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| 1 | PNPLA3 I148M polymorphism and progressive liver disease显示文摘The 148 Isoleucine to Methionine protein variant(I148M)of patatin-like phospholipase domain-containing 3(PNPLA3),a protein is expressed in the liver and is involved in lipid metabolism,has recently been identified as a major determinant of liver fat content.Several studies confirmed that the I148M variant predisposes towards the full spectrum of liver damage associated with fatty liver:from simple steatosis to steatohepatitis and progressive fibrosis.Furthermore,the I148M variant represents a major determinant of progression of alcohol related steatohepatitis to cirrhosis,and to influence fibrogenesis and related clinical outcomes in chronic hepatitis C virus hepatitis,and possibly chronic hepatitis B virus hepatitis,hereditary hemochromatosis and primary sclerosing cholangitis.All in all,studies suggest that the I148M polymorphism may represent a general modifier of fibrogenesis in liver diseases.Remarkably,the effect of the I148M variant on fibrosis was independent of that on hepatic steatosis and inflammation,suggesting that it may affect both the quantity and quality of hepatic lipids and the biology of non-parenchymal liver cells besides hepatocytes,directly promoting fibrogenesis.Therefore,PNPLA3 is a key player in liver disease progression.Assessment of the I148M polymorphism will possibly inform clinical practice in the future,whereas the determination of the effect of the 148M variant will reveal mechanisms involved in hepatic fibrogenesis. | Paola Dongiovanni Benedetta Donati Roberta Fares Rosa Lombardi Rosellina Margherita Mancina Stefano Romeo Luca Valenti | 2013 | World Journal of Gastroenterology2013，19，41： | 17 |
| 2 | Current position of ALPPS in the surgical landscape of CRLM treatment proposals显示文摘The Authors summarize problems,criticisms but also advantages and indications regarding the recent surgical proposal of associating liver partition and portal vein ligation(PVL)for staged hepatectomy(ALPPS)for the surgical management of colorectal liver metastases.Looking at published data,the technique,when compared with other traditional and well established methods such as PVL/portal vein embolisation(PVE),seems to give real advantages in terms of volumetric gain of future liver remnant.However,major concerns are raised in the literature and some questions remain unanswered,preliminary experiences seem to be promising.The method has been adopted all over the world over the last 2 years,even if oncological long-term results remain unknown,and benefit for patients is questionable.No prospective studies comparing traditional methods(PVE,PVL or classical 2 staged hepatectomy)with ALPPS are available to date.Technical reinterpretations of the original method were also proposed in order to enhance feasability and increase safety of the technique.More data about morbidity and mortality are also expected.The real role of ALPPS is,to date,still to be established.Large clinical studies,even if,for ethical reasons,in well selected cohorts of patients,are expected to better define the indications for this new surgical strategy. | Marcello Donati Gregor A Stavrou Karl J Oldhafer | 2013 | World Journal of Gastroenterology2013，19，39： | 16 |
