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| 1 | HPLC–MS and HPLC–MS/MS analysis of seven active constituents of Xiao-Xu-Ming decoction and application to a pharmacokinetic study after oral administration to rat显示文摘Xiao-xu-ming decoction(XXMD)is a traditional Chinese medicine that has been widely used to treat theoplegia and its sequelae.This paper reports the development of three separate assays based on reversed phase high-performance liquid chromatography–mass spectrometry(HPLC–MS)and HPLC–MS/MS for the determination of seven active constituents of XXMD viz oroxylin A-7-O-glucuronide,wogonoside,liquiritigenin,cimifugin,5-O-methylvisammiol,glycyrrhizic acid and glycyrrhetinic acid in rat plasma.All calibration curves were linear(r >0.99)with lower limits of quantitation(LLOQs)<12.4 ng/mL.Intra-and inter-day precisions(as relative standard deviation)were all <10.7% with recoveries in the range of 88.7–113%.In addition,the seven analytes were shown to be stable in rat plasma samples under relevant storage conditions.The validated methods were successfully applied to a pharmacokinetic study in rat after oral administration of XXMD. | Yilin Wang Chunguang Ding Caisheng Wu Kehe Du Jinlan Zhangn Hailin Qin Jinfeng Hou Guanhua Du | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 6 |
| 2 | Source complexity of the 2016 M_W7.8 Kaikoura (New Zealand) earthquake revealed from teleseismic and InSAR data显示文摘On November 13, 2016, an MW7.8 earthquake struck Kaikoura in South Island of New Zealand. By means of back-projection of array recordings, ASTFs-analysis of global seismic recordings, and joint inversion of global seismic data and co-seismic In SAR data, we investigated complexity of the earthquake source. The result shows that the 2016 MW7.8 Kaikoura earthquake ruptured about 100 s unilaterally from south to northeast(~N28°–33°E), producing a rupture area about 160 km long and about 50 km wide and releasing scalar moment 1.01×1021 Nm. In particular, the rupture area consisted of two slip asperities, with one close to the initial rupture point having a maximal slip value ~6.9 m while the other far away in the northeast having a maximal slip value ~9.3 m. The first asperity slipped for about 65 s and the second one started 40 s after the first one had initiated. The two slipped simultaneously for about 25 s.Furthermore, the first had a nearly thrust slip while the second had both thrust and strike slip. It is interesting that the rupture velocity was not constant, and the whole process may be divided into 5 stages in which the velocities were estimated to be 1.4 km/s, 0 km/s, 2.1 km/s, 0 km/s and 1.1 km/s, respectively. The high-frequency sources distributed nearly along the lower edge of the rupture area, the highfrequency radiating mainly occurred at launching of the asperities, and it seemed that no high-frequency energy was radiated when the rupturing was going to stop. | HaiLin Du Xu Zhang LiSheng Xu WanPeng Feng Lei Yi Peng Li | 2018 | Earth and Planetary Physics2018，2，4： | 4 |
| 3 | Source process of M_s6.4 earthquake in Ning’er, Yunnan in 2007显示文摘The moment tensor solution, source time function and spatial-temporal rupture process of the MS6.4 earthquake, which occurred in Ning’er, Yunnan Province, are obtained by inverting the broadband waveform data of 20 global stations. The inverted result shows that the scalar seismic moment is 5.51×1018 Nm, which corresponds to a moment magnitude of MW 6.4. The correspondent best double couple solution results in two nodal planes of strike 152°/dip 54°/rake 166°, and strike 250°/dip 79°/ rake 37°, respectively. Considering the isoseismals and geological structures in the meizoseismal region, the first nodal plane (strike 152°/ dip 54°/ rake 166°) is preferred to be the seismogenic fault. Thus, the MS6.4 earthquake occurred mainly along a right-lateral fault striking 152°. The source time function shows that the duration time of the earthquake is about 14 s. The most of the energy releases within the first 11 s and in 11-14 s the rupture is weak. The snapshots of the slip-rate indicate that the rupture process has 3 more detailed stages. In the first stage of the first 4 s after rupture initiation, the rupture propagates simultaneously toward both strike and dip directions; in the second stage of the following 3 s, the rupture extends to down-dip