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| 1 | 甲状腺结节颈动脉搏动超声弹性成像的鉴别显示文摘目的探索利用颈动脉搏动作为压力源的超声弹性成像对甲状腺结节诊断的敏感性和特异性。方法本研究符合HIPAA要求,并经伦理委员会批准,所有受试者都签署了知情同意书。58例病人(男13例,女45例;年龄20-76岁,平均51岁)纳入本研究。在对甲状腺进行细针活检前,进行了常规超声检查和利用颈动脉搏动作为压力源的超声弹性成像检查。US基本频带数据下载后进行离线分析,形成弹性影像图并计算甲状腺硬度指数。采用非参数秩和的Knlskal—Wallis检验评价不同类型甲状腺结节的总体中位数值。 | M. Dighe U. Bae M.L. Richardson T.J. Dubinsky S. Minoshima Y.Kim. 高莉(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 28 |
| 2 | A review of UHMWPE wear-induced osteolysis:the role for early detection of the immune response显示文摘In a world where increasing joint arthroplasties are being performed on increasingly younger patients,osteolysis as the leading cause of failure after total joint arthroplasty(TJA) has gained considerable attention.Ultra-high molecular weight polyethylene wear-induced osteolysis is the process by which prosthetic debris mechanically released from the surface of prosthetic joints induces an immune response that favors bone catabolism, resulting in loosening of prostheses with eventual failure or fracture. The immune response initiated is innate in that it is nonspecific and self-propagating, with monocytic cells and osteoclasts being the main effectors. To date, detecting disease early enough to implement effective intervention without unwanted systemic side effects has been a major barrier. These barriers can be overcome using newer in vivo imaging techniques and modules linked with fluorescence and/or chemotherapies. We discuss the pathogenesis of osteolysis, and provide discussion of the challenges with imaging and therapeutics. We describe a positron emission tomography imaging cinnamoyl-Phe-(D)-Leu-Phe-(D)-Leu-Phe-Lys module,specific to macrophages, which holds promise in early detection of disease and localization of treatment.Further research and increased collaboration among therapeutic and three-dimensional imaging researchers are essential in realizing a solution to clinical osteolysis in TJA. | Adrese M Kandahari Xinlin Yang Kevin A Laroche Abhijit S Dighe Dongfeng Pan Quanjun Cui | 2016 | Bone Research2016，4，2： | 7 |
| 3 | 以干细胞为基础的基因治疗促进骨缺损的修复研究进展显示文摘理想的骨移植材料能够模拟人类骨组织的三维结构,同时能使细胞在其结构上生长,能够传递细胞因子、抗体和化学试剂等,以促进骨损伤的自然修复。但是,目前的骨移植替代物和生长因子与理想中的相距甚远。因此,需要探索骨再生替代治疗的新策略。研究的核心是能够携带治疗基因的骨祖细胞负载在人工骨传导基质,使其具备骨传导性能和骨诱导性能。 | 张翼 王义生 刘宏建 Abhijit S. Dighe 崔全军 | 2011 | 中华实验外科杂志2011，28，4： | 4 |
| 4 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 5 | Workshop III Report: Scaleup of Liquid and Semisolid Disperse Systems显示文摘 | G. A. Van Buskirk V. P. Shah D. Adair H. M. Arbit S. V. Dighe M. Fawzi T. Feldman G. L. Flynn M. A. González V. A. Gray R. H. Guy A. K. Herd S. L. Hem C. Hoiberg R. Jerussi A. S. Kaplan L. J. Lesko H. J. Malinowski N. M. Meltzer R. L. Nedich D. M. Pearce | 1994 | Pharmaceutical Research1994，，8： | 2 |
| 6 | Analysis of laboratory critical value reporting at a large academic medical center 显示文摘 | Dighe A S Rao A Coakley A B | 2006 | Am J Clin Pathol2006，125，： | 1 |
| 7 | Analytical methods validation: Bioavailability, bio-equivalence and pharmacokinetic studies 显示文摘 | SHAH V P MIDHA K K DIGHE S | 1992 | J Pharm Sci1992，81，： | 1 |
| 8 | Analysis of Laboratory CriticalValue Reporting at a Large Academic Medical Center 显示文摘 | Anand S Dighe MD Aijun Rao | 2006 | Am JClin Pathol2006，125，： | 1 |
| 9 | Demonstrationof an interferon gamma-dependent tumor surveillance sys-tem in immunocompetent mice显示文摘 | Kaplan DH Shankaran V Dighe AS | 1998 | Proc Natl Acad Sci USA1998，95，13： | 1 |
| 10 | Specific immunoneutralization of FSH leads to apoptotic cell death of the pachytene spermatocytes and spermatogonial cells in the rat显示文摘 | Shetty J Marathe GK Dighe RR | 1996 | Endocrinology1996，137，5： | 1 |
| 11 | Analysis of laboratory critical value reporting at a large academic medicalcenter显示文摘 | Dighe AS Ran A Coakley AB | 2006 | Am J Clin Pathol2006，125，5： | 1 |
| 12 | Specific immunoneutralization of FSH leads to apoptotic cell death of the pachytene spermatocytes and spermatogonial cell in the rat显示文摘 | Shetty J Marathe GK Dighe RR | 1996 | Endorinology1996，137，5： | 1 |
| 13 | Specific immunoneutralization of FSH leads to apoptotic cell death of the pachytene spermatocytes and spermatogonial cells in the rat显示文摘 | Shetty J Marathe GK Dighe RR | 1996 | Endocrinology1996，137，5： | 1 |
| 14 | Analysis of laboratory critical value reporting at a large academic medical center显示文摘 | Dighe AS Ran A Coakley AB | 2006 | Am J Clin Pathol2006，125，5： | 1 |
| 15 | Analysis of labo- ratory critical value reporting at a large academic medical center显示文摘 | Dighe A S Rao A Coakley A B | 2006 | Am J Clin Pathol2006，125，5： | 1 |
| 16 | Hyperexpression of bio-logically active human chorionic gonado-tropin usingthe methylotropic yeast,Pichia pastoris显示文摘 | SEN GUPTA C DIGHE R R | 1999 | Mol Endo-crinol1999，22，： | 1 |
| 17 | Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice显示文摘 | Shankaran V Dighe AS | 1998 | Pro Natl Acad Sci USA1998，95，13： | 1 |
| 18 | Biological activity of sin-gle chain chorionic gonadotropin,hCGαβ,is decreasedupon deletion of Wve carboxyl terminal amino acids ofthe alpha subunit without a fecting its receptor binding显示文摘 | SEN GUPTA C DIGHE R R | 2000 | Mol Endocrinol2000，24，： | 1 |
| 19 | Aanlysis of transmit-receive diversity in rayleigh fading显示文摘 | DIGHE P MALLIK R JAMUAR S | 2003 | IEEE Trans on Communications2003，51，4： | 1 |
| 20 | Epidermal growth factor receptor(EGFR) and the estrogen receptor modulator amplisied in breast cancer(AIB1) for predicting clinical outcome after adjuvant tamoxifen in breast cancer显示文摘 | Dighe L Bendahi PO Grabau D | 2008 | Breast Cancer Res Treat2008，109，2： | 1 |
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