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| 1 | Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction显示文摘Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction,but the mechanisms underlying this protection remain unclear.To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis,we induced a photochemical model of cerebral infarction in an inbred line of mice(BALB/c).Mice were then exposed to hypoxic preconditioning 30 minutes prior to model establishment.Results showed significantly increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra at 24 and 72 hours post infarction,mainly in neurons and vascular endothelial cells.Hypoxic preconditioning increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra and the expression of vascular endothelial growth factor was positively related to that of CD31.Moreover,hypoxic preconditioning reduced the infarct volume and improved neurological function in mice.These findings indicate that the protective role of hypoxic preconditioning in acute cerebral infarction may possibly be due to an increase in expression of vascular endothelial growth factor and CD31 in the ischemic penumbra,which promoted angiogenesis. | Sijie Li Yanbo Zhang Guo Shao Mingfeng Yang Jingzhong Niu Guowei Lv Xunming Ji | 2013 | Neural Regeneration Research2013，8，31： | 31 |
| 2 | Development and prospect of unmanned aerial vehicle technologies for agricultural production management显示文摘Unmanned aerial vehicles have been developed and applied to support agricultural production management.Compared with piloted aircraft,an Unmanned Aerial Vehicle(UAV)can focus on small crop fields at lower flight altitudes than regular aircraft to perform site-specific farm management with higher precision.They can also“fill in the gap”in locations where fixed winged or rotary winged aircraft are not readily available.In agriculture,UAVs have primarily been developed and used for remote sensing and application of crop production and protection materials.Application of fertilizers and chemicals is frequently needed at specific times and locations for site-specific management.Routine monitoring of crop plant health is often required at very high resolution for accurate site-specific management as well.This paper presents an overview of research involving the development of UAV technology for agricultural production management.Technologies,systems and methods are examined and studied.The limitations of current UAVs for agricultural production management are discussed,as well as future needs and suggestions for development and application of the UAV technologies in agricultural production management. | Yanbo Huang Steven J.Thomson W.Clint Hoffmann Yubin Lan Bradley K.Fritz | 2013 | International Journal of Agricultural and Biological Engineering2013，6，3： | 22 |
| 3 | Study of ADS-B Data Evaluation显示文摘在西方的中国,地面和气象学的条件是那么复杂的构造新雷达车站不是合适的。自动依赖监视广播(ADS-B ) 是一个完全新的监视方法,那么在实际上在中国,丰富的测试和评估适用并且操作以前是必要的验证 ADS-B 的表演并且保证运作的安全。在飞行测试期间,我们收集雷达, ADS-B 和高精确性位置的数据并且基于高精确性位置把 ADS-B 的性能与雷达作比较。在雷达数据之中解决异步的问题, ADS-B 数据并且即时运动学(RTK ) 不同更改引起的数据评价,这篇文章建议同步的技术由从低更改率的数据外推高根据速度和标题更新率的多监视数据。同时,因为雷达数据, ADS-B 数据和 RTK 数据在不同坐标被表示并且不能互相被比较,这篇文章提供一个方法给统一多监视数据的坐标。由分析和评估,我们能断定 ADS-B 的表演比雷达好。 | ZHANG Jun LIU Wei ZHU Yanbo | 2011 | Chinese Journal of Aeronautics2011，24，4： | 21 |
| 4 | MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6显示文摘Osteosarcoma 是骨头的最普通的主要肉瘤,并且它是在青少年和年轻成年人之中的癌症死亡的一个领先的原因。然而,糟糕位于 osteosarcoma carcinogenesis 遗体下面的分子的机制理解。最近, cyclin 依赖的 kinase (CDK6 ) 6 作为重要 oncogene 被识别。我们发现了那 CDK6 蛋白质水平,而非 CDK6 mRNA 水平,比的在 osteosarcoma 纸巾是高得多的在正常邻近的纸巾,它显示在 osteosarcoma 涉及 CDK6 规定的 post-transcriptional 机制。MiRNAs 是镇压的小非编码的 RNA 在 post-transcriptional 水平的基因表示并且广泛地被显示了在许多人的癌症起重要作用。在这研究,我们用生物信息学方法作为 CDK6 的一个新奇管理者调查了 miR-29b 的角色。我们证明 CDK6 能是由经由到在 osteosarcoma 房间的 3-UTR 区域的绑定的 miR-29b 的 downregulated。而且,我们在 osteosarcoma 纸巾识别了在 miR-29b 和 CDK6 蛋白质层次之间的反的关联。最后,我们在 osteosarcoma 房间检验了 CDK6 表示的 miR-29b-driven 压抑的功能。结果表明 miR-29b 由在增长和移植进程指向 CDK6 充当 osteosarcoma 的肿瘤 suppressor。一起拿,我们的结果在 osteosarcoma 在 CDK6 的规定为 miR-29b 加亮一个重要角色并且可以为未来 osteosarcoma 治疗打开新大街。 | Kegan Zhu Lei Liu Junliang Zhang Yanbo Wang Hongwei Liang Gentao Fan Zhenhuan Jiang Chen-Yu Zhang Xi Chen Guangxin Zhou | 2016 | Protein & Cell2016，7，6： | 18 |
