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| 1 | Rapid improvement of PM2.5 pollution and associated health benefits in China during 2013–2017显示文摘Exposure to fine particulate matter(PM2.5)is known to harm public health.In China,after implementation of aggressive emissions control measures under the Action Plan of Air Pollution Prevention and Control(2013-2017),air quality has significantly improved.In this work,we investigated changes in PM2.5 exposure and the associated health impacts in China for the period 2013-2017.We used an optimal estimator of PM2.5 combining in-situ observations,satellite measurements,and simulations from a chemical transport model to derive the spatial and temporal variations in PM2.5 exposure,and then used welldeveloped exposure-response functions to estimate the premature deaths attributable to PM2.5 exposure.We found that national population-weighed annual mean PM2.5 concentrations decreased from 67.4μgm-3 in 2013 to 45.5μgm-3 in 2017(32%reduction).This rapid decrease in PM2.5 pollution led to a 14%reduction in premature deaths due to long-term exposure.We estimated that,during 2013-2017,the premature deaths attributable to long-term PM2.5 exposure decreased from 1.2 million(95%CI:1.0,1.3;fraction of total mortality:13%)in 2013 to 1.0 million(95%CI:0.9,1.2;10%)in 2017.Despite the rapid decrease in annual mean PM2.5 concentrations,health benefits associated with reduced long-term exposure were limited,because for many cities,the PM2.5 levels remain at the portion where the exposure-response function is less steeper than that at the lowconcentration end.We also found that the deaths associated with acute exposure decreased by 61%during 2013-2017 due to rapid reduction in the number of heavily polluted days.Our results confirm that clean air policies in China have mitigated the air pollution crisis;however,continuous emissions reduction efforts are required to protect citizens from air pollution. | Tao XUE Jun LIU Qiang ZHANG Guannan GENG Yixuan ZHENG Dan TONG Zhu LIU Dabo GUAN Yu BO Tong ZHU Kebin HE Jiming HAO | 2019 | Science China Earth Sciences2019，62，12： | 17 |
| 2 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 3 | Identifying the molecular basis of Jinhong tablets against chronic superficial gastritis via chemical profile identification and symptom-guided network pharmacology analysis显示文摘Chronic superficial gastritis(CSG)is a common disease of the digestive system that possesses a serious pathogenesis.Jinhong tablet(JHT),a traditional Chinese medicine(TCM)prescription,exerts therapeutic effects against CSG.However,the molecular basis of its therapeutic effect has not been clarified.Herein,we employed ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC-Q/TOF-MS)based chemical profile identification to determine the chemical components in JHT.Further,we applied network pharmacology to illustrate its molecular mechanisms.A total of 96 chemical constituents were identified in JHT,31 of which were confirmed using reference standards.Based on the bioinformatics analysis using the symptom-guided pharmacological networks of“chi,”“blood,”“pain,”and“inflammation,”and target screening through the interaction probabilities between compounds and targets,matrix metalloproteinase 2(MMP2),dopamine d2 receptor(DRD2),and Aldo-keto reductase family 1 member B1(AKR1B1)were identified as key targets in the therapeutic effect exhibited by JHT against CSG.Moreover,according to the inhibitory activities presented in the literature and binding mode analysis,the structural types of alkaloids,flavonoids,organic acids,including chlorogenic acid(10),caffeic acid(13),(-)-corydalmine(33),(-)-isocorypalmine(36),isochlorogenic acid C(38),isochlorogenic acid A(41),quercetin-3-O-a-L-rhamnoside(42),isochlorogenic acid B(47),quercetin(63),and kaempferol(70)tended to show remarkable activities against CSG.Owing to the above findings,we systematically identified the chemical components of JHT and revealed its molecular mechanisms based on the symptoms associated with CSG. | Danfeng Shi Lingxian Liu Haibo Li Dabo Pan Xiaojun Yao Wei Xiao Xinsheng Yao Yang Yu | 2022 | Journal of Pharmaceutical Analysis2022，12，1： | 6 |
| 4 | Estimating inter-regional trade flows in China: A sector-specific statistical model显示文摘中国以社会经济的开发,工业结构,自然资源天赋,和工艺的前进在它的区域之中有巨大的差别。这些差别在中国创造了在区域之间的复杂连接。在这研究,在严肃模型和地点商技术之上造,我们开发一个扇区特定的模型估计内部省的贸易流动,它是为做一张多地区性的输入产量表格的底。在模型,我们与更大的 intra 扇区输入与更少的 intra 扇区输入把部门与那些区分开来,并且当时,假设以前的部门趋于在区域之中竞争后者趋于在区域之中合作。然后,我们把内部地区性的贸易评价的这个新方法用于三个部门:食物和烟草,熔炼并且处理的金属,和电的设备。结果证明带宽的那种选择在对内部地区性的贸易的评价以后有重要影响。贸易流动是随带宽的增加散布的更多。作为结果,带宽反映地理活动的空间集中,它应该为不同工业是可区分的。我们断定扇区特定的空间模型能增加内部地区性的贸易流动的估计的可靠。 | LIU Weidong LlXin LIU Hongguang TANG Zhipeng GUAN Dabo | 2015 | Journal of Geographical Sciences2015，25，10： | 5 |
