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| 1 | AZF microdeletions associated with idiopathic and non idiopathic cases with cryptorchidism and varicocele显示文摘Aim:To identify submicroscopic interstitital deletions in azoospermia factor (AZF) loci in idiopathic and non-idiopathic cases of male infertility in Indians.Methos:One hundred and twenty two infertile males with oligozoospermia or azoospermia were included in this study.Semen analysis was done to determine the sperm density,i.e.,normospermia(>20million/mL),oligozoospermia(<20million/mL) or azoospermia.They were subjected to detailed clinical examination and endocrinological and cytogenetic study.Thirty G-banded metaphases were analyzed in the 122 cases and polymerase chain reaction (PCR) microdeletion analysis was done in 70 cytogenetically normal subjects.For this genomic DNA was extracted using peripheral blood.The STS primers tested in each case were sY84,sY86(AZFa);sY127,sY134(AZFb);sY254,sY255(AZFc).PCR amplifications found to be negative were repeated at least 3 times to confirm the deletion of a given marker.The PCR products were analyzed on a 1.8% agarose gel.Results:Eight of the 70 cades(11.4%) showed deletion of at least one of the STS markers.Deletions were detected in cases with known and unknown aetiology with bilateral severe testiculopathy and also in cryptorchid and varicocele subjects.Conclusion.AZF microdeletions were seen in both idiopathic and non-idiopathic cases with cryptorchidism and varicocele.The finding of a genetic aetiology in infertile men with varicocele and cryptorchidism suggests the need for molecular screening in non-idiopathic cases. | Rima Dada N.P. Gupta K. Kucheria | 2002 | Asian Journal of Andrology2002，4，4： | 22 |
| 2 | Y chromosome microdeletions in azoospermic patients with Klinefelter's syndrome显示文摘瞄准:与 Klinefelter 的症候群(KFS ) 在 azoospermic 病人学习 Y 微删除的出现。方法:血和精液样品与 KFS 从 azoospermic 病人被收集(n = 14 ) 并且证明富饶的人的一个控制组(n = 13 ) 。精液分析根据世界卫生组织被做() 指南。血样品为 karyotyping,荧光灯的原位杂交(鱼) 和由放射性免疫测定刺激荷尔蒙(FSH ) 的血浆滤泡的测量被处理。决定 Y 微删除, 16 顺序的聚合酶链反应(PCR ) 标注了地点(圣) ,三基因(DFFRY, XKRY 和 RBM1Y ) 在孤立的 genomic DNA 上被执行。阴囊的好针渴望细胞学(FNAC ) 在选择情况中被做。结果:跨越一个 and AZFb 部位与 KFS 在 14 个 azoospermic 病人中的四个被发现的精子缺乏因素(AZF ) 的 Y 微删除。染色质组型和鱼分析表明显示出 Y 微删除的四个盒子,三个盒子有一 47, XXY/46, XY 染色体的模式和一个盒子有一 46, XY/47, XXY/48, XXXY/48, XXYY 染色体的模式。有 Y 微删除的一件样品的阴囊的 FNAC 揭示了形态学的 Sertoli 房间唯一的类型。然而,没有 Y 微删除在任何 13 个肥沃的人被观察。有 KFS 的所有病人提高了血浆 FSH 层次。结论:有 KFS 的病人可以怀有 Y 微删除并且为这些屏蔽应该是他们的诊断病情的检查的部分,特别地在那些考虑帮助了繁殖技术。 | Anurag Mitra Rima Dada Rajeev Kumar Narmada Prasad Gupta Kiran Kucheria Satish Kumar Gupta | 2006 | Asian Journal of Andrology2006，8，1： | 8 |
| 3 | 一种新识别的脂肪细胞因子vaspin能改善葡萄糖耐量和胰岛素敏感性显示文摘日本学者报告Vaspin是一种新识别出来的脂肪细胞因子,是由内脏脂肪组织产生的丝氨酸蛋白酶,2型糖尿病模型的大鼠它被上调,而非肥胖和耐糖尿病大鼠,它被下调。 | Jan Dada | 2005 | 中国分子心脏病学杂志2005，5，5： | 8 |
| 4 | Higher frequency of Yq microdeletions in sperm DNA as compared to DNA isolated from blood显示文摘瞄准:决定删除的 Yq 微删除频率和 loci 是否在不同胚胎学的起源的二纸巾(血和精子) 是类似的。方法:现在的学习包括了 52 个不肥沃的 oligozoospermic 盒子。在每种情况中, DNA 从血和精子被孤立,微删除分析从 genomic DNA 被做的聚合酶链反应(PCR ) 从两个孤立纸巾。PCR 产品在 1.8% 统帅玫瑰胶化上被分析。发现否定的 PCR 扩大被重复至少三次证实一个给定的标记的删除。结果:仅仅 1 个盒子在血 DNA 怀有微删除,而 4 个盒子在精子 DNA 怀有微删除。结论:Yq 微删除的频率作为与血相比在细菌房间是更高的。为帮助繁殖生产技术(艺术) 作为不肥沃的夫妇的多数抉择, Yq 微删除从细菌房间屏蔽是重要的理解不孕的基因基础,提供全面建议和大多数改编治疗学给不肥沃的夫妇。 | Rima Dada Rakesh Kumar M. B. Shamsi Rajeev Kumar Kiran Kucheria Raj K. Sharma Satish K. Gupta Narmada P. Gupta | 2007 | Asian Journal of Andrology2007，9，5： | 6 |
| 5 | Financing newsvendor inventory显示文摘 | Maqbool Dada Qiaohai Hu | 2008 | Operations Research Letters2008，，5： | 6 |
