|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Free radicals alter maximal diaphragmatic mitochondrial oxygen consumption in endotoxin-induced sepsis显示文摘 | Leigh AC Daniel A Luke IS | 2001 | Free Radical Biology & Medicine2001，30，1： | 1 |
| 3 | Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer显示文摘 | Daniele B Sazzad H Young AC | 2013 | Neoplasia2013，15，10： | 1 |
| 4 | Efficacy of neoadju-vant cisplatin in triple-negative breast cancer显示文摘 | Daniel PS Andrea L Richardson AC | 2010 | Clin Oncol2010，28，7： | 1 |
| 5 | Diversity of bacteria associated with natural aphid populations 显示文摘 | Haynes S Darby AC Daniell TJ | 2003 | Applied and Environmental Microbiology2003，69，12： | 1 |
| 6 | Switching between executive and default mode networks in posttraumatic stress disorder-alterations in functional connectivity显示文摘 | Daniels JK McFarlane AC Bluhm RL | 2010 | J Psychiatry Neurosci2010，35，4： | 1 |
| 7 | Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection显示文摘AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis. | HMC Shantha Kumara Elizabeth A Myers Sonali AC Herath Joon Ho Jang Linda Njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic Martin Luchtefeld Richard L Whelan | 2014 | World Journal of Gastrointestinal Oncology2014，6，10： | 1 |
| 8 | Endometrial cancer in an adolescent : a possible manifestation of Cowden syndrome 显示文摘 | Schmeler KM Daniels MS Brandt AC | 2009 | Obstet Gynecol2009，114，2： | 1 |
| 9 | The relationship between physical activity, restless legs syndrome, and health- related quality of life in type 2 diabetes显示文摘 | Daniele TM de Bruin VM e Forte AC | 2013 | Endocrine2013，44，1： | 1 |
| 10 | Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis显示文摘 | Gregory AC Kempen JH Daniel E | 2013 | Ophthalmology2013，120，1： | 1 |
| 11 | Factors that interfere the medication compliance in hypertensive patients 显示文摘 | Daniel AC Veiga EV | 2013 | Einstein2013，11，3： | 1 |
| 12 | Diversity of bacteria associated with natural aphid populations 显示文摘 | Haynes S Darby AC Daniell TJ | 2003 | Applied and Environmental Microbiology2003，69，12： | 1 |
| 13 | Psychosis in mania: specificity of its role in severity and treatment response 显示文摘 | Swann AC Daniel DG Kochan LD | 2004 | Cfin Psychiatry2004，65，6： | 1 |
| 14 | Radiofrequencydriven skinmicrochanneling as a new way for electrically assisted transdennal de-livery of hydrophilic drugs 显示文摘 | Sintov AC Krymberk I Daniel D | 2003 | J Controlled Release2003，89，2： | 1 |
| 15 | Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis显示文摘 | Jones AC Daniells CE Snell RG | | 0，，12： | 1 |
| 16 | Ultrasonic biophysical measurements in the nor- real human fetus for optimal design of the monolithic fetal pace- maker显示文摘 | Evgueni F Howard AC DaeGyun P Daniel HZ Betfina FC Vicki LM | 2005 | Am J Cardiol2005，95，10： | 1 |
| 17 | Radiofrequency-driven skin microehanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs显示文摘 | SINTOV AC KRYMBERK I DANIEL D | 2003 | J Controlled Release2003，89，2： | 1 |
| 18 | Molecular genetic and phenotypie analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis 显示文摘 | Jones AC Daniells CE Snell RG | 1997 | Hum Mol Genet1997，6，12： | 1 |
| 19 | Long-term fate of neural precursor cells following transplantation into developing and adult CNS显示文摘 | Lepore AC Neuhuber B Connors TM Han SS Liu Y Daniels MP | 2006 | Neuroscience2006，142，1： | 1 |
| 20 | Alveolar Macrophage Cathelicidin Deficiency in Severe Sarcoidosis 显示文摘 | Barbara PB Daniel AC Ali K | 2012 | J Innate Ira- mutt2012，4，56： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员