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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Decline of semen quality during IVF is not associated with subjective male stress显示文摘如果精液质量衰退在期间,现在的学习的目的是估计在 vitro 授精(IVF ) 并且这现象是否被长期的男应力触发。以便测试这个假设,我们首先调查了 155 个男 IVF 病人(严峻的队) 的一个回顾的队。随后,我们在经历他们的第一 IVF 的人开始了未来的队研究并且用一个验证工具估计了精液质量和主观男长期的应力,即富饶问题库存(FPI ) 问询表。在应力和精子质量衰落之间的协会在 IVF (T1 ) 的开始前是 4-6 星期,在卵母细胞的日子,检索(T2 ) 是主要结果。实时出生率,第一三个月流产和差的应答者的率是第二等的结果。在严峻的队,吝啬的进步活动性,然而并非吝啬的精子密度显著地衰退了。有 78/154 (51%) 人和在进步活动性显示出衰落的 50/154 (32%) 人,在精液密度看了衰落。在确认队,进步活动性衰退了,而,从 T1 增加到 T2 的精子密度。78 个人, 27 个人增加了应力(FPI 分数 >146 ) 。精子密度和进步活动性不在有或没有应力的人是显著地不同的。面对男应力,然而,夫妇们有差的应答者,流产和实时出生的更低的率的更高的率。主观应力没在在 IVF 期间观察的精液质量与衰落被联系,但是可以与不利怀孕结果被联系。 | Kazem Nouri Brigitte Litschauer Michael Sator Denise Tiringer Johannes Ott Katherina Walch Lukas A Hefler Clemens B Tempfer | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 4 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 5 | CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges显示文摘 | Philipp Grosse‐Gehling Christine A Fargeas Claudia Dittfeld Yvette Garbe Malcolm R Alison Denis Corbeil Leoni A Kunz‐Schughart | 2012 | J. Pathol2012，，3： | 2 |
| 6 | Predicting wood decay in Eucalypts using an expert system and the IMLResistograph drill显示文摘 | Denise M J Peter K A Gregory M M | 2007 | Arboriculture & Urban Forestry2007，32，2： | 1 |
| 7 | Wood-polymer composite: Physi- cal and mechanical properties of some wood species impregnated with styrene and methyl methacrylate 显示文摘 | Denise O S Francisco A R L | 2004 | Materials Research2004，7，4： | 1 |
| 8 | ADSA FOUNDATION SYMPOSIUM:Feed and animal factors influencing milk fat composition显示文摘 | Palmquist DL Denise Beanlieu A Barbano DM | 1993 | J Dairy Sci1993，76，： | 1 |
| 9 | Toward a the of organization culture and effectiveness显示文摘 | Denision D R Mishra A K | | 0，，： | 1 |
| 10 | Scrutinizing the relationship between shyness and social phobia显示文摘 | Denise A Chavira Murray B Stein Vanessa L Malcarne | 2002 | Journal of Anxiety Disorders2002，，6： | 1 |
| 11 | Severe 2009 H1N1 Influenza in Pregnant and Postpartum Women in California显示文摘 | Janice KL Meileen A Denise JJ | 2010 | N Engl J Med2010，362，： | 1 |
| 12 | Copolymerization and degradation of poly (lactic acidco-lysine) 显示文摘 | Denise A Barrera Eric Zylstra Peter T Lansbury | 1995 | Macromolecules1995，28，2： | 1 |
| 13 | Gallbladder emptying in normal volunteers com- parative study between cholescintigraphy and ultasonography 显示文摘 | Carlos A Buchpiguel Marcelo T Sapien-Za Denise P Vez- zozzo | 1996 | Clinical Nuclear Medicine1996，21，： | 1 |
| 14 | Canine Population Data Generated fi:om a Multiplex STR Kit for Use in Forensic Casework 显示文摘 | Kanthaswamy S Ttom BK Mattila A-M Johnston E Dayton M Kinaga J Erickson B J-A Halverson J Fantin D Denise S Kou A Malladi V Satkoski J Budowle B Smith DG Koskinen MT | 2009 | Journal of Forensic Sciences2009，54，4： | 1 |
| 15 | Comparative bioleaching and mineralogy of eomposited sulfide ores contai- ning enargite, covellite and ehaleoeite by mesophilic and thermophilic microorganisms 显示文摘 | JAEHEON L SEVKET A DENISE L D | 2011 | Hydrometallurgy2011，105，34： | 1 |
| 16 | Neuroanatomic correlates of the post-stroke aphasias studiedwith cerebral blood flow SPECT scan- ning显示文摘 | Krzysztof J Dariusz G Denise A | 2003 | Med Sci Monit2003，9，： | 1 |
| 17 | Rare events and conditional events on random strings显示文摘 | REGNIER M DENISE A | 2004 | Discrete Mathematics & Theoretical Computer Science2004，6，： | 1 |
| 18 | Methodologyfor zinc phosphate pigment incorporation into polypyrrole matrix 显示文摘 | DENISE M LENZ MICHEL DELAMAR CARLOS A FERREIRA | 2005 | Journal of Applied Electrochemistry2005，，35： | 1 |
| 19 | Leverage and investment in diversified firms显示文摘 | Seoungpil A Denis D J Diane K D | | 0，，： | 1 |
| 20 | Corrosion Behaviour of Iron and AISI 304 Stainless Steel in Tungstate Aque-ous Solutions Containing Chloride显示文摘 | Denise S Azambuja Emilse M A Martini Iduvirges L Müller | 2003 | Journal of Brazilian Chemical Society2003，14，4： | 1 |
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