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| 1 | Pre-operative hypoalbuminemia is a major risk factor for postoperative complications following rectal cancer surgery显示文摘AIM:To determine the relationship between pre-operative hypoalbuminemia and the development of complications following rectal cancer surgery, as well as postoperative bowel function and hospital stay. METHODS:The medical records of 244 patients undergoing elective oncological resection for rectal adenocarcinoma at Siriraj Hospital during 2003 and 2006 were reviewed. The patients had pre-operative serum albumin assessment. Albumin less than 35 g/L was recognized as hypoalbuminemia. Postoperative outcomes, including mortality, complications, time to first bowel movement, time to first defecation, time to resumption of normal diet and length of hospital stay, were analyzed. RESULTS:The patients were 139 males (57%) and 105 females (43%) with mean age of 62 years. Fifty-six patients (23%) had hypoalbuminemia. Hypoalbuminemic patients had a significantly larger tumor size and lower body mass index compared with non-hypoalbuminemic patients (5.5 vs 4.3 cm;P < 0.001 and 21.9 vs 23.2 kg/m2;P = 0.02, respectively). Thirty day postoperative mortality was 1.2%. Overall complication rate was 25%. Hypoalbuminemic patients had a significantly higher rate of postoperative complications (37.5% vs 21.3%;P = 0.014). In univariate analysis, hypoalbuminemia and ASA status were two risk factors for postoperative complications. In multivariate analysis, hypoalbuminemia was the only significant risk factor (odds ratio 2.22,95% CI 1.17-4.23;P < 0.015). Hospitalization in hypoalbuminemic patients was significantly longer than that in non-hypoalbuminemic patients (13 vs 10 d, P = 0.034), but the parameters of postoperative bowel function were not significantly different between the two groups. CONCLUSION:Pre-operative hypoalbuminemia is an independent risk factor for postoperative complications following rectal cancer surgery. | Varut Lohsiriwat Darin Lohsiriwat Wiroon Boonnuch Vitoon Chinswangwatanakul Thawatchai Akaraviputh Narong Lert-akayamanee | 2008 | World Journal of Gastroenterology2008，14，8： | 24 |
| 2 | 新疆阿尔泰全新世双湖沉积物正构烷烃分布及其环境意义显示文摘文章对新疆阿尔泰双湖沉积物进行了古气候、古环境变化研究。双湖(48°52'N,87°02'E)位于阿尔泰山中部,是山谷岩石滑塌阻塞形成的堰塞湖,湖长约1200 m,宽度约300 m,最大水深9 m。项目使用重力钻在双湖中心钻取了172 cm无扰动岩芯,根据核素测年(^(137)Cs,^(210)Pb,AMS^(14)C)建立了9.1 cal.ka B.P.以来的时间标尺,以正构烷烃分布特征(ACL_(23~33)、nC_(27)/nC_(31)、P_(aq))为指标,重建了该区的古植被、古气候变化。沉积物中正构烷烃以高碳数为主,中长链正构烷烃存在显著的奇碳优势。链长指标(ACL_(23~33))、nC_(27)/nC_(31)指标、Paq之间具有很强的相关性关系,表明指标可能受到相似的气候驱动因素影响,反映了区域植被和湖泊水生生物的演替历史:9.1~8.8 cal.ka B.P.期间水生植被输入较少,陆生植被中草本植物相对占比较高;8.8~3.3 cal.ka B.P.期间大型水生植物大量繁殖,汇水区木本植物增多;3.3 cal.ka B.P.至今湖泊周围的木本植物减少,草本植物相对占比增多,水生植物输入减少。双湖沉积物ACL_(23~33)指标自9.1 cal.ka B.P.以来呈逐渐增加的趋势,可能表明温度逐渐增加,这一结果与前人在该区利用泥炭br-GDGT重建的温度序列具有相似的变化趋势,但在百-千年尺度上,温度变化不一致,可能与指标的敏感性和定年精度有关。 | 赵佳玉 王淑贤 Andrey Darin 孙青 董浩伟 储国强 | 2021 | 第四纪研究2021，41，4： | 9 |
