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| 1 | Liver biochemistry profile,significance and endoscopic management of biliary tract complications post orthotopic liver transplantation显示文摘AIM: To correlate the significance of liver biochemical tests in diagnosing post orthotopic liver transplantation (OLT) biliary complications and to study their profile before and after endoscopic therapy. METHODS: Patients who developed biliary complications were analysed in detail for the clinical information,laboratory tests,treatment offered,response to it,follow up and outcomes. The profile of liver enzymes was determined. The safety,efficacy and outcomes of endoscopic retrograde cholangiography (ERC) were also analysed. RESULTS: 40 patients required ERC for 70 biliary complications. GGT was found to be > 3 times (388.1 ± 70.9 U/mL vs 168.5 ± 34.2 U/L,P = 0.007) and SAP > 2 times (345.1 ± 59.1 U/L vs 152.7 ± 21.4 U/L,P = 0.003) the immediate post OLT values. Most frequent complication was isolated anastomotic strictures in 28 (40%). Sustained success was achieved in 26 (81%) patients. CONCLUSION: Biliary complications still remain an important problem post OLT. SAP and GGT can be used as early,non-invasive markers for diagnosis and also to assess the adequacy of therapy. Endoscopic management is usually effective in treating the majority of these biliary complications. | Yogesh M Shastri Nicolas M Hoepffner Bora Akoglu Christina Zapletal Wolf O Bechstein Wolfgang F Caspary Dominik Faust | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Recent advances in microvascular autologous breast reconstruction after ablative tumor surgery显示文摘Breast cancer is a ubiquitous disease and one of the leading causes of death in women in western societies. With overall increasing survival rates, the number of patients who need post-mastectomy reconstruction is on the rise. Especially since its psychological benefits have been broadly recognized, breast reconstruction has become a key component of breast cancer treatment. Evolving from the early beginnings of breast reconstruction with synthetic implants in the 1960 s, microsurgical tissue transfer is on the way to become the gold standard for post oncology restoration of the breast. Particularly since the advent of perforator based free flap surgery, free tissue transfer has become as safe option for breast reconstruction with low morbidity. The lower abdominal skin and subcutaneous fat tissue typically offer enough volume to create an aesthetically satisfying breast mound. Nowadays, the most commonly used flap from this donor site is the deep inferior epigastric artery perforator flap. If the lower abdomen is not available as a donor site, the gluteal area and thigh provide a number of flaps suitable for breast recon-struction. If the required breast volume is small, and there is enough tissue available on the upper medial thigh, then a transverse upper gracilis flap may be a practicable method to reconstruct the breast. In case of a higher amount of required volume, a gluteal artery perforator flap is the best choice. However, what is crucial in addition to selecting the best flap option for the individual patient is the timing of the operation. In patients with confirmed post-mastectomy radiation therapy, it is advisable to perform microvascular breast reconstruction only in a delayed fashion. | Michael S Pollhammer Dominik Duscher Manfred Schmidt Georg M Huemer | 2016 | World Journal of Clinical Oncology2016，7，1： | 6 |
| 3 | Assessment of stricturing Crohn's disease:Current clinicalpractice and future avenues显示文摘Crohn's disease(CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy(anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of noninvasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD. | Dominik Bettenworth Tobias M Nowacki Friederike Cordes Boris Buerke Frank Lenze | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 4 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 5 | Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores显示文摘 | Thomas Karlas Maria Hempel Michael Tr?ltzsch Dominik Huster Peter Günther Hannelore Tenckhoff Joachim M?ssner Thomas Berg Volker Keim Johannes Wiegand | 2012 | Scandinavian Journal of Gastroenterology2012，，11： | 2 |
| 6 | Cortical activation with deep brain stimulation of the anterior thalamus for epilepsy 显示文摘 | Dominik Zumsteg Andres M Lozano Heinz Gregor Wieser | 2006 | Clini Neurophysiol2006，117，： | 1 |
| 7 | Depth electrode recorded ceredbral responses with deepbrain stimulation of the anterior thalamus for epilepsy 显示文摘 | Dominik Zumsteg Andres M Lozano Richard A Wennberg | 2006 | Clinical Neurophysiology2006，117，： | 1 |
| 8 | Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer显示文摘 | Dominik R Haudens C Sahrina M | 2004 | Cancer Res2004，64，22： | 1 |
| 9 | Mesial temporal inhibition in a patient with deep brain stimulation of the anterior thalamus for epilepsy 显示文摘 | Dominik Zumsteg Andres M Lozano Richard A Wennberg | 2006 | Epilepsia2006，47，11： | 1 |
| 10 | Water slippage versus contact angle: a quasiuniversal relationship显示文摘 | DAVID M H CHRISTIAN S DOMINIK H | 2008 | Physical Review Letters2008，101，22： | 1 |
| 11 | Uremic pruritus- new perspectives and insights from recent trials显示文摘 | Thomas M Christiane PM and Dominik MA | 2002 | Nephrol Dial Transplant2002，17，： | 1 |
| 12 | Increase of regulatory T cells in the peripheral blood of cancer patients 显示文摘 | Anna M W Dominik W Michael S | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 13 | Stochastic stability in three-player games显示文摘 | Dominik K Jacek M Marcin Z | 2005 | Bulletin of Mathematical Biology2005，67，6： | 1 |
| 14 | New observa- tions with the gas electron multiplier(GEM) 显示文摘 | Bouclier R Dominik W Hoch M | 1997 | Nu- clear Instruments and Methods in Physics Research A1997，396，12： | 1 |
| 15 | Market penetration of fuel cell cehicles-Analysis based on agent behavior显示文摘 | DOGAN K MARTIN W DOMINIK M | 2008 | International journal of hydrogen energy2008，33，2008： | 1 |
| 16 | The posterolateral approach for the treatment of trimalleolar fractures 显示文摘 | Naeder H Dominik M Patrick V | 2007 | Tech Foot Ankle Surg2007，6，1： | 1 |
| 17 | Laser speckle spectral correlation and surface roughness 显示文摘 | DOMINIK P OHLIDAL M | 2001 | SPIE2001，4356，： | 1 |
| 18 | Seasonal dynamics of bacterioplankton community structure in a eutrophic lake as determined by 5S rRNA analysis 显示文摘 | Hofle M G Haas H Dominik K | 1999 | Applied and Environmental Microbiology1999，65，7： | 1 |
| 19 | Ponsitional MRI of the lumbar spine:Does it demonstrate nerve root compromise not visible at conven tiona MRI显示文摘 | Dominik W Zanetti M | 2000 | Radiology2000，215，： | 1 |
| 20 | Forms of Particulate Phosphorus in Suspension and in Bottom Sediment in the Danube Delta显示文摘 | Dominik J Bostina M | 2000 | Lakes and Research and Management2000，5，： | 1 |
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