| 3 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 4 | Postoperative biliary adverse events following orthotopic liver transplantation: Assessment with magnetic resonance cholangiography显示文摘Biliary adverse events following orthotopic liver transplantation(OLT) are relatively common and continue to be serious causes of morbidity, mortality, and transplant dysfunction or failure. The development of these adverse events is heavily influenced by the type of anastomosis during surgery. The low specificity of clinical and biologic findings makes the diagnosis challenging. Moreover, direct cholangiographic procedures such as endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiography present an inadmissible rate of adverse events to be utilized in clinically low suspected patients. Magnetic resonance(MR) maging with MR cholangiopancreatography is crucial in assessing abnormalities in the biliary system after liver surgery, including liver transplant. MR cholangiopancreatography is a safe, rapid, noninvasive, and effective diagnostic procedure for the evaluation of biliary adverse events after liver transplantation, since it plays an increasingly important role in the diagnosis and management of these events. Onthe basis of a recent systematic review of the literature the summary estimates of sensitivity and specificity of MR cholangiopancreatography for diagnosis of biliary adverse events following OLT were 0.95 and 0.92, respectively. It can provide a non-invasive method of imaging surgical reconstruction of the biliary anastomoses as well as adverse events including anastomotic and non-anastomotic strictures, biliary lithiasis and sphincter of Oddi dysfunction in liver transplant recipients. Nevertheless, conventional T2-weighted MR cholangiography can be implemented with T1-weighted contrast-enhanced MR cholangiography using hepatobiliary contrast agents(in particular using Gd-EOBDTPA) in order to improve the diagnostic accuracy in the adverse events' detection such as bile leakage and strictures, especially in selected patients with biliaryenteric anastomosis. | Piero Boraschi Francescamaria Donati | 2014 | World Journal of Gastroenterology2014，20，32： | 9 |
| 5 | 用于光电仪器和相关测量的自混合干涉技术(特邀)显示文摘回顾了一种全新结构的干涉仪—自混合干涉仪(SMI)的发展情况。SMI由于其在激光器外部无需任何光学元件且应用范围广泛而倍受关注。SMI可用于测量与光路长度有关的一些量(如位移、小幅度振动、速度),也可用于测量弱光的回波(即回波损耗和隔离因子的测量)并可表征与介质相互作用特性相关的物理参数(如激光线宽、相干长度以及α因子等)。SMI是一种相干探测方法,其工作在靠近接收场的量子极限处,目前对散射目标物的最小探测幅值可达槡20 pm/(Hz)~(1/2)甚至更高,使用角锥棱镜使其计数步长为半波长,在动态范围为2 m时其分辨率约为0.5μm。另外,SMI结构紧凑、易于现场安装且可用于MEMS测试、旋转机械振动测试和生物运行测试等各种实验。 | DONATI Silvano 王昭 禹延光 | 2012 | 中国光学2012，5，2： | 8 |
| 6 | Hepatorenal syndrome: Update on diagnosis and treatment显示文摘Acute kidney injury(AKI) is a common complication in patients with end-stage liver disease and advanced cirrhosis regardless of the underlying cause. Hepatorenal syndrome(HRS), a functional form of kidney failure, is one of the many possible causes of AKI. HRS is potentially reversible but involves highly complex pathogenetic mechanisms and equally complex clinical and therapeutic management. Once HRS has developed, it has a very poor prognosis. This review focuses on the diagnostic approach to HRS and discusses the therapeutic protocols currently adopted in clinical practice. | Olga Baraldi Chiara Valentini Gabriele Donati Giorgia Comai Vania Cuna Irene Capelli Maria Laura Angelini Maria Ilaria Moretti Andrea Angeletti Fabio Piscaglia Gaetano La Manna | 2015 | World Journal of Nephrology2015，4，5： | 5 |