| 6 | Sediment records of environmental changes in the south end of the Zhejiang-Fujian coastal mud area during the past 100 years显示文摘Previous studies carried out in the East China Sea(ECS) mud area focused on long-term environmental changes in sedimentary records during the Holocene, especially during the mid-Holocene high-stand water levels period. These results indicate that sensitive grain size groups can be used as a sedimentary proxy to reconstruct the evolution of the East Asian Winter Monsoon(EAWM). The studies have been carried out mainly in the northern and middle portions of the Zhejiang-Fujian coastal mud, however, similar research in the southern portion and the comparison between sedimentary proxy and modern measured data of EAWM are lacking. In this paper, we focused on a sedimentary record of the past 100 years with an enhanced resolution of 1.8 years. Investigations of the southern end of the Zhejiang-Fujian coastal mud area were conducted on the basis of 210 Pb chronology, grain-size analysis and chemical element analysis. The correspondence between the mean grain size(Mz) of sediment sensitive grain size and the measured EAWM was confirmed for the first time. We found that during the recent 100 years, the variation of the mean grain size of the sensitive population in the southern portion of the Zhejiang-Fujian mud was mainly controlled by the EAWM intensity changes; and not directly related to changes in the sediment discharge from Datong station of the Changjiang River(DTSD). Finally, recent changes in the content of heavy metals in study area refl ect the impact of human activities on the environment. | 王琳淼 李广雪 高飞 刘玲 刘勇 DADA Olusegun A | 2014 | Chinese Journal of Oceanology and Limnology2014，32，4： | 5 |
| 7 | Mild oxidative stress is beneficial for sperm telomere length maintenance显示文摘AIM:To evaluate telomere length in sperm DNA and its correlation with oxidative stress(normal,mild,severe).METHODS:The study included infertile men(n=112)and age matched fertile controls(n=102).The average telomere length from the sperm DNA was measured using a quantitative real time PCR based assay.Seminal reactive oxygen species(ROS)and 8-Isoprostane(8-IP)levels were measured by chemiluminescence assay and ELISA respectively.RESULTS:Average sperm telomere length in infertile men and controls was 0.609±0.15 and 0.789±0.060,respectively(P<0.0001).Seminal ROS levels in infertile was higher[66.61±28.32 relative light units(RLU)/s/million sperm]than in controls(14.04±10.67RLU/s/million sperm)(P<0.0001).The 8-IP level in infertile men was significantly higher(421.55±131.29pg/mL)than in controls(275.94±48.13 pg/mL)(P<0.001).When correlated to oxidative stress,in normal range of oxidative stress(ROS,0-21.3 RLU/s/million sperm)the average telomere length in cases was 0.663±0.14,in mild oxidative stress(ROS,21.3-35 RLU/s/million sperm)it was elevated(0.684±0.12)and in severe oxidative stress(ROS>35 RLU/s/million sperm)average telomere length was decreased to 0.595±0.15.CONCLUSION:Mild oxidative stress results in lengthening of telomere length,but severe oxidative stress results in shorter telomeres.Although telomere maintenance is a complex trait,the study shows that mild oxidative stress is beneficial in telomere length maintenance and thus a delicate balance needs to be established to maximize the beneficial effects of free radicals and prevent harmful effects of supra physiological levels.Detailed molecular evaluation of telomere structure,its correlation with oxidative stress would aid in elucidating the cause of accelerated telomere length attrition. | Swetasmita Mishra Rajeev Kumar Neena Malhotra Neeta Singh Rima Dada | 2016 | World Journal of Methodology2016，6，2： | 4 |
