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| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | Quality of life, physical performance and nutritional status in older patients hospitalized in a cardiology department显示文摘Objectives Quality of life(QoL) is a priority outcome in older adults suffering from cardiovascular diseases. Frailty and poor nutritional status may affect the QoL through mobility disorders and exhaustion. The objective of this study was to determine if physical frailty and nutritional status were associated with QoL, in older cardiology patients. Methods Cross sectional, observational study conducted in a cardiology department from a university hospital. Participants(n = 100) were aged 70 and older. Collected data included age, sex, cardiac diseases, New York Heart Association(NYHA) classification, comorbidities(Charlson Index) and disability. A Short Physical Performance Battery(SPPB), including walking speed assessment was performed;handgrip strength were measured as well as Fried’s frailty phenotype. Nutritional status was assessed using the Mini Nutritional Assessment(MNA) and Body Mass Index(BMI), inflammation by C-reactive protein(CRP). QoL was assessed using the EORTC–QLQ questionnaire. Univariate and multivariate analyses were performed to study the associations between all recorded parameters and QoL. Results In participants(mean age: 79.3 ± 6.7 years;male: 59%), Charlson index, arrhythmia, heart failure, NYHA class III-IV, MNA, disability, walking speed, SPPB score, frailty and CRP were significantly associated with QoL in univariate analysis. Multivariate analysis showed that NYHA class III-IV(P < 0.001), lower MNA score(P = 0.03), frailty(P < 0.0001), and higher CRP(P < 0.001) were independently associated with decreased QoL. Conclusions Frailty, nutritional status and inflammation were independently associated with poor QoL. Further studies are needed to assess the efficacy of nutritional and physical interventions on QoL in this population. | Matthieu Lilamand Mariannick Saintout Marie Vigan Astrid Bichon Laure Tourame Aurélie Brembilla Diet Bernard Iung Dominique Himbert Cédric Laouenan Agathe Raynaud-Simon | 2020 | Journal of Geriatric Cardiology2020，17，7： | 3 |
| 3 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 4 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 5 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 6 | Empirical estimation of tail dependence using Copulas application to Asian mar- kets 显示文摘 | CYRIL C DOMINIQUE G | 2005 | Quantitative Finance2005，，5： | 1 |
| 7 | Atomic force micro-scopy imaging of hair: Correlations between surface potential and wetting at the nanometer scale显示文摘 | Vincent D Terri C Dominique L | 2004 | Journal of Colloid and Interface Science2004，269，2： | 1 |
| 8 | Myostatin regulation of muscle development:molecular basis,natural mutations,physiopalhological aspects 显示文摘 | Dominique JE Gerard C | 2006 | Exp Cell Res2006，312，6： | 1 |
| 9 | Empirical estimation of tail correlation using copulas:application to Asian markets显示文摘 | Cyril C Dominique M G | 2005 | Quantitative Finance2005，5，5： | 1 |
| 10 | A new material model for 2D numerical simulation of serrated chip formation when machining titanium alloy Ti-6Al-4V显示文摘 | MADALINA C DOMINIQUE C FRANCK G | | 0，，03： | 1 |
| 11 | Detection of irradiated deepl-Mfrozen foodstuffs by comparison of DEFT and APC counts显示文摘 | Mariel-MPierre Copln Dominique Jehanno and Bourgeois C M | 1993 | Journal of AppLied Bacteriology1993，75，： | 1 |
| 12 | Inter- conversion between active and inactive TATA-binding protein transcription complexes in the mouse genome 显示文摘 | Mohamed-Amin C Dominique K Igor M | 2012 | Nucleic Acids Research2012，40，4： | 1 |
| 13 | Arterial and portal circulation and parenchymal changes in Budd-Chiari syndrome:a study in 17 explanted livers显示文摘 | Vilgrain V Genin P | 2003 | Hepatology2003，37，3： | 1 |
| 14 | Expression of three members of the ACC synthase gene family in deep water rice by submergence, wounding and hormonal treatments 显示文摘 | Dominique V D S Somboon A Wim V C | 1997 | Plant Science1997，124，： | 1 |
| 15 | A new polymorphism in the ApoE promoter associ-ated with risk of developing Alzheimer′s Disease显示文摘 | Jean-chaarles L Florence P Dominique C | 1998 | Human Molecular Genetics1998，7，3： | 1 |
| 16 | Physicochemical changes induced in carp (Cyprinus carpio) fillets by high pressure processing at low temperature 显示文摘 | Amaral S M Dominique C Alain L | 2006 | Innovative Food Science and Emerging Technologies2006，7，： | 1 |
| 17 | Residual stresses in surface induction hardening of steel: comparison between experiment and simulation 显示文摘 | Dominique C Thierry P L Philippe B | 2008 | Materials Science and Engineer2008，25，2： | 1 |
| 18 | Water-solu- ble binders for MCMB carbon anodes for lithium-ion batteries显示文摘 | FABRICE M C SVETI~NA N DOMINIQUE D | 2011 | J Power Sources2011，196，2： | 1 |
| 19 | Changes in quantitative patterns of dead wood in Maritime pine plantations over time显示文摘 | Antoine B Céline M Dominique P | 2008 | Forest Ecology and Management2008，256，5： | 1 |
| 20 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 1 |
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