| 7 | Titanium elastic nailing in diaphyseal femoral fractures of children below six years of age显示文摘AIM To report the clinical and radiographic results of titanium elastic nail(TEN) in diaphyseal femoral fractures of children below age of six years.METHODS A retrospective analysis of 27 diaphyseal femoral fractures in children younger than six years treated with TEN between 2005 and 2015 was conducted. Patients were immobilized in a cast for 5 wk and the nails were removed from 6 to 12 wk after surgery. Twenty-four cases were clinically and radiographically re-evaluated using the Flynn's scoring criteria, focusing on: Limb length discrepancy, rotational deformity, angulation, hip and knee range of motion(ROM), functional status, complications, and parent's satisfaction.RESULTS Sixteen males and eight females with a mean age of 3.2 years at the time of treatment were re-evaluated at an average follow-up of 58.9 mo. No cases of delayed union were observed. The mean limb lengthening was 0.3 cm. Four cases experienced limb lengthening greater than 1 cm and always minor than 2 cm. Twelve point five percent of the cases showed an angulation < 10°. Complete functional recovery(hip and knee ROM, ability to run and jump on the operated limb) occurred in 95.7% of cases. Complications included two cases of superficial infection of the TEN entry point, one case of refracture following a new trauma, and one TEN mobilization. According to the Flynn's scoring criteria, excellent results were obtained in 79.2% of patients and satisfactory results in the remaining 20.8%, with an average parent's satisfaction level of 9.1/10.CONCLUSION TEN is as a safe, mini-invasive and surgeon-friendly technique and, considering specific inclusion criteria, it represents a useful and efficacy option for the treatment of diaphyseal femoral fractures even in patients younger than six years of age. | Fabrizio Donati Giuseppe Mazzitelli Marco Lillo Amerigo Menghi Carla Conti Antonio Valassina Emanuele Marzetti Giulio Maccauro | 2017 | World Journal of Orthopedics2017，8，2： | 5 |
| 8 | Laparoscopic step 1 ALPPS with microwave transection of theliver for Klatskin tumors:Is it worthwhile?显示文摘To the Editor:Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)was introduced in 2007[1].This technique is now used worldwide and has a wide spectrum of indications.However,scientific debate and un-regulated surgical experimentation concerning the application of this technique led the surgeons to organize the first Consensus Meeting[2]to build a scientific consensus.One of the most controversial indications to ALPPS is its application for Klatskin tumors.The aim of this letter is to ana- | marcello donati francesco basile karl j oldhafer | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，3： | 4 |
| 9 | Biosorption of mercury by Macrocystis pyrifera and Undaria pinnatifida:Influence of zinc,cadmium and nickel显示文摘This study investigated the adsorption of Hg(Ⅱ) on Macrocystis pyrifera and Undaria pinnatifida in monometallic system in the presence of Zn(II),Cd(Ⅱ) and Ni(II).The two biosorbents reached the same maximum sorption capacity (q m = 0.8 mmol/g) for mercury.U.pinnatifida showed a greater affinity (given by the coefficient b of the Langmuir equation) for mercury compared to M.pyrifera (4.4 versus 2.7 L/mmol).Mercury uptake was significantly reduced (by more than 50%) in the presence of competitor heavy metals such as Zn(II),Cd(II) and Ni(Ⅱ).Samples analysis using an environmental scanning electron microscopy equipped with an energy dispersive X-ray microanalysis showed that mercury was heterogeneously adsorbed on the surface of both biomaterials,while the other heavy metals were homogeneous distributed.The analysis of biosorbents by Fourier transform infrared spectrometry indicated that Hg(Ⅱ) binding occurred on S=O (sulfonate) and N-H (amine) functional groups. | Josefina Plaza Marisa Viera Edgardo Donati Eric Guibal | 2011 | Journal of Environmental Sciences2011，23，11： | 3 |
