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| 1 | Evaluation of hepatic cystic lesions显示文摘Hepatic cysts are increasingly found as a mere coincidence on abdominal imaging techniques, such as ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI). These cysts often present a diagnostic challenge. Therefore, we performed a review of the recent literature and developed an evidence-based diagnostic algorithm to guide clinicians in characterising these lesions. Simple cysts are the most common cystic liver disease, and diagnosis is based on typical USG characteristics. Serodiagnostic tests and microbubble contrast-enhanced ultrasound (CEUS) are invaluable in differentiating complicated cysts, echinococcosis and cystadenoma/cystadenocarcinoma when USG, CT and MRI show ambiguous findings. Therefore, serodiagnostic tests and CEUS reduce the need for invasive procedures. Polycystic liver disease (PLD) is arbitrarily defined as the presence of > 20 liver cysts and can present as two distinct genetic disorders: autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (PCLD). Although genetic testing for ADPKD and PCLD is possible, it is rarely performed because it does not affect the therapeutic management of PLD. USG screening of the liver and both kidneys combined with extensive family history taking are the cornerstone of diagnostic decision making in PLD. In conclusion, an amalgamation of these recent advances results in a diagnostic algorithm that facilitates evidence-based clinical decision making. | Marten A Lantinga Tom JG Gevers Joost PH Drenth | 2013 | World Journal of Gastroenterology2013，19，23： | 12 |
| 2 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 3 | Prevention of overuse: A view on upper gastrointestinal endoscopy显示文摘Many upper gastrointestinal(GI) endoscopies worldwide are performed for inappropriate indications. This overuse of healthcare negatively affects healthcare quality and puts pressure on endoscopy services. Dyspepsia is one of the most common inappropriate indications for upper GI endoscopy as diagnostic yield is low. Reasons for untimely referral are: unfamiliarity with dyspepsia guidelines,uncertainty about etiology of symptoms, and therapy failure. Unfiltered openaccess referrals feed upper GI endoscopy overuse. This review highlights strategies applied to diminish use of upper GI endoscopies for dyspepsia. First,we describe the impact of active guideline implementation. We found improved guideline adherence, but resistance was encountered in the process. Secondly, we show several forms of clinical assessment. While algorithm use reduced upper GI endoscopy volume, effects of referral assessment of individual patients were minor. A third strategy proposed Helicobacter pylori test and treat for all dyspeptic patients. Many upper GI endoscopies can be avoided using this strategy, but outcomes may be prevalence dependent. Lastly, empirical treatment with Proton pump inhibitors achieved symptom relief for dyspepsia and avoided upper GI endoscopies in about two thirds of patients. Changing referral behavior is complex as contributing factors are manifold. A collaboration of multiple strategies is most likely to succeed. | Judith J de Jong Marten A Lantinga Joost PH Drenth | 2019 | World Journal of Gastroenterology2019，25，2： | 3 |
| 4 | A molecular phylogeny of Phytophthora and related oomycetes显示文摘 | COOKE D E L DRENTH A DUNCAN J M | 2000 | Fungal Genetics and Biology2000，30，： | 1 |
| 5 | Whole-genome a-nalysis of dorsal-ventral patterning in the Drosophila embryo显示文摘 | STATHOPOULOS A Van DRENTH M ERIVES A | 2002 | Cell2002，111，5： | 1 |
| 6 | Origin of the A2 mating type of Phytophthora infestans outside Mexico显示文摘 | Goodwin S B Drenth A | 1997 | Phytopathology1997，87，： | 1 |
| 7 | A molecular phylogeny of Phytophthora and related oomycetes显示文摘 | COOKE D E L DRENTH A DUNCAN J M | 2000 | Fungal Genet Biol2000，30，1： | 1 |
| 8 | Molecular anal- ysis of MVK mutations and enzymatic activity in hyper- IgD and periodic fever syndrome 显示文摘 | Cuisset L Drenth J P Simon A | 2001 | Eur J Hum Gen- et2001，9，4： | 1 |
| 9 | AFLP linkage map of oomycet Phytophthora infestans 显示文摘 | Vander L T Write D E Drenth A | 1997 | Fungal Genet Biol1997，21，： | 1 |
| 10 | DNA fingerprinting uncovers a new sexually reproducing populatin of Phtophthora infestans in the Netherlands显示文摘 | DRENTH A TAS L C Q GOVER F | 1994 | Europeas Joural of Plant Disease1994，100，： | 1 |
| 11 | A mo- lecular phylogeny of Phytophthora and related oomyce- tes显示文摘 | Cooke D E L Drenth A Duncan J M | 2000 | Fungal Genetics and Biology2000，30，1： | 1 |
| 12 | Phytophthora sojae avirulence genes, RAPD, and RFLP markers used to construct a detailed genetic linkage map显示文摘 | Whisson S C Drenth A Maclean D J | 1995 | Mol Plant-Microbe Interaction1995，，8： | 1 |
| 13 | Formation and survival of cospores of Phytophthora infestans under natural conditions显示文摘 | DRENTH A JANSSEN EM GOVERS F | 1995 | Plant Pathol - ogy1995，44，： | 1 |
| 14 | Evolutionary relationships among Phytophthora species deduced from rDNA sequence analysis显示文摘 | Crawford A R Bassam B J Drenth A | 1996 | Mycol Res1996，100，： | 1 |
| 15 | A second worldwide migration and population displacement of Phytophthora infestans? 显示文摘 | Spielman L J Drenth A Davidse L C | 1991 | Plant Pathology1991，40，3： | 1 |
| 16 | Cloning and genetic analyses of two highly polymorphic, moderately repetitive nuclear DNAs from Phytophthora infestans显示文摘 | Goodwin S B Drenth A Fry W E | 1992 | Current Genetics1992，22，： | 1 |
| 17 | Formation and survival of oospores of Phytophthora infestans under natural conditions显示文摘 | DRENTH A JANSSEN E M GOVERS F | 1995 | Plant pathology1995，44，： | 1 |
| 18 | Population genetic structure of Phytophora infestans in the Netherlands 显示文摘 | FRY W E DRENTH A PIELMAN L J | 1991 | Phytopathotogy1991，81，： | 1 |
| 19 | Historical and recant migrations of Phytophthora infestans:chronology,pathways,and implications显示文摘 | Fry W E Goodwin S B Dyer A T Matuszak J M Drenth A Tooley P W Sujkowski L S Koh Y J Cohen B A Spielman L J Deahl K L Inglis D A Sandlan K P | | 0，，07： | 1 |
| 20 | The occurrence of the A2 mating type of Phytophthora infestans in the Netherlands; significance and consequences显示文摘 | Drenth A Turkensteen L J Govers F | | 0，，3： | 1 |
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