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| 1 | Circulating endothelial and progenitor cells:Evidence from acute and long-term exercise effects显示文摘Circulating bone-marrow-derived cells,named endothelial progenitor cells(EPCs),are capable of maintaining,generating,and replacing terminally differentiated cells within their own specific tissue as a consequence of physiological cell turnover or tissue damage due to injury.Endothelium maintenance and restoration of normal endothelial cell function is guaranteed by a complex physiological procedure in which EPCs play a significant role.Decreased number of peripheral blood EPCs has been associated with endothelial dysfunction and high cardiovascular risk.In this review,we initially report current knowledge with regard to the role of EPCs in healthy subjects and the clinical value of EPCs in different disease populations such as arterial hypertension,obstructive sleep-apnea syndrome,obesity,diabetes mellitus,peripheral arterial disease,coronary artery disease,pulmonary hypertension,and heart failure.Recent studies have introduced the novel concept that physical activity,either performed as a single exercise session or performed as part of an exercise training program,results in a significant increase of circulating EPCs.In the second part of this review we provide preliminary evidence from recent studies investigating the effects of acute and long-term exercise in healthy subjects and athletes as well as in disease populations. | Matina Koutroumpi Stavros Dimopoulos Katherini Psarra Theodoros Kyprianou Serafim Nanas | 2012 | World Journal of Cardiology2012，4，12： | 18 |
| 2 | 羟乙基淀粉溶液在复苏肠缺血-再灌注休克中的作用显示文摘目的 比较不同剂量羟乙基淀粉溶液 ( HES)对兔肠缺血再灌注损伤所致休克的复苏作用。方法 32只新西兰白兔随机分为 4组 :模型对照、乳酸林格液复苏组 ( L RS,2 0 m l· kg- 1 · h- 1 ) ,小剂量 HES复苏组 ( HES2 ml· kg- 1· h- 1 + L RS18m l· kg- 1· h- 1 ) ,大剂量 HES复苏组 ( HES2 0 ml· kg- 1· h- 1 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠缺血再灌注休克模型 ,松夹再灌注时同步进行液体复苏。观测各时间点的血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 ) ,并通过测定肠黏膜CO2 分压和动脉血 CO2 分压的差值 (动脉二氧化碳间隙 )、肠黏膜 p H值、动脉血乳酸浓度和氧输送等指标间接评估组织氧合情况。实验结束后累计动物死亡数。结果 HES能明显提高肠缺血再灌注休克时的血流动力学参数 ,与对照组和 L RS组比较差异均有显著性 ( P均 <0 .0 5 ) ;小剂量 HES比大剂量 HES改善血流动力学参数的作用更平稳 ( P均 <0 .0 5 ) ,且较其他 3组能明显降低血乳酸浓度和动脉二氧化碳间隙 ,减轻 p Hi的降低 ( P均 <0 .0 5 ) ;而大剂量 HES对上述参数的影响不明显 ,并可见动物口鼻出血及死亡 ;小剂量或大剂量HES与其他两组比较均能使氧输送回升 ( P均 <0 .0 5 )。 | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo Daniel de Backer 肖献忠 Jean-Louis Vincent | 2004 | 中国危重病急救医学2004，16，8： | 6 |
| 3 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 4 | Sonographic muscle mass assessment in patients after cardiac surgery显示文摘BACKGROUND Patients undergoing cardiac surgery particularly those with comorbidities and frailty,experience frequently higher rates of post-operative morbidity,mortality and prolonged hospital length of stay.Muscle mass wasting seems to play important role in prolonged mechanical ventilation(MV)and consequently in intensive care unit(ICU)and hospital stay.AIM To investigate the clinical value of skeletal muscle mass assessed by ultrasound early after cardiac surgery in terms of duration of MV and ICU length of stay.METHODS In this observational study,we enrolled consecutively all patients,following their admission in the Cardiac Surgery ICU within 24 h of cardiac surgery.Bedside ultrasound scans,for the assessment of quadriceps muscle thickness,were performed at baseline and every 48 h for seven days or until ICU discharge.Muscle strength was also evaluated in parallel,using the Medical Research Council(MRC)scale.RESULTS Of the total 221 patients enrolled,ultrasound scans and muscle strength assessment were finally performed in 165 patients(patients excluded if ICU stay<24 h).The muscle thickness of rectus femoris(RF),was slightly decreased by 2.2%[(95%confidence