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| 1 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 2 | Association between nondisjunction and maternal age in meiosis Ⅱ human oocytes显示文摘 | Dale B Cohen J Munne S | 1996 | Am J Genet1996，59，： | 1 |
| 3 | Fatigue testing and microscopic evaluation of post and core restorations under artificial crowns 显示文摘 | Gatean P Sabek M Dailey B | 1999 | J Prosthet Dent1999，82，3： | 1 |
| 4 | Characterization of hydroxyapatite films obtained by pulsed-laser deposition on Ti and Ti-6A1-4V substrates显示文摘 | Blind O Klein L H Dailey B | 2005 | Dental Materials2005，21，： | 1 |
| 5 | A method for GPS positioning显示文摘 | DAILEY D J BELL B M | 1996 | Aerospace and Electronic Systems1996，32，3： | 1 |
| 6 | Fatigue testing and microscopic evaluation of post and core restorations under artificial crowns 显示文摘 | Gateau P Sabek M Dailey B | 1999 | J Prosthet Dent1999，82，3： | 1 |
| 7 | In vitro fatigue resistance of glass ionomer cements used in post - and - core applications 显示文摘 | Gateau P Sabek M Dailey B | 2001 | J Prosthet Dent2001，86，2： | 1 |
| 8 | Association between nondisjunction and maternal age in meiosis-Ⅱ human oocytes detected by FISH analysis显示文摘 | Dailey T Dale B Cohen J Munne S | 1996 | American Journal of Human Genetics1996，59，： | 1 |
| 9 | Sparing methyla- tion of β-cyclodextrin mitigates cytotoxicity and permeabili- ty induction in respiratory epithelial cell layers in vitro 显示文摘 | Salem L B Bosquillon C Dailey L A | 2009 | J Controlled Release2009，136，2： | 1 |
| 10 | A method for GPS positioning显示文摘 | Dailey D J Bell B M | 1996 | Aerospace and Electronic Systems1996，32，3： | 1 |
| 11 | Polymeric microcapsules of alachlor and metolachlor: preparation and evaluation of controlled-release properties 显示文摘 | DOWLER C C DAILEY O D MULLINIX B G | 1999 | J Agric Food Chem1999，47，7： | 1 |
| 12 | Characterization of hydroxyapatite films obtained by pulsed-laser deposition on Ti and Ti-6AL- 4v substrates显示文摘 | Blind O Klein LH Dailey B | 2005 | Dent Mater2005，21，11： | 1 |
| 13 | Polymeric Microcapsules of the Herbicides Atrazine and Metribuzin: Preparation and Evaluation of Controlled Release Properties 显示文摘 | Dailey OD Dowler C C Mullinix B | 1993 | Journal of Agricultund and Food Chemistry1993，41，： | 1 |
| 14 | A survey of people's attitudes and beliefs about false confes-sions显示文摘 | Henkel L.A Coffman K.A.J Dailey B Elizabeth M | | 0，，05： | 1 |
| 15 | Association between non-disjunction and naternal age in meiosis human oocytes detected by FISHanalysis显示文摘 | Dailey T Dale B Cohen J | 1996 | Am JHun Genet1996，59，： | 1 |
| 16 | Changes of maternal transcripts in o0cytes from persistent follicles in cattle显示文摘 | Lingenfelter B M Dailey R A Inskeep E K | 2007 | Mol Reprod Dev2007，74，： | 1 |
| 17 | Using TENS for pain control: the state of the evidence 显示文摘 | VANCE C G DAILEY D L RAKEL B A | 2014 | Pain Management2014，4，3： | 1 |
| 18 | Specific interference between a cognitive task and sensory organization for stance balance control in healthy young adults: Visuospatial effects 显示文摘 | Chong RKY Mills B Dailey L et at | 2010 | Neuropsychologia2010，48，9： | 1 |
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