| 3 | Diurnal changes in retinal nerve fiber layer thickness with obstructive sleep apnea/hypopnea syndrome显示文摘AIM:To compare the retinal nerve fiber layer(RNFL)thickness in the morning and evening in Thai patients with varying degrees of obstructive sleep apnea/hypopnea syndrome(OSAHS).METHODS:In this cross-sectional study,potential OSAHS patients at Siriraj Hospital underwent polysomnography to determine the severity of OSAHS and an eye examination(including best corrected visual acuity,slit-lamp examination,and Goldmann applanation tonometry).RNFL thickness was recorded once in the morning and once in the evening,using spectral domain optical coherence tomography.Thickness was expressed as an average and given for each quadrant.Patients with ocular or systemic diseases that might affect RNFL thickness were excluded.RESULTS:Forty-one eyes of 41 patients were classified into 4 OSAHS groups.The average and mean RNFL thickness in most of the four quadrants of the severe OSAHS group trended toward being less than those in the comparable quadrants of the other groups in both the morning and evening.In the moderate OSAHS group,the average RNFL thickness and temporal and superior quadrant thickness in the morning were significantly higher than in the evening(P=0.01,P=0.01,and P=0.03,respectively).In the severe OSAHS group,the inferior quadrant thickness in the morning was significantly higher than in the evening(P=0.03).CONCLUSION:The RNFL thickness in the morning was higher than in the evening in moderate OSAHS. | Niphon Chirapapaisan Techawit Likitgorn Mintra Pleumchitchom Darin Sakiyalak Wish Banhiran Manatsawin Saiman Wanicha Chuenkongkaew | 2016 | International Journal of Ophthalmology(English edition)2016，9，7： | 7 |
| 4 | Colonoscopic perforation:A report from World Gastroenterology Organization endoscopy training center in Thailand显示文摘瞄准:决定 colonoscopic 穿孔(CP ) 的发生,并且从在泰国训练中心的世界肠胃病学组织(WGO ) 内视镜检查法与 CP 评估病人的临床的调查结果,管理和结果。方法:所有 colonoscopies 和 sigmoidoscopies 在内视镜的单位表现在 1999 和 2007 之间,药 Siriraj 医院的教师, Mahidol 大学,曼谷被考察。CP,病人的特征,内视镜的信息, intra 起作用的调查结果,管理和结果的发生被分析。结果:结肠(13699 colonoscopies 和 3658 灵活 sigmoidoscopies ) 的 17357 内视镜的过程的一个总数在 9 年的经期上在 Siriraj 医院里被执行。十五个病人(0.09%) 有 CP:14 从结肠镜检查并且 1 从乙状结肠镜检查。穿孔的最普通的地点在 S 字形的冒号(80%) ,由横向的冒号(13%) 列在后面。穿孔被直接损伤从柄或内诊镜的尖端引起(n = 12, 80%) 并且内视镜的 polypectomy (n = 3, 20%) 。有 CP 的所有病人经历了外科的管理:主要修理(27%) 和肠切除术(73%) 。死亡率是 13% ,手术后的复杂并发症率是 53% 。结论:CP 是稀罕却严肃的复杂并发症追随者结肠镜检查和乙状结肠镜检查,与病态和死亡的高率。CP 的发生是 0.09% 。外科仍然是 CP 管理的支柱。 | Varut Lohsiriwat Sasithorn Sujarittanakarn Thawatchai Akaraviputh Narong Lertakyamanee Darin Lohsiriwat Udom Kachinthorn | 2008 | World Journal of Gastroenterology2008，14，43： | 6 |
| 5 | Low Thrust Minimum Time Orbit Transfer Nonlinear Optimization Using Impulse Discretization via the Modified Picard–Chebyshev Method显示文摘The Modified Picard-Chebyshev Method(MPCM)is implemented as an orbit propagation solver for a numerical optimization method that determines minimum time orbit transfer trajectory of a satellite using a series of multiple impulses at intermediate waypoints.The waypoints correspond to instantaneous impulses that are determined using a nonlinear constrained optimization routine,SNOPT with numerical force models for both Two-Body and J2 perturbations.It is found that using the MPCM increases run-time performance of the discretized lowthrust optimization method when compared to other sequential numerical solvers,such as Adams-Bashforth-Moulton and Gauss-Jackson 8th order methods. | Darin Koblick Shujing Xu Joshua Fogel Praveen Shankar | 2016 | Computer Modeling in Engineering & Sciences2016，，1： | 4 |
| 6 | 佳洁士电动牙刷的使用效果及其对口腔健康的影响显示文摘本文介绍了第一代与第二代佳洁士电动牙刷 (佳洁士SpinBrush和佳洁士SpinBrushProTM)的设计特点与功效的试验。实验证明两代佳洁士电动牙刷比手动牙刷和普通电动牙刷能更有效地去除牙菌斑 ,去除率可提高 10 %~ 5 0 %。同时可以显著降低牙龈炎与牙龈出血程度。对这两种电动牙刷的安全性评价显示 ,它们与一般手动牙刷和电动牙刷一样安全。对使用者依从性的研究表明使用佳洁士电动牙刷后 ,成人和儿童的刷牙时间比使用手动牙刷刷牙时间分别自行延长 35 .8%和 38.3%。 | Aaron R. Biesbrock Linda M. Bayuk Marie-Vee Santana Darin S. Yates Robert D. Bartizek 王漪涛 | 2003 | 牙体牙髓牙周病学杂志2003，13，7： | 4 |
