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| 1 | Genetic diversity of Tricholoma matsutake in Yunnan Province显示文摘To investigate the genetic diversity of Tricholoma matsutake,we studied ITS and IGS1 sequences and PCR polymorphism of a retrotransposon in 56 fruit bodies collected from 13 counties of 9 regions in Yunnan Province. We found one and three haplotypes based on ITS and IGS1 sequences,respectively. Moreover,there was no significant difference in PCR polymorphism of the retrotransposon among different populations. Compared with Jilin Province(China) and Japanese populations,although Yun-nan was highly homogenous to Japanese populations,low genetic diversity of T. matsutake in Yunnan did not support the view that this species originated from Yunnan. | SHA Tao ZHANG HanBo DING HuaSun LI ZongJu CHENG LiZhong ZHAO ZhiWei ZHANG YaPing | 2007 | Chinese Science Bulletin2007，52，9： | 8 |
| 2 | Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma显示文摘Chemotherapy is among the limited choices approved for the treatment of hepatocellular carcinoma(HCC) at intermediate and advanced stages. Preferential and prolonged drug exposure in diseased sites is required to maximize the therapeutic index of the drug. Here, we report an injectable supramolecular peptide hydrogel as an intraperitoneal depot for localized and sustained release of triptolide for the treatment of orthotopic HCC. We chose peptide amphiphile C16-GNNQQNYKD-OH-based nanofibers as gelators and carriers for triptolide. Sustained triptolide release from the hydrogel was achieved over 14 days in vitro, with higher accumulation in and cytotoxicity against human HCC Bel-7402 in comparison with L-02 fetal hepatocytes. After intraperitoneal injection, the hydrogel showed prolonged retention over 13 days and preferential accumulation in the liver, realizing HCC growth inhibition by99.7 ± 0.1% and animal median survival extension from 19 to 43 days, without causing noticeable pathological changes in the major organs. These results demonstrate that injectable peptide hydrogel can be a potential carrier for localized chemotherapy of HCC. | Xiyue Zhao Xiaoyu Liu Pengcheng Zhang Yiran Liu Wei Ran Ying Cai Junyang Wang Yihui Zhai Guanru Wang Yaping Ding Yaping Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 7 |
| 3 | Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species/JUN Pathway显示文摘Oleic acid(OA),a monounsaturated fatty acid(MUFA),has previously been shown to reverse saturated fatty acid palmitic acid(PA)-induced hepatic insulin resistance(IR).However,its underlying molecular mechanism is unclear.In addition,previous studies have shown that eicosapentaenoic acid(EPA),aω-3 polyunsaturated fatty acid(PUFA),reverses PA-induced muscle IR,but whether EPA plays the same role in hepatic IR and its possible mechanism involved need to be further clarified.Here,we confirmed that EPA reversed PA-induced IR in HepG2 cells and compared the proteomic changes in HepG2 cells after treatment with different free fatty acids(FFAs).A total of 234 proteins were determined to be differentially expressed after PA+OA treatment.Their functions were mainly related to responses to stress and endogenous stimuli,lipid metabolic process,and protein binding.For PA+EPA treatment,the PA-induced expression changes of 1326 proteins could be reversed by EPA,415 of which were mitochondrial proteins,with most of the functional proteins involved in oxidative phosphorylation(OXPHOS)and tricarboxylic acid(TCA)cycle.Mechanistic studies revealed that the protein encoded by JUN and reactive oxygen species(ROS)play a role in OA-and EPA-reversed PA-induced IR,respectively.EPA and OA alleviated PA-induced abnormal adenosine triphosphate(ATP)production,ROS generation,and calcium(Ca^(2+))content.Importantly,H_(2)O_(2)-activated production of ROS increased the protein expression of JUN,further resulting in IR in HepG2 cells.Taken together,we demonstrate that ROS/JUN is a common response pathway employed by HepG2 cells toward FFA-regulated IR. | Yaping Sun Jifeng Wang Xiaojing Guo Nali Zhu Lili Niu Xiang Ding Zhensheng Xie Xiulan Chen Fuquan Yang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 6 |