| 5 | Agricultural remote sensing big data:Management and applications显示文摘Big data with its vast volume and complexity is increasingly concerned, developed and used for all professions and trades. Remote sensing, as one of the sources for big data, is generating earth-observation data and analysis results daily from the platforms of satellites, manned/unmanned aircrafts, and ground-based structures. Agricultural remote sensing is one of the backbone technologies for precision agriculture, which considers within-field variability for site-specific management instead of uniform management as in traditional agriculture. The key of agricultural remote sensing is, with global positioning data and geographic information, to produce spatially-varied data for subsequent precision agricultural operations. Agricultural remote sensing data, as general remote sensing data, have all characteristics of big data. The acquisition, processing, storage, analysis and visualization of agricultural remote sensing big data are critical to the success of precision agriculture. This paper overviews available remote sensing data resources, recent development of technologies for remote sensing big data management, and remote sensing data processing and management for precision agriculture. A five-layer-fifteenlevel(FLFL) satellite remote sensing data management structure is described and adapted to create a more appropriate four-layer-twelve-level(FLTL) remote sensing data management structure for management and applications of agricultural remote sensing big data for precision agriculture where the sensors are typically on high-resolution satellites, manned aircrafts, unmanned aerial vehicles and ground-based structures. The FLTL structure is the management and application framework of agricultural remote sensing big data for precision agriculture and local farm studies, which outlooks the future coordination of remote sensing big data management and applications at local regional and farm scale. | Yanbo Huang CHEN Zhong-xin YU Tao HUANG Xiang-zhi GU Xing-fa | 2018 | Journal of Integrative Agriculture2018，17，9： | 18 |
| 6 | A New Optimal Hatch Filter to Minimize the Effects of Ionosphere Gradients for GBAS显示文摘At present,the main problem faced by ground-based augment system (GBAS) is that though carrier smoothing filter and local dif-ferential global positioning system (LDGPS) improve the accuracy of the pseudorange by reducing the noise in it and eliminating almost all the common errors between the user and the reference station,they also cause extra errors on account of the effects of the ionosphere temporal and spatial gradients.Based on the analysis of these errors as well as the smoothing noise,this article suggests a new algorithm to design the optimal Hatch filter,whose smoothing window width varies real-time with the satellite elevation,ionosphere variation,and distance from the user to the reference station.By conducting the positioning process in the GBAS emulation platform for several hours and after its comparison with the performances of traditional Hatch filters,it is found that the errors in the differential correction become smaller and the positioning accuracy gets heightened with this new method. | Huang Zhenggang Huang Zhigang Zhu Yanbo | 2008 | Chinese Journal of Aeronautics2008，21，6： | 16 |
| 7 | Characterization of spray deposition and drift from a low drift nozzle for aerial application at different application altitudes显示文摘A complex interaction of controllable and uncontrollable factors is involved in aerial application of crop production and protection materials.Although it is difficult to completely characterize spray deposition and drift,these important factors can be estimated with appropriate sampling protocol and analysis.Application height is an important variable influencing off-target spray drift,but this variable has not been easily measured or logged.A custom-configured aircraft-mounted laser with logging capabilities makes this possible.This study was designed to investigate droplet size and deposition characteristics of a low drift CP flat-fan nozzle at application altitudes 3.7 m,4.9 m,and 6.1 m.In the study,CP flat-fan nozzles were set to a downward angle of 30 degrees applying a mixture of water,Syl-Tac®adjuvant,and Rubidium Chloride(RbCl)tracer at a 28.5 L/ha application rate.Spray droplets were collected using water sensitive paper(WSP)cards placed in the spray swath.Mylar sheets were also placed in the swath and downwind for drift sampling.Statistical analysis indicated that median droplet diameter as determined by WSP in the spray swath was not significantly influenced by spray application height.Similarly,statistical analysis also indicated that concentration of RbCl tracer from Mylar samplers in the spray swath was not significantly influenced by application height.Application height had a significant effect on spray deposition from drift samplers,along with wind direction and relative humidity.Final results for drift samplers may have been influenced by shifts in wind direction that altered the relationship between orientation of samplers and wind. | Yanbo Huang Steven J.Thomson | 2011 | International Journal of Agricultural and Biological Engineering2011，4，4： | 16 |
