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| 1 | 慢性肝病问卷在乙肝病毒携带者中的初步试用显示文摘目的:初步评价Younossi的慢性肝病问卷(CLDQ)试用于我国乙型肝炎病毒携带者生存质量的信度和效度。方法:采用CLDQ对乙肝病毒携带者进行调查。结果:共108例乙型肝炎病毒携带者完成调查。研究结果显示CLDQ内部一致性信度较高,与其他研究一致;特征根大于1的公因子有6个,能解释总方差的66.89%;结构效度分析未与原量表设计完全一致。结论:CLDQ用于我国乙型肝炎病毒携带者生存质量评价时有一定的信度和效度,但仍需改进,并对其用于此部分人群时的修改提供了建议。 | 郭新峰 朱泉 吕渭辉 李建婷 周大桥 童光东 贺劲松 | 2010 | 吉林医学2010，31，11： | 7 |
| 2 | Psychometrics of chronic liver disease questionnaire in Chinese chronic hepatitis B patients显示文摘AIM: To evaluate psychometrics of the Chinese (mainland) chronic liver disease questionnaire (CLDQ) in patients with chronic hepatitis B (CHB). METHODS: A cross-sectional sample of 460 Chinese patients with CHB was selected from the Outpatient Department of the Eighth Hospital of Xi'an, including CHB (CHB without cirrhosis) (n = 323) and CHB-related cirrhosis (n = 137). The psychometrics includes reliability, validity and sensitivity. Internal consistency reliability was measured using Cronbach's α. Convergent and discriminant validity was evaluated by item-scale correlation. Factorial validity was explored by principal component analysis with varimax rotation. Sensitivity was assessed using Cohen's effect size (ES), and independent sample t test between CHB and CHB-related cirrhosis groups and between alanine aminotransferase (ALT) normal and abnormal groups after stratifying the disease (CHB and CHB-related cirrhosis).RESULTS: Internal consistency reliability of the CLDQ was 0.83 (range: 0.65-0.90). Most of the hypothesized item-scale correlations were 0.40 or over, and all of such hypothesized correlations were higher than the alternative ones, indicating satisfactory convergent and discriminant validity. Six factors were extracted after varimax rotation from the 29 items of CLDQ. The eligible Cohen's ES with statistically significant independent sample t test was found in the overall CLDQ and abdominal, systematic, activity scales (CHB vs CHBrelated cirrhosis), and in the overall CLDQ and abdominal scale in the stratification of patients with CHB (ALT normal vs abnormal). CONCLUSION: The CLDQ has acceptable reliability, validity and sensitivity in Chinese (mainland) patients with CHB. | Kai-Na Zhou Min Zhang Qian Wu Zhen-Hao Ji Xiao-Mei Zhang Gui-Hua Zhuang | 2013 | World Journal of Gastroenterology2013，19，22： | 5 |
| 3 | 呼吸道传染病健康素养综合评价体系的建立与评估显示文摘目的:建立与评估呼吸道传染病健康素养综合评价体系。方法:对影响呼吸道传染病健康素养的因素进行抽样调查,抽样内容包括年龄、性别与文化程度,在笔者所在县范围内对200例成年人开展调查,调查问卷中共计四个部分,52道题目,主要包括健康素养知识、基本人口学特征、健康行为测评、健康素养能力测评。测试结果完成后,由专业人员将测试结果输入电脑,整个评价体系包括评价对象、权重系数、评价指标、评价者、集结模型,对调查结果进行统计学分析。结果:在原始工具中共计42项维度,筛选出其中28项,其中3项为指标评价知识,8项为评价行为,其余为指标评价,各个指标赋予权重后,维度一致性得到显著的改善,呼吸道传染病健康素养综合评价信度系数达到0.873,高于0.7,有着良好的稳定性与稳定性。结论:综合评价是对多个指标体系采用数学模式进行评价的模式,本研究考虑到公众的健康水平、呼吸道传染病实际情况,并结合实际情况建立了综合性的评价体系,经过效度与信度评估证实评价体系的效度与信度良好,该种评价体系值得进行推广和使用。 | 周东林 | 2014 | 中外医学研究2014，12，19： | 3 |
| 4 | Translation and validation of the Greek chronic liver disease questionnaire显示文摘AIM:To translate into Greek and validate the chronic liver disease questionnaire (CLDQ).METHODS:Two hundred and six consecutive adult patients with the diagnosis of a chronic liver disease from 2 general hospitals in Athens were enrolled in the study from May to September 2008.In order to assess their quality of life (QOL) the CLDQ was applied.The instrument was translated from English,back translated and reviewed in focus groups within the framework of a large multicenter study.The measurements that were performed included:2 independent sample t tests,oneway analysis of variance,reliability coefficients,explanatory factor analysis using a varimax rotation and the principal components method.RESULTS:One hundred and twenty five (61%) patients were men,half were aged 40-59 years and > 33% were > 60 years old.Among the patients,48 (23%) were hospitalized and 97 (47%) were cirrhotic according to the Child-Pugh score.The internal consistency of the Greek CLDQ version using Cronbach's alpha coefficient was found to be 0.93.Exploratory factor analysis identified 7 domains accounting for 65% of the variance of CLDQ items and only partially overlapping with those found in the original version.The area under the receiver operating characteristics curve was calculated at 0.813 and the logistic estimate for the threshold score of 167.50 provided a sensitivity of 74.3% and a specificity of 71.6% for the model.CONCLUSION:Our data confirmed the validity of the Greek version of the CLDQ in identifying the QOL among patients with chronic liver disease. | Zoi Kollia Evridiki Patelarou Victoria Vivilaki Eleni Kollia Florentia Kefou Ioannis Elefsiniotis Spyros P Dourakis Hero Brokalaki | 2010 | World Journal of Gastroenterology2010，16，46： | 2 |
