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| 1 | 非线性准则下三维加筋边坡稳定性的上限分析显示文摘为了研究非线性摩尔-库仑破坏准则下的三维加筋边坡在均匀加筋和三角形加筋2种加筋模式下的稳定性,采用极限分析上限理论,构建加筋边坡破坏的三维破坏机构,推导不同加筋模式下的筋材内能耗散方程,并根据上限定理将三维加筋边坡的稳定性问题转化为显式优化问题,得到三维边坡稳定性指标的计算公式。采用MATLAB软件计算,将结果与已有研究成果进行比较,验证了所提出计算方法的正确性,并进一步讨论了非线性参数m、宽高比B/H、不同加筋模式以及不同加筋强度k0对三维边坡稳定性的影响。结果表明:稳定性系数Ns随着m的增加而非线性减小,在坡角较小(不大于60°)的情况下,m对边坡稳定性系数Ns的影响较大,边坡的非线性特性比较明显;稳定性系数Ns随着B/H的增加而减小,在B/H<5尤其B/H<2时,稳定性系数下降速率较快,B/H越接近10时稳定性系数逐渐趋于稳定;三角形加筋模式的加固效果优于均匀加筋模式,稳定系数性Ns随着加筋强度k0的增加而线性增大,但变化规律并不显著。在实际工程中,建议B/H较小时,要对加筋边坡进行三维分析以符合工程实际;坡角较小时需要考虑土体的非线性破坏特征,选取合适的非线性参数可避免不安全的设计;在工程条件允许的情况下,优先选择三角形加筋模式进行边坡加固。 | 侯超群 邓欣 孙志彬 DIAS D 许敬叔 | 2018 | 中国公路学报2018，31，2： | 13 |
| 2 | Infliximab to treat severe ulcerative colitis显示文摘A 48-year-old female with severe ulcerative colitis refractory to conventional therapy was referred to our facility for management. The patient showed extensive ulcerative colitis since the age of 20 years and had failed therapy with 5-aminosalicylic acid agents and azathioprine. The disease remained active despite treatment with steroids and cyclosporine. The clinical and endoscopic parameters were consistent with severe disease. Infectious precipitants were ruled out. Given the severity of the disease and in order to avoid a colectomy, we started the patient on infliximab therapy. A dramatic clinical and endoscopic response was observed and she remained in remission at the end of a 1-year follow-up period. We discuss findings in the literature regarding the use ofinfliximab therapy in patients with ulcerative colitis who have failed steroids and cyclosporine. | Dídia Bisamra Cury Marcelo de Souza Cury Geraldo Vinicius Hemerly Elias Sender Jankiel Mizsputen | 2009 | World Journal of Gastroenterology2009，15，14： | 6 |
| 3 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 4 | Characteristics of wave amplitude and currents in South China Sea induced by a virtual extreme tsunami显示文摘This paper investigates the potential extreme tsunami hazards of the worst case scenario of the magnitude M_w=9.30 in South China Sea(SCS)as the Manila Trench is becoming one of the most hazardous tsunami source regions.Using nonlinear shallow water equations model,the time series of surface elevation,arrival time,spatial distributions of maximum wave amplitude and velocity distribution are presented.The characteristics of wave and currents are analyzed.The numerical results indicate that most of the energy of tsunami wave distributes in central and north part of SCS.The offshore regions around SCS will be influenced significantly by the tsunami currents generated by an earthquake in the Manila subduction zone.The maximum wave amplitude near Guangdong Province,Hainan Island,and Taiwan Island exceeds 4 m and velocities at the majority of measured locations near coast exceeds 2 m/s.Nested grid with high resolution is used to study the impacts of the tsunami on Hainan Island,Taiwan Island,and Lingding Bay.The regions with high hazard risk due to strong currents are identified.Finally,a fast tsunami warning method in SCS is developed and discussed,which can provide tsunami warning information in 5 min. | 任智源 赵曦 王本龙 Frédéric Dias 刘桦 | 2017 | Journal of Hydrodynamics2017，29，3： | 5 |
| 5 | Epidemiology of upper gastrointestinal symptoms in Brazil(Epi Gastro):A population-based study according to sex and age group显示文摘AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease(GERD)and dyspepsia in South America.METHODS:A telephone survey was conducted among adult owners of land-based telephones in S?o Paulo,Brazil,using previously validated computer-assisted sampling and survey protocols.The Portugueselanguage survey included(1)sociodemographic characteristics(e.g.,weight,height,smoking)and comorbidities;(2)dietary habits;(3)presence of symptoms consistent with GERD or dyspepsia within the prior 3mo;and(4)use of medications and other therapies to manage symptoms.Data were stratified post-hoc into three homogeneous geographical regions of S?o Paulo according to the Social Exclusion Indices of the districts and postal codes.Survey response data from each respondent were weighted by the numbers of adults and landline telephones in each household.The analyses were weighted to account for sampling design and to be representative of the S?o Paulo population according