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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Zinc Phosphating显示文摘 | Donofrio John | 2000 | Metal Finishing2000，98，6： | 1 |
| 3 | Differences Between Nouns and Verbs After Anterior Temporal Lobectomy 显示文摘 | GUILA GLOSSERI and NANCY DONOFRIO | 2001 | Neuropsychology2001，15，： | 1 |
| 4 | Histopathology of pressure ulcers as a result of sequential computer-controlled pressure sessions in a fuzzy rat model显示文摘 | Salcido R Donofrio J C Fisher S B | 1994 | Adv Wound Care1994，7，24： | 1 |
| 5 | Global gene expression during nitrogen starvation in the rice blast fungus, Magnaporthe grisea 显示文摘 | N M Donofrio Y Oh R Lundy | 2006 | Fungal Genetics and Biology2006，43，9： | 1 |
| 6 | Brain Volume and Neurobehavior in Newborns with Complex Congenital Heart Defects显示文摘 | Mallory Owen Michael Shevell Mary Donofrio Annette Majnemer Robert McCarter Gilbert Vezina Marine Bouyssi-Kobar Iordanis Evangelou Dena Freeman Neil Weisenfeld Catherine Limperopoulos | 2013 | The Journal of Pediatrics2013，，： | 1 |
| 7 | Caspases activation in equine influenza virus induced apoptotic cell death 显示文摘 | Holland RE Donofrio JC McCoy MH Tudor LR Chambers TM | 2002 | Vet Microbiol2002，84，4： | 1 |
| 8 | Tricholemmal carcinoma:a study of seven cases显示文摘 | Boscaino A Terracciano LM Donofrio V | 1992 | Cutan Pathol1992，19，2： | 1 |
| 9 | Zinc Phosphating 显示文摘 | DONOFRIO JOHN | 2000 | Metal Finishing2000，98，6： | 1 |
| 10 | Inter-do- main Work-family, Family-work Conflict and Police Work Satisfaction显示文摘 | Howard W G Donofrio H H Boles J S | 2004 | Policing2004，27，3： | 1 |
| 11 | Classic Kaposi Sarcoma:to treat or not to treat?显示文摘 | Vincenzi B Donofrio L Frezza AM | 2015 | BMC Res Notes2015，8，： | 1 |
| 12 | Diagnosis and treatment of fetal cardiac disease a scientific statement from the American Heart Association 显示文摘 | Donofrio MT Moon-Grady AJ Hornberger LK | 2014 | Circulation2014，129，21： | 1 |
| 13 | Sequential electrodiagnostic abnormalities in acute inflammatory demyeIinating polyradieuloneuropathy显示文摘 | Albers JW Donofrio PD McGonagle TK | 1985 | Muscle Nerve1985，8，： | 1 |
| 14 | Expanding the use of neurotoxins in facial aestheties:a consensus panel's assessment and recommendations显示文摘 | KANE M DONOFRIO L ASCHER B | 2010 | J Drugs Dermatol2010，9，1： | 1 |
| 15 | Global gene expression dur- ing nitrogen starvation in the rice blast fungus, Magnaporthe grisea 显示文摘 | Donofrio NM Oh Y Lundy R | 2006 | Fungal Geaet Biol2006，43，9： | 1 |
| 16 | On pulse vaccination strategy in the SIR epidemic model with vertical transmission 显示文摘 | Donofrio A | 2005 | AppliedMathematics Letters2005，18，7： | 1 |
| 17 | Endothelial dysfunction but not increased carotid intima-media thickness in young European women with endometriosis显示文摘 | Santoro L Donofrio F Campo S | 2012 | Human Reproduction2012，27，5： | 1 |
| 18 | Abnormal callose response phenotype and hypersusceptibility to Peronospora parasitica in defense-compromised Arabidopsis nim 1-1 and salicylate hydroxylase-expressing plants显示文摘 | Delaney T P | 2001 | Mol Plant-Microbe Interact2001，14，： | 1 |
| 19 | Panfaeial volume restoration with fat 显示文摘 | Donofrio LM | 2005 | Der- matol Surg2005，31，11： | 1 |
| 20 | Intrahepaticperipheral cholangiocarcinoma (IPCC) : comparison between perfusion ultrasound and CT imaging 显示文摘 | Donofrio M Vecchiato F Cantisani V | 2008 | Radiol Med2008，113，1： | 1 |
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