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| 1 | Value of adipokines in predicting the severity of acute pancreatitis:Comprehensive review显示文摘AIM:To analyze the prognostic value of adipokines in predicting the course,complications and fatal outcome of acute pancreatitis(AP).METHODS:We performed the search of PubMed database and the systemic analysis of the literature for both experimental and human studies on prognostic value of adipokines in AP for period 2002-2012.Only the papers that described the use of adipokines for prediction of severity and/or complications of AP were selected for further analysis.Each article had to contain information about the levels of measured adipokines,diagnosis and verification of AP,to specify presence of pancreatic necrosis,organ dysfunction and/or mortality rates.From the very beginning,study was carried out adhering to the PRISMA checklist and flowchart for systemic reviews.To assess quality of all included human studies,the Quality Assessment of Diagnostic Accuracy Studies tool was used.Because of the high heterogeneity between the studies,it was decided to refrain from the statistical processing or meta-analysis of the available data.RESULTS:Nine human and three experimental studies were included into review.In experimental studies significant differences between leptin concentrations at 24 and 48 h in control,acute edematous and acute necrotizing pancreatitis groups were found(P = 0.027 and P < 0.001).In human studies significant differences between leptin and resitin concentrations in control and acute pancreatitis groups were found.1-3 d serum adiponectin threshold of 4.5 μg/mL correctly classified the severity of 81% of patients with AP.This threshold yielded a sensitivity of 70%,specificity 85%,positive predictive value 64%,negative predictive value88%(area under curve 0.75).Resistin and visfatin concentrations differ significantly between mild and severe acute pancreatitis groups,they correlate with severity of disease,need for interventions and outcome.Both adipokines are good markers for parapancreatic necrosis and the cut-off values of 11.9 ng/mL and 1.8 ng/mL respectively predict the high ranges of radiological scores.However,the review revealed that all nine human studies with adipokines are very different in terms of methodology and objectives,so it is difficult to generalize their results.It seems that concentrations of the leptin and resistin increases significantly in patients with acute pancreatitis compared with controls.Serum levels of adiponectin,visfatin and especially resitin(positive correlation with Acute Physiology and Chronic Health Evaluation Ⅱ,Ranson and C-reactive protein) are significantly different in mild acute pancreatitis and severe acute pancreatitis patients,so,they can serve as a markers for the disease severity prediction.Resistin and visfatin can also be used for pancreatic and parapancreatic necrosis prediction,interventions needs and possible,outcome.CONCLUSION:High levels of adipokines could allow for prediction of a severe disease course and outcome even in small pancreatic lesions on computed tomography scans. | Andrius Karpavicius Zilvinas Dambrauskas Audrius Sileikis Dalius Vitkus Kestutis Strupas | 2012 | World Journal of Gastroenterology2012，18，45： | 20 |
| 2 | Disease-specific health-related quality of life and its determinants in liver cirrhosis patients in Lithuania显示文摘AIM: To evaluate disease-specific quality of life (QOL) in liver cirrhosis patients and to compare it with those of a healthy population. Also an important objective was to assess whether QOL in liver cirrhosis patients differs by age and gender, by type and severity of disease. METHODS: The case group of 131 liver cirrhosis patients was selected. The control group of 262 was enrolled from a healthy population according to the scheme of case-control study. Clinical, demographic, laboratory data were collected. QOL was measured with a specific chronic liver disease questionnaire (CLDQ), which was translated and validated in Lithuanian. QOL scores were compared between groups by age, gender, type and severity of disease. Cronbach’s alpha statistics calculation was used for evaluation of internal consistency reliability. Student’s t test or ANOVA were used for evaluation hypothesis about probability equation. RESULTS: QOL was significantly lower in liver cirrhosis patients than in healthy population (59.5 ± 18.3 vs 85.3 ± 12.3, P < 0.001). The significant QOL differences between case and control groups were observed in domains of worry and abdominal symptoms, the smaller differences-in emotional functions and systematic symptom domains. Significantly worse QOL was in observed patients with increased clinical severity of the disease measured by Child-Pugh class. Age, gender and etiology of disease had an insignificant effect on QOL in cirrhotic patients. CONCLUSION: QOL was significantly impaired in all CLDQ domains in liver cirrhosis patients. Increase in severity of disease was the major factor associated with poorer QOL. | Jolanta Sumskiene Linas Sumskas Dalius Petrauskas Limas Kupcinskas | 2006 | World Journal of Gastroenterology2006，12，48： | 6 |
