|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 2 | The cognitive effects of in- terietal epileptiform EEG discharges and short nonconvulsive eplep- tie seizures 显示文摘 | Joost N Saskia E Danielle PB | 2012 | Epilepsia2012，53，6： | 1 |
| 3 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent PB McMinn DJ | 2004 | J Bone Joint Surg (Br)2004，86，： | 1 |
| 4 | Carson TUMOR necrosis factor-αconveting enzyme/ADAM17 mediate MUC1 sheding 显示文摘 | Amantha T Cal PB Daniel D | 2003 | BJU Int2003，278，5： | 1 |
| 5 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent PB McMinn DJW | 2004 | J Bone Joint Surg Br2004，2，： | 1 |
| 6 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent PB McMinn DJ | | 0，，02： | 1 |
| 7 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent PB McMinn DJ | 2004 | J Bone Joint Surg Br2004，86，2： | 1 |
| 8 | The cognitive effects of interictal epileptiform EEG discharges and short nonconvulsive epleptic seizures显示文摘 | Joost N Saskia E Danielle PB | 2012 | Epilepsia2012，53，6： | 1 |
| 9 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent PB McMinn DJW | 2004 | J Bone Joint Surg[Br]2004，86，2： | 1 |
| 10 | Human monkey pox:an emerging zoonosis显示文摘 | Daniel B Di Giulio Eckbnrg PB | 2004 | Lancet Infectious Dis2004，4，： | 1 |
| 11 | The validity of serum levels as a surrogate measure of systemic exposure to metal ions in hip replacement显示文摘 | Daniel J Ziaee H Pynsent PB | 2007 | J Bone Joint Surg Br2007，89，6： | 1 |
| 12 | Oral Exposure to Genisteinthe Glycosylated Form of Genisteinduring Neonatal Life Adversely Affects the Female Reproductive System显示文摘 | Wendy NJ Daniel D Elizabeth PB | 2009 | En viron Health Perspect2009，117，12： | 1 |
| 13 | Targeting the HGF/Met signa ling pathway in cancer显示文摘 | Fabiola C Daniel CR Donald PB | 2010 | Euro J Cancer2010，46，7： | 1 |
| 14 | Alveolar Macrophage Cathelicidin Deficiency in Severe Sarcoidosis 显示文摘 | Barbara PB Daniel AC Ali K | 2012 | J Innate Ira- mutt2012，4，56： | 1 |
| 15 | Metal on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent PB McMinn DJW | 2004 | J Bone Joint Surg[Br]2004，86，2： | 1 |
| 16 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent PB McMinn DJW | 2004 | J Bone Joint Surg(Br)2004，86，： | 1 |
| 17 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent PB Mcminn DJW | 2004 | J Bone Joint Surg Br2004，86，： | 1 |
| 18 | The validity of serum levels asa surrogate measure of systemic exposure to metal ions in hipreplacement显示文摘 | Daniel J Ziaee H Pynsent PB | 2007 | J Bone Joint Surg Br2007，89，： | 1 |
| 19 | Comparision of patient age with MRI imaging features of gangliogliomas显示文摘 | James MP Unzila A Daniel PB | 2000 | AIR2000，174，3： | 1 |
| 20 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis 显示文摘 | Daniel J Pynsent PB McMinn DJ | 2004 | J Bone Joint Surg Br2004，86，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员