| 8 | ZmMs30 Encoding a Novel GDSL Lipase Is Essential for Male Fertility and Valuable for Hybrid Breeding in Maize显示文摘Genic male sterility (GMS) is very useful for hybrid vigor utilization and hybrid seed production. Although a large number of GMS genes have been identified in plants, little is known about the roles of GDSL lipase members in anther and pollen development. Here, we report a maize GMS gene, ZmMs30, which encodes a novel type of GDSL lipase with diverged catalytic residues. Enzyme kinetics and activity assays show that ZmMs30 has lipase activity and prefers to substrates with a short carbon chain. ZmMs30 is specifically expressed in maize anthers during stages 7-9. Loss of ZmMs30 function resulted in defective anther cuticle, irregular foot layer of pollen exine, and complete male sterility. Cytological and lipidomics analyses demonstrate that ZmMs30 is crucial for the aliphatic metabolic pathway required for pollen exine formation and anther cuticle development. Furthermore, we found that male sterility caused by loss of ZmMs30 function was stable in various inbred lines with different genetic background, and that it didn't show any negative effect on maize heterosis and production, suggesting that ZmMs30 is valuable for crossbreeding and hybrid seed production. We then developed a new multi-control sterility system using ZmMs30 and its mutant line, and demonstrated it is feasible for generating desirable GMS lines and valu. able for hybrid maize seed production. Taken together, our study sheds new light on the mechanisms of anther and pollen development, and provides a valuable male-sterility system for hybrid breeding maize. | Xueli An Zhenying Dong Youhui Tian Ke Xie Suowei Wu Taotao Zhu Danfeng Zhang Van Zhou Canfang Niu Biao Ma Quancan Hou Jianxi Bao Simiao Zhang Ziwen Li Yanbo Wang Tingwei Yan Xiaojing Sun Yuwen Zhang Jinping Li Xiangyuan Wan | 2019 | Molecular Plant2019，12，3： | 15 |
| 9 | Weak martingale Hardy spaces and weak atomic decompositions显示文摘In this paper we define some weak martingale Hardy spaces and three kinds of weak atoms. They are the counterparts of martingale Hardy spaces and atoms in the classical martingale Hp-theory. And then three atomic decomposition theorems for martingales in weak martingale Hardy spaces are proved. With the help of the weak atomic decompositions of martingale, a sufficient condition for a sublinear operator defined on the weak martingale Hardy spaces to be bounded is given. Using the sufficient condition, we obtain a series of martingale inequalities with respect to the weak Lp-norm, the inequalities of weak (p ,p)-type and some continuous imbedding relationships between various weak martingale Hardy spaces. These inequalities are the weak versions of the basic inequalities in the classical martingale Hp-theory. | HOU Youliang & REN Yanbo School of Mathematics and Statistics, Wuhan University, Wuhan 430072, China Department of Mathematics & Physics, Henan University of Science and Technology, Luoyang 471003, China | 2006 | Science China Mathematics2006，49，7： | 15 |
| 10 | Effects of silica nanoparticles on growth and photosynthetic pigment contents of Scenedesmus obliquus显示文摘To assess the aquatic ecosystem safety for silica (SiO2) nanoparticles (NPs), the growth inhibition and photosynthetic pigment contents of Scenedesmus obliquus in logarithm growth phase exposed to SiO2 NPs and SiO2 bulk particles (BPs) suspensions were measured. SiO2 NPs with 10-20 nm diameters were found to be toxic. The 20% effective concentration (EC20) values for 72 and 96 hr were 388.1 and 216.5 mg/L, respectively. The contents of chlorophyll decreased significantly under moderate and high concentration (50, 100, and 200 mg/L) of SiO2 NPs after 96-hr exposure, but the carotenoids did not. SiO2 BPs were found to be nontoxic up to 200 mg/L. The toxicity of SiO2 NPs probablely due to their sorption to algal cells surface. The results imply that there is potential harm to aquatic environment by using SiO2 NPs, and it should deserve special concern. | Chenxi Wei, Yanbo Zhang, Jing Guo, Bing Han, Xu Yang, Junlin Yuan Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Huazhong Normal University, Wuhan 430079, China. | 2010 | Journal of Environmental Sciences2010，22，1： | 14 |
| 11 | Multispectral imaging systems for airborne remote sensing to support agricultural production management显示文摘This study investigated three different types of multispectral imaging systems for airborne remote sensing to support management in agricultural application and production.The three systems have been used in agricultural studies.They range from low-cost to relatively high-cost,manually operated to automated,multispectral composite imaging with a single camera and integrated imaging with custom-mounting of separate cameras.Practical issues regarding use of the imaging systems were described and discussed.The low-cost system,due to band saturation,slow imaging speed and poor image quality,is more preferable to slower moving platforms that can fly close to the ground,such as unmanned autonomous helicopters,but not recommended for low or high altitude aerial remote sensing on fixed-wing aircraft.With the restriction on payload unmanned autonomous helicopters are not recommended for high-cost systems because they are typically heavy and difficult to mount.The system with intermediate cost works well for low altitude aerial remote sensing on fixed-wing aircraft with field shapefile-based global positioning triggering.This system also works well for high altitude aerial remote sensing on fixed-wing aircraft with global positioning triggering or manually operated.The custom-built system is recommended for high altitude aerial remote sensing on fixed-wing aircraft with waypoint global positioning triggering or manually operated. | Yanbo Huang Steven J.Thomson Yubin Lan Stephan J.Maas | 2010 | International Journal of Agricultural and Biological Engineering2010，3，1： | 12 |
