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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Leptin levels in the differential diagnosis between benign and malignant ascites显示文摘AIM: To evaluate the role of leptin levels in the differential diagnosis of ascites. METHODS: Ascitic leptin, TNFα and serum leptin levels were measured in 77 patients with ascites (35 with malignancies, 30 cirrhosis and 12 tuberculosis). Control serum samples were obtained from 20 healthy subjects. Leptin and TNFα levels were measured by ELISA. Body mass index (BMI) and percentage of body fat (BFM) by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS: In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFα levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION: In patients with malignant ascites, levels of leptin and TNFα were significantly lower than in patients with tuberculous ascites. | Mehmet Buyukberber Mehmet Koruk M Cemil Savas Murat T Gulsen Yavuz Pehlivan Rukiye Deveci Alper Sevinc Serdar Gergerlioglu | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 3 | Use of CA15-3 ,CEA and prolactin for the primary diagnosis of breast cancer and correlation with the prognostic factors at the time of initial diagnosis显示文摘 | Arslan N Serdar M Deveci S | 2000 | Ann Nucl Med2000，14，： | 1 |
| 4 | Spiral computed tomography:role in determination of chemical compositions of pure and mixed urinary stone--an in vitro study显示文摘 | Deveci S Coskun M Tekin MI | 2004 | Urology2004，64，2： | 1 |
| 5 | Effects of cerium nitrate bathing and prompt burn wound excision on IL-6 and TNF-alpha levels in bruned rats显示文摘 | ESKI M SENGEZER M | 2000 | Burns2000，26，： | 1 |
| 6 | Effect of type I tympa-noplasty on the quality of life of children显示文摘 | Habesoglu TE Habesoglu M Deveci I | | 0，，05： | 1 |
| 7 | Experimental assessment of the neo-vaseularisation of acellular dermal matrix in the wound bed pretreated with mesenchymal stem cell under subatmospheric pressure显示文摘 | Sahin I Ozturk S Deveci M | 2014 | J Plast Reconstr Aesthet Surg2014，67，1： | 1 |
| 8 | Evaluation of insulin resistance in normoglycemic patients with coronary artery disease显示文摘 | Deveci E Yesil M Akinci B | 2009 | ClinCar- diol2009，32，1： | 1 |
| 9 | Androgen depriva- tion therapy before radical prostateetomy is associated with poo- rer postoperative erectile function outcomes显示文摘 | MAZZOLA CR DEVECI S HECK M | 2012 | BJU Int2012，110，1： | 1 |
| 10 | Experimental assessment of the neo-vascularisation of acellular dermal matrix in the wound bed pretreated with mesenchymal stem cell under subatmospheric pressure显示文摘 | Sahin I Ozturk S Deveci M | 2014 | J Plast Reconstr Aesthet Surg2014，67，1： | 1 |
| 11 | A comparative analysis of biclustering algorithms for gene expression data显示文摘 | EREN K DEVECI M KUCUKTUNC O | 2013 | Briefings in Bioinfor- matics2013，14，3： | 1 |
| 12 | Spiral computed tomography:role in determination of chemical compositions of pure and mixed urinary stones-an in vitro study显示文摘 | Deveci S Cokun M Tekin MI | | 0，，： | 1 |
| 13 | Villoglandular papillary adenocarcinoma of the uterine cervix in a pregnant women: a case report and review of literature显示文摘 | Dede M Deveci G Deveci MS | 2004 | Tohoku J Exp Med2004，202，4： | 1 |
| 14 | A restrospective analysis of 101 zygomatico- orbital frtunes 显示文摘 | Eski M Sahin I Deveci M | 2006 | J Craniofac Surg2006，17，： | 1 |
| 15 | Spiral computed tomography:role in determination of chemical compositions of pure and mixed urinary stones-an in vitro study显示文摘 | Deveci S Coskun M Tekin M I | 2004 | Urology2004，64，2： | 1 |
| 16 | Villoglandular papillary adenocarcinoma of the uterine cervix in a pregnant woman : a case report and review of literature显示文摘 | Dede M Deveci G Deveci MS | 2004 | Tohoku J Exp Med2004，202，4： | 1 |
| 17 | Effects of cerium nitrate bathing and prompt bum wound excision on IL-6 and TNF-alpha levels in burned rats 显示文摘 | Deveci M Eski M Sengezer M | 2000 | Bums2000，26，1： | 1 |
| 18 | Measurement of orbital volume by a 3-dimensional software program:an experimental study显示文摘 | Deveci M Ozturk S Sengezer M | 2000 | Oral Maxillofac Surg2000，58，6： | 1 |
| 19 | The early cardiovascular changes in pediatric patients with systemic lupus erythematosus显示文摘 | Sozeri B Deveci M Dincel Nj | 2013 | Pediatr Nephrol2013，28，3： | 1 |
| 20 | Measurement of orbital volume by a 3-dimensional software program:an experimental study显示文摘 | Deveci M Ozturk S Sengezer M | 2000 | J Oral Maxillofac Surg2000，58，6： | 1 |
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