direction; and in the third stage, the rupture looks to be scattering on the fault. In general, this earthquake is of bilateral rupture, and the rupture mainly takes place in strike-dip direction. The major ruptured area is in the shape of a diamond with a dimension of 19 km. On the whole fault plane, the maximum slip is about 1.2 m, the average slip is about 0.1 m, the maxi-mum slip-rate is 0.4 m/s and the average slip-rate is 0.1 m/s. The features of the co-seismic theoretical displacement field of the Ning’er earthquake fault, calculated based on the inverted fault parameters, are consistent with those of the observed isoseismals. | ZHANG Yong XU LiSheng CHEN YunTai FENG WanPeng DU HaiLin | 2009 | Science China Earth Sciences2009，52，2： | 4 |
| 4 | Tree species classification using deep learning and RGB optical images obtained by an unmanned aerial vehicle显示文摘The diversity of tree species and the complexity of land use in cities create challenging issues for tree species classification.The combination of deep learning methods and RGB optical images obtained by unmanned aerial vehicles(UAVs) provides a new research direction for urban tree species classification.We proposed an RGB optical image dataset with 10 urban tree species,termed TCC10,which is a benchmark for tree canopy classification(TCC).TCC10 dataset contains two types of data:tree canopy images with simple backgrounds and those with complex backgrounds.The objective was to examine the possibility of using deep learning methods(AlexNet,VGG-16,and ResNet-50) for individual tree species classification.The results of convolutional neural networks(CNNs) were compared with those of K-nearest neighbor(KNN) and BP neural network.Our results demonstrated:(1) ResNet-50 achieved an overall accuracy(OA) of 92.6% and a kappa coefficient of 0.91 for tree species classification on TCC10 and outperformed AlexNet and VGG-16.(2) The classification accuracy of KNN and BP neural network was less than70%,while the accuracy of CNNs was relatively higher.(3)The classification accuracy of tree canopy images with complex backgrounds was lower than that for images with simple backgrounds.For the deciduous tree species in TCC10,the classification accuracy of ResNet-50 was higher in summer than that in autumn.Therefore,the deep learning is effective for urban tree species classification using RGB optical images. | Chen Zhang Kai Xia Hailin Feng Yinhui Yang Xiaochen Du | 2021 | Journal of Forestry Research2021，32，5： | 3 |
| 5 | Application of dynamic analysis of strength reduction in the slope engineering under earthquake显示文摘At present,the methods of analyzing the stability of slope under earthquake are not accurate and reasonable because of some limitations. Based on the real dynamic tensile-shear failure mechanism of slope,the paper proposes dynamic analysis of strength reduction FEM (finite element method) and takes the reduction of shear strength parameters and tensile strength parameters into consideration. And it comprehensively takes the transfixion of the failure surface,the non-convergence of calculation and mutation of displacement as the criterion of dynamic instability and failure of the slope. The strength reduction factor under limit state is regarded as the dynamic safety factor of the slope under earthquake effect and its advantages are introduced. Finally,the method is applied in the seismic design of anchors supporting and anti-slide pile supporting of the slope. Calculation examples show that the application of dynamic analysis of strength reduction is feasible in the seismic design of slope engineering,which can consider dynamic interaction of supporting structure and rock-soil mass. Owing to its preciseness and great advantages,it is a new method in the seismic design of slope supporting. | Ye Hailin Zheng yingren Huang Runqiu Li Anhong Du Xiuli | 2010 | Engineering Sciences2010，8，3： | 2 |