| 8 | A geomorphological response of beaches to Typhoon Meari in the eastern Shandong Peninsula in China显示文摘Eight representative beach profiles on the eastern coast of the Shandong Peninsula are observed and measured in2011 and 2012 to determine the coastal processes under the lower tropical wind speed condition and the beach response to and recovery from the tropical storm Meari in a rare typhoon region. The results show that it is the enhancement and directional change of cross-shore and longshore sediment transports caused by Meari that leads to the beach morphological changes, and most of the sediment transports occur during the pre-Meari landing phase. The erosional scarp formation and the berm or beach face erosion are the main geomorphological responses of the beaches to the storm. The storm characteristics are more important than the beach shapes in the storm response process of the beaches on Shandong Peninsula. The typhoon is a fortuitous strong dynamic event,and the effect on the dissipative beach is more obvious than it is on the reflective beach in the study region.Furthermore, the beach trend is the main factor that controlls the storm effect intensity, and it is also closely related to the recovery of the beach profiles. | DING Dong YANG Jichao LI Guangxue DADA Olusegun A GONG Lixin WANG Nan WANG Xiangdong ZHANG Bin | 2015 | Acta Oceanologica Sinica2015，34，9： | 4 |
| 9 | 近60年来南黄海沉积物高分辨率敏感粒级对东亚冬季风的响应显示文摘对南黄海中部泥质区F306柱状样的沉积物进行分析,运用粒径—标准偏差法,得出该孔敏感粒级组分为23.10~65.30μm(5.44Φ~3.94Φ),其粒级的含量15.6%~22.3%,平均粒径38.5~41.4μm(4.70Φ~4.59Φ),证明敏感粒级可以作为东亚冬季风的高分辨率替代指标,进一步阐明了敏感粒级作为东亚冬季风替代指标在更高分辨率上的可行性。根据敏感粒级沉积记录,在1950—1986年期间,将东亚冬季风分为强—弱—强3个阶段,指示了该阶段东亚冬季风存在近10年的周期。1986/1987为近60多年来东亚冬季风由强变弱的转折点,与东亚气候变化具有较好的对应关系,首次在中国东部海域中记录了此逆转事件,认为1986年后沉积物敏感粒级的变粗可能与长江物源变粗、东亚冬季风的减弱以及夏季风增强有关。 | 高星华 李广雪 张海啟 Dada Olusegun A 刘世东 陈中亚 李亨健 王琳淼 刘玲 | 2016 | 海洋地质前沿2016，32，8： | 3 |
| 10 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 11 | The Marine Dynamics and Changing Trend off the Modern Yellow River Mouth显示文摘Topography around the Yellow River mouth has changed greatly in recent years, but studies on the current state of ma- rine dynamics off the Yellow River mouth are relatively scarce. This paper uses a two-dimension numerical model(MIKE 21) to reveal the tidal and wave dynamics in 2012, and conducts comparative analysis of the changes from 1996 to 2012. The results show that M2 amphidromic point moved southeastward by 11 km. It further reveals that the tides around the Yellow River mouth are relatively stable due to the small variations in the tidal constituents. Over the study period, there is no noticeable change in the distribution of tidal types and tidal range, and the mean tidal range off the river mouth during the period studied is 0.5–1.1 m. However, the tidal currents changed greatly due to large change in topography. It is observed that the area with strong tidal currents shifted from the old river mouth(1976–1996) to the modern river mouth(1996–present). While the tidal current speeds decreased continually off the old river mouth, they increased off the modern river mouth. The Maximum Tidal Current Speed(MTCS) reached 1.4 m s-1, and the maximum current speed of 50-year return period reached 2.8 m s-1. Waves also changed greatly due to change in topography. The significant wave height(H1/3) of 50-year return period changed proportionately with the water depth, and the ratio of H1/3 to depth being 0.4–0.6. H1/3 of the 50-year return period in erosion zone increased continually with increasing water depth, and the rate of change varied between 0.06 and 0.07 m yr-1. Based on the results of this study, we infer that in the future, the modern river mouth will protrude gradually northward, while the erosion zone, comprising the old river mouth