| 7 | Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation显示文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation. | Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles H Scudamore Andrzej K Buczkowski Eric M Yoshida | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 8 | Does training and experience influence the accuracy of computed tomography colonography interpretation?显示文摘AIM: To evaluate the effect of experience on the accuracy rate of computed tomography colonography(CTC) interpretation and patient preferences/satisfaction for CTC and colonoscopy. METHODS: A prospective, non-randomized, observational study performed in a single, tertiary care center involving 90 adults who underwent CTC followed by colonoscopy on the same day. CTC was interpreted by an abdominal imaging radiologist and then a colonoscopy was performed utilizing segmental un-blinding and re-examination as required. A radiology resident and two gastroenterology(GI) fellows blinded to the results also interpreted the CTC datasets independently. Accuracy rates and trend changes were determined for each reader to assess for a learning curve. RESULTS: Among 90 patients(57% male) aged 55 ± 8.9 years, 39 polyps ≥ 6 mm were detected in 20 patients and 13 polyps > 9 mm in 10 patients. Accuracy rates were 88.9%(≥ 6 mm) and 93.3%(> 9 mm) for the GI Radiologist, 89.8%(≥ 6 mm) and 98.9%(> 9 mm) for the Radiology Resident and 86.7% and 95.6%(≥ 6 mm) and 87.8% and 94.4%(> 9 mm) for each of the GI fellows respectively. The reader's accuracy rate did not change significantly with the percentage change rate ranging between-1.7 to 0.9(P = 0.12 to 0.56). Patients considered colonoscopy more satisfactory than CTC(30% vs 4%, P < 0.0001), they felt less anxiety during colonoscopy(36% vs 7%, P < 0.0001), they experienced less pain or discomfort during colonoscopy compared to CTC(69% vs 4%, P < 0.0001) and colonoscopy was preferred by 77% of the participants as a repeat screening test for the future. CONCLUSION: No statistically significant learning curve was identified in CTC interpretation suggesting that further study is required to identify the necessary training to adequately interpret CTC scans. | Greg Rosenfeld Yi Tzu Nancy Fu Brendan Quiney Hong Qian Darin Krygier Jacquie Brown Patrick Vos Pari Tiwari Jennifer Telford Brian Bressler Robert Enns | 2014 | World Journal of Gastroenterology2014，20，6： | 2 |
| 9 | 猪丹毒造成的损失到底有多少显示文摘当养猪牛产的利润很微薄时,哪怕是仅有的五分或一角的盈利机会也会产生很大的影响。如,肥育猪偶尔出现的跛行和在屠宰场中的折损是那些有时似乎我们无法控制的常见事实。然而,近期的研究表明,我们仍需要提高诊断技术,以控制猪场的“旧病”——猪丹毒。 | Joe Bender Darin Madson 何晓芳 | 2012 | 国外畜牧学(猪与禽)2012，，9： | 2 |
| 10 | Co-occurrence of Cell Lines, Basal Media and Supplementation in the Biomedical Research Literature显示文摘Purpose: The use of in vitro cell culture and experimentation is a cornerstone of biomedical research, however, more attention has recently been given to the potential consequences of using such artificial basal medias and undefined supplements. As a first step towards better understanding and measuring the impact these systems have on experimental results, we use text mining to capture typical research practices and trends around cell culture.Design/methodology/approach: To measure the scale of in vitro cell culture use, we have analyzed a corpus of 94,695 research articles that appear in biomedical research journals published in ScienceDirect from 2000–2018. Central to our investigation is the observation that studies using cell culture describe conditions using the typical sentence structure of cell line, basal media, and supplemented compounds. Here we tag our corpus with a curated list of basal medias and the Cellosaurus ontology using the Aho-Corasick algorithm. We also processed the corpus with Stanford CoreNLP to find nouns that follow the basal media, in an attempt to identify supplements used. Findings: Interestingly, we find that researchers frequently use DMEM even if a cell line's vendor recommends less concentrated media. We see long-tailed distributions for the usage of media and cell lines, with DMEM and RPMI dominating the media, and HEK293, HEK293 T, and HeLa dominating cell lines used. Research limitations: Our analysis was restricted to documents in ScienceDirect, and our text mining method achieved high recall but low precision and mandated manual inspection of many tokens.Practical implications: Our findings document current cell culture practices in the biomedical research community, which can be used as a resource for future experimental design.Originality/value: No other work has taken a text mining approach to surveying cell culture practices in biomedical research. | Jessica Cox Darin McBeath Corey Harper Ron Daniel | 2020 | Journal of Data and Information Science2020，5，3： | 2 |
| 11 | Water transport and the distribution of aquaporin - 1 in pulmonary air spaces显示文摘 | Effros RM Darin C Jacobs ER | 1997 | J Appl Physiol1997，83，3： | 1 |
| 12 | Sliding mode predictive control of a solar air conditioning plant显示文摘 | Winston Garcia-Gabin Darine Zambrano Eduardo F. Camacho | 2008 | Control Engineering Practice2008，，6： | 1 |
| 13 | The impact of patient expectations on outcome following treatment for spinal trauma (part 1): What are spine surgeons telling their patients? 显示文摘 | Darin Davidson Marcel F Dvorak A | 2010 | Soine2010，35，19： | 1 |
| 14 | No evidence of real progress in treat- ment of acute pain, 1993 -20121 scientometric analysis显示文摘 | Darin JC Kamen VV | 2014 | Journal of Pain Research2014，，7： | 1 |
| 15 | 显示文摘 | Darin N Amemiya T | 1992 | Metabolism1992，41，： | 1 |
| 16 | CAMP factor is not essential for systemic virulence of group B streptococcus显示文摘 | Mary E H Darin Q Chia-Jun H | 2008 | Microb Pathogenesis2008，44，1： | 1 |
| 17 | Early onset myopathy with a novel mutation in the Selenoprotein N gene(SEPN1)显示文摘 | Tajsharghi H Darin N Tulinius M | | 0，，： | 1 |
| 18 | POLG1 mutations associated with progressive encephalopathy in childhood 显示文摘 | Kollberg G Moslemi AR Darin N | 2006 | J Neuropathol Exp Neurol2006，65，8： | 1 |
| 19 | Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition显示文摘 | Joel P French John C Quindry Darin J Falk | 2006 | Am J Physiol Heart Circ Physiol2006，290，： | 1 |
| 20 | Complement Fragment 3a Priming of Umbilical Cord Blood Progenitors: Safety Profile显示文摘 | Claudio G. Brunstein David H. McKenna Todd E. DeFor Darin Sumstad Philip Paul Daniel J. Weisdorf Mariusz Ratajczak Mary J. Laughlin John E. Wagner | 2013 | Biology of Blood and Marrow Transplantation2013，，： | 1 |
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