interval(CI):-0.21 to 0.15),n=9;P=0.729]and the combined muscle thickness of the vastus intermedius(VI)and RF decreased by 3.5%[(95%CI:-0.4 to 0.22),n=9;P=0.530].Patients whose combined VI and RF muscle thickness was below the recorded median values(2.5 cm)on day 1(n=80),stayed longer in the ICU(47±74 h vs 28±45 h,P=0.02)and remained mechanically ventilated more(17±9 h vs 14±9 h,P=0.05).Moreover,patients with MRC score≤48 on day 3(n=7),required prolonged MV support compared to patients with MRC score≥49(n=33),(44±14 h vs 19±9 h,P=0.006)and had a longer duration of extracorporeal circulation was(159±91 min vs 112±71 min,P=0.025).CONCLUSION Skeletal quadriceps muscle thickness assessed by ultrasound shows a trend to a decrease in patients after cardiac surgery post-ICU admission and is associated with prolonged duration of MV and ICU length of stay. | Stavros Dimopoulos Vasiliki Raidou Dimitrios Elaiopoulos Foteini Chatzivasiloglou Despoina Markantonaki Efterpi Lyberopoulou Ioannis Vasileiadis Katerina Marathias Serafeim Nanas Andreas Karabinis | 2020 | World Journal of Cardiology2020，12，7： | 4 |
| 5 | Reliability of the ocular trauma score for the predictability of traumatic and post-traumatic retinal detachment after open globe injury显示文摘AIM: To elucidate the question of whether the ocular trauma score(OTS) and the zones of injury could be used as a predictive model of traumatic and post traumatic retinal detachment(RD) in patients with open globe injury(OGI).METHODS: A retrospective observational chart analysis of OGI patients was performed. The collected variables consisted of age, date, gender, time of injury, time until repair, mechanism of injury, zone of injury, injury associated vitreous hemorrhage, trauma associated RD, post traumatic RD, aphakia at injury, periocular trauma and OTS in cases of OGI. RESULTS: Totally 102 patients with traumatic OGI with a minimum of 12 mo follow-up and a median age at of 48.6 y(range: 3-104 y) were identified. Final best corrected visual acuity(BCVA) was independent from the time of repair, yet a statistically significant difference was present between the final BCVA and the zone of injury. Severe trauma presenting with an OTS score Ⅰ(P<0.0001) or Ⅱ(P<0.0001) revealed a significantly worse BCVA at last follow up when compared to the cohort with an OTS score >Ⅲ. OGI associated RD was observed in 36/102 patients(35.3%), whereas post traumatic RD(defined as RD following 14 d after OGI) occurred in 37 patients(36.3%). OGI associated RD did not correlate with the OTS and the zone of injury(P=0.193), yet post traumatic RD correlated significantly with zone Ⅲ injuries(P=0.013). CONCLUSION: The study shows a significant association between lower OTS score and zone Ⅲ injury with lower final BCVA and a higher number of surgeries, but only zone Ⅲ could be significantly associated with a higher rate of RD. | Simon Dulz Vasilis Dimopoulos Toam Katz Robert Kromer Eileen Bigdon Martin Stephan Spitzer Christos Skevas | 2021 | International Journal of Ophthalmology(English edition)2021，14，10： | 4 |
| 6 | Exercise training in heart transplantation显示文摘Heart transplantation remains the gold standard in the treatment of end-stage heart failure(HF).Heart transplantation patients present lower exercise capacity due to cardiovascular and musculoskeletal alterations leading thus to poor quality of life and reduction in the ability of daily self-service.Impaired vascular function and diastolic dysfunction cause lower cardiac output while decreased skeletal muscle oxidative fibers,enzymes and capillarity cause arteriovenous oxygen difference,leading thus to decreased peak oxygen uptake in heart transplant recipients.Exercise training improves exercise capacity,cardiac and vascular endothelial function in heart