| 10 | 本地混合菌群微生物氧化难处理含金硫化精矿(英文)显示文摘采用含铁氧化菌和硫氧化菌的混合嗜中温菌群浸出阿根廷Andacollo矿的含金硫化浮选精矿。实验在摇瓶中进行,矿浆浓度为10%,采用pH 1.8的含亚铁离子的基础盐溶液作为介质。采用不同的方法对浸出液的pH值、氧化还原电位、亚铁离子和总金属浓度进行测定。结果表明,该种混合菌能够很好地还原浸出该难处理金矿,金的回收率可达91.6%,同时,铜和锌的浸出率也较高。动力学研究表明金属的溶解符合收缩核模型。其中,铜的溶解速率受生成产物层的扩散控制,而锌的溶解没有明显的控制步骤。 | N. MARCHEVSKY M. M. BARROSO QUIROGA A. GIAVENO E. DONATI | 2017 | Transactions of Nonferrous Metals Society of China2017，27，5： | 3 |
| 11 | Pathways of flower infection and pollen-mediated dispersion of Pseudomonas syringae pv. actinidiae, the causal agent of kiwifruit bacterial canker显示文摘Flowers can provide a protected and nutrient-rich environment to the epiphytic microflora,thus representing a sensible entry point for pathogens such as Pseudomonas syringae pv.actinidiae(Psa).This bacterium can colonize both male and female Actinidia flowers,causing flower browning and fall,and systemic invasion of the host plant,eventually leading to its death.However,the process of flower colonization and penetration into the host tissues has not yet been fully elucidated.In addition,the presence of Psa in the pollen from infected flowers,and the role of pollination in the spread of Psa requires confirmation.The present study employed a Psa strain constitutively expressing the fluorescent GFPuv protein,to visualize in vivo flower colonization.Microscopy observations were performed by means of confocal laser scanning and wide-field fluorescent microscopy,and were coupled with the study of Psa population dynamics by quantitative PCR(q-PCR).The pathogen was shown to colonize stigmata,move along the stylar furrow,and penetrate the receptacles via the style or nectarhodes.Once the receptacle was invaded,the pathogen migrated along the flower pedicel and became systemic.Psa was also able to colonize the anthers epiphytically and endophytically.Infected male flowers produced contaminated pollen,which could transmit Psa to healthy plants.Finally,pollinators(Apis mellifera and Bombus terrestris)were studied in natural conditions,showing that,although they can be contaminated with Psa,the pathogen’s transmission via pollinators is contrasted by its short survival in the hive. | Irene Donati Antonio Cellini Giampaolo Buriani Sofia Mauri Callum Kay Gianni Tacconi Francesco Spinelli | 2018 | Horticulture Research2018，5，1： | 3 |
| 12 | Singing on the wings! Male wing fanning performances affect female willingness to copulate in the aphid parasitoid Lysiphlebus testaceipes (Hymenoptera: Braconidae: Aphidiinae)显示文摘Lysiphlebus testaceipes (Hymenoptera:Braconidae:Aphidiinae ) 是攻击超过 100 aphid 种类的通晓各方面知识经验丰富的人 endoparasitoid。在 L。testaceipes,翅膀扇是忍受女性的性 pheromone 唤起的主要男求爱显示。然而,没有信息在特征和在这 parasitoid 的在求爱期间的男性扇的行为的角色上是可得到的。这里, L 的野紧张的求爱行为。testaceipes 被确定,扇表演的男翅膀通过高速度的录像记录被分析并且在与交配成功的关系检验了。野 L 的求爱顺序。testaceipes 实质地没不同于那以前为质量在蚜虫上饲养了的另外的人口报导了。我们观察到男求爱持续时间没假装交配成功。然而,录像分析表明生产高周波的扇的信号的男性更高完成了在显示低频率的扇的那些上交配成功。翅膀在成功、失败的求爱前扇向配偶在翅膀运动和排列的振幅不同,断然加亮那正面的求爱影响交配决定的女性。这研究在蚜虫的关键 parasitoid 在性行为上增加知识,强调翅膀在在 L 的性通讯使用的感觉形式的范围之中扇的重要性。testaceipes。从一个实际观点,这个信息在 L 是有用的。基于 testaceipes 的 biocontrol 策略,后来,它能帮助为随着时间的过去的饲养团的黄蜂的优秀检查建立参数。 | Giovanni Benelli Nickolas G. Kavallieratos Elisa Donati Giulia Giunti Cesare Stefanini Angelo Canale | 2016 | Insect Science2016，23，4： | 2 |
| 13 | Bimanual microincision cataract surgery with implantation of the new Incise~? MJ14 intraocular lens through a 1.4 mm incision显示文摘AIM: To analyze the visual outcomes and the posterior capsule opacification(PCO) with the new Incise? MJ14 intraocular lens(IOL) implanted through a 1.4 mm clear corneal incision(CCI) in patients who underwent bimanual microincision cataract surgery(B-MICS). METHODS: Eighty eyes which underwent cataract surgery using B-MICS technique performed by the same experienced surgeon were included in the study: 40 eyes were implanted with an Incise? MJ14 IOL through a 1.4 mm CCI(group