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| 1 | Mi R-122 in hepatitis B virus and hepatitis C virus dual infection显示文摘Hepatitis B virus(HBV) and hepatitis C virus(HCV) infections are the most common causes of chronic liver diseases and hepatocelluar carcinomas. Over the past few years, the liver-enriched micro RNA-122(mi R-122) has been shown to differentially regulate viral replication of HBV and HCV. It is notable that thelevel of mi R-122 is positively and negatively regulated by HCV and HBV, respectively. Consistent with the welldocumented phenomenon that mi R-122 promotes HCV accumulation, inhibition of mi R-122 has been shown as an effective therapy for the treatment of HCV infection in both chimpanzees and humans. On the other hand, mi R-122 is also known to block HBV replication, and HBV has recently been shown to inhibit mi R-122 expression; such a reciprocal inhibition between mi R-122 and HBV suggests an intriguing possibility that mi R-122 replacement may represent a potential therapy for treatment of HBV infection. As HBV and HCV have shared transmission routes, dual infection is not an uncommon scenario, which is associated with more advanced liver disease than either HBV or HCV mono-infection. Thus, there is a clear need to further understand the interaction between HBV and HCV and to delineate the role of mi R-122 in HBV/HCV dual infection in order to devise effective therapy. This review summarizes the current understanding of HBV/HCV dual infection, focusing on the pathobiological role and therapeutic potential of mi R-122. | Kyoungsub Song Chang Han Srikanta Dash Luis A Balart Tong Wu | 2015 | World Journal of Hepatology2015，7，3： | 6 |
| 2 | 以肝脏为靶器官的基因治疗时重组腺病毒引起的急性肝炎显示文摘目的 研究腺病毒为载体的基因治疗时淋巴细胞在肝组织免疫反应中的作用,探讨免疫抑制疗法在腺病毒载体基因治疗中的可行性。 方法 取8只恒河猴,经不同路径输入携带大肠杆菌lacZ基因或荧火虫荧光素酶基因luc的重组腺病毒6只。其中4只进行免疫抑制治疗。将含lacZ的质粒DNA注入2只动物作为对照。用免疫组织化学法检测β2-MG、HLA-DR、CD3、CD4、CD8及CD20。 结果 腺病毒介导的基因治疗时肝脏的β2-MG、HLA-DR、CD3、CD4及CD8阳性细胞明显增多。腺病毒载体和转基因均与肝损害有关, 表现为一过性, 呈轻、中度无黄疸性肝炎。免疫抑制的动物只要处于免疫抑制状态下就没有肝炎的表现,基因表达的时间延长。质粒介导的基因转导效果差, 无肝损害及免疫反应。所有动物B淋巴细胞抗原CD20始终阴性。 结论 腺病毒介导的基因治疗时肝脏的β2-MG、HLA-DR、CD3、CD4及CD8阳性细胞明显增多, 造成轻、中度一过性肝损害。使用免疫抑制药物可避免肝损害的发生并延长基因表达的时间。 | 鲁慧英 Deborah Sullivan Srikanta Dash Michael A Gerber | 2001 | 中华肝脏病杂志2001，9，5： | 3 |
| 3 | Characteristics of a GaN-based Gunn diode for THz signal generation显示文摘A generalized large-signal computer simulation program for a Gunn oscillator has been developed.The properties of a Gunn diode oscillator based on the widely explored GaN,are investigated using the developed program.The results show some interesting properties in GaN Gunn diodes which are not seen in GaAs and InP diodes.An output power of 1400 kW/cm^2 is achieved from the GaN Gunn diode,as compared to 4.9 kW/cm^2 from a GaAs diode. | R K Parida N C Agrawala G N Dash A K Panda | 2012 | Journal of Semiconductors2012，33，8： | 2 |
| 4 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 5 | Data compression of power quality events using the slantlet transform 显示文摘 | PANDA G DASH K P PRADHAN K A | 2002 | IEEE Trans on Power Delivery2002，17，2： | 1 |
| 6 | An adaptive linear combiner for on-line tracking of power system harmonic显示文摘 | Dash P K Swain D P Liew A C | 1996 | IEEE Trans on Power Systems1996，11，4： | 1 |