| 3 | Linear inertial piezoelectric motor with bimorph disc显示文摘 | DALIUS M PIOTR V | 2013 | Mechanical Systems and Signal Processing2013，36，： | 1 |
| 4 | Detection of colon cancer by terahertz techniques显示文摘 | Faustino Wahaia Gintaras Valusis Luis M. Bernardo Abílio Almeida Joaquim A. Moreira Patricia C. Lopes Jan Macutkevic Irmantas Kasalynas Dalius Seliuta Ramunas Adomavicius Rui Henrique Machado Lopes | 2011 | Journal of Molecular Structure2011，，1： | 1 |
| 5 | Med19 Promotes Osteosarcoma Growth and Metastasis and Associates with Prognosis显示文摘 | Wenxi Yu Zhang Zhichang Min Daliu Yang Qingcheng Du Xuefei Tang Lina Lin Feng Sun Yuanjue Zhao Hui Zheng Shuier He Aina Li Hongtao Yao Yang Zan Shen | 2014 | European Journal of Cancer2014，，： | 1 |
| 6 | Plasma Nogo-A and placental growth factor levels are associated with portal hypertension in patients with liver cirrhosis显示文摘BACKGROUND Clinically significant portal hypertension(CSPH) and severe portal hypertension(SPH) increase the risk for decompensation and life-threatening complications in liver cirrhosis. Pathologic angiogenesis might contribute to the formation of these conditions. Placental growth factor(PlGF) and Nogo-A protein are biomarkers of pathological angiogenesis, but data on their role in liver cirrhosis and portal hypertension is scarce.AIM To determine plasma levels of PlGF and Nogo-A in patients with liver cirrhosis,CSPH, SPH and potential to predict portal hypertension.METHODS A cohort of 122 patients with hepatitis C virus and/or alcohol-induced liver cirrhosis with characterized hepatic venous pressure gradient(HVPG) were included in the study. Demographic data, medical history, Child-Turcotte-Pugh and Model of End Stage liver disease score, clinical chemistry, liver stiffnessvalues were recorded on the day of the procedure prior HVPG measurement. The degree of portal hypertension was determined by the invasive HVPG measurement. Nogo-A and PlGF plasma levels were evaluated using enzyme linked immunosorbent assay. The control group consisted of 30 healthy age-and sex-matched individuals.RESULTS Peripheral PlGF levels were higher and Nogo-A levels were lower in patients with liver cirrhosis(23.20 vs 9.85;P < 0.0001 and 2.19 vs 3.12;P = 0.004 respectively). There was a positive linear correlation between peripheral levels of PlGF and HVPG(r = 0.338, P = 0.001) and negative linear correlation between the peripheral Nogo-A levels and HVPG(r =-0.267, P = 0.007). PlGF levels were higher in CSPH and SPH(P = 0.006;P < 0.0001) whereas Nogo-A levels were lower(P = 0.01;P < 0.033). Area under the curve for the diagnosis of CSPH for PlGF was 0.68(P = 0.003) and for Nogo-A-0.67(P = 0.01);for SPH 0.714(P <0.0001) and 0.65(P = 0.014) respectively. PlGF levels were higher and Nogo-A levels were lower in patients with esophageal varices(P < 0.05). PlGF cut-off value of 25 pg/mL distinguished patients with CSPH at 55.7% sensitivity and76.7% specificity;whereas Nogo-A cut-off value of 1.12 ng/mL was highly specific(93.1%) for the diagnosis of CSPH.CONCLUSION Plasma PlGF levels were higher while Nogo-A levels were lower in patients with liver cirrhosis and portal hypertension. Biomarkers showed moderate predictive value in determining CSPH and SPH. | Sigita Gelman Violeta Salteniene Andrius Pranculis Jurgita Skieceviciene Romanas Zykus Dalius Petrauskas Limas Kupcinskas Ali Canbay Alexander Link Juozas Kupcinskas | 2019 | World Journal of Gastroenterology2019，25，23： | 1 |
| 7 | Magnetic imaging of craniovertebral structures : clinical significance in cervicogenic headache 显示文摘 | Heidi K Jostein K Dalius B | 2012 | J Headache Pain2012，，13： | 1 |
| 8 | Pipe line break detection using pressure transient monitoring显示文摘 | Dalius M Jolm V Gustaf O | 2005 | Journal of zvater Resources Planning and Management2005，131，4： | 1 |
| 9 | Financing instruments and channels for the increasing production and consumption of renewable energy:Lithuanian case显示文摘 | Viktorija Bobinaite Dalius Tarvydas | 2014 | Renewable and Sustainable Energy Reviews2014，，38： | 1 |