| 6 | Towards carbon neutrality:A study on China's long-term low-carbon transition pathways and strategies显示文摘As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 years.This study fully considered the carbon-neutrality goal and the temperature rise constraints required by the Paris Agreement,by developing six long-term development scenarios,and conducting a quantitative evaluation on the carbon emissions pathways,energy transformation,technology,policy and investment demand for each scenario.This study combined both bottom-up and top-down methodologies,including simulations and analyses of energy consumption of end-use and power sectors(bottom-up),as well as scenario analysis,investment demand and technology evaluation at the macro level(top-down).This study demonstrates that achieving carbon neutrality before 2060 translates to significant efforts and overwhelming challenges for China.To comply with the target,a high rate of an average annual reduction of CO_(2) emissions by 9.3%from 2030 to 2050 is a necessity,which requires a huge investment demand.For example,in the 1.5℃ scenario,an investment in energy infrastructure alone equivalent to 2.6%of that year's GDP will be necessary.The technological pathway towards carbon neutrality will rely highly on both conventional emission reduction technologies and breakthrough technologies.China needs to balance a long-term development strategy of lower greenhouse gas emissions that meets both the Paris Agreement and the long-term goals for domestic economic and social development,with a phased implementation for both its five-year and long-term plans. | Jiankun He Zheng Li Xiliang Zhang Hailin Wang Wenjuan Dong Ershun Du Shiyan Chang Xunmin Ou Siyue Guo Zhiyu Tian Alun Gu Fei Teng Bin Hu Xiu Yang Siyuan Chen Mingtao Yao Zhiyi Yuan Li Zhou Xiaofan Zhao Ying Li Danwei Zhang | 2022 | Environmental Science and Ecotechnology2022，，1： | 2 |
| 7 | EGF enhances the migration of cancer cells by up-regulation of TRPM7显示文摘 | Haixia Gao Xingjuan Chen Xiaona Du Bingcai Guan Yani Liu Hailin Zhang | 2011 | Cell Calcium2011，，6： | 1 |
| 8 | EGF enhances the migration of cancer cells by up-regulation of TRPM7显示文摘 | Haixia Gao Xingjuan Chen Xiaona Du Bingcai Guan Yani Liu Hailin Zhang | 2011 | Cell Calcium2011，，6： | 1 |
| 9 | N^(6)-methyladenine is incorporated into mammalian genome by DNA polymerase显示文摘Dear Editor,DNA N^(6)-methylade nine(6mA),one of the most prevale nt epigenetic base modifications in prokaryotes,1 is recently found in multicellular eukaryotes.2-8 This nucleobase may have epigenetic roles in regulation of retrotransposons,chromatin organization,and so on.2-8 However,both our group9 and Greeks group10 noticed that eukaryotic DNA is easily contaminated with a minute of bacterial DNA,which carries overwhelmingly abundant 6mA(〜2%6mA/dA). | Xiaoling Liu Weiyi Lai Yao Li Shaokun Chen Baodong Liu Ning Zhang Jiezhen Mo Cong Lyu Jing ZhengL Ya-Rui Du Guibin Jiang Guo-Liang Xu Hailin Wang | 2021 | Cell Research2021，31，1： | 0 |
| 10 | Using GMOSTNet for Tree Detection Under Complex Illumination and Morphological Occlusion显示文摘Trees are an integral part of the forestry ecosystem.In forestry work,the precise acquisition of tree morphological parameters and attributes is affected by complex illumination and tree morphology.In order to minimize a series of inestimable problems,such as yield reduction,ecological damage,and destruction,caused by inaccurate acquisition of tree location information,this paper proposes a ground tree detection method GMOSTNet.Based on the four types of tree species in the GMOST dataset and Faster R-CNN,it extracted the features of the trees,generate candidate regions,classification,and other operations.By reducing the influence of illumination and occlusion factors during experimentation,more detailed information of the input image was obtained.Meanwhile,regarding false detections caused by inappropriate approximations,the deviation and proximity of the proposal were adjusted.The experimental results showed that the AP value of the four tree species is improved after using GMOSTNet,and the overall accuracy increases from the original 87.25%to 93.25%. | Zheng Qian Hailin Feng Yinhui Yang Xiaochen Du Kai Xia | 2020 | 国际计算机前沿大会会议论文集2020，，1： | 0 |
| 11 | Author Correction:N^(6)-methyladenine is incorporated into mammalian genome by DNA polymerase显示文摘We apologize for the mistake of the fund information in the acknowledgements.The correct information is as follows.This correction does not affect the description of the results or the conclusion of this work. | Xialing Liu Weiyi Lai Yao Li Shaokun Chen Baodong Liu Ning Zhang Jiezhen Mo Cong Lyu Jing Zheng Ya-Rui Du Guibin Jiang Guo-Liang Xu Hailin Wang | 2021 | Cell Research2021，31，2： | 0 |
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