| 7 | A real-time shortterm load forecasting system using functional link network显示文摘 | Dash P K Satpathy H P Liew A C | 1997 | IEEE Trans on PWRS1997，12，2： | 1 |
| 8 | Full genome sequence of peste des petits ruminants virus,a member of the Morbillivirus genus显示文摘 | Bailey D Banyard A Dash P | 2005 | Virus Research2005，110，12： | 1 |
| 9 | A control methodology and characterization of dynamics for a photovoltaic (PV) system interfaced with a distribution network显示文摘 | Yazdani A Dash P P | 2009 | IEEE Trans on Power Delivery2009，24，3： | 1 |
| 10 | Dynamic analysis of power systems with multi-terminal HVDC links and static compensators 显示文摘 | Dash P K Rahman M A Panda P C | 1982 | IEEETrans onPower Systems1982，101，6： | 1 |
| 11 | Enthalpy increments of strontium and barium zirconates显示文摘 | BANERJEE A DASH S PRASAD R SOOD D D | 1997 | Therm Acta1997，298，： | 1 |
| 12 | Mesenchymal stem cells within lumour stroma promote breast cancer metastasis 显示文摘 | Kamoub A E Dash A B Vo A P | 2007 | Nature2007，449，7162： | 1 |
| 13 | A control methodology and character- ization of dynamics for a photovoltaic system interfaced with a dis- tribution network 显示文摘 | YAZDANI A DASH P P | 2009 | IEEE Transactions on Power Delivery2009，24，3： | 1 |
| 14 | Lymphomas and high-grade astrocytomas: comparison of water dif- fusibility and histologic characteristics 显示文摘 | Guo A C Cummings T J Dash R C | 2002 | Radiology2002，224，1： | 1 |
| 15 | A simple LC method with UA detection for the analysis of ereatine and ereatinine and its application to sev- eral creatine formulations 显示文摘 | DASH A K SAWHNEY A | 2002 | J Pharm Biomed Aral2002，29，5： | 1 |
| 16 | Input-output linearization and robust sliding mode controller for the VSC-HVDC transmission link显示文摘 | Moharana A Dash P K | 2010 | IEEE Transactions on Power Delivery2010，25，1： | 1 |
| 17 | A role for neoadjuvant gemcitabine plus cisplatin in muscle invasive urothelial carcinoma of the bladder: a retrospective experience显示文摘 | Dash A Pettus JA Herr HW | 2008 | Cancer2008，113，9： | 1 |
| 18 | Modulation of stretch-in- duced myocyte remodeling and gene expression by nitric oxide:a novel role for lipomapreferred partner in myofibrillogenesis 显示文摘 | Hooper CL Paudyai A Dash PR | 2013 | Am J Physiol Heart Circ Physiol2013，304，10： | 1 |
| 19 | 锐钛型钛二氧化物纳米颗粒对小鼠的影响:证据表明短时间而不是长时间的暴露会导致小鼠精子结构和功能的异常显示文摘锐钛型钛二氧化物纳米颗粒(TNPs)广泛应用在商业领域,并且存在于不同的产品中。为明确更小剂量的锐钛型钛二氧化物纳米颗粒(ATNPs)间隔一定距离进入体内到达阴囊后是否能诱导精子缺陷的发生,雄性成年小鼠持续3天腹腔内注射100%ATNP(2.5或5mg/kg),然后在注射后1周、2周、3周或5周(长时间暴露)或者是注射后24小时、48小时或120小时(短时间暴露)处死。透射电镜表明在注射后120小时收集到的阴囊脂肪组织中,附睾组织和附睾液均出现炎症反应。在注射后120小时和3周后,睾丸组织间质间隙增大。利用末端脱氧核糖核酸转移酶介导的缺口末端标记技术发现在注射后的雄鼠体内阳性(即凋亡)精子(P=0.002)和间质细胞(P=O.04)数目均显著增加。与对照组相比,短时间暴露而不是长时间暴露的附睾尾部精子鞭毛异常、过量胞浆残余(ERC)的发生率增加,精子无顶体反应的发生率增加(呈剂量依赖性)。ERC与无顶体反应是否存在相关性目前尚不清楚。与对照组相比,暴露120小时组快速运动精子数量和线粒体膜电位均显著下降(P〈0.05),同时,活性氧水平显著增加(P〈0.00001)。这些结果表明在注射后4.8天,ANTP能够引发不育的精子结构和功能的异常,并且通过氧化应激造成DNA的损伤。同时,在暴露后的10天到5周末检测到精子的异常,这表明精子的这种异常是暂时性的。 | Michelle A Smith Rowan Michael Rolands G Aravindan Soma Dash Syed I Shah Deni S Galileo Patricia A Martin-DeLeon | 2015 | Asian Journal of Andrology2015，17，2： | 1 |
| 20 | Hypothyroidism : a possible risk factor for liver cancer in patients with no known underlying cause of liver disease显示文摘 | Reddy A Dash C Leerapun A | 2007 | Clin Gastroenterol Hepato12007，5，1： | 1 |
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