| 5 | Epstein-Barr virus-encoded RNAs as a survival predictor in nasopharyngeal carcinoma显示文摘 | Ke Kengjian Wang Haiyun Fu Sha Zhang Zichen Duan Liping Liu Dabo Ye Jin | 2014 | Chinese Medical Journal2014，，2： | 5 |
| 6 | The contribution of Chinese exports to climate change显示文摘 | Christopher L. Weber Glen P. Peters Dabo Guan Klaus Hubacek | 2008 | Energy Policy2008，，9： | 4 |
| 7 | Rifaximin Alters Intestinal Bacteria and Prevents Stress-Induced Gut Inflammation and Visceral Hyperalgesia in Rats显示文摘 | Dabo Xu Jun Gao Merritt Gillilland Xiaoyin Wu Il Song John Y. Kao Chung Owyang | 2014 | Gastroenterology2014，，2： | 4 |
| 8 | 1H nuclear magnetic resonance spectroscopy-basedmetabonomic study in patients with cirrhosis and hepaticencephalopathy显示文摘AIM: To identify plasma metabolites used as biomarkers in order to distinguish cirrhotics from controls and encephalopathics.METHODS: A clinical study involving stable cirrhotic patients with and without overt hepatic encephalopathy was designed. A control group of healthy volunteers was used. Plasma from those patients was analysed using 1H- nuclear magnetic resonance spectroscopy. We used the Carr Purcell Meiboom Gill sequence to process the sample spectra at ambient probe temperature. We used a gated secondary irradiation field for water signal suppression. Samples were calibrated and referenced using the sodium trimethyl silyl propionate peak at 0.00 ppm. For each sample 128 transients(FID's) were acquired into 32 K complex data points over a spectral width of 6 KHz. 30 degree pulses were applied with an acquisition time of 4.0 s in order to achieve better resolution, followed by a recovery delay of 12 s, to allow for complete relaxation and recovery of the magnetisation. A metabolic profile was created for stable cirrhotic patients without signs of overt hepatic encephalopathy and encephalopathic patients as well as healthy controls. Stepwise discriminant analysis was then used and discriminant factors were created to differentiate between the three groups.RESULTS: Eighteen stabled cirrhotic patients, eighteen patients with overt hepatic encephalopathy and seventeen healthy volunteers were recruited. Patients with cirrhosis had significantly impaired ketone body metabolism, urea synthesis and gluconeogenesis. This was demonstrated by higher concentrations of acetoacetate(0.23 ± 0.02 vs 0.05 ± 0.00, P < 0.01), and b-hydroxybutarate(0.58 ± 0.14 vs 0.08 ± 0.00, P < 0.01), lower concentrations of glutamine(0.44 ± 0.08 vs 0.63 ± 0.03, P < 0.05), histidine(0.16 ± 0.01 vs 0.36 ± 0.04, P < 0.01) and arginine(0.08 ± 0.01 vs 0.14 ± 0.02, P < 0.03) and higher concentrations of glutamate(1.36 ± 0.25 vs 0.58 ± 0.04, P < 0.01), lactate(1.53 ± 0.11 vs 0.42 ± 0.05, P < 0.01), pyruvate(0.11 ± 0.02 vs 0.03 ± 0.00, P < 0.01) threonine(0.39 ± 0.02 vs 0.08 ± 0.01, P < 0.01) and aspartate(0.37 ± 0.03 vs 0.03 ± 0.01). A five metabolite signature by stepwise discriminant analysis could separate between controls and cirrhotic patients with an accuracy of 98%. In patients with encephalopathy we observed further derangement of ketone body metabolism, impaired production of glycerol and myoinositol, reversal of Fischer's ratio and impaired glutamine production as demonstrated by lower b-hydroxybutyrate(0.58 ± 0.14 vs 0.16 ± 0.02, P < 0.0002), higher acetoacetate(0.23 ± 0.02 vs 0.41 ± 0.16, P < 0.05), leucine(0.33 ± 0.02 vs 0.49 ± 0.05, P < 0.005) and isoleucine(0.12 ± 0.02 vs 0.27 ± 0.02, P < 0.0004) and lower glutamine(0.44 ± 0.08 vs 0.36 ± 0.04, P < 0.013), glycerol(0.53 ± 0.03 vs 0.19 ± 0.02, P < 0.000) and myoinositol(0.36 ± 0.04 vs 0.18 ± 0.02, P < 0.010) concentrations. A four metabolite signature by stepwise discriminant analysis could separate between encephalopathic and cirrhotic patients with an accuracy of 87%.CONCLUSION: Patients with cirrhosis and patients with hepatic encephalopathy exhibit distinct metabolic abnormalities and the use of metabonomics can select biomarkers for these diseases. | Konstantinos John Dabos John Andrew Parkinson Ian Howard Sadler John Nicholas Plevris Peter Clive Hayes | 2015 | World Journal of Hepatology2015，7，12： | 3 |
