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| 1 | Type 2 diabetes mellitus and Alzheimer's disease显示文摘Epidemiological and biological evidences support a link between type 2 diabetes mellitus(DM2) and Alzheimer's disease(AD). Persons with diabetes have a higher incidence of cognitive decline and an increased risk of developing all types of dementia. Cognitive deficits in persons with diabetes mainly affect the areas of psychomotor efficiency, attention, learning and memory, mental flexibility and speed, and executive function. The strong epidemiological association has suggested the existence of a physiopathological link. The determinants of the accelerated cognitive decline in DM2, however, are less clear. Increased cortical and subcortical atrophy have been evidenced after controlling for diabetic vascular disease and inadequate cerebral circulation. Most recent studies have focused on the role of insulin and insulin resistance as possible links between diabetes and AD. Disturbances in brain insulin signaling mechanisms may contribute to the molecular, biochemical, and histopathological lesions in AD. Hyperglycemia itself is a risk factor for cognitive dysfunction and dementia. Hypoglycemia may also have deleterious effects on cognitive function. Recurrent symptomatic and asymptomatic hypoglycemic episodes have been suggested to cause sub-clinical brain damage, and permanent cognitive impairment. Futuretrials are required to clarify the mechanistic link, to address the question whether cognitive decline may be prevented by an adequate metabolic control, and to elucidate the role of drugs that may cause hypoglycemic episodes. | Mario Barbagallo Ligia J Dominguez | 2014 | World Journal of Diabetes2014，5，6： | 22 |
| 2 | Magnesium and type 2 diabetes显示文摘Type 2 diabetes is frequently associated with both extracellular and intracellular magnesium(Mg) deficits. A chronic latent Mg deficit or an overt clinical hypomagnesemia is common in patients with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulinand glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, postreceptorial impairment in insulin action and worsening of insulin resistance in diabetic patients. A low Mg intake and an increased Mg urinary loss appear the most important mechanisms that may favor Mg depletion in patients with type 2 diabetes. Low dietary Mg intake has been related to the development of type 2 diabetes and metabolic syndrome. Benefits of Mg supplementation on metabolic profiles in diabetic patients have been found in most, but not all clinical studies and larger prospective studies are needed to support the potential role of dietary Mg supplementation as a possible public health strategy in diabetes risk. The aim of this review is to revise current evidence on the mechanisms of Mg deficiency in diabetes and on the possible role of Mg supplementation in the prevention and management of the disease. | Mario Barbagallo Ligia J Dominguez | 2015 | World Journal of Diabetes2015，6，10： | 4 |
| 3 | Optimization of the enzymatic treatment during aqueous oil extraction from sunflower seeds显示文摘 | SINEIRO J DOMINGUEZ H NUNEA M J | 1998 | Food Chemistry1998，61，4： | 1 |
| 4 | Evalua- tion of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit 显示文摘 | Gil-Bea FJ Garcia-Alloza M Dominguez J | 2005 | Neurosci Lett2005，375，1： | 1 |
| 5 | Clinicopathological characteristics of breast carcinomas with allelic in the p73 region 显示文摘 | Dominguez G Silva J Silva JM | 2000 | Breast Cancer Res Trear2000，63，1： | 1 |
| 6 | Assessment of a new test to detect Legionella urinary antigen for the diagnosis of Legionnaires' disease显示文摘 | Dominguez J Gali N Blanco S | 2001 | Diagn Microbiol Infect Dis2001，41，4： | 1 |
| 7 | Dilute acid hemicellulose hydrolysates from corn cobs for xylitol production by yeast显示文摘 | DOMINGUEZ J M CAO N J GONG C S | 1997 | Bioresource Technology1997，61，1： | 1 |
| 8 | Understanding Candida rugosa lipases: an overview显示文摘 | de Dominguez M P Sdnchez-Montero J M Sinisterra J V | 2006 | Biotechnol Adv2006，24，： | 1 |
| 9 | A high-quality sine-wave oscillator for analog built-in self-testing显示文摘 | DOMINGUEZ M A AUSIN J L DUQUECARILLO J F TORELLI G | 2006 | IEEE Circuits and Systems2006，，5： | 1 |
| 10 | Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells显示文摘 | BARBERA M J PUIG I DOMINGUEZ D | 2004 | Oncogene2004，23，： | 1 |
| 11 | Xylitol Production from Wood Hydrolyzaties by Entrapped Debammyas Hansenii and Candida Guilliermondi Cells显示文摘 | Dominguez J M Cruz J M Roca E | | 0，，： | 1 |
| 12 | Effect of pyrolysis temperature on the composition of the oils obtained from sewage sludge显示文摘 | Snchez M E Men6ndez J A Dominguez A | 2009 | Biomass and Bioenergy2009，33，： | 1 |
| 13 | Conventional and microwave induced pyrolysis of coffee hulls for the production of hydrogen rich fuel gas显示文摘 | DOMINGUEZ A MENENDEZ J A FERNANDEZ Y PIS J J VALENTE NABAIS JM CARROTT J M RIBEIRO CARROTT M M L | | 0，，1： | 1 |
| 14 | Aging and estrogen status:a possible endothelium-dependent vascular coupling mechanism in bone remodeling显示文摘 | Prisby RD Dominguez JM 2nd Muller-Delp J Allen MR Delp MD | | 0，，： | 1 |
| 15 | Triterpene acetates and D-(+)-pinitol from Dryanaria drummondii 显示文摘 | Dominguez XA Marroquin J Gutierrez MM | 1975 | Phytochemistry1975，14，： | 1 |
| 16 | Long term prognosis value:of anemia in a non-selected population with heart failure显示文摘 | Dominguez A Pena J Perez M | 2007 | Med Clin2007，128，10： | 1 |
| 17 | Production of bio-fuels by high temperature pyrolysis of sewage sludge using conventional and microwave heating显示文摘 | Dominguez A Menendez J A Inguanzo M | 2006 | Bioresource Technology2006，，97： | 1 |
| 18 | Paracrine interactions during human implantation 显示文摘 | Dominguez F Remohi J Pellicer A | 2002 | Endocr Metab Disord2002，3，2： | 1 |
| 19 | An elec- tronically controlled piezoelectric insulin pump and valves显示文摘 | Spence W J Corbett W T Dominguez L R | 1978 | IEEE Transactions on Sonics and Ultraso- nics1978，25，3： | 1 |
| 20 | Effect of pyrolysis temperature on the composition of the oils obtained from sewage sludge显示文摘 | Sanchez M E Menendez J A Dominguez A | | 0，，6： | 1 |
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