A)without enlargement of the main CCI, while 40 eyes were implanted with an Akreos? MI60 IOL with enlargement of the main CCI to 1.8 mm(group B). Best corrected visual acuity(BCVA), astigmatism and endothelial cell loss were evaluated before and after surgery at 7, 30 d and 6 mo.Anterior segment-optical coherence tomography(AS-OCT) of CCI was performed at 1, 3, 7, 30 d, 6 and 18 mo. PCO incidence was evaluated at 18 mo using EPCO 2000 Software. RESULTS: Mean BCVA improvement and endothelial cell loss were statistically significant at 18 mo in both groups with no difference between the two groups; no statistically significant difference in surgically induced astigmatism(SIA) was noticed in the two groups. At AS-OCT the only significant alterations in the CCI were endothelial gaping and local detachment of Descemet's membrane at 1 and 7 d after surgery; no statistically significant alterations were found at 1, 6 and 18 mo. PCO score at 18 mo was 0.03±0.07 for group A and 0.08±0.18 for group B(P=0.11) with no sign of central optic plate invasion in both groups.CONCLUSION: The implant of the new Incise? MJ14 IOL through a 1.4 mm CCI and B-MICS technique appeared to be a safe and effective procedure with rapid visual recovery. PCO rate resulted very low and the CCI presented few morphological alterations which were only detectable in the first days postoperatively and achieved fast corneal healing during the long-term follow-up. | Gian Maria Cavallini Tommaso Verdina Michele De Maria Elisa Fornasari Giulio Torlai Veronica Volante Simone Donati Carlo Cagini | 2017 | International Journal of Ophthalmology(English edition)2017，10，11： | 2 |
| 14 | Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke: A Statement for Health Care Professionals From the CRP Pooling Project Members显示文摘 | Mario Di Napoli Markus Schwaninger Roberto Cappelli Elena Ceccarelli Giacinto Di Gianfilippo Cristina Donati Hedley C.A. Emsley Sandro Forconi Stephen J. Hopkins Luca Masotti Keith W. Muir Anna Paciucci Francesca Papa Sabina Roncacci Dirk Sander Kerstin S | 2005 | Stroke2005，，6： | 2 |
| 15 | Is bigger better? Male body size affects wing-borne courtship signals and mating success in the olive fruit fly, Bactrocera oleae (Diptera: Tephritidae)显示文摘在男身体尺寸的变化被知道影响内部 -- 并且在大量动物的 intrasexual 选择结果。在交配包含在交配前的性发信号的系统,身体尺寸经常充当影响信号力量和配偶选择的一个关键因素。我们在求爱显示和橄榄水果苍蝇的交配成功上评估了男尺寸的效果, Bactrocera oleae (双翅目:Tephritidae ) 。大、小的男性在成功、失败的求爱期间执行的翅膀颤动被高速度的录像记录并且通过 frame-by-frame 分析了分析。交配大、小的男性的成功被调查。交配成功上的男性男性的竞争的效果被评估。男身体尺寸影响了两个男求爱信号和交配结果。成功的男性与高频率和短 interpulse 间隔显示出忍受翅膀的信号。成功的大男性在交媾期间显示的翅膀颤动在更小的男性和失败的大男性上尝试有的更高的频率。处于没有比赛条件,大男性更高完成了关于更小的交配成功。允许大、小的男性为女性,竞争大男性超过更小的获得更多的交配成功。由女性的配偶选择可以基于更大的男性,的选择能生产高周波的翅膀颤动。如此的特点可能 “good 基因是指示的, ”它在性选择下面能意味着好社会相互作用的基因,或 conspecifics 的一个好竞争操纵者。 | Giovanni Benelli Elisa Donati Donato Romano Giacomo Ragni Gabriella Bonsignori Cesare Stefanini Angelo Canale | 2016 | Insect Science2016，23，6： | 2 |
| 16 | Potentiation of atracurium neuromuscular blockade by enflurane:Timecourse of effect显示文摘 | Donati F Bevan DR | 1991 | Anaesth Analg1991，72，4： | 1 |
| 17 | 显示文摘 | Donati L | 2005 | Journal of Materials Processing Technology2005，，： | 1 |
| 18 | The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures显示文摘 | DONATI F GOBBI G CAMPISTOL J | 2007 | Seizure2007，16，5： | 1 |
| 19 | Coagulation factors and tumor cell biology:the role of tissue factor 显示文摘 | Donati MB Lorenzet R | 2003 | Pathophysiol Haemost Thromb2003，33，1： | 1 |
| 20 | Morphological correlates of the differential responses of muscles to vecuronium显示文摘 | Ibebunjo C Srikant CB Donati F | 1999 | Br J Anaesth1999，83，2： | 1 |
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