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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005,11,6: | 9 |
| 2 | Should doctors perform an elective caesarean section on request? 显示文摘 | Devendra K Arulkumaran S | 2006 | Obstet Gynecol2006,108,: | 1 |
| 3 | Empirical modeling of chemoviscosity of hydroxy terminated polybutadiene based solid composite propellant slurry显示文摘 | Mahanta Abhay K Goyal Monika Pathak Devendra D | 2010 | Malaysian Polymer Journal2010,5,1: | 1 |
| 4 | On Channel or Thogo-nalization Using Space-time Block Coding with Partial Feedback显示文摘 | Klutto M J Giridhar K Devendra J | | 0,,06: | 1 |
| 5 | Laparoscopically-assisted vaginal hysterectomy(LAVH)-an alternative to abdominal hysterectomy显示文摘 | Devendra K Tay SK | 2002 | Singapore Med J2002,43,3: | 1 |
| 6 | Should doctors perform an elective caesarean section on request 显示文摘 | Devendra K Arulkumaran S | 2006 | Obstet Gynecol2006,108,: | 1 |
| 7 | Rheokinetic analysis of hydroxy terminated polybutadiene based solid propellant slurry显示文摘 | Mahanta Abhay K Goyal Monika Pathak Devendra D | 2010 | Journal of Chemistry2010,7,17: | 1 |
| 8 | DNA methylation in breast and colorectal cancer显示文摘 | Anshu Agrawal Richard F Murphy Devendra K Agrawal | 2007 | Modern Pathology2007,20,: | 1 |
| 9 | Serum procalcitomin and C-reactive protein levels as markers of bacterial infection:a systematic review and meta-analysis 显示文摘 | Liliana S France G Devendra K | 2004 | Clin Infect Dis2004,39,2: | 1 |
| 10 | B-Lynch suture for the treatment of uterine atony显示文摘 | Koh E Devendra K Tan LK | 2009 | Singapore Med J2009,50,7: | 1 |
| 11 | Lessons Learnt from two women with morbidly a herent placent as and a review of literature显示文摘 | Thia EW Tan LK Devendra K | | 0,,4: | 1 |
| 12 | Lessons learnt from two women with morbidly adherent placentas mad a review of literature 显示文摘 | Thia E W Tan L K Devendra K | 2007 | Ann Acad Med Singapore2007,36,4: | 1 |
| 13 | Naturally occurring and inducible T-regu-latory cells modulating immune response in allergic asthma显示文摘 | Halvor S Devendra K | 2009 | Am J Respir Crit Care Med2009,180,3: | 1 |
| 14 | Influence of apoptosis on neurological outcome following traumatic cerebral contusion 显示文摘 | NERENDRA N PREADEE PK DEVENDRA K | 2004 | J Neurosurg2004,101,2: | 1 |
| 15 | Recent progress in the development of nano-structured conducting poly-mers/nanocomposites for sensor applications显示文摘 | Rajesh Tarushee A Devendra K | 2009 | Sensors and Actuators B2009,136,: | 1 |
| 16 | Should doctors perform an elective caesarean section on request?显示文摘 | Devendra K Arulkumaran S | 2003 | Ann Acard MeD Singapore2003,32,5: | 1 |
| 17 | B-Lynch suture for the treatment of uterine atony显示文摘 | KOH E DEVENDRA K TAN LK | 2009 | Singapore Med J2009,50,: | 1 |
| 18 | Naturally occurring and Inducible t-regulatoot cells modulating immune response in allergic: asthma显示文摘 | Halvor S Devendra K | 2009 | Am J Respir Crit Care Med2009,180,3: | 1 |
| 19 | Depressed femoral condyle fracture显示文摘 | Devendra M Christopher C Jonathan K | 2008 | Injury Extra2008,39,: | 1 |
| 20 | Body Weight,Waist-to-Hip Ratio,Breasts,andHips:role in judgments of female attractiveness and desirability for rela-tionships显示文摘 | Devendra S Robert K | 1995 | Ethology and Sociobiology1995,16,: | 1 |