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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | Characterisation of human non-proliferative diabetic retinopathy using the fractal analysis显示文摘· AIM: To investigate and quantify changes in the branching patterns of the retina vascular network in diabetes using the fractal analysis method.·METHODS: This was a clinic-based prospective study of 172 participants managed at the Ophthalmological Clinic of Cluj-Napoca, Romania, between January 2012 and December 2013. A set of 172 segmented and skeletonized human retinal images, corresponding to both normal(24 images) and pathological(148 images)states of the retina were examined. An automatic unsupervised method for retinal vessel segmentation was applied before fractal analysis. The fractal analyses of the retinal digital images were performed using the fractal analysis software Image J. Statistical analyses were performed for these groups using Microsoft Office Excel2003 and Graph Pad In Stat software.·RESULTS: It was found that subtle changes in the vascular network geometry of the human retina are influenced by diabetic retinopathy(DR) and can be estimated using the fractal geometry. The average of fractal dimensions D for the normal images(segmented and skeletonized versions) is slightly lower than the corresponding values of mild non-proliferative DR(NPDR) images(segmented and skeletonized versions).The average of fractal dimensions D for the normal images(segmented and skeletonized versions) is higher than the corresponding values of moderate NPDR images(segmented and skeletonized versions). The lowestvalues were found for the corresponding values of severe NPDR images(segmented and skeletonized versions).· CONCLUSION: The fractal analysis of fundus photographs may be used for a more complete understanding of the early and basic pathophysiological mechanisms of diabetes. The architecture of the retinal microvasculature in diabetes can be quantitative quantified by means of the fractal dimension.Microvascular abnormalities on retinal imaging may elucidate early mechanistic pathways for microvascular complications and distinguish patients with DR from healthy individuals. | Stefan Tǎlu Dan Mihai Cǎlugǎru Carmen Alina Lupascu | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 4 |
| 3 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
| 4 | Silkroute-trading between relation and XML显示文摘 | Wang C T Dan S | 2000 | Computer Networks2000，33，： | 1 |
| 5 | An integrated database of chemo sensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines显示文摘 | Dan S Tsunoda T Kitahara O | 2002 | Cancer Res2002，62，4： | 1 |
| 6 | Effect of addition fluoroethers to organic solvents for lithium ion secondary batteries 显示文摘 | NAKAJIMA T DAN K I KOH M | 2001 | Journal of Fluorine Chemistry2001，111，： | 1 |
| 7 | Commonly used disease-modifying antirheumatic drugs in the treatment of inflammatory arthritis:an update on mechanisms of action 显示文摘 | Danning C L Boumpas D T | 1998 | Clin Exp Rheumatol1998，16，5： | 1 |
| 8 | The Ste 20 group kinases as regulators of MAP kinase cascades 显示文摘 | DAN T WATANABE NM KUSUMI A | 2001 | Trends Cell Biol2001，11，5： | 1 |
| 9 | Characterization of petro physical flow units in carbonate reservoirs显示文摘 | Alden J M Stephen T S Dan J H | 1997 | AAPG Bulletin1997，81，5： | 1 |
| 10 | 查看详情显示文摘 | Zhang J Chu T S Dong S L Yuan S P Fu A E Dan Y B | | 0，，： | 1 |
| 11 | Characterization of spatiotemporal stress distribution during food fracture by image texture analysis methods显示文摘 | DAN H AZUMA T KOHYAMA K | 2007 | Journal of Food Engineering2007，81，2： | 1 |
| 12 | Collecting electro- spun nanofibers with patterned electrodes显示文摘 | Li Dan Ouyang Gong Mceann J T | 2005 | N ano Lett2005，5，5： | 1 |
| 13 | Oxaliplatin -- induced hyperensitivityreaction displayingrnarked elevation of immunoglobulin E显示文摘 | Kitada N Dan T Takara K | 2007 | Joncol Pharm Pratt2007，13，4： | 1 |
| 14 | Hydrogen peroxide pre-treatment induces salt-stress acclimation in maize plant显示文摘 | ANDRE DAN JOSE T P JOAQUIM E | 2005 | Plant physiology2005，，162： | 1 |
| 15 | miR-198 represses the pro- liferation of HaCaT cells by targeting cyclin D2 显示文摘 | Wang J Dan G Shangguan T | 2015 | Int J Mol Sci2015，16，17： | 1 |
| 16 | Response of tree legumes to rhizobial inoculation in relation to the population density of indigenous rhizobia显示文摘 | Dan T Harold H K Paul W S | 1993 | Soil Biology and Biochemistry1993，25，1： | 1 |
| 17 | Detection of Cyclospora Cayet- anensis Animal Fecal isolates from NEPAL using an FTA filter -base PCR method显示文摘 | Dan M Y T Palmer A O | 2004 | Am J Trop Med Hyg2004，71，4： | 1 |
| 18 | Emerging drugs to replace current leaders in first-line therapy for breast cancer显示文摘 | Cox M C DAN T D SWAIN S M | 2006 | Expert Opinion on Emerging Drugs2006，11，3： | 1 |
| 19 | Chatacterisation of Hungarian porcine circovirus 2 genomes associated with PMWS and PDNS cases显示文摘 | DAN A MOLNAR T BIKSI I | 2003 | Acta Vet Hung2003，51，4： | 1 |
| 20 | Xaliplatin-induced hyper-sensitivity reaction displaying marked elevation of immunoglobulin E显示文摘 | Kitada N Dan T Takara K | 2007 | J Oncolpharm Pract2007，13，4： | 1 |
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