| 12 | Gabapentin inhibits central sensitization during migraine显示文摘Peripheral and central sensitizations are phenomena that occur during migraine.The role of gabapentin,a migraine preventive drug,on central sensitization remains unclear.In this study,a rat model of migraine was established by electrical stimulation of the trigeminal ganglion,and the animals were given intragastric gabapentin.Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensitization during migraine.Electrophysiology,liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve,decreases excitatory amino acid content and inhibits the activation of protein kinase C.This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine.Gabapentin inhibits migraine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C activation. | Yanbo Zhang Guo Shao Wei Zhang Sijie Li Jingzhong Niu Dongmei Hu Mingfeng Yang Xunming Ji | 2013 | Neural Regeneration Research2013，8，32： | 12 |
| 13 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 14 | Centrifugal casting processes of manufacturing in situ functionally gradient composite materials of Al-19Si-5Mg alloy显示文摘Cylindrical components of in situ functionally gradient composite materials of Al-19Si-5Mg alloy were manufactured by centrifugal casting. Microstructure characteristics of the manufactured components were observed and the effects of the used process factors on these characteristics were analyzed. The results of observations shows that, in thickness, the components possess microstructures accumulating lots of Mg2Si particles and a portion of primary silicon particles in the inner layer, a little Mg2Si and primary silicon particles in the outer layer, and without any Mg2Si and primary silicon particle in the middle layer. The results of the analysis indicate that the rotation rate of centrifugal casting, mould temperature, and melt pouring temperature have evidently affected the accumulation of the second phase particles. Also, the higher the centrifugal rotation rate, mould temperature, and melt pouring temperature are, the more evident in the inner layer the degree of accumulation of Mg2Si and primary silicon particles is. | XIE Yong LIU Changming ZHAI Yanbo WANG Kai LING Xuedong | 2009 | Rare Metals2009，28，4： | 11 |
| 15 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 16 | Optical properties of the micro/nano structures of Morpho butterfly wing scales显示文摘The micro/nano structures of the wing scales in Morpho butterfly are responsible for the structural coloration,with a major part ascribed to interference and diffraction of light.The optical properties of the butterfly wings were investigated by simulating a two-dimensional model using rigorous coupled-wave analysis technique.It is proved that they depend strongly on the structural parameters,incidence angle and refractive index.The peak value and the peak wavelength of the reflection efficiency increase as the vertical periodic thickness increases.The peak value decreases observably,while both of the bandwidth and the peak wavelength increase when the number of the vertical periods decreases.Increase of the horizontal periodic width causes a decrease of the peak value and an increase of the peak wavelength,although the variations are small.The peak value decreases distinctly and the peak wavelength increases as the ambient refractive index increases,which corresponds to the variation in ambient conditions.The research reveals the mechanisms of the brilliant structural color in Morpho butterfly,and is of great significance to the design,manufacture and applications of the bionic micro/nano structures for gas detection. | LIAO GuangLan,ZUO HaiBo,CAO YanBo & SHI TieLin State Key Laboratory of Digital Manufacturing Equipment and Technology,Huazhong University of Science and Technology,Wuhan 430074,China | 2010 | Science China(Technological Sciences)2010，53，1： | 10 |