to city census data.RESULTS:Among 4570 households contacted,an adult from 3050(66.7%)agreed to participate.The nonresponse rate was 33.3%.The mean(SE)respondent age was 42.6(16.0)years.More than half of all respondents were women(53.1%),aged 18 through 49 years(66.7%),married or cohabitating(52.5%),and/or above normal-weight standards(i.e.,35.3%overweight and 16.3%obese).A total of 26.5%of women were perimenopausal.More than 20%of respondents reported highly frequent symptoms consistent with GERD(e.g.,gastric burning sensation=20.8%)or dyspepsia(e.g.,abdominal swelling/distension=20.9%)at least once per month.Prevalences of these symptoms were significantly(approximately 1.5-to 2.0-fold)higher among women than men but did not vary significantly as a function of advancing age.For instance,14.1%of women reported that they experienced stomach burning(symptom of GERD)at least twice per week,compared to 8.4%of men(P=0.012 byχ2 test).A total of 15.7%of women reported that they experienced abdominal swelling(symptom of dyspepsia)at least twice per week,compared to 6.4%of men(P<0.001byχ2 test).Despite frequent manifestations of GERD or dyspepsia,most(≥90%)respondents reported that they neither received prescription medications fromphysicians,nor took behavioral measures(e.g.,dietary modifications),to manage symptoms.CONCLUSION:Symptoms consistent with dyspepsia and GERD are prevalent in Brazil and represent major public-health and clinical challenges. | Maria do Rosário Dias de Oliveira Latorre Aline Medeiros da Silva Décio Chinzon Jaime N Eisig Telma RP Dias-Bastos | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 6 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 7 | A parallel sort merge JOIN algorithm for managing data skew显示文摘 | Wolf J L Dias D M Yu P S | 1993 | IEEE Transactions Parallel and Distributed Systems1993，4，1： | 2 |
| 8 | Inorganic ceramic/polymer ferroe lectric composite electrets 显示文摘 | DIAS C J DAS-Gupta D K | 1996 | IEEE Trans Dielectr Electr Insul1996，3，5： | 1 |
| 9 | Solution conformation of brazzein by 1H nuclear magnetic resonance:resonance assignent and secondary structure 显示文摘 | Dia J X Ming D | 1999 | International Journal of Biological Macromolecules1999，24，： | 1 |
| 10 | ATR-FTIR: studies of poly ( propylene oxide)/polybutadiene hi-soft segment urethane/urea membranes 显示文摘 | Queiroz D P De Pinho M N Dias C | 2003 | Macromolecules2003，36，11： | 1 |
| 11 | CamilalCarotid intima-media thickness is associated with cognitivedeficiency in hypertensive patients with elevated central systolicblood pressure 显示文摘 | Dias Eda M Giollo L T Jr Martinelli D D | 2012 | Cardiovascular Ultrasound2012，10，1： | 1 |
| 12 | Cytotoxic flavone analogues of vitexicarpiu, a constituent of the leaves of Vitex negundo 显示文摘 | Dia F Chavez D Lee D | 2003 | J Nat Prod2003，66，6： | 1 |
| 13 | Fracture toughness of geopolymetric concretes reinforced with basalt fibers显示文摘 | Dias D P Thaumaturgo C | 2005 | Cement and Concrete Composites2005，27，： | 1 |
| 14 | Impaired recruitment of bone marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth 显示文摘 | Lyden D Hattori K Dias S | 2001 | Nat Med2001，7，11： | 1 |
| 15 | The effect of stirring and seeding on the AcPheLeuNH2 synthesis and crystallization in a reversed micellar system显示文摘 | FELICIANO A S DIAS A I PRAZERES D M F | 2000 | Enzy & Microb Tech2000，27，： | 1 |
| 16 | Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth显示文摘 | LYDEN D HATTORI K DIAS S | 2001 | Nat Med2001，7，11： | 1 |
| 17 | Ultrasound-guided retrograde intubation显示文摘 | Vieira D Lages N Dias J | 2013 | Anaesthesia2013，68，10： | 1 |
| 18 | Properties of Ni/YSZ porous cermets for SOFC by tape casting and coat-mix process 显示文摘 | SIMWONIS D THULEN H DIAS F J | 1999 | J Mater Proc Tech1999，92，93： | 1 |
| 19 | The effectiveness of a home care program for supporting caregivers of persons with dementia in developing countries: a randomised controlled tri- al from Goa, India显示文摘 | Dias A Dewey ME D Souza J | 2008 | Plos ONE2008，3，6： | 1 |
| 20 | Probabilistic analysis of pressurized tunnels against face stability using collocation-based stochastic response surface method显示文摘 | MoUon G Dias D Soubra A H | 2011 | Journal of Geotechnical & Geoenvironmental Engineering2011，137，4： | 1 |
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