| 4 | Highly efficient Zr doped-TiO_2/glass fiber photocatalyst and its performance in formaldehyde removal under visible light显示文摘Zr-doped-TiO_2 loaded glass fiber(ZT/GF) composite photocatalysts with different Zr/Ti ratios were prepared with a sol–gel process. Zr4+can replace Ti4+in the TiO_2 lattice, which is conducive to forming the anatase phase and reducing the calcination temperature. The glass fiber carrier was responsible for better dispersion and loading of Zr-doped-TiO_2 particles, improving the applicability of the Zr-doped-TiO_2. The ZT/GF photocatalysts were characterized by X-ray diffraction(XRD), scanning electron microscope(SEM), Fourier transform infrared spectroscopy(FT-IR), ultraviolet–visible spectroscopy(UV–vis) and Barrett–Joyner–Halenda(BJH). The performance of photocatalysts with different loading was evaluated in formaldehyde degradation under visible light at room temperature. ZT/GF0.2exhibited the highest activity, with a formaldehyde removal rate as high as 95.14% being observed, which is better than that of the photocatalyst particles alone. The stability of the catalyst was also tested, and ZT/GF exhibited excellent catalytic performance with 94.38%removal efficiency, even after seven uses. | Chao Huang Yaping Ding Yingwen Chen Peiwen Li Shemin Zhu Shubao Shen | 2017 | Journal of Environmental Sciences2017，29，10： | 6 |
| 5 | Neural Stem Cells Transfected with Leukemia Inhibitory Factor Promote Neuroprotection in a Rat Model of Cerebral Ischemia显示文摘Leukemia inhibitory factor(LIF) contributes to the neuroprotection by neural stem cells(NSCs) after ischemic stroke. Our aim was to explore whether LIFtransfected NSCs(LIF-NSCs) can ameliorate brain injury and promote neuroprotection in a rat model of cerebral ischemia. To accomplish this goal, we transfected NSCs with a lentivirus carrying the LIF gene to stably overexpress LIF. The LIF-NSCs reduced caspase 3 activation under conditions of oxygen-glucose deprivation in vitro.Transient cerebral ischemia was induced in rats by 2 h of middle cerebral artery occlusion(MCAo), and LIF-NSCs were intravenously injected at 6 h post-ischemia. LIF-NSC treatment reduced the infarction volume and improved neurological recovery. Moreover, LIF-NSCs improved glial cell regeneration and ameliorated white matter injuryin the MCAo rats. The NSCs acted as carriers and increased the expression of LIF in the lesions to protect against cerebral infarction, suggesting that LIF-NSCs could be a potential treatment for cerebral infarction. | Lili Tian Wenli Zhu Yuanchu Liu Ye Gong Aowei Lv Zhen Wang Xiaoli Ding Shaowu Li Ying Fu Yi Lin Yaping Yan | 2019 | Neuroscience Bulletin2019，35，5： | 5 |
| 6 | A review of the interaction between the cryosphere and atmosphere显示文摘The interaction between the cryosphere and atmosphere is an essential and extremely sensitive mutual action process on the earth.Due to global warming and the cryospheric melting,more and more attention has been paid to the interaction process between the cryosphere and atmosphere,especially the feedback of the cryosphere change to the atmosphere.A comprehensive review of the studies on the interaction between the cryosphere and atmosphere is conducted from two aspects:(1)effects of climate change on the cryosphere or responses of the cryosphere to climate change;and(2)feedback of the cryosphere change to the climate.The response of the cryosphere to climate change is lagging.Such a lagging and cumulative effect of temperature rise within the cryosphere have resulted in a rapid change in the cryosphere in the 21st century,and its impacts have become more significant.The feedback from cryosphere change on the climate are omnifarious.Among them,the effects of sea ice loss and snow cover change,especially the Arctic sea ice loss and the Northern Hemisphere snow cover change,are the most prominent.The Arctic amplification(AA)associated with sea ice feedback is disturbing,and the feedback generated by the effect of temperature rise on snow properties in the Northern Hemisphere is also of great concern.There are growing evidence of the impact of the Arctic cryosphere melting on mid-latitude weather and climate.Weakened storm troughs,steered jet stream and amplified planetary waves associated with energy propagation become the key to explaining the links between Arctic cryosphere change and atmospheric circulation.There is still a great deal of uncertainty about how cryosphere change affects the weather and climate through different atmospheric circulation processes at different spatial and temporal scales due to observation and simulation problems. | YongJian Ding JianPing Yang ShengXia Wang YaPing Chang | 2020 | Research in Cold and Arid Regions2020，12，6： | 4 |
| 7 | Uniform ordered mesoporous ZnCo2O4 nanospheres for super-sensitive enzyme-free H2O2 biosensing and glucose biofuel cell applications显示文摘一致、订的 mesoporous ZnCo 2 O 4(meso-ZnCo 2 O 4) nanospheres 成功地用一个牺牲的模板方法被综合。meso-ZnCo 2 O 4 nanospheres 为 H 2 O 2 biosensing 并且在葡萄糖 biofuel,房间(GBFC ) 作为酶模仿。meso-ZnCo 2 O 4 nanospheres 不仅在 H 2 O 2 传感器,完成高敏感(658.92 A ??? ? ??? 洠捩潲猭灵牥慣慰楣潴獲?? | Shiqiang Cui Li Li Yaping Ding Jiangjiang Zhang QingshengWu Zongqian Hu | 2017 | Nano Research2017，10，7： | 3 |
