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| 1 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 2 | Analyse tridimensionnelle en différences finies de l'interaction entre une structure en béton et le creusement d'un tunnelàfaible profondeur:3D-finite difference analysis of the interaction between concrete building and shallow tunnelling显示文摘 | Jenck O Dias D | 2004 | Geotechnique2004，54，8： | 1 |
| 3 | A pericyte ori- gin of spinal cord scar tissue显示文摘 | GORITZ C DIAS D O TOMILIN N | 2011 | Science2011，333，： | 1 |
| 4 | Two-dimensional Physical and Numerical Modeling of a Pile-supported Earth Platform Over Soft Soil显示文摘 | Jenck O Dias D Kastner R | 2007 | Journal of Geotechnical and Geoenvironmental Engineering2007，33，3： | 1 |
| 5 | Three-dimensional numerical modeling of a piled Embankment 显示文摘 | Jenck O Dias D Kastner R | 2009 | International Journal of Geomechanics2009，9，3： | 1 |
| 6 | Two-dimensional physical and numerical modeling of a pile-supported earth platform over soft soil显示文摘 | JENCK O DIAS D KASTNER R | 2007 | Journal of Geotechnical and Geoenvironmental Engineering2007，133，3： | 1 |
| 7 | SOft ground improvement by vertical rigid piles two-dimensional physical modelling and comparison with current design methods 显示文摘 | Jenck O Dias D Kastner R | 2005 | Soils and Foundations2005，45，6： | 1 |
| 8 | Two-dimensional physical and numerical modeling of a pile-supported earth platform over soft soil 显示文摘 | Jenck O Dias D Kastner R | 2007 | Journal of Geotechnical and Geoenvironmental Engineering2007，133，3： | 1 |
| 9 | Discrete element modelling of a granular platform supported by piles in soft soil-validation on a small scale model test and comparison to a numerical analysis in a continuum显示文摘 | JENCK O DIAS D KASTNER R | 2009 | Computers and Geotechnics2009，36，6： | 1 |
| 10 | Discrete element modeling of a granular platform supported by piles in soft soil-Validation on a small scale model test and comparison to a numerical analysis in a continuum显示文摘 | Jenck O Dias D Kastner R | 2009 | Computers and Geotechnics2009，36，： | 1 |
| 11 | Improved operational stability of peroxidases by coimmo-bilization with glucose oxidase显示文摘 | van de Velde Fred Nl'dia D Lourenc o Martin Bakker | 2000 | Biotechn Bioeng2000，69，3： | 1 |
| 12 | Malignant carotid body tumor:A case report显示文摘 | Dias Da Silva A O'Donnell S Gillespie D etal | 2000 | J Vasc Surg2000，32，4： | 1 |
| 13 | 3D-Finite Difference Analysis of the Interaction Between Concrete Building and Shallow Tunneling显示文摘 | JENCK O DIAS D | 2004 | Geotechnique2004，54，8： | 1 |
| 14 | 3D-finite difference analysis of the interac- tion between concrete building and shallow tunneling 显示文摘 | Jenck O Dias D | 2004 | Geotechnique2004，54，8： | 1 |
| 15 | Monitoring of Activated Sludge Settling Ability Through Image Analysis: Validation on Full-Scale Wastewater Treatment Plants显示文摘 | Mesquita D P Dias O Amaral A L | 2009 | Bioprocess and Biosystems Engineering2009，32，3： | 1 |
| 16 | Biodegradable films based on rice starch and rice flour显示文摘 | DIAS A B MOLLER C M O LAROTONDA F D S | 2010 | Journal of Cereal Science2010，51，： | 1 |
| 17 | Mechanical and barrier properties of composite films based on rice flour and cellulose fibers显示文摘 | Dias A B M QIler C M O Larotonda F D S | 2011 | LWT-Food Science and Technology2011，44，2： | 1 |
| 18 | Malignant carotid body tumor:a case repor t显示文摘 | O'Donnell S Gillespie D | 2000 | J Vasc Surg2000，32，： | 1 |
| 19 | Two-dimensional physical and numerical modeling of a pile-supported earth plat- form over soft soil 显示文摘 | Jenck O Dias D Kastner R | 2007 | Journal of Geotechnical and Geoenvironmental Engineering2007，133，3： | 1 |
| 20 | 3D-finite difference analysis of the interaction between concrete building and shallow tunneling 显示文摘 | Jenck O Dias D | 2004 | Geotechnique2004，54，8： | 1 |
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