| 17 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 18 | Assessment of the sources and transformations of nitrogen in a plain river network region using a stable isotope approach显示文摘The great spatial and temporal variability in hydrological conditions and nitrogen(N)processing introduces large uncertainties to the identification of N sources and quantifying N cycles in plain river network regions. By combining isotopic data with chemical and hydrologic measurements, we determined the relative importance of N sources and biogeochemical N processes in the Taige River in the East Plain Region of China. The river was polluted more seriously by anthropogenic inputs in winter than in summer. Manure and urban sewage effluent were the main nitrate(NO-3) sources, with the nitrification of N-containing organic materials serving as another important source of NO-3. In the downstream, with minor variations in hydrological conditions, nitrification played a more important role than assimilation for the decreasing ammonium(NH+4-N) concentrations.The N isotopic enrichment factors(ε) during NH+4utilization ranged from- 13.88‰ in March to- 29.00‰ in July. The ratio of the increase in δ18O and δ15N of river NO-3in the downstream was 1.04 in January and 0.92 in March. This ratio indicated that NO-3assimilation by phytoplankton was responsible for the increasing δ15N and δ18O values of NO-3in winter. The relationships between δ15N of particulate organic nitrogen and isotopic compositions of dissolved inorganic nitrogen indicated that the phytoplankton in the Taige River probably utilized NH+4preferentially and mainly in summer, while in winter, NO-3assimilation by phytoplankton was dominant. | Jingtao Ding Beidou Xi Qigong Xu Jing Su Shouliang Huo Hongliang Liu Yijun Yu Yanbo Zhang | 2015 | Journal of Environmental Sciences2015，27，4： | 9 |
| 19 | Integrated modeling environment and a preliminary application on the Heihe River Basin, China显示文摘Environmental and water issues are essentially complex interdisciplinary problems. Multiple models from different disciplines are usually integrated to solve those problems. Integrated modeling environment is an effective technical approach to model integration. Although a number of modeling environments worldwide are available, they cannot meet current challenges faced. Their old-fashion designs and original development purposes constrain their possible applications to the domain of hydrologic or land surface modeling. One of the challenges is that we intend to link knowledge database or ontology system to the modeling environment in order to make the modeling support more intelligent and powerful. In this paper, we designed and implemented an integrated modeling environment (HIME) for hydrological and land surface modeling purpose in a much extendable, efficient and easy use manner. With such design, a physical process was implemented as a module, or component. A new model can be generated in an intuitive way by linking module icons together and establishing their relationships. Following an introduction to the overall architecture, the designs for module linkage and data transfer between modules are described in details. Using XML based meta-information, modules in either source codes or binary form can be utilized by the environment. As a demonstration, with the help of HIME, we replaced the evaporation module of TOPMODEL with the evapotranspiration module from the Noah land surface model which explicitly accounts for vegetation transpiration. This example showed the effectiveness and efficiency of the modeling environment on model integration. | NAN ZhuoTong SHU LeLe ZHAO YanBo LI Xin DING YongJian | 2011 | Science China(Technological Sciences)2011，54，8： | 8 |
| 20 | A strategic flight conflict avoidance approach based on a memetic algorithm显示文摘Conflict avoidance(CA) plays a crucial role in guaranteeing the airspace safety. The current approaches,mostly focusing on a short-term situation which eliminates conflicts via local adjustment,cannot provide a global solution. Recently,long-term conflict avoidance approaches,which are proposed to provide solutions via strategically planning traffic flow from a global view,have attracted more attentions. With consideration of the situation in China,there are thousands of flights per day and the air route network is large and complex,which makes the long-term problem to be a large-scale combinatorial optimization problem with complex constraints. To minimize the risk of premature convergence being faced by current approaches and obtain higher quality solutions,in this work,we present an effective strategic framework based on a memetic algorithm(MA),which can markedly improve search capability via a combination of population-based global search and local improvements made by individuals. In addition,a specially designed local search operator and an adaptive local search frequency strategy are proposed to improve the solution quality. Furthermore,a fast genetic algorithm(GA) is presented as the global optimization method. Empirical studies using real traffic data of the Chinese air route network and daily flight plans show that our approach outperformed the existing approaches including the GA based approach and the cooperative coevolution based approach as well as some well-known memetic algorithm based approaches. | Guan Xiangmin Zhang Xuejun Han Dong Zhu Yanbo Lv Ji Su Jing | 2014 | Chinese Journal of Aeronautics2014，27，1： | 8 |
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