| 5 | Validation of the chronic liver disease questionnaire in Serbian patients显示文摘AIM:To translate into Serbian and to investigate the validity of the cross-culturally adapted the chronic liver disease questionnaire(CLDQ).METHODS:The questionnaire was validated in 103 consecutive CLD patients treated between October 2009 and October 2010 at the Clinic for Gastroenterology,Clinical Centre of Serbia,Belgrade(Serbia).Exclusion criteria were:age < 18 years,psychiatric disorders,acute complications of CLD(acute liver failure,variceal bleeding,and spontaneous bacterial peritonitis),hepatic encephalopathy(grade > 2)and liver transplantation.Evaluation of the CLDQ was done based on the following parameters:(1)acceptance is shown by the proportion of missing items;(2)internal reliabilities were assessed for multiple item scales by using Cronbach alpha coefficient;and(3)in order to assess whether the allocation of items in the domain corresponds to their distribution in the original questionnaire(construction validity),an exploratory factor analysis was conducted.Discriminatory validity was determined by comparing the corresponding CLDQ score/sub-score in patients with different severity of the diseases.RESULTS:The Serbian version of CLDQ questionnaire completed 98% patients.Proportion of missing items was 0.06%.The total time needed to fill the questionnaire was ranged from 8 to 15 min.Assistance in completing the questionnaire required 4.8% patients,while 2.9% needed help in reading,and 1.9% involved writing assistance.The mean age of the selected patients was 53.8 ± 12.9 years and 54.4% were men.Average CLDQ score was 4.62 ± 1.11.Cronbach's alpha for the whole scale was 0.93.Reliability for all domains was above 0.70,except for the domain 'Activity'(0.49).The exploratory factor analysis model revealed 6 factors with eigenvalue of greater than 1,explaining 69.7% of cumulative variance.The majority of the items(66%)in the Serbian version of the CLDQ presented the highest loading weight in the domain assigned by the CLDQ developers:'Fatigue'(5/5),'Emotional function'(6/8),'Worry'(5/5),'Abdominal symptoms'(0/3),'Activity'(0/3),'Systemic symptoms'(3/5).The scales 'Fatigue' and 'Worry' fully corresponded to the original.The factor analysis also revealed that the factors 'Activity' and 'Abdominal symptoms' could not be replicated,and two new domains 'Sleep' and 'Nutrition' were established.Analysis of the CLDQ score/sub-score distribution according to disease severity demonstrated that patients without cirrhosis had lower total CLDQ score(4.86 ± 1.05)than those with cirrhosis Child's C(4.31 ± 0.97).Statistically significant difference was detected for the domains 'Abdominal symptoms' [F(3)= 5.818,P = 0.001] and 'Fatigue' [F(3)= 3.39,P = 0.021].Post hoc analysis revealed that patients with liver cirrhosis Child's C had significantly lower sub-score 'Abdominal symptoms' than patients without cirrhosis or liver cirrhosis Child's A or B.For domain 'Fatigue',patients with cirrhosis Child's C had significantly lower score,than non-cirrhotic patients.CONCLUSION:The Serbian version of CLDQ is well accepted and represents a valid and reliable instrument in Serbian sample of CLD patients. | Dusan Dj Popovic Nada V Kovacevic Darija B Kisic Tepavcevic Goran Z Trajkovic Tamara M Alempijevic Milan M Spuran Miodrag N Krstic Rada S Jesic Zobair M Younossi Tatjana D Pekmezovic | 2013 | World Journal of Gastroenterology2013，19，30： | 1 |
| 6 | 慢性乙型肝炎和乙型肝炎后肝硬化患者心理状况的相关研究进展显示文摘近年来,有关慢性乙型肝炎(以下简称为慢乙肝)和乙肝后肝硬化患者心理状况的临床相关研究的报道逐年增多,患者存在不同程度的焦虑、抑郁、躯体化等心理健康问题与疾病和生活质量互为影响。本文从其所表现的心理健康问题,主要影响因素,心理状况对病程的影响,心理状况与生活质量的关系以及心理干预的疗效等方面进行综述,为全面了解慢性乙肝和乙肝后肝硬化患者的心理状况提供参考。 | 刘沁毅 叶军 | 2010 | 世界感染杂志2010，10，1： | 1 |
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