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| 1 | Clinical impact of selective transarterial chemoembolization on hepatocellular carcinoma:A cohort study显示文摘AIM:To prospectively evaluate the short and long term clinical impact of selective transarterial chemoembolization (TACE) on liver function in patients with hepatocellular carcinoma (HCC).To assess side effects in relation to treatments.To analyze the overall survival and HCC progression free survival probability. METHODS:One hundred and seventeen cirrhotic patients with HCC were enrolled.Baseline liver function included Child-Pugh score and serum levels of alanineaminotransferase (ALT),prothrombin time(PT)and bilirubin.According to Cancer Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer (BCLC) staging systems,71 patients were eligible for TACE; 32 had previously received treatment for HCC.No significant differences in liver function were observed between previously treated and not treated patients. TACE was performed by selective catheterization of the arteries nourishing the lesions.While hospitalized, patient sunder went clinical,hematologicand ultrasonographic assessments.One month after TACE a CT scan was performed to assess tumor response. A second TACE was performed'on demand'.Liver function tests were checked in all patients every four months.RESULTS:After first TACE,the mean Child-Pugh score increased from a mean baseline 5.62±1.12 to 6.11±1.57 at discharge time (P<0.0001),decreasing after four months to 5.81±0.73 (not significant).ALT,PT and bilirubin significantly (P<0.0001)increased 24 h after TACE and progressively decreased until discharge. After the second TACE,variations in Child-Pugh score,ALT,PT and bilirubin were comparable to that described after the first TACE.No major complications were observed.The mean follow-up was 14.7±6.3 mo (median:16 mo).Only one patient died.No other patient experienced important long term worsening of clinical status.The overall survival probability at twenty-four months was 98.18%with a correspondent HCC progression free survival probability of 69%. CONCLUSION:Selectiv TAC Emayproduce significant,but transitory increases in ALT values, with no major impact on liver function and Child-Pugh score.Preservation of liver function is achievable also in patients previously treated with other therapeutic modalities and in patients undergoing multiple TACE cycles.Liver function can remain stable in the long-term, with optimal medium term survival.This result can be achieved through rigorous patient selection on the basis of tumour characteristics and clinical conditions. | Rodolfo Sacco Marco Bertini Pasquale Petruzzi Michele Bertoni Irene Bargellini Giampaolo Bresci Graziana Federici Luigi Gambardella Salvatore Metrangolo Giuseppe Parisi Antonio Romano Antonio Scaramuzzino Emanuele Tumino Alessandro Silvestri Emanuele Altomare Claudio Vignali Alfonso Capria | 2009 | World Journal of Gastroenterology2009，15，15： | 7 |
| 2 | Clinical effectiveness of palifermin in prevention and treatment of oral mucositis in children with acute lymphoblastic leukaemia: a case–control study显示文摘The aim of this study was to evaluate the efficacy of palifermin, an N-terminal truncated version of endogenous keratinocyte growth factor, in the control of oral mucositis during antiblastic therapy. Twenty patients undergoing allogeneic stem-cell transplantation for acute lymphoblastic leukaemia were treated with palifermin, and compared to a control group with the same number of subjects and similar inclusion criteria. Statistical analysis were performed to compare the outcomes in the treatment vs. control groups. In the treatment group, we found a statistically significant reduction in the duration of parenteral nutrition(P50.002), duration of mucositis(P50.003) and the average grade of mucositis(P50.03). The statistical analysis showed that the drug was able to decrease the severity of mucositis. These data, although preliminary, suggest that palifermin could be a valid therapeutic adjuvant to improve the quality of life of patients suffering from leukaemia. | Dorina Lauritano Massimo Petruzzi Dario Di Stasio Alberta Lucchese | 2014 | International Journal of Oral Science2014，6，1： | 3 |
| 3 | A Newsvendor’s Procurement Problem when Suppliers Are Unreliable显示文摘 | Maqbool Dada Nicholas C. Petruzzi Leroy B. Schwarz | 2007 | Manufacturing & Service Operations Management2007，，1： | 2 |
| 4 | Pricing and the newsvendor problem: A review with extensions显示文摘 | Petruzzi N C Dada M | 1999 | Operations Research1999，47，： | 1 |
| 5 | Pricing and the newsvendor prob- lem: a review with extensions 显示文摘 | Petruzzi N C Dada M | 1999 | Operations Research1999，47，2： | 1 |
| 6 | Dada Pricing and the Newsvendor Problem: A review with extensions 显示文摘 | PETRUZZI MAQBOOL | 1999 | Operations Research1999，47，2： | 1 |
| 7 | Pricing and newsvendor problem : a review with extensions显示文摘 | Petruzzi N C Dada M | 1999 | Operations Research1999，47，2： | 1 |
| 8 | Pricing and the Newsvendor Problem: a Review with Extensions 显示文摘 | Petruzzi N C Dada M | 1999 | Operations Research1999，47，2： | 1 |
| 9 | Criteria to restore the sagittai balance in deformity and degenerative spondylolisthesis 显示文摘 | Lamartina C Berjano P Petruzzi M | 2012 | Eur Spine J2012，21，1： | 1 |
| 10 | Pricing and the newsvendor problem: A review with extensions显示文摘 | Petruzzi N C Dada M | 1999 | Operations Research1999，47，2： | 1 |
| 11 | A newsvendor's procurement problem when suppliers are unreliable 显示文摘 | Dada M Petruzzi N C Schwarz L B | 2007 | Manufacturing & Service Operations Manage- ment2007，9，1： | 1 |
| 12 | Chemoembolization of hepatocellu- lar carcinoma 显示文摘 | Lencioni R Petruzzi P Crocetti L | 2013 | Semin Intervent Radiol2013，30，1： | 1 |
| 13 | Pricing and the Newsvendor Problem: A Re- view With Extensions显示文摘 | Petruzzi N C Dada M | 1999 | Operations Research1999，47，2： | 1 |
| 14 | Criteria to restore the sagittal balance in deformity and degenerative spondylolisthesis显示文摘 | Lamartina C Berjano P Petruzzi M | 2012 | Eur Spine J2012，21，1： | 1 |
| 15 | Note: The newsvendormodel with endogenous demand 显示文摘 | J D DANA JR N C PETRUZZI | 2001 | Management Science2001，47，11： | 1 |
| 16 | An integrated productreturns model with logistics and marketing coordination显示文摘 | Yabalik B Petruzzi N C Chhajed D | 2005 | European Journal of Operational Research2005，161，1： | 1 |
| 17 | Pricing and the newsvendor problem: A review with extensions 显示文摘 | Petruzzi N C M Dada | 1999 | Operations Research1999，，2： | 1 |
| 18 | Consumer heterogeneity, product quality, and distributioncehannels显示文摘 | Shi H Y Liu Y C Petruzzi N C | 2013 | Management Science2013，59，5： | 1 |
| 19 | Pricing and the newsvendor problem: areview with extensions显示文摘 | N C PETRUZZI M DADA | 1999 | Operations Research1999，47，2： | 1 |
| 20 | Criteria to restore the sagit- tal balance in deformity and degenerative spondylolisthesis 显示文摘 | Lamartina C Berjano P Petruzzi M | 2012 | Eur Spine J2012，21，1： | 1 |
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