and area between the modern river mouth and the old river mouth(Intermediate region) will continue to erode. As the modern river mouth protrudes towards the sea, there will be a gradual increase in the current speed and decrease in wave height. Conversely, the old river mouth will retreat, with gradual decrease in current speed and increase in wave height. As more coastal constructions spring up around the Yellow River mouth in the future, we recommend that variation in hydrodynamics over time should be taken into consideration when designing such coastal constructions. | WANG Nan LI Guangxue XU Jishang QIAO Lulu DADA Olusegun A. ZHOU Chunyan | 2015 | Journal of Ocean University of China2015，14，3： | 3 |
| 12 | A Newsvendor’s Procurement Problem when Suppliers Are Unreliable显示文摘 | Maqbool Dada Nicholas C. Petruzzi Leroy B. Schwarz | 2007 | Manufacturing & Service Operations Management2007，，1： | 2 |
| 13 | Improving the Antibacterial Property of Chitosan Hydrogel Wound Dressing with Licorice Polysaccharide显示文摘A series of hydrogels with different ratios of chitosan and licorice polysaccharide(LP)were prepared by crosslinking to different concentrations of genipin(gp).They were characterized by FTIR(Fourier transform infrared spectroscopy),SEM(Scanning electron microscope),swelling ratio,rheological measurements,degradation with time,cytotoxicity,and antibacterial efficacy.Results show that the hydrogels have porous structures.With an increase in LP content,the swelling rate grows in the early stage of immersion in buffer and drops later.The swelling ratio ranged from 986%to 1677%,and stiffness varied from 777 Pa to 1792 Pa.The addition of LP reduced the mechanical strength and delayed gelation and degradation of the hydrogels.However,the most important discovery was that gp increases the viability of NIH 3T3 cells from 94%to 137%,and LP raises the bacteriostatic efficacy from 51%to 78%.Hydrogels synthesized from 1%genipin,3%chitosan,and 4%licorice polysaccharide showed the best antibacterial and fibroblast proliferation promoting activities.They exhibited moderate swelling and degradation rates over time,while being more suitable to affect healing of chronic wound infections.These results provide a new strategy to improve the antibacterial effectiveness and cyto-compatibility of chitosan hydrogels with water soluble active LPs from Glycyrrhiza that derive from traditional Chinese medicine. | Haiwei Ren Li Wang Hui Bao Yunya Xia Dada Xu Weijie Zhang Zhiye Wang | 2020 | Journal of Renewable Materials2020，8，10： | 2 |
| 14 | Ultrasound biomicroscopy in the subtypes of primary angle closure glaucoma显示文摘 | Sihota R Dada T Gupta R | | 0，，： | 2 |
| 15 | Pricing and the newsvendor problem: A review with extensions显示文摘 | Petruzzi N C Dada M | 1999 | Operations Research1999，47，： | 1 |
| 16 | Comparison of anterior segment optical coherence tomography and ultrasound biomicroscopy for assessment of the anterior segment 显示文摘 | Dada T Sihota R Gadia R | 2007 | Cataract Refract Surg2007，33，5： | 1 |
| 17 | Pricing and the newsvendor prob- lem: a review with extensions 显示文摘 | Petruzzi N C Dada M | 1999 | Operations Research1999，47，2： | 1 |
| 18 | Pricing and newsvendor problem : a review with extensions显示文摘 | Petruzzi N C Dada M | 1999 | Operations Research1999，47，2： | 1 |
| 19 | Plasmapheresis treatment in Guillain-Barré syndrome:potential benefit over IVIg in patients with axonal involvement显示文摘 | Dada MA Kaplan AA | | 0，，05： | 1 |
| 20 | Molecular screening for Yq Microdeletion in men with idiopathic oligozooospermia and zooaperia 显示文摘 | Dada R Gupta NP Kucheria K | 2003 | Iosci2003，28，2： | 1 |
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