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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
| 3 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
| 4 | Metal influence on metallothionein synthesis in the hydrothermal vent mussel Ba thymodiolus thermophilus 显示文摘 | Hardivillier Y Denis F Demattei M V | 2006 | Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology2006，143，3： | 1 |
| 5 | The SiC technology is ready for the next generation of extremely large telescopes 显示文摘 | BOUGOIN M DENY P | 2004 | Proc SPIE2004，，5494： | 1 |
| 6 | Gertain aspects of molecular endocrinology that relate to the influence of dietary factors on the pathogeneses of prostate cancer显示文摘 | Griffitha K Morton M S Denis L | 1999 | Eur Urol1999，35，： | 1 |
| 7 | Effectiveness of continuous passive motion and conventional physical therapy after total knee arthroplasty: a randomized clinical trial 显示文摘 | Denis M Moffet H Caron F | 2006 | Phys Ther2006，86，2： | 1 |
| 8 | Spatial bandwidth extended reconstruction for digital color Fresnel holograms显示文摘 | PASCAL P PATRICE T DENIS M | | 0，，11： | 1 |
| 9 | Silicon carbide components for optics: Present and near future Capabilities显示文摘 | Deny P Bougoin M | 2005 | Proceedings of SPIE2005，5868，58： | 1 |
| 10 | The effect of incentive policies on the practice location of doctors: a multinomial Probit analysis 显示文摘 | Denis B Fortin B Fournier M | 1996 | J Labor Economics1996，14，4： | 1 |
| 11 | An application of multivariate simulation in the cement industry显示文摘 | Denis M Keyvan M Claude B | 2005 | Mathematical Geology2005，37，5： | 1 |
| 12 | Implicit learning deficitin children with developmental dyslexia显示文摘 | Stefano V Luigi M Deny M | 2003 | N europsychologia2003，，41： | 1 |
| 13 | SMART-1: ananalysis of flight data 显示文摘 | DI CARA Davina M ESTUBLIER Denis | 2004 | Acta Astronautica2004，57，2： | 1 |
| 14 | Wavelet transform domain filters:a spatially selective noise filtration technique 显示文摘 | Xu Y S John B W Denis M H | 1994 | Trans on Image Processing1994，3，6： | 1 |
| 15 | Cellular physiology of cholesterol efflux in vascular endothelial cells 显示文摘 | O'Connell B J Denis M Genest J | 2004 | Circulation2004，110，18： | 1 |
| 16 | Molecular characterization of integrons in Acinetobacter baumannii:description of a hybrid class 2 integron显示文摘 | Poly M C Denis F Courvalin P | 2000 | Antimicrobial Agents and Chemotherapy2000，44，10： | 1 |
| 17 | Improvement of the high energy ball-milling preparation procedure of CO tolerant Pt and Ru containing catalyst for polymer fuel cells显示文摘 | DENIS M C GOUEREC P GUAY D | 2000 | J Appl Electrochem2000，30，： | 1 |
| 18 | Absolute radiometric calibration of the RapidEye multispectral imager using the reflectance-based vicarious calibration method显示文摘 | DENIS N ANDREAS B JEFF C M | | 0，，： | 1 |
| 19 | Spatial discourse and navigation:An analysis of route directions in the city of Venice显示文摘 | DENIS M PAZZAGLIA F CORNOLDI C | 1999 | Applied Cognitive Psychology1999，13，2： | 1 |
| 20 | 显示文摘 | Harvey S N Denis C W Clifford M K | 1996 | Proc SPIE1996，2842，： | 1 |
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