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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Functional studies of mesenchymal stem cells derived from adult human adipose tissue显示文摘 | Andrea Dicker Katarina Le Blanc Gaby ?str?m Vanessa van Harmelen Cecilia G?therstr?m Lennart Blomqvist Peter Arner Mikael Rydén | 2005 | Experimental Cell Research2005，，2： | 2 |
| 3 | Are temporary inferior vena cava filters really temporary显示文摘 | Kirilcuk NN Herget EJ Dicker RA | 2005 | Am J Surg2005，190，6： | 1 |
| 4 | Targeting angiogenic processes by combination rofecoxib and ionizing radiation显示文摘 | Dicker AP Williams TL Grant DS | 2001 | Am J Clin Oncol2001，24，： | 1 |
| 5 | Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction显示文摘 | Peng J Dicker B Du W | 2007 | J Autoimmun2007，28，4： | 1 |
| 6 | Menstrual characteristics of women suffering from insulin-dependent diabetes mellitus显示文摘 | Yeshaya A Orvieto R Dicker D | 1995 | Int J Fertil Menopausal Stud1995，40，5： | 1 |
| 7 | Gold nanorod assisted near-infrared plasmonie photothermal therapy (PPTT) of squamous cell carcinoma in mice显示文摘 | Dicker'son EB Dreaden EC Huang X | 2008 | Cancer Lett2008，269，1： | 1 |
| 8 | Ricin poisoning显示文摘 | Bradberry SM Dickers KJ Rice P | 2003 | Toxicol Rev2003，22，1： | 1 |
| 9 | Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes显示文摘 | van Harmelen V Dicker A Ryden M | 2002 | Diabetes2002，51，7： | 1 |
| 10 | Hyperspectral ima- ging= a non-invasive method of imaging melanoma lesions in a patient with stage IV melanoma, being treated with a RAF inhibitor显示文摘 | Dicker DT Kahn N Flaherty KT | 2011 | Cancer BiolTher2011，12，4： | 1 |
| 11 | Functional studies of mesenchymal stem cells derived from adult human adipose tissue 显示文摘 | Dicker A Le Blanc K Astrom G | 2005 | Exp Cell Res2005，308，2： | 1 |
| 12 | Work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome:a comparison between volume and pres- sure-regulated breathing modes 显示文摘 | Kallet RH Campbell AR Dicker RA | 2005 | Respir Care2005，50，12： | 1 |
| 13 | Differential radiation sensitization of human cervical cancer cell lines by the proteasome inhibitor velcade(bortezomib,PS-341)显示文摘 | Kamer S Ren Q Dicker AP | 2009 | Arch Gynecol Obstet2009，279，1： | 1 |
| 14 | Differential radiation sensitization of human cervical cancer cell lines by the proteasome inhibitor velcade (bortezomib,PS-341)显示文摘 | Kamer S Ren Q Dicker AP | 2009 | Arch Gynecol Obstet2009，279，1： | 1 |
| 15 | A polymorphismin ACE2 is associated with a lower risk for fatal cardiovascularevents in females: The MORGAM project 显示文摘 | Vangjeli C Dicker P Tregouet DA | 2011 | J ReninAngiotensin Aldosterone Syst2011，12，4： | 1 |
| 16 | Effects of a high- fat- sucrose diet on enzyme in homocysteine metabolism in the rat 显示文摘 | Fonseca V Dicker - Brown A Ranganathan S | 2000 | Metabolism2000，49，6： | 1 |
| 17 | Work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome:a comparison between volume and pressure- regulated breathing modes显示文摘 | Kallet RH Campbell AR Dicker RA | 2005 | Respir Care2005，50，12： | 1 |
| 18 | Relationship between varicocecle size and response to varicocelectomy 显示文摘 | STECKEL J DICKER A P GOLDSTEIN M | 1993 | J Urol1993，149，4： | 1 |
| 19 | Microsugical Inguinal Varicocelectomy with Delivery of the Testis: an artery and lymphatic sparing technigue 显示文摘 | Goldstein M Gibert BR Dicker AP | 1992 | J Urol1992，148，6： | 1 |
| 20 | Green compo- sites: A review of material attributes and complementary applications 显示文摘 | Dicker M P Duckworth P F Baker A B | 2014 | Composites Part A: Appl Sci Manuf2014，56，： | 1 |
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