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| 1 | Bitter melon: a panacea for inflammation and cancer显示文摘Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. Momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the Caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds(Kuguacin J, Karaviloside XI, Kuguaglycoside C, Momordicoside Q-U, Charantin, α-eleostearic acid) and proteins(α-Momorcharin, RNase MC2, MAP30) possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents. | Prasad R. Dandawate Dharmalingam Subramaniam Subhash B. Padhye Shrikant Anant | 2016 | Chinese Journal of Natural Medicines2016，14，2： | 14 |
| 2 | FTIR Spectroscopic Studies on Molecular Interaction between Alcohols and N,N-dimethylacetamide显示文摘The association between alcohols and N,N-dimethylacetamide in carbon tetrachloride was investigated using FTIR spectroscopy at 298 K.The formation constants for 1∶1 and 1∶2 complexes were calculated using the method of Whetsel and Kagarise.The observed 1∶1 complex values were also verified using the method of Nash.The rate of change in C=O bond moment on complexing with alcohols increased with increasing acidity of alcohols.The formation constant and values of free energy change increased with the increase in carbon chain length of alcohols,which suggested that the degree of complex formation varied with the length of the carbon chain of alcohols. | SIVAGURUNATHAN P RAMACHANDRAN K DHARMALINGAM K | 2007 | 物理化学学报2007，23，3： | 2 |
| 3 | Solvent effects on hydrogen bonding between primary alcohols and esters显示文摘The interaction by hydrogen bond formation of some primary alcohols (1-heptanol, 1-octanol and 1-decanol) with esters (methyl methacrylate, ethyl methacrylate and butyl methacrylate) was investigated in non-polar solvents viz., n-heptane, CCl4 and benzene by means of FTIR spectroscopy. Formation constants and free energy changes of complex formation were determined. The dependence of the equilibrium constants and free energy changes of complex formation on the alkyl chain length of both the alcohols and esters are discussed. The solvent effect on the hydrogen bond formation is discussed in terms of specific interaction between the solute and solvent. | DHARMALINGAM K. RAMACHANDRAN K. SIVAGURUNATHAN P. | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，11： | 2 |
| 4 | Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium显示文摘 | Karthikeyan RS Leal SM Jr Prajna NV Dharmalingam K Geiser DM Pearlman E Lalitha P | | 0，，06： | 1 |
| 5 | Survey on matemal satisfaction in receiving spinal anaesthesia for caesarean section显示文摘 | Dharmalingam TK Ahmad Zainuddin NA | | 0，，03： | 1 |
| 6 | Liraglutide:A review of its therapeutie use as a once daily GLP-1analog for the management of type 2 diabetes mellitus显示文摘 | Dharmalingam M Sriam U Baruah MP | 2011 | Indian J Endocrinol Metab2011，15，1： | 1 |
| 7 | Impact of patch size on woody tree species richness and abundance in a tropical montane evergreen forest patches of south India显示文摘We examined the effects of forest patch size on woody tree species richness and abundance in tropical montane evergreen forest patches of the Nilgiri region,south India. We sampled woody trees(>1 cm dbh) from 21 forest patches in the upper Nilgiri hills(> 2000 m elevation) and recorded a total of 35,146 individuals of 61 species, 45 genera and 30 families. Species richness and abundance of sapling/shrubs(≥ 1 to < 10 cm dbh)increased significantly with increasing patch size, but the species richness and abundance of small, medium and larger trees(≥ 10 to < 30, ≥ 30 to < 60 and ≥ 60 cm dbh,respectively) did not. Overall, forest interior species richness and abundance increased significantly with increasing patch size but edge species richness did not. Species richness and abundance of shade-tolerant and shade-demanding tree species also increased with increasing patch size. The abundance of zoochory dispersed tree species was significantly related to increasing patch size, but those dispersed by autochory did not display any clear relationship between patch size and species richness or abundance.Our findings suggest that with increasing forest patch area,tree compositional patterns may be driven by species specific shade-tolerance adaptations and dispersal patterns.Differential responses in these traits by the plant community within the individual habitat zones of forest edge and interiors likely plays a major role in determining the inherent plant community and thus the subsequent ecological processes of forest patches, including their responses to increasing patch area. | Dharmalingam Mohandass Mason J.Campbell Priya Davidar | 2018 | Journal of Forestry Research2018，29，6： | 1 |
| 8 | Liraglutide:A review of itstherapeutic use as a once daily GLP-1 analog for management oftype 2 diabetes mellitus显示文摘 | Dharmalingam M Sriram U Baruah MP | 2011 | Indian J Endocrinol Metab2011，15，1： | 1 |
| 9 | Transparent QoS Support of Network Applications Using Netlets显示文摘 | Dharmalingam K Collier M | 2002 | Lecture Notes in Computer Science2002，2521，2002： | 1 |
| 10 | Liraglutide:A review of its therapeutic use as a once daily GLP- 1 analog for the management of type 2 diabetes mellitus显示文摘 | Dharmalingam M Sriam U Baruah MP | 2011 | Indian J Endocri- nol2011，15，1： | 1 |
| 11 | Old Age Support: Expectations and Experiences in a South Indian Village显示文摘 | A. Dharmalingam | 1994 | Population Studies1994，，1： | 1 |
| 12 | Efficacy and tolerability of GLP-1 agonists in patients with type 2 diabetes mellitus: an Indian perspective 显示文摘 | Dharmalingam M | 2014 | Ther Adv Endocrinol Metab2014，5，6： | 1 |
| 13 | Enhanced response of microbial fuel cell using sulfonated poly ether ether ketone membrane as a biochemical oxygen demand sensor显示文摘 | Ayyaru S Dharmalingam S | 2014 | Anal Chim Acta2014，818，： | 1 |
| 14 | Psychological distress and diabetes: Clinical and metabolic connections显示文摘 | Dharmalingam M | 2005 | Int J Diab Dev Ctries2005，25，： | 1 |
| 15 | Large - restriction - fragment polymorphism analysis of Myco- bacterium chelonae and Mycobacterium terrae isolates显示文摘 | VANITHA J D VENKATASUBRAMANI R DHARMALINGAM K | 2003 | Appl Envi- ron Microbio12003，69，7： | 1 |
| 16 | Liraglutide:A review of its thera- peutic use as aonce daily GLP-1 analog for the management of type 2 dia- betes mellitus显示文摘 | Dharmalingam M Sriram U Baruah IMP | 2011 | Indian J Endocrinol and Metab2011，15，1： | 1 |
| 17 | Liraglutide: a review of its therapeutic use as a once daily GLP-1 analog for the management of type 2 diabetes mellitus 显示文摘 | Dharmalingam M Sriram U Baruah MP | 2011 | Indian J Endocrinol Metab2011，15，1： | 1 |
| 18 | Liraglutide:A review of its therapeutic use as a once daily GLP-1 analog for the management of type 2 diabetes mellitus显示文摘 | DHARMALINGAM M SRIRAM U BARUAH M P | | 0，，01： | 1 |
| 19 | Liraglutide:a review of its therapeutic use as a once daily GLP-1 analog for the management of type 2 diabetes mellitus显示文摘 | Dharmalingam M Sriram U Baruah MP | 2011 | Indian J Endocrinol Metab2011，15，： | 1 |
| 20 | Liraglutide : a review of its thera- peutic use as a once daily GLP - 1 analog for the management of type 2 di- abetes mellitus 显示文摘 | Dharmalingam M Sriram U Baruah MP | 2011 | Indian J Endocrinol Metab2011，15，1： | 1 |
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