treatment? Examination of its independenteffect in a targe cohort with low cardiovascular risk显示文摘 | Wen CP David Cheng TY Chan HT | 2010 | Am J KidneyDis2010，56，： | 1 |
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