transplant recipients.Pre-rehabilitation regular aerobic or combined exercise is beneficial for patients with end-stage HF awaiting heart transplantation in order to maintain a higher fitness level and reduce complications afterwards like intensive care unit acquired weakness or cardiac cachexia.All hospitalized patients after heart transplantation should be referred to early mobilization of skeletal muscles through kinesiotherapy of the upper and lower limbs and respiratory physiotherapy in order to prevent infections of the respiratory system prior to hospital discharge.Moreover,all heart transplant recipients after hospital discharge who have not already participated in an early cardiac rehabilitation program should be referred to a rehabilitation center by their health care provider.Although high intensity interval training seems to have more benefits than moderate intensity continuous training,especially in stable transplant patients,individualized training based on the abilities and needs of each patient still remains the most appropriate approach.Cardiac rehabilitation appears to be safe in heart transplant patients.However,long-term follow-up data is incomplete and,therefore,further high quality and adequately-powered studies are needed to demonstrate the long-term benefits of exercise training in this population. | Christos Kourek Eleftherios Karatzanos Serafim Nanas Andreas Karabinis Stavros Dimopoulos | 2021 | World Journal of Transplantation2021，11，11： | 3 |
| 7 | 不同液体复苏条件下多巴酚丁胺对肠缺血-再灌注休克的疗效比较显示文摘目的 比较多巴酚丁胺在不同液体复苏条件下对兔肠缺血再灌注损伤 (I/ R)所致休克的治疗效果。方法 32只新西兰白兔随机分为乳酸林格液 (L RS)复苏组、L RS+羟乙基淀粉溶液 (HES)复苏组、L RS复苏 +多巴酚丁胺治疗组 (L RS+DOB组 )和 L RS+HES复苏 +多巴酚丁胺治疗组 (L RS+HES+DOB组 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠 I/ R休克模型 ,松夹再灌注时同步进行液体复苏和多巴酚丁胺治疗。观察各时间点血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 )的变化 ,并通过测定动脉二氧化碳间隙〔 Pt a CO2 间隙 =肠黏膜 CO2 分压 (Pt CO2 ) -动脉血 CO2 分压 (Pa CO2 )〕、肠黏膜 p H值 (p Hi)、动脉血乳酸浓度和氧输送 (DO2 )等指标间接评价组织氧合情况。结果 多巴酚丁胺能显著减轻兔肠I/ R休克后平均动脉压、心率、心排血量和肠系膜上动脉血流的下降 ,两多巴酚丁胺治疗组与两复苏组比较 ,差异均有显著性 (P均 <0 .0 5 ) ;且 L RS+HES+DOB组平均动脉压下降程度较 L RS+DOB组明显减轻 (P<0 .0 5 )。与 L RS组比较 ,两多巴酚丁胺治疗组均能明显降低血乳酸浓度和 Pt a CO2 间隙 ,升高 p Hi和 DO2 (P均<0 .0 5 ) ,尤其在 L RS+HES+DOB组效果更显著 (P均 <0 .0 5 ) ,与 L | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo DanielDe Backer 肖献忠 Jean-Louis Vincent | 2005 | 中国危重病急救医学2005，17，2： | 3 |
| 8 | 急性心肌梗死阿昔单抗、瑞替普酶、支架联合研究(CARESS-in-AMI)中的即刻恤管成形术与常规治疗联合挽救性血管成形术的比较:一项前瞻性、开放、多中心随机试验显示文摘背景当90min内不能进行直接经皮冠状动脉介入术(PCI)时,溶栓就仍是ST段抬高型心肌梗死(STEMI)的治疗选择。然而,溶栓治疗之后患者的最佳后续处理仍不确定。为了评估最佳处理方案,作者把在非介入医院用溶栓和阿昔单抗治疗的STEMI患者随机分为即刻进行PCI与常规药物治疗联合挽救性血管成形术两组。
方法给予法国、意大利和波兰等国家的600例年龄≤75岁、有≥1项高危特征(广泛性ST段抬高、新发左柬支传导阻滞、既往有心肌梗死、Killip分级≥2级或左室射血分数≤35%)的住院患者半量瑞替普酶、阿昔单抗、肝素和阿司匹林治疗,并随机分配为转诊至最近的介入中心进行即刻PCI或仅在持续ST段抬高、临床征象加重时转诊。主要结局为30d时死亡、再梗死或顽固性心肌缺血的复合指标,采用意向治疗分析。研究在Clinical Trials.gov的注册编号为00220571。
结果分配至即刻PCI组的299例患者中,289例(97.0%)进行了血管造影,255例(85.6%)进行了PCI。在常规治疗/挽救性PCI组中有91例(30.3%)患者进行了挽救性PCI。即刻PCI组出现主要结局指标的患者为13例(4.4%),而常规治疗辟乞救性PCI组为32例(10.7%)(HR0-40,95%C10.21~0.76;对数秩检验P=0.004)。即刻PCI组严重出血患者为10例,而常规治疗/挽救性PCI组为7例(3.4%vs2.3%,P=0.47)。即刻PCI组卒中患者为2例.而常规治疗/挽救性PCI组为4例(0.7%vs 1.3%.P=0.50)。
结论 在非介入中心,采用半量瑞替普酶和阿昔单抗治疗的高危STEMI患者即刻转诊进行PCI可改善结局。 | Carlo Di Maria Dariusz Duded Federico Piscione Waldemar Mielecki Stefano Savonitto Ernesto Murena Konstantinos Dimopoulos 郭占宏(译) | 2008 | 世界临床医学2008，2，5： | 3 |