| 9 | Factors associated with coverage of praziquantel for schistosomiasis control in the communitydirect intervention (CDI) approach in Mali (West Africa)显示文摘Background:Despite the progress made in the control of Neglected Tropical Diseases(NTD),schistosome and soil-transmitted helminth infections are far from being effectively managed in many parts of the world.Chemotherapy,the key element of all control strategies,is faced with some difficulties in terms of access to treatment.Our study aims to describe the factors involved in the success or failure of the community-directed intervention(CDI)approach through control programmes,which aims to achieve consistent high coverage at affordable and sustainable costs in endemic areas.Methods:The CDI approach was carried out from December 2007 to October 2008 in ten villages of the district of Diéma,Mali.At inclusion,each child part of the study’s sample was interviewed and submitted for a physical examination.The study focused on:data collection,treatment of the eligible population,evaluation of the treatment coverage,performance of community drug distributors(CDDs),and the involvement and perception of populations.Results:A total of 8,022 eligible people were studied with a mean coverage rate of 76.7%.Using multiple regression,it was determined that receiving praziquantel as treatment was associated with five factors:belonging to the Fulani or Moorish ethnic minority versus the Bambara/Soninke,use of the central versus the house-to-house drug distribution mode,the ratio of the population to the number of CDDs,the lack of supervision and belonging to the age group of 15 years or above(p<0.05).As well as that,it was found that the presence of parallel community-based programmes(HIV,tuberculosis)that provide financial incentives for community members discouraged many CDDs(who in most cases are volunteers)to participate in the CDI approach due to a lack of incentives.Conclusions:The findings indicate that the success of the CDI approach depends on,amongst other things,the personal characteristics of the respondents,as well as on community factors. | Abdoulaye Dabo Boubacar Bary Bourema Kouriba Oumar Sankaré Ogobara Doumbo | 2013 | Infectious Diseases of Poverty2013，2，1： | 3 |
| 10 | Performance Assessment and Outlook of China's Emission-Trading Scheme显示文摘 | Dabo Guan Yuli Shan Zhu Liu Kebin He | 2016 | Engineering2016，2，4： | 3 |
| 11 | Quantum-continuum simulation of underpotential deposition at electrified metal–solution interfaces显示文摘The underpotential deposition of transition metal ions is a critical step in many electrosynthetic approaches.While underpotential deposition has been intensively studied at the atomic level,first-principles calculations in vacuum can strongly underestimate the stability of underpotentially deposited metals.It has been shown recently that the consideration of co-adsorbed anions can deliver more reliable descriptions of underpotential deposition reactions;however,the influence of additional key environmental factors such as the electrification of the interface under applied voltage and the activities of the ions in solution have yet to be investigated.In this work,copper underpotential deposition on gold is studied under realistic electrochemical conditions using a quantum-continuum model of the electrochemical interface.We report here on the influence of surface electrification,concentration effects,and anion co-adsorption on the stability of the copper underpotential deposition layer on the gold(100)surface. | Stephen E.Weitzner Ismaila Dabo | 2017 | npj Computational Materials2017，，1： | 2 |
| 12 | The drivers of Chinese CO 2 emissions from 1980 to 2030显示文摘 | Dabo Guan Klaus Hubacek Christopher L. Weber Glen P. Peters David M. Reiner | 2008 | Global Environmental Change2008，，4： | 2 |
| 13 | Five tips for China to realize its co-targets of climate mitigation and Sustainable Development Goals(SDGs)显示文摘In 2018,a total of US$166 billion global economic losses and a new high of 55.3 Gt of CO_(2)equivalent emission were generated by 831 climate-related extreme events.As the world’s largest CO_(2)emitter,we reported China’s recent progresses and pitfalls in climate actions to achieve climate mitigation targets(i.e.,limit warming to 1.5-2°C above the pre-industrial level).We first summarized China’s integrated actions(2015 onwards)that benefit both climate change mitigation and Sustainable Development Goals(SDGs).These projects include re-structuring organizations,establishing working goals and actions,amending laws and regulations at national level,as well as increasing social awareness at community level.We then pointed out the shortcomings in different regions and sectors.Based on these analyses,we proposed five recommendations to help China improving its climate policy strategies,which include:1)restructuring the economy to balance short-term and long-term conflicts;2)developing circular economy with recycling mechanism and infrastructure;3)building up unified national standards and more accurate indicators;4)completing market mechanism for green economy and encouraging green consumption;and 5)enhancing technology innovations and local incentives via bottom-up actions. | Chi Zhang Wenjia Cai Zhu Liu Yi-Ming Wei Dabo Guan Zheng Li Jinyue Yan Peng Gong | 2020 | Geography and Sustainability2020，1，3： | 2 |