| 8 | Microsatellite DNA analysis proves nucleus of interspecies reconstructed blastocyst coming from that of donor giant panda显示文摘A method for DNA isolation from early development of blastocyst and further analysis of nuclear and mitochondrial DNA was developed in present study. Total DNA was prepared from interspecies reconstructed blastocyst and a giant panda specific microsatellite locus g010 was successfully amplified. DNA sequencing of the PCR product showed that two sequences of reconstructed blastocysts are the same as that of positive control giant panda. Our results prove that the nucleus of interspecies reconstructed blastocyst comes from somatic nucleus of donor giant panda. | DING Bo SHI Peng XIANGYU Jinggong ZHANG Yaping CHEN Dayuan SUN Qingyuan LI Guangpeng WANG Minkang LIU Yilong KANG Li HAN Zhiming SONG Xiangfen LI Jingsong CHEN Yuchun | 2000 | Chinese Science Bulletin2000，45，20： | 3 |
| 9 | Synergistie effect of nickel formate on the thermal and flame-retardant properties of polypropylene显示文摘 | Xuecheng Chen Yaping Ding Tao Tang | 2005 | Polymer international2005，54，： | 1 |
| 10 | The Preparation and Properties of Microcrystalline and Nanocrystalline CuCr Contact Materials显示文摘 | Wang Yaping Ding Bingjun | 1999 | IEEE Trans on CPMT1999，22，3： | 1 |
| 11 | The Brachypodium distachyon BdWRKY36 gene confers tolerance to drought stress in transgenic tobacco plants显示文摘 | Jiutong Sun Wei Hu Run Zhou Lianzhe Wang Xiatian Wang Qiong Wang Zhijuan Feng Yaping Li Ding Qiu Guangyuan He Guangxiao Yang | 2015 | Plant Cell Reports2015，，1： | 1 |
| 12 | Mullite fibres prepared by sol–gel method using polyvinyl butyral显示文摘 | Yabin Zhang Yaping Ding Jiqiang Gao Jianfeng Yang | 2008 | Journal of the European Ceramic Society2008，，6： | 1 |
| 13 | Mullite fi-bers prepared from an inorganic sol-gel precursor显示文摘 | Tan Hongbin Ding Yaping Yang Jianfeng | 2010 | Journal of Sol-Gel Science and Technology2010，53，2： | 1 |
| 14 | Volta-mmetric determination of Pb2+and Cd2+with mont-morillonite-bismuth-carbon electrodes显示文摘 | Liqiang Luo Xia Wang Yaping Ding | 2010 | AppliedClay Science2010，50，1： | 1 |
| 15 | Synergistic effect of nickel formate on the thermal and flame-retardant properties of polypropylene显示文摘 | Chen Xuecheng Ding Yaping Tang Tao | 2005 | Polymer International2005，54，6： | 1 |
| 16 | Direct simultaneous determination of dihydroxybenzene isomers at C-nanotube-modified electrodes by derivative voltammetry显示文摘 | Ding Yaping Liu Weili Wu Qingsheng | 2005 | Journal of Electroanalytical Chemistry2005，575，： | 1 |
| 17 | 显示文摘 | DING Yaping LIU Weili WU Qingsheng | 2005 | J Electroanal Chem2005，575，： | 1 |
| 18 | Mullite fibres prepared by sol–gel method using polyvinyl butyral显示文摘 | Yabin Zhang Yaping Ding Jiqiang Gao Jianfeng Yang | 2008 | Journal of the European Ceramic Society2008，，6： | 1 |
| 19 | 显示文摘 | WANG Xiaogang WU Qingsheng DING Yaping | 2006 | Electroanalysis2006，18，5： | 1 |
| 20 | Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer显示文摘Nucleic acid drugs are highly applicable for cancer immunotherapy with promising therapeutic effects, while targeting delivery of these drugs to disease lesions remains challenging. Cationic polymeric nanoparticles have paved the way for efficient delivery of nucleic acid drugs, and achieved stimuli-responsive disassembly in tumor microenvironment(TME). However, TME is highly heterogeneous between individuals, and most nanocarriers lack active-control over the release of loaded nucleic acid drugs, which will definitely reduce the therapeutic efficacy. Herein, we have developed a lightcontrollable charge-reversal nanoparticle(LCCN) with controlled release of polyinosinic-polycytidylic acid [Poly(I:C)] to treat triple negative breast cancer(TNBC) by enhanced photodynamic immunotherapy. The nanoparticles keep suitably positive charge for stable loading of Poly(I:C), while rapidly reverse to negative charge after near-infrared light irradiation to release Poly(I:C). LCCN-Poly(I:C) nanoparticles trigger effective phototoxicity and immunogenic cell death on 4 T1 tumor cells, elevate antitumor immune responses and inhibit the growth of primary and abscopal 4 T1 tumors in mice. The approach provides a promising strategy for controlled release of various nucleic acid-based immune modulators, which may enhance the efficacy of photodynamic immunotherapy against TNBC. | Lei Fang Zitong Zhao Jue Wang Ping Xiao Xiangshi Sun Yaping Ding Pengcheng Zhang Dangge Wang Yaping Li | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 1 |
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