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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | On Channel or Thogo-nalization Using Space-time Block Coding with Partial Feedback显示文摘 | Klutto M J Giridhar K Devendra J | | 0，，06： | 1 |
| 3 | Depressed femoral condyle fracture显示文摘 | Devendra M Christopher C Jonathan K | 2008 | Injury Extra2008，39，： | 1 |
| 4 | Fire- and heatresistant laminating resins based on maleimido-substituted aromatic cyclotriphosphazenes显示文摘 | Devendra K George M F John A Parker | 1983 | Macromolecules1983，16，： | 1 |
| 5 | Dielectric materials for electrowetting-on-dielectric actuation 显示文摘 | HONG S D DEVENDRA K M | 2010 | Mi- crosyst Technol2010，16，3： | 1 |
| 6 | Formation of low angle boundaries in Ni-based superalloys显示文摘 | D'SOUZA N NEWELL M DEVENDRA K | 2005 | Materials Science and Engineering A-Structural Materials:Properties Microstructure and Processing2005，413，6： | 1 |
| 7 | Cellular, molecular and immunological mechanisms in the pathophysiology of vein graft intimal hyperplasia显示文摘 | AMIT K MITRA DEEPAK M GANGAHAR DEVENDRA K AG RAWAL | 2006 | Immunology and Cell Biology2006，84，2： | 1 |
| 8 | Formation of low angle boundaries in Ni-based superalloys 显示文摘 | Souza N D Newell M Devendra K | 2005 | Materials Science and Engineering A2005，412，： | 1 |
| 9 | Role of dendrite branching and growth kinetics in the formation of low angle boundaries in Ni-base superalloys 显示文摘 | Newell M Devendra K Jennings P A | 2005 | Materials Science and Engineering A2005，412，： | 1 |
| 10 | An X-Band Microwave Life-Detection System显示文摘 | Chen K M Devendra M Wang H | 1986 | IEEE Transaction on Biomedical Engineering1986，33，7： | 1 |
| 11 | Formation of low angle boundaries in Ni-based superalloys显示文摘 | Souza N D Newell M Devendra K | 2005 | Mater Sci Eng A2005，，： | 1 |
| 12 | Role of dendrite branching and growth kinetics in the formation of low angle boundaries in Ni-base superalloys显示文摘 | NEWELL M DEVENDRA K JENNINGS P A | 2005 | Materials Science and Engineering A2005，，： | 1 |
| 13 | Role of Dendrite Branching and Growth Kinetics in the Formation of Low Angle Boundaries in Ni-Base Superalloys显示文摘 | Newel| M Devendra K Jennings P A | 2005 | Materials Science and En- gineering A2005，412，： | 1 |
| 14 | Phenotypic and genotypic analysis of rice lesion mimic mutants显示文摘 | Nurul M Devendra P Hyun B Sun L Heon L Duck K Gu K | 2010 | The Plant Pathology Journal2010，26，2： | 1 |
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