|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 2 | Principles of time domain reflectometry applied to measurement of rock mass deformation显示文摘 | Dowding C H Su M B O'Connor K | 1988 | International Journal of Rock Mechanics Mining Sciences & Geomechanics Abstracts1988，25，5： | 2 |
| 3 | Measurement of rock mass deformation with grouted coaxial antenna cables显示文摘 | Dowding C H Su M B O'Connor K | 1989 | Rock Mechanics and Rock Engineering1989，22，1： | 2 |
| 4 | Association of central obesity with early Carotid intima-media thickening is independent of that from other risk factors显示文摘 | Maher V O'Dowd M Carey M | 2009 | Int J Obes ( Lond)2009，33，1： | 1 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Future CH4 emissions from rice production显示文摘 | Anastasi C Dowding M Simpson V J | 1992 | Journal of Geophysical Research1992，97，： | 1 |
| 7 | An assessment of the effect of pulsed electrical fields on tenderness and selected quality attributes of post rigour beef muscle显示文摘 | O'Dowd L P Arimi J M Noci F Cronin D A Lyng J G | 2013 | Meat Sicence2013，93，2： | 1 |
| 8 | A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11 显示文摘 | O'Dowd BF Heiber M Chan A | 1993 | Gene1993，136，12： | 1 |
| 9 | Predictive factors for successful clinical outcome 1 year after an intensive com- bined physical and psychological programme for chronic low back pain显示文摘 | van Hooff M L Spruit M O'Dowd J | 2014 | Eur Spine J2014，23，1： | 1 |
| 10 | The relative importance of non-sea-salt sulphate and sea-salt aerosol to the marine cloud condensation nuclei population:Animproved multi-component aerosol-cloud droplet parametrization显示文摘 | O'Dowd C D Lowe J A Smith M H | 1999 | Quart J Roy Meteor Soc1999，125，556： | 1 |
| 11 | Isolation of 6-methoxy gossypol and 6,6'-dimethoxy gossypol from Gossypium barbadense sea island cotton显示文摘 | Dowd M K Pelitire S M | 2006 | Journal of Agricultural and Food Chemistry2006，54，9： | 1 |
| 12 | A human gene that shows identity with the gene enconding the angiotensin receptor is located on chromosome 11显示文摘 | O′Dowd BF Heiber M Chan A | 1993 | Gene1993，136，12： | 1 |
| 13 | A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome II 显示文摘 | O'Dowd B F Heiber M Chan A | 1993 | Gene1993，136，8： | 1 |
| 14 | Cottonseed Extraction with Mixtures of Acetone and Hexane显示文摘 | M S Kuk R Tetlow M K Dowd | 2005 | Journal of the American Oil Chemists'' Society2005，82，8： | 1 |
| 15 | Numericalsolution of the general two-dimensional inverse heatconduction problem(IHCP)显示文摘 | OSMAN A M DOWDING K J BECK J V | 1997 | Journal of HeatTransfer1997，119，： | 1 |
| 16 | Leaking underground storage tanks显示文摘 | Dowd R M | 1984 | Environmental Science and Technology1984，18，： | 1 |
| 17 | The impact of an electronic health record on nurse sensitive patient outcomes: An interrupted time series analysis显示文摘 | Dowding D W Turley M Garrido T | 2012 | Journal of the American Medical Informatics Association2012，19，4： | 1 |
| 18 | Benzodiazepine premedication may attenuate the stress response in daycase anesthesia: a pilor study显示文摘 | Duggan M Dowd N Omara D | 2002 | Can J Anaesth2002，49，9： | 1 |
| 19 | Improvements to laboratory-scale maize wetmilling proeedure显示文摘 | Dowd M K | 2003 | Industrial Corps and Produets2003，18，11： | 1 |
| 20 | Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus显示文摘 | Mellon J E Zelaya C A Dowd M K | 2011 | Letters in Applied Microbiology2011，52，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员