|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 3 | Anti-osteoarthritis effect of a combination treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin 2 in rabbits显示文摘BACKGROUND Osteoarthritis(OA),a chronic age-related disease characterized by the slowly progressive destruction of articular cartilage,is one of the leading causes of disability.As a new strategy for treatment of OA,mesenchymal stem cells(MSCs)have the potential for articular cartilage regeneration.Meanwhile,thrombospondin 2(TSP2)promotes the chondrogenic differentiation of MSCs.AIM To investigate whether TSP2 induces chondrogenic differentiation of human adipose-derived MSCs(hADMSCs)and potentiates the therapeutic effects of hADMSCs in OA rabbits.METHODS We investigated the chondrogenic potential of TSP2 in hADMSCs by analyzing the expression of chondrogenic markers as well as NOTCH signaling genes in normal and TSP2 small interfering RNA(siRNA)-treated stem cells.Anterior cruciate ligament transection surgery was performed in male New Zealand white rabbits,and 8 wk later,hADMSCs(1.7×10^6 or 1.7×10^7 cells)were injected into the injured knees alone or in combination with intra-articular injection of TSP2(100 ng/knee)at 2-d intervals.OA progression was monitored by gross,radiological,and histological examinations.RESULTS In hADMSC culture,treatment with TSP2 increased the expression of chondrogenic markers(SOX9 and collagen Ⅱ)as well as NOTCH signaling genes(JAGGED1 and NOTCH3),which were inhibited by TSP2 siRNA treatment.In vivo,OA rabbits treated with hADMSCs or TSP2 alone exhibited lower degree of cartilage degeneration,osteophyte formation,and extracellular matrix loss 8 wk after cell transplantation.Notably,such cartilage damage was further alleviated by the combination of hADMSCs and TSP2.In addition,synovial inflammatory cytokines,especially tumor-necrosis factor-α,markedly decreased following the combination treatment.CONCLUSION The results indicate that TSP2 enhances chondrogenic differentiation of hADMSCs via JAGGED1/NOTCH3 signaling,and that combination therapy with hADMSCs and TSP2 exerts synergistic effects in the cartilage regeneration of OA joints. | Kyungha Shin Yeseul Cha Young-Hwan Ban Da Woom Seo Ehn-Kyoung Choi Dongsun Park Sung Keun Kang Jeong Chan Ra Yun-Bae Kim | 2019 | World Journal of Stem Cells2019，11，12： | 2 |
| 4 | Sp1 binding activity increases in activated ho cells 显示文摘 | Rippe RA Almounajed G Brenner DA | 1995 | Hepatology1995，，： | 1 |
| 5 | Familial pre- disposition to developmental dysplasia of the hip 显示文摘 | Stevenson DA Mineau G Kerber RA | 2009 | J Ped- iatr Orthop2009，29，： | 1 |
| 6 | Systematic and integrative a- nalysis of large gene lists using DAVID bioinformatics resources显示文摘 | Huang da W Sherman BT Lempicki RA | 2009 | Nat Protoc2009，4，1： | 1 |
| 7 | A structural model of health behavior:a pragmatic approach to explain and influence health behaviors at the population level 显示文摘 | Cohen DA Scribner RA Farley TA | 2000 | Preventive Medicine2000，30，： | 1 |
| 8 | Leiomyosarcoma of the buccal mucosa: A Case report 显示文摘 | Mesquita RA Migliari DA Macbado SO | 1998 | J Oral Maxillofac Surg1998，56，： | 1 |
| 9 | The structure of the potassium channel :Molecular basis of K conduction and selectivity显示文摘 | Doyle DA Morais Cabral J Pfuetzner RA | 1998 | Science1998，280，： | 1 |
| 10 | A technique to immobilize bioactive proteins, including bone morphogenetic protein-4 (BMP-4) on titanium alloy显示文摘 | Puleo DA Kissling RA Shet MS | 2002 | Biomaterials2002，23，9： | 1 |
| 11 | The effect of nitrous oxide on the inhibition of somatosensory evoked potentials by sevoflurane in children显示文摘 | da Costa VV Saraiva RA de Almeida AC | 2001 | Anesthesia2001，56，3： | 1 |
| 12 | Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum显示文摘 | Fidock DA Nomura T Cooper RA | 2000 | Mol Biochem Parasitol2000，110，1： | 1 |
| 13 | Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection 显示文摘 | Petrovas C Chaon B Amhrozak DR Price DA Melen- horst JJ Hill BJ Geldmacher C Casazza JP Chatto- padhyay PK Roederer M Douek DC Mueller YM Jacob- son JM Kulkarni V Felber BK Pavlakis GN Katsikis PD Koup RA | 2009 | J Immunol2009，183，2： | 1 |
| 14 | Choroid plexus cyst and echogenic intracardiac focus in women at low risk for chromosomal anomalies 显示文摘 | Filly RA Benacerraf BR Nyberg DA Hobbins JC | 2004 | J Ultrasound Med2004，23，： | 1 |
| 15 | Lineage choice and differentiation in mouse embryos and embryonic stem cells显示文摘 | Loebel DA Watson CM de Young RA | 2003 | Dev Biol2003，264，1： | 1 |
| 16 | Surface ex- pression patterns of negative regulatory molecules identify determinants of virus-specific CD8 T-cell exhaustion in HIV infection 显示文摘 | Yamamoto T Price DA Casazza JP Ferrari G Nason M Chattopadhyay PK Roederer M Gostick E Katsikis PD Douek DC Haubrich R Petrovas C Koup RA | 2011 | Blood2011，117，18： | 1 |
| 17 | Pretreatment serum antimüllerian hormone predicts long-term ovarian function and bone mass after chemotherapy for early breast cancer显示文摘 | Anderson RA Cameron DA | 2011 | J Clin Endocrinol Metab2011，96，： | 1 |
| 18 | Influence of body mass index on median nerve function, carpal tunnel pressure, and cross-sectional area of the median nerve 显示文摘 | Werner RA Jacobson JA Jamadar DA | 2004 | Muscle Nerve2004，30，3： | 1 |
| 19 | Negative Thermal Ion Mass Spectrometry of Osmium, Rhenium and Iridium显示文摘 | Creaser RA Papanastassiou DA Wasserburg GJ | 1991 | Geochim Cosmochim Acta1991，55，： | 1 |
| 20 | Characterization of fatty acid synthase in cell linesderived from experimental mammary tumors显示文摘 | Hennigar RA Pochet M Hunt DA | 2005 | Biochim Biophy Acta2005，1392，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员