| 10 | Oscillator-Based Reconfigurable Sinusoidal Signal Generator for ADC BIST 显示文摘 | HSIN Wenting CHENG Wulin BIN Daliu | 2007 | Electron Test2007，23，： | 1 |
| 11 | Iterated Tabu Search:An Improvement to Standard Tabu Search 显示文摘 | Alfonsas Misevicius Antanas Lenkevicius Dalius Rubliauskas | 2004 | Information Technology and Control2004，35，： | 1 |
| 12 | Pipeline Break Detection Using Pressure Transient Monitoring显示文摘 | Dalius Misiunas John Vitkovsky Gustaf Olsson | 2005 | Journal of Water Resources Planning and Management2005，131，4： | 1 |
| 13 | Pipeline break detection using pressure transient monitor- ing 显示文摘 | Misiunas Dalius Vitkovski John Olsson Gustaf | 2005 | Journal of Water Resources Planning and Man- agement2005，131，4： | 1 |
| 14 | CONSTITUTIONAL COURT'S JUDGEMENTS INFLUENCE ON THE ADMINISTRATIVE LAW显示文摘 | Janis Naciscionis Dalius Gintautas | 2014 | US-China Law Review2014，11，11： | 0 |
| 15 | 肢体骨肉瘤合并病理性骨折44例患者的临床特征及预后相关因素分析(英文)显示文摘Objective: The aim of this study was to identify the clinical features and prognostic factors associated with extremity osteosarcoma with pathologic fracture. Methods: The clinical records of 271 patients with extremity osteosarcomas were retrospectively reviewed. The data obtained covered the period from October 2003 to May 2012, and included sex, age, tumor site etc. The mean follow-up time was 25.2 months(ranged from 1 to 117). Chi-square method and Kaplan-Meier method were used to compare clinical differences and overall survival between patients with or without pathologic fracture, respectively. The univariate analysis was used to determine the prognostic factors related with survival rate by log-rank test. The multivariate analysis of prognosis was performed by COX proportional hazards regression model. Results: The proportions of patients having a tumor's diameter of 10 cm or more(P = 0.038), locating upper limbs(P = 0.004) and receiving amputation surgery(P = 0.02) were significantly higher with pathological fracture group than without pathological fracture group. The local recurrence rate(P = 0.000) was also significantly higher in the pathological fracture group. The median survival time of patients with or without pathological fracture was 16(95% confidence interval: 14.6–17.4) months and 22(95% confidence interval: 19.8–24.1) months(P = 0.002). The Log-rank univariate analysis indicated that the tumor size, Enneking's surgical staging, Karnofsky performance status(KPS) score, cycles of adjuvant chemotherapy, local recurrence and metastasis were significantly related to overall survival. Multivariate Cox regression analysis revealed KPS score, cycles of adjuvant chemotherapy and metastasis were independent prognostic factors(P < 0.05). Conclusion: Compared with the patients without pathological fracture, a higher proportion of patients receiving amputation surgery or having larger tumor size, humeral osteosarcoma or local recurrence was observed in patients with pathological fracture, and the prognosis of these patients was poor. The independent prognostic factors of extremity osteosarcoma with pathologic fracture were the KPS score, cycles of adjuvant chemotherapy and metastasis. | Cong Tian Yujing Hang Lina Tang Feng Lin Daliu Min Yang Yao | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，1： | 0 |
| 16 | The single-cell landscape reveals unique tumor subsets and microenvironments associated with poor clinical outcomes in primary testicular diffuse large B-cell lymphoma显示文摘Diffuse large B cell lymphoma(DLBCL)is one of the most prevalent lymphoid malignancies.The current standard of care can cure about two-thirds of DLBCL patients.1 Primary testicular diffuse large B-cell lymphoma(PT-DLBCL)is a rare but highly aggressive form of mature B-cell lymphoma that accounts for approximately 1%-9%of testicular malignancies.Different from nodal DLBCL,PT-DLBCL has a markedly worse prognosis because of inferior response to the current treatment regimens and significant extranodal tropism.2 Three main questions remained unresolved in the field of PT-DLBCL research. | Zhouliang Bian Benhong Gu Guohai Shi Jiahui Guo Dong Li Hanlin Zengg Bin Jiang Daliu Min Hengchuan Su Yanjie Zhang | 2024 | Genes & Diseases2024，11，1： | 0 |
| 17 | 多重互动——上海Kik公园显示文摘Kik公园位于近年来专为附近复旦大学和同济大学的学生建造的创智坊八口处,作为一块位置显赫的城市空地,居然在快速的城市营造中成了漏网之鱼,这令Francesco Gatti大为惊讶。自从这位意大利建筑师将他的部分业务活动转移到中国以来,他一直对此类罅隙空间的设计可能性饶有兴趣。 | Nicole Ni Francesco Negri Dalius Ripley Michele Ruju Muavii Sun Charles Mariambourg Shen Qiang | 2013 | 中国建筑装饰装修2013，，2： | 0 |
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