| 9 | Immune response-related genes associated to blocking midgut dengue virus infection in Aedes aegypti strains that differ in susceptibility显示文摘Aedes (Stegomyia) aegypti, the principal global vector of dengue viruses, has difTerences in its susceptibility to dengue virus infection. We compared the global expres? sion of genes in the midguts of Colombian Ae. aegypti dengue-susceptible (Cali-S) and dengue-refractory (Cali-MIB) field derived strains after ingesting either a sugarmeal, a bloodmeal, or a bloodmeal containing dengue virus serotype 2 (DENV-2). Microarraybased transcriptome analysis among treatments indicated a total of 4725 transcripts with differential expression between the two strains. Eleven genes were selected from different functional groups based on their significant up or down expression levels as well as reports in the literature suggesting they are associated with dengue virus elimination. We measured mRNA abundance of these 11 genes at 0, 8, 24, and 36 h postinfection using quantitative real time PCR (qPCR) to confirm the microarray results and assess any temporal patterns. Four genes were selected (Gram-negative binding protein—GNBP [AAEL009176], Niemann Pick Type-C2一NPC2 [AAEL015136], Keratinocyte lectin [AAEL009842], and Cathepsin-b [AAEL007585]) for knockdown experiments using RNA interference (RNAi) methodology to determine the phenotype (DENV-2 susceptible or refractory). Silencing GNBP、Cathepsin-b and Keratinocyte lectin reduced the percentage of mosquitoes with disseminated virus in the Cali-S strain to 8%, 20%, and 12% respectively compared with 96% in the controls. Sile ncing of NPC2 increased the percentage of mosquitos with disseminated virus infections in Cali-MIB to 66% compared with 35% in the controls. This study provides in sight into genes that may contribute to the Cali-S susceptible and Cali-MIB refractory phenotypes in 昇匕 aegypti. | Paola A. Caicedo Idalba Mildred Serrato Shuzhen Sim George Dimopoulos Heather Coatsworth Carl Lowenberger Clara B. Ocampo | 2019 | Insect Science2019，26，4： | 2 |
| 10 | Pars plana vitrectomy and silicone oil injection proliferative diabetic retinopathy显示文摘 | Dahl B Dimopoulos S | 1989 | Graefe Arch Clin Exp Ophthalmol1989，227，2： | 1 |
| 11 | Genome expression analysis of Anopheles gambiae:responses to injury,bacterial challenge,and malaria infection 显示文摘 | Dimopoulos G Christophides G K Meister S | 2002 | Proceeding of National Academy of Science of United states of America2002，99，： | 1 |
| 12 | Prevention of thalidomide - and lenalidomide - associated thrombosis in myeloma 显示文摘 | Palumbo A Rajkumar SV Dimopoulos MA | 2008 | Leukemia2008，22，2： | 1 |
| 13 | Primary ovarian non-Hodgkin' s lymphoma: outcome after treatment with combination chemotherapy显示文摘 | Dimopoulos MA Daliani D Pugh W etal | 1997 | Gynecol Oncol1997，64，： | 1 |
| 14 | Treatment of Walden- strom's Macroglobulinemia 显示文摘 | Dimopoulos MA Anagnostopoulos A | 2007 | Curr Treat Options Oncol2007，8，2： | 1 |
| 15 | Innate immune defense against malaria infection in the mosquito显示文摘 | Dimopoulos G Müller HM Elena A | 2001 | Current Opinion in Immunology2001，13，1： | 1 |
| 16 | Interaction between the skeletaland immune systems in cancer: mechanisms and clinical im-plications 显示文摘 | Terpos E Dimopoulos MA | 2011 | Cancer Immunol Immunother2011，60，3： | 1 |
| 17 | Viral epidemiology of acute exacerbations of chronic obstructive pulmonary disease 显示文摘 | Dimopoulos G Lerikou M Tsiodras S | 2012 | Pulm Pharmacol Ther2012，25，1： | 1 |
| 18 | Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma显示文摘 | Stewart AK Rajkumar SV Dimopoulos MA | 2015 | N EnglJ Med2015，372，2： | 1 |
| 19 | Carfihomib and dexamethasone vs bortezomib and dexamethasone in patients with relapsed multiple myeloma: results of the phase 3 study endeavor ( NCT01568866 ) according to age subgroup 显示文摘 | Palumbo A Dimopoulos MA Moreau P | 2015 | Blood2015，126，23： | 1 |
| 20 | Abnormal bone remodeling process is due to an imbalance in the receptor activator of nuclear factor -kappa B ligand (RANKL)/ osteoprotegerin (OPG) axis in patients with solid tumors metastatic to the skeleton显示文摘 | Mountzios G Dimopoulos MA Bamias A | 2007 | Acta Oncol2007，46，2： | 1 |
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