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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | Challenges in diagnosing mesenteric ischemia显示文摘Early identification of acute mesenteric ischemia (AMI) is challenging. The wide variability in clinical presentation challenges providers to make an early accurate diagnosis. Despite major diagnostic and treatment advances over the past decades, mortality remains high. Arterial embolus and superior mesenteric artery thrombosis are common causes of AMI. Non-occlusive causes are less common, but vasculitis may be important, especially in younger people. Because of the unclear clinical presentation and non-specific laboratory findings, low clinical suspicion may lead to loss of valuable time. During this diagnostic delay, progression of ischemia to transmural bowel infarction with peritonitis and septicemia may further worsen patient outcomes. Several diagnostic modalities are used to assess possible AMI. Multi-detector row computed tomographic angiography is the current gold standard. Although computed tomographic angiography leads to an accurate diagnosis in many cases, early detection is a persistent problem. Because early diagnosis is vital to commence treatment, new diagnostic strategies are needed. A non-invasive simple biochemical test would be ideal to increase clinical suspicion of AMI and would improve patient selection for radiographic evaluation. Thus, AMI could be diagnosed earlier with follow-up computed tomographic angiography or high spatial magnetic resonance imaging. Experimental in vitro and in vivo studies show promise for alpha glutathione S transferase and intestinal fatty acid binding protein as markers for AMI. Future research must confirm the clinical utility of these biochemical markers in the diagnosis of mesenteric ischemia. | Teun C van den Heijkant Bart AC Aerts Joep A Teijink Wim A Buurman Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，9： | 31 |
| 3 | NLRP3炎症小体对急性胰腺炎小鼠全身炎症反应及代偿性抗炎反应综合征的调节作用显示文摘【据《Gastroenterology》2019年10月报道】题:NLRP3炎症小体对急性胰腺炎小鼠全身炎症反应及代偿性抗炎反应综合征的调节作用(作者Sendler M等)胰腺炎开始时主要是无菌的局部炎症,其引起全身性炎症反应综合征(SIRS),然后是代偿性抗炎反应综合征(CARS)。来自德国格赖夫斯瓦尔德大学的Sendler等通过研究探讨了小鼠和人类血清中该过程的机制。 | 李德钊 郭晓林 SENDLER M van den BRANDT C GLAUBITZ J | 2020 | 临床肝胆病杂志2020，36，3： | 24 |
| 4 | 神经网络补偿机床热变形误差的机器学习技术显示文摘研究了以神经网络(NN)为模型的软件补偿不同机床热误差。提出知识获取是神经网络建模的关键环节。两种数控机床被用来研究分析热变形,通过测量实验获取学习数据,特别是温度测量和传感器数目的选取。介绍了机器学习技术和学习数据组织方法,包括归纳学习和推理学习。给出了预报补偿的结果和精度评价。 | 杨庆东 Van Den Bergh C Venherck P KruthJP | 2000 | 机械工程学报2000，36，1： | 15 |
| 5 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 6 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 7 | Growth hormone modulation of the rat hepatic bile transporter system in endotoxin-induced cholestasis显示文摘 | Mesotten D Van den Berghe G Liddle C | 2003 | Endocrinology2003，144，9： | 2 |
| 8 | Can deterministic chaos create order in fluidized bed scale up 显示文摘 | van den Bleek C M Schouten J C | 1993 | Chem Eng Sci1993，48，13： | 2 |
| 9 | Argon plasma coagulation in flexible gastrointestinal endoscopy: pilot experiences 显示文摘 | Wahab PJ Mulder C J Den Hattog G | 1997 | Endoscopy1997，29，3： | 2 |
| 10 | Stability of oriented Silicalite-1 films in view of zeolite membrane preparation 显示文摘 | Den Exter M J Van Bekkum H Rijn C J M | 1997 | Zeolites1997，19，： | 1 |
| 11 | Orthogonal polarization spectral imaging of the microcirculation during acute hypervolemic hemodilution and epidural lidocaine injection显示文摘 | Van den Oever HLA Dzoljic M Inee C | 2006 | Anesth Analg2006，103，2： | 1 |
| 12 | Modeling of intelligent pressure sensor using functional link artificial neural networks 显示文摘 | Patra J C Bos A Van Den | 2000 | ISA Transactions2000，，9： | 1 |
| 13 | Medical Innovation Revisited:Social Contagion Versus Marketing Effort显示文摘 | LILIEN G | 2001 | American Journal of Sociology2001，106，5： | 1 |
| 14 | eal-time PCR assay for the identification of Thrips palmi显示文摘 | KOX L F F van den BELD H E ZIJLSTRA C | 2005 | Bulletin OEPP/EPPO Bulletin2005，35，： | 1 |
| 15 | Postprandial blood hormone and metabolite concentrations influenced by feeding frequency and feeding level in veal calves显示文摘 | VICARI T VAN DEN BORNE J J G C GERRITS W J J | 2008 | Domestic Animal Endocrinology2008，34，： | 1 |
| 16 | Orthogonal polarization spectral imaging of the microcirculation during acute hypervolemic hemodilution and epidural lidocaine injection显示文摘 | Van den Oever HLA Dzoljic M Ince C | 2006 | Anesth Analg2006，2，： | 1 |
| 17 | Development of a combined new mechanical and enzymatic method for the isolation of intact preantral follicles from fetal calf and adult bovine ovaries 显示文摘 | FIGUEIREDO J R HULSHOF S C J VAN DEN HURK R | 1993 | Theriogenology1993，40，： | 1 |
| 18 | Randomized study to compare balloon angioplasty and elective stent implantation in venous bypass grafts: the venestent study 显示文摘 | Hanekamp C E E Jacques J K den Heijer P | 2003 | Catheter Cardiovasc Interv2003，60，： | 1 |
| 19 | Experimental evidence for water weakening of quartzite by microcracldng plus solution-precipitation creep显示文摘 | Den Brok S W J Spiers C J | 1991 | Journal of Geologlcal Society1991，148，3： | 1 |
| 20 | Leading edge vortices in insect flight显示文摘 | Ellington C P van den Berg C Willmott A P | 1996 | Nature1996，347，： | 1 |
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