| 14 | Embodied carbon emissions in China-US trade显示文摘China-US trade holds great significance for the world’s political and economic landscape.Since 2018,the US government has imposed additional tariffs on Chinese exports on the grounds of the US trade deficit with China.However,the transfer of pollutants embodied in trade and the differences in environmental costs between China and the US have not been widely recognized.In this study,we quantify the embodied carbon emissions(the'virtual'emissions associated with trade and consumption)in China-US trade by constructing a carbon dioxide emissions inventory and a multiregional input-output model.The study shows that the US benefits from a trade surplus of environmental costs by importing energy-intensive and pollutionintensive products from China,which increases China’s environmental pollution and abatement costs.In 2017,288 Mt CO2 emissions were associated with products produced in China but finally consumed in the US,and only 46 Mt CO2 were associated with the US products that were consumed in China.From this perspective,China-US trade results in a net transfer of 242 Mt CO2 per year from the US to China,accounting for approximately 5%of the total CO2 emissions in the US.More importantly,for Chinese products exported to the US,the carbon emissions embodied in one unit of economic value amount to 0.92 kg/$(RMB:USD=6.8:1),but for US products exported to China,the carbon emissions embodied in one unit of economic value amount to 0.53 kg/$,which means China will incur environmental costs that are 74%higher than those of the US while enjoying the same economic benefits.This environmental trade deficit has burdened China with higher environmental costs than economic benefits.To address this environmental trade deficit,China should actively promote further industrial upgrading and energy structure adjustment and increase investment in innovation and R&D,thereby increasing the value added per unit of export products and reducing the environmental cost of producing export products. | Zhu LIU Jing MENG Zhu DENG Ping LU Dabo GUAN Qiang ZHANG Kebin HE Peng GONG | 2020 | Science China Earth Sciences2020，63，10： | 2 |
| 15 | COVID-19:A pluralistic and integrated approach for efficient management of the pandemic显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which triggered the ongoing pandemic,was first discovered in China in late 2019.SARSCoV-2 is a respiratory virus responsible for coronavirus disease 2019(COVID-19)that often manifests as a pneumonic syndrome.In the context of the pandemic,there are mixed views on the data provided by epidemiologists and the information collected by hospital clinicians about their patients.In addition,the literature reports a large proportion of patients free of pneumonia vs a small percentage of patients with severe pneumonia among confirmed COVID-19 cases.This raises the issue of the complexity of the work required to control or contain the pandemic.We believe that an integrative and pluralistic approach will help to put the analyses into perspective and reinforce collaboration and creativity in the fight against this major scourge.This paper proposes a comprehensive and integrative approach to COVID-19 research,prevention,control,and treatment to better address the pandemic.Thus,this literature review applies a pluralistic approach to fight the pandemic. | Nouhoum Bouare Daouda Kassim Minta Abdoulaye Dabo Christiane Gerard | 2022 | World Journal of Virology2022，11，1： | 2 |
| 16 | Outsourcing CO2 within China显示文摘 | Kuishuang Feng Steven J. Davis Laixiang Sun Xin Li Dabo Guan Weidong Liu Zhu Liu Klaus Hubacek | 2013 | Proceedings of the National Academy of Sciences2013，，28： | 2 |
| 17 | dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection显示文摘 | Dabo S Meurs EF | 2012 | Viruses2012，4，： | 1 |
| 18 | Bermudagrass cultivars identification by use of isozymeelectrophoretic patterns显示文摘 | Dabo S M | 1990 | Euphytica1990，51，： | 1 |
| 19 | The drivers of Chinese C02 emissions from 1980 to 2030 显示文摘 | Guan Dabo Hubacek K Weber C L | 2008 | Global Environmental Change2008，，62： | 1 |
| 20 | TCP transcription factors predate the emergence of land plants 显示文摘 | Navaud O Dabos P Carnus E | 2007 | J